2D MOF@Fe₃O₄@rGO as magnetic solid-phase extraction and supercritical fluids chromatography-tandem mass spectrometry quantification of strigolactones stereoisomers in rice (Oryza sativa L.).

Strigolactones (SLs) are novel plant hormones that play crucial roles in regulating plant growth and development. The stereoisomers of SLs often exhibit distinct biological activities, making their chiral separation and analysis essential for understanding their regulatory roles in plant branching. This study focused on the chiral separation and characterization of SL stereoisomers, including GR24 (synthetic) and strigol (natural).

Nanoscale Rhodium(I) Based Metal-Organic Framework Demonstrating Intense NIR-II Luminescence for Bioimaging.

Although luminescent metal-organic frameworks (MOFs) have been widely reported, rare examples were found to emit in the second near-infrared (NIR-II, 1000-1700 nm) window. In this work, two nanoscale rhodium(I)-based MOFs ( and ) have been controllably constructed in the aqueous dispersions of sodium dodecyl sulfate (SDS) and 1,2-distearoyl--glycero-3-phosphoethanolamine--methoxy-poly(ethylene glycol) (DSPE-PEG), wherein micelle- and vesicle-like aggregates form, respectively, with high colloidal stability. The vesicular dispersion of exhibits intense NIR-II luminescence at 1125 (1245, shoulder) nm.

The relationship between ecosystem functions and air pollutants based on spatial distribution patterns of forest and grassland: A case study of the Mongolian Plateau.

Revealing how spatial distribution patterns of forest and grassland affect ecosystem functions (EF) and hence control air pollutant (AP) concentrations is a key precondition for the development of ecological spatial layouts. However, there are not enough large-scale studies analyzing this interaction. Firstly, this study is based on the topological properties of forest and grass spatial distribution patterns to establish the relationship between EF and AP.

A retrospective study of the Dual-channels Bolus Contrast Injection (Dc-BCI) technique during endovascular mechanical thrombectomy in the management of acute ischemic stroke due to large-vessel occlusion: a technical report.

Endovascular mechanical thrombectomy (EMT) is an effective treatment for acute ischemic stroke and identifying the precise thrombus size remains key to a successful EMT. However, no imaging modality has been able to provide this information simultaneously and efficiently in an emergency setting. The present study introduces a novel technique named dual-channel bolus contrast injection (Dc-BCI) for determining thrombus size and location during EMT.

Poor Sleep Quality Worsens Static and Dynamic Balance Control in Individuals With Chronic Low Back Pain: A Cross-Sectional Study.

To investigate the influence of sleep quality and associated factors on balance control in individuals with chronic low back pain (CLBP). 85 participants (mean age 33.2 ± 12.

Association of early versus late tracheostomy with prognosis in hypoxic-ischaemic encephalopathy patients: A propensity-matched cohort study.

Background: The optimal timing for exchanging an endotracheal tube for a tracheostomy cannula in patients with hypoxic-ischaemic encephalopathy is controversial.

Aim: This study aimed to evaluate the effects of early versus late tracheostomy on the prognosis of patients with hypoxic-ischaemic encephalopathy.

Study Design: The study was an observational retrospective study that followed the Strengthening the Reporting of Observational Studies in Epidemiology guidelines.

Electrochemical 1,2-Alkylarylation of Styrenes with Malonates and -Heteroarenes via Direct C(sp)-H/C(sp)-H Functionalization.

A general and atom-economical electrochemical dehydrogenative method for the intermolecular 1,2-alkylarylation of styrenes with malonates and nucleophilic -heteroarenes (including indoles and pyrroles) has been developed. This transformation provides a regioselective route to construct highly valuable 1,1-diarylalkanes enabled by C(sp)-H/C(sp)-H functionalization under mild conditions, and H is the only theoretical byproduct. Mechanistic studies indicated that the reaction proceeded through the oxidative of the C(sp)-H bond to generate alkyl radical, radical addition across the C═C bond, single electron oxidation and C(sp)-H functionalization cascades.

Improving reliability of movement assessment in Parkinson's disease using computer vision-based automated severity estimation.

Background: Clinical assessments of motor symptoms rely on observations and subjective judgments against standardized scales, leading to variability due to confounders. Improving inter-rater agreement is essential for effective disease management.

Objective: We developed an objective rating system for Parkinson's disease (PD) that integrates computer vision (CV) and machine learning to correct potential discrepancies among raters while providing the basis for model performance to gain professional acceptance.

Temporal trends and future projections of incidence rate and mortality for asthma in China: an analysis of the Global Burden of Disease Study 2021.

Background: Asthma poses a significant public health burden in China, affecting millions with substantial incidence and mortality. Understanding the trends and future projections of asthma incidence and mortality is crucial for healthcare planning.

Methods: We analyzed asthma incidence and mortality data sourced from the Global Burden of Disease (GBD) 2021 study from 1990 to 2021, calculated the age-standardized incidence and mortality rates (ASIR and ASMR) and the estimated annual percentage change (EAPC), meanwhile, employed Joinpoint regression model to assess the trends.

A frequency attention-embedded network for polyp segmentation.

Gastrointestinal polyps are observed and treated under endoscopy, so there presents significant challenges to advance endoscopy imaging segmentation of polyps. Current methodologies often falter in distinguishing complex polyp structures within diverse (mucosal) tissue environments. In this paper, we propose the Frequency Attention-Embedded Network (FAENet), a novel approach leveraging frequency-based attention mechanisms to enhance polyp segmentation accuracy significantly.

Genome-Wide Characterization of Extrachromosomal Circular DNA in the Midgut of BmCPV-Infected Silkworms and Its Potential Role in Antiviral Responses.

Extrachromosomal circular DNAs (eccDNAs) has been found to be widespread and functional in various organisms. However, comparative analyses of pre- and post-infection of virus are rarely known. Herein, we investigated the changes in expression patterns of eccDNA following infection with cytoplasmic polyhedrosis virus (BmCPV) and explore the role of eccDNA in viral infection.

A comprehensive review of the efficacy and safety of ertugliflozin.

Introduction: Ertugliflozin is the fourth sodium-glucose co-transporter (SGLT2) inhibitor approved by the US FDA in 2017 for the treatment of type 2 diabetes mellitus.

Areas Covered: The main purpose of this review is to evaluate the clinical efficacy and safety of ertugliflozin. We conducted a search of relevant literature on ertugliflozin in the PubMed and Web of Science databases up to 22 October 2024.

Anti-obesity and gut microbiota modulation effects of chondroitin sulfate on obese mice induced by high-fat diet.

Despite the extensive application of chondroitin sulfate (CS), a type of biological macromolecule, in various fields, including biomedicine, cosmetics, food, and pharmaceuticals, research into its potential anti-obesity properties remains limited. In this study, the impacts of CS on obese mice induced by a high-fat diet (HFD) were investigated. The results showed that supplementing CS effectively controlled body weight gain and fat accumulation (perirenal fat and epididymal fat) compared to the control group of obese mice.

Understanding designers' switching intention to AI painting tools using the PPM framework.

In recent years, the emergence of artificial intelligence painting tools has significantly changed the creative activities and future development of designers, but studies specifically addressing designers' inclinations to transition to AI painting tools are scarce. Therefore, to understand designers' switching intentions toward AI painting tools, this study proposed a research model based on the push-pull-mooring framework. Data were collected from 320 Chinese designers and analyzed using structural equation modeling.

Seed pretreatment with cloquintocet-mexyl protects wheat seedlings from fomesafen injury by promoting photosynthesis and decreasing oxidative stress.

Background: Fomesafen is a selective herbicide widely used to control post-emergent broad-leaf weeds in soybean and peanut fields. Because of its persistent nature in soil, it can suppress subsequent crops, including wheat. There is limited information focusing on methods of protecting wheat from fomesafen injury by soil residue.

Dichlormid protect wheat from fomesafen residual injury by increasing PPO expression and the photosynthesis characterize.

Fomesafen is a herbicide with long persistence in soil, causing damage to succeeding crops. Dichlormid is a widely used safener protecting maize from chloroacetanilide and thiocarbamate injury. We found that dichlormid treatment could restore the growth of wheat seedlings exposed to fomesafen stress.

The valuation of older adult homecare services under a joint medical-social budgetary perspective.

Background: Homecare, a cornerstone of public health, is essential for health systems to achieve the Sustainable Development Goal (SDG) of universal health coverage while maintaining its own sustainability. Notwithstanding homecare's system-level significance, there is a lack of economic evaluations of homecare services in terms of their system-wide cost-savings. Specifically, decisions informed by a joint medical-social budgetary perspective can maximize the allocative efficiency of assigning a diverse service mix to address the complex needs of the older adult population.

Differential Expression of miR-26b-5p, EGR1, and STAT1 in Peripheral Blood of Schizophrenia Patients.

Background: This study aimed to investigate miRNAs and upstream regulatory transcription factors involved in schizophrenia (SZ) pathogenesis.

Methods: Differential expression of miRNAs and genes in SZ patients was investigated utilizing the gene expression omnibus dataset, gene ontology annotations, and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis. Real-time quantitative polymerase chain reaction experiments were conducted to validate the predictive screening of regulatory genes in peripheral blood samples from 20 SZ patients and 20 healthy controls.

True-bone-ceramics / type I collagen scaffolds for repairing osteochondral defect.

In recent years, the incidence of cartilage defects has increased dramatically, and its etiology is complex and varied. Osteochondritis dissecans (OCD), as one of the main etiologies, damages both cartilage and bone tissues and can progress to severe osteoarthritis, which has been one of the difficult problems for clinicians. The vigorous development of material science and tissue engineering provides new ideas for the treatment of OCD, in which the selection of scaffold materials is particularly important.

Architecture-Agnostic Untrained Network Priors for Image Reconstruction with Frequency Regularization.

Untrained networks inspired by deep image priors have shown promising capabilities in recovering high-quality images from noisy or partial measurements . Their success is widely attributed to implicit regularization due to the spectral bias of suitable network architectures. However, the application of such network-based priors often entails superfluous architectural decisions, risks of overfitting, and lengthy optimization processes, all of which hinder their practicality.

Screening for frequent hospitalization risk among community-dwelling older adult between 2016 and 2023: machine learning-driven item selection, scoring system development, and prospective validation.

Background: Screening for frequent hospitalizations in the community can help prevent super-utilizers from growing in the inpatient population. However, the determinants of frequent hospitalizations have not been systematically examined, their operational definitions have been inconsistent, and screening among community members lacks tools. Nor do we know if what determined frequent hospitalizations before COVID-19 continued to be the determinant of frequent hospitalizations at the height of the pandemic.

Trichilemmal carcinoma treated by excision combined with photodynamic therapy: a case report and review of literature.

Trichilemmal carcinoma is an extremely rare malignant cutaneous tumor derived from the outer root sheath of the hair follicles, which most commonly occurs in the sun-exposed areas of elderly individuals. This article introduces a case of trichilemmal carcinoma that occurred on the scalp of a 36-year-old male patient, the first case reported and treated with surgical excision combined with photodynamic therapy.

Hsp90α promotes lipogenesis by stabilizing FASN and promoting FASN transcription via LXRα in hepatocellular carcinoma.

Excessive lipid accumulation promotes the occurrence and progression of hepatocellular carcinoma (HCC), accompanied by high levels of fatty acid synthetase (FASN) and more active lipogenesis. Heat shock protein 90 (Hsp90) acts as a chaperone to maintain the stability and activity of the client proteins. Studies have revealed that Hsp90 regulates the lipid metabolism of HCC, but the effect of Hsp90 on FASN still remains unknown.

Integrated self-powered sensors based on cubic nanostructure and cascade amplification strategies.

The advantages of simple structure and easy portability inherent to self-powered biosensors have broad application prospects in clinical diagnosis and implantable medical devices. In light of the limitations of the clinical detection sensitivity, this study devised and fabricated a three-dimensional (3D) cubic structure of MoS₂ that was self-assembled by 2D nanosheets. The multi-dimensional structure design provides a broad binding site for the incubation of biological probes and the loading of biological enzymes, which can accelerate the electron transfer rate and effectively improve the detection sensitivity.

Acceleration of Simultaneous Multislice Magnetic Resonance Fingerprinting With Spatiotemporal Convolutional Neural Network.

Magnetic Resonance Fingerprinting (MRF) can be accelerated with simultaneous multislice (SMS) imaging for joint T and T quantification. However, the high inter-slice and in-plane acceleration in SMS-MRF causes severe aliasing artifacts, limiting the multiband (MB) factors to typically 2 or 3. Deep learning has demonstrated superior performance compared to the conventional dictionary matching approach for single-slice MRF, but its effectiveness in SMS-MRF remains unexplored.