Novel Sesquiterpene and Diterpene Aminoglycosides from the Deep-Sea-Sediment Fungus sp. SCSIOW21.

Six new sesquiterpene aminoglycosides, trichaspside F () and cyclonerosides A-E (-), two new diterpene aminoglycosides, harzianosides A and B (), and three known sesquiterpenes, trichodermoside (), cycloneran-3,7,10,11-tetraol (), and cyclonerodiol (), have been isolated from the n-butanol extract of sp. SCSIOW21 (Hypocreaceae), a deep-sea-sediment-derived fungus. The structures and relative configurations of the new compounds were determined using spectroscopic techniques and comparisons with those reported in the literature.

Softening by charging: how collective modes of ionic association in concentrated redoxmer/electrolyte solutions define the structural and dynamic properties in different states of charge.

Understanding the physical and chemical processes occurring in concentrated electrolyte solutions is required to achieve redox flow batteries with high energy density. Highly concentrated electrolyte solutions are often studied in which collective crowded interactions between molecules and ions become predominant. Herein, experimental and computational methods were used to examine non-aqueous electrolyte solutions in two different states of charge as a function of redoxmer concentration.

Multi-scene visual hydrazine hydrate detection based on a dibenzothiazole derivative.

Hydrazine (NH) produced by industries is distributed into different environments, and seriously threatens ecology and human security. Hence, it is important to develop probes that detect NH in various environments. In this study, a novel NH fluorescent probe was prepared based on a dibenzothiazole derivative (DBTD).

Serum Proteomics Combined with Metabolomics Analysis Explore the Molecular Biological Characteristics of Eruptive Syringoma.

Background: Eruptive syringoma (ES) is a clinical variant of the appendageal tumor syringoma. Around 75% of ES arise in the head or neck, which makes them unsightly. ES is common in patients with amyloidosis, diabetes, and Down's syndrome, suggesting that it may be associated with potential systemic effects.

WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice.

Brain size abnormality is correlated with an increased frequency of autism spectrum disorder (ASD) in offspring. Genetic analysis indicates that heterozygous mutations of the WD repeat domain 62 (WDR62) are associated with ASD. However, biological evidence is still lacking.

Pediatric pulmonary actinomycosis: A misdiagnosed case report.

Background: Pulmonary actinomycosis is an uncommon kind of bacterial illness caused by actinomycetes, involving the chest wall in extraordinarily rare cases. Due to non-specific clinical signs and perplexing radiological characteristics, this kind of pulmonary actinomycosis is frequently misinterpreted as a malignant tumor or lung abscess.

Case Presentation: An 11-year-old child presented with a palpable lump on his left chest and periodic chest discomfort.

mA-Mediated PPARA Translational Suppression Contributes to Corticosterone-Induced Visceral Fat Deposition in Chickens.

Excess fat deposition in broilers leads to great economic losses and is harmful to consumers' health. Chronic stress in the life cycle of chickens could be an important trigger. However, the underlying mechanisms are still unclear.

The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases.

Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating gene expression. Phase separation is increasingly being considered a driving force of chromatin folding. In this review, we have summarized the dynamic features of 3D chromatin and phase separation during physiological and pathological cell fate transitions and systematically analyzed recent evidence of phase separation facilitating the chromatin structure.

Miz1 promotes KRAS-driven lung tumorigenesis by repressing the protocadherin Pcdh10.

Targeting KRAS-mutated non-small-cell lung cancer (NSCLC) remains clinically challenging. Here we show that loss of function of Miz1 inhibits lung tumorigenesis in a mouse model of oncogenic KRAS-driven lung cancer. In vitro, knockout or silencing of Miz1 decreases cell proliferation, clonogenicity, migration, invasion, or anchorage-independent growth in mutant (MT) KRAS murine or human NSCLC cells but has unremarkable impact on non-tumorigenic cells or wild-type (WT) KRAS human NSCLC cells.

The impact of family function on mental health status in patient with inflammatory bowel disease: The mediating role of self-esteem.

Objective: Family function is a protective factor for mental health status in IBD patients; however, the underlying processes are unknown. This study aimed to investigate the mediating influence of self-esteem on family functioning and mental health.

Methods: This cross-sectional study comprised a total of 133 IBD patients who were assessed for family function (APGAR) and depression symptoms.

Contributors to reductions of PM-bound heavy metal concentrations and health risks in a Chinese megacity during 2013, 2016 and 2019: An advanced method to quantify source-specific risks from various directions.

PM-bound heavy metals were measured in a Chinese megacity (Tianjin) in 2013, 2016 and 2019, and analyzed by a new RSDA method (source directional apportionment of risks). Through combining the receptor model, cluster analysis of back trajectories, and risk assessment, the RSDA was developed in this work to quantify source-specific risks from each direction. Concentrations of PM and most species (especially for heavy metals) underwent various reductions, and the incremental lifetime cancer risk (ILCR) and non-cancer risk (HQ) declined by more than 80% from 2013 to 2019.

Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification.

Background: There is significant interest in treatment de-escalation for human papillomavirus-associated (HPV) oropharyngeal squamous cell carcinoma (OPSCC) patients given the generally favourable prognosis. However, 15-30% of patients recur after primary treatment, reflecting a need for improved risk-stratification tools. We sought to develop a molecular test to risk stratify HPV OPSCC patients.

Anxiety and sleep quality among front-line nurses treating first wave COVID-19 in China: The mediating role of mindfulness.

Aim: To explore anxiety, sleep quality, and mindfulness of frontline nurses at the initial epicenter of the pandemic, to examine the mediating effects of mindfulness.

Background: COVID-19 was first identified in Wuhan, China in January 2020. Nurses were at the forefront of care and treatment across hospitals in response to the pandemic.

Contribution bias of parental genomes to the hybrid lineages of black Amur bream and topmouth culter revealed by low-coverage whole-genome sequencing.

Interspecific hybridization has the potential to increase animal genetic diversity, enable the introgression of advantageous genetic variation, and even create hybrid lineages. Using the low-coverage whole-genome sequencing data of black Amur bream (Megalobrama terminalis [SJ]), topmouth culter (Culter alburnus [QZ]), and their hybrid progeny, we focused on the sequence variation and contribution bias to the genomic composition of the hybrid lineages of SJ♀ × QZ♂ [ZJ] and QZ♀ × SJ♂ [FJ]. Both mash-based genetic distance analysis and variant analysis based on various reference genomes revealed that the hybrid lineages' genomes are more prone to QZ composition.

Mechanical Force-Induced Blue-Shifted and Enhanced Emission for AIEgens.

Mechanochromic (MC) luminescence of organic molecules has been emerging as a promising smart material for optical recording and memory devices. At the same time, pressure-induced blue-shifted and enhanced luminescence are rarely reported now. Herein, a series of cyanostilbene-based AIEgens with different substituents were synthesized to evaluate the influence of morphology transformation and push-pull electronic effect on the MC luminescence.

Multifunctional plasmonic micro/nanobeads for sensitive suspension array assay and mass spectrometry analysis.

Plasmonic micro/nanobeads exhibit unique physicochemical properties attributed to their localized surface plasmon resonance (LSPR), enabling use in sensitive suspension array assays and matrix-assisted laser deposition/ionization mass spectrometry (MALDI-MS) analysis. Herein, we report a facile method for the preparation of magnetic plasmonic micro/nanobeads by the combination of Shirasu porous glass (SPG) membrane emulsification and polydopamine (PDA)-assisted in-situ reduction. The magnetic responsiveness properties endowed by doped FeO nanoparticles result in easy and complete separation of unwanted components during the preparation and bio-reaction processes.

Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells.

Background And Objectives: Non-small cell lung cancer (NSCLC) is a global health concern. NSCLC treatment outcomes are generally poor due to treatment resistance or toxicity. Ferroptosis is a novel cell death triggered by iron accumulation, reactive oxygen species (ROS), and lipid peroxidation.

Local Electric Field Promoted Kinetics and Interfacial Stability of a Phosphorus Anode with Ionic Covalent Organic Frameworks.

A phosphorus anode is a promising option for energy-storage applications because of its high theoretical specific capacity and safe lithiation potential. However, the multiphase phosphorus lithiation/delithiation reactions and soluble reaction intermediates cause sluggish reaction kinetics and loss of active materials. Herein, a novel local electric field (LEF) strategy is proposed to inhibit the intermediates dissolution and promote the reaction kinetics by optimizing ionic covalent organic frameworks (iCOFs).

Spontaneous Formation of Heterostructured Perovskite Films for Photovoltaic Application.

Perovskite solar cells (PSCs) are the one of most promising photovoltaic technologies that can be achieved by a simple solution process. At the current stage, the key issues concern further improvements in efficiency and operational lifetime. Constructing a self-assembled perovskite structure with manipulated chemical and physical properties is a useful and effective strategy to solve these problems.

Room temperature bilayer water structures on a rutile TiO(110) surface: hydrophobic or hydrophilic?

The lack of understanding of the molecular-scale water adsorbed on TiO surfaces under ambient conditions has become a major obstacle for solving the long-time scientific and applications issues, such as the photo-induced wetting phenomenon and designing novel advanced TiO-based materials. Here, with the molecular dynamics simulation, we identified an ordered water bilayer structure with a two-dimensional hydrogen bonding network on a rutile TiO(110) surface at ambient temperature, corroborated by vibrational sum-frequency generation spectroscopy. The reduced number of hydrogen bonds between the water bilayer and water droplet results in a notable water contact angle (25 ± 5°) of the pristine TiO surface.

Silent region barcode particle arrays for ultrasensitive multiplexed SERS detection.

Suspension arrays are a critical components of next generation multiplexed detection technologies. Current fluorescence suspension arrays are limited by a multiplexed coding ceiling and difficulties with ultrasensitive detection. Raman mode is a promising substitute, but the complex spectral peak distributions and extremely weak intrinsic signal intensity severely diminish Raman signal performance in suspension arrays.

Micro-LED with red-green-blue super-pixel integration for simultaneous display and optical near field communication.

This work presents a novel all-in-one Micro-LED pixel (µLEDP) technology by integrating red-green-blue super-pixels (RGBSP) in a single unit cell. Measurement results show that the proposed µLEDP delivers excellent optical and electrical characteristics, including wide color gamut (109% NTSC), wide correlated color temperature range (2831.7-10016.

Association of body composition with clinical outcome in Chinese women diagnosed with breast cancer.

Objective: This study aims to explore the association of body composition with clinical outcomes in Chinese women diagnosed with breast cancer.

Method: A total of 2,948 Chinese female patients with breast cancer have been included in this retrospective study. Body composition mainly includes the measurements of adiposity and muscle mass.