Machine learning algorithms in constructing prediction models for assisted reproductive technology (ART) related live birth outcomes.

Currently applicable models for predicting live birth outcomes in patients who received assisted reproductive technology (ART) have methodological or study design limitations that greatly obstruct their dissemination and application. Models suitable for Chinese couples have not yet been identified. We conducted a retrospective study by using a database includes a total of 11,938 couples who underwent in vitro fertilization (IVF) treatment between January 2015 and December 2022 in a medical institution of southwest China Yunnan province.

The Potential of Metabolomics in Colorectal Cancer Prognosis.

Colorectal cancer (CRC) is one of the most common cancers worldwide, posing a serious threat to human health. Metabolic reprogramming represents a critical feature in the process of tumor development and progression, encompassing alterations in sugar metabolism, lipid metabolism, amino acid metabolism, and other pathways. Metabolites hold promise as innovative prognostic biomarkers for cancer patients, which is crucial for targeted follow-up care and interventions.

Revolutionizing Epithelial Differentiability Analysis in Small Airway-on-a-Chip Models Using Label-Free Imaging and Computational Techniques.

Organ-on-a-chip (OOC) devices mimic human organs, which can be used for many different applications, including drug development, environmental toxicology, disease models, and physiological assessment. Image data acquisition and analysis from these chips are crucial for advancing research in the field. In this study, we propose a label-free morphology imaging platform compatible with the small airway-on-a-chip system.

Aortic valve replacement in a bicuspid aortic valve patient followed by reoperation for ascending aorta rupture: a case report.

Bicuspid aortic valve (BAV), the most common congenital cardiac anomaly, predisposes individuals to aortic stenosis and regurgitation due to valve degeneration. Abnormal hemodynamics, arterial wall characteristics, and genetic factors contribute to ascending aorta dilatation, potentially leading to severe complications like aortic dissection. Presently, the most recent guidelines propose that individuals with BAV requiring valve replacement due to valve dysfunction should undergo simultaneous replacement of the ascending aorta when the diameter of aortic dilatation exceeds 4.

Excitonic-Vibrational Interaction at 2D Material/Organic Molecule Interfaces Studied by Time-Resolved Sum Frequency Generation.

The hybrid heterostructures formed between two-dimensional (2D) materials and organic molecules have gained great interest for their potential applications in advanced photonic and optoelectronic devices, such as solar cells and biosensors. Characterizing the interfacial structure and dynamic properties at the molecular level is essential for realizing such applications. Here, we report a time-resolved sum-frequency generation (TR-SFG) approach to investigate the hybrid structure of polymethyl methacrylate (PMMA) molecules and 2D transition metal dichalcogenides (TMDCs).

Type I interferon-stimulated genes predict clinical response to belimumab in systemic lupus erythematosus.

The type I interferon (IFN-I) response is crucial in systemic lupus erythematosus (SLE). The mRNA level of interferon-stimulated genes (ISGs) is widely used for evaluating the activity of IFN in SLE. However, the character of ISGs in belimumab-treated SLE patients has not be reported.

Neuroprotective effects of healthful plant-based diets on retinal structure: insights from a large cohort.

Background: Retinal sublayer thickness is associated with both ophthalmic and neurodegenerative diseases, serving as a valuable biomarker. Despite the established role of diet in chronic disease prevention, the relationship between healthy dietary patterns and retinal sublayer thickness remains underexplored.

Objective: This study aims to investigate the associations between four commonly used diet assessment scores and retinal sublayer thickness in a large-scale population.

Nuclear remodeling during cell fate transitions.

Totipotent stem cells, the earliest cells in embryonic development, can differentiate into complete embryos and extra-embryonic tissues, making them essential for understanding both development and regenerative medicine. This review examines recent advances in the dynamic remodeling of nuclear structures during the transition between totipotency and pluripotency, as well as other cell fate transition processes. Additionally, we highlight innovative experimental and computational methods that elucidate the relationship between nuclear architecture and cell fate decisions.

Public Perceptions of Very Low Nicotine Content on Twitter: Observational Study.

Background: Nicotine is a highly addictive agent in tobacco products. On June 21, 2022, the US Food and Drug Administration (FDA) announced a plan to propose a rule to establish a maximum nicotine level in cigarettes and other combusted tobacco products.

Objective: This study aimed to understand public perception and discussion of very low nicotine content (VLNC) on Twitter (rebranded as X in July 2023).

[Distribution, Accumulation Characteristics, and Risk Assessment of Heavy Metals in Vegetable Soils of Different Planting Years].

To ascertain the influence of prolonged planting on the distribution and accumulation of heavy metals in protected vegetable soil, samples from typical vegetable planting areas in Shenyang were gathered to evaluate the distribution features of Cr, Ni, Cu, Zn, Cd, and Pb in such soil. The Hakanson index, heavy metal risk assessment standard, and secondary phase to primary ratio methods were employed to evaluate the ecological hazard of soil in the research area, while the human health risk model was utilized to evaluate the health of inhabitants. The findings indicated that：① The amount of heavy metals Zn, Cr, Cu, Ni, Pb, and Cd in the topsoil （0~20 cm） of protected vegetable land in the study region decreased successively, and the content of heavy metals in the topsoil increased with the extension of planting years, of which Cd, Zn, and Cu increased most obviously, with maximum increases of 219%, 189%, and 134%, respectively.

Positive Coping Style and Family Resilience of Caregivers of COPD Patients: The Chain Mediating Roles of Caregiver Burden and Resilience.

Aims: To investigate the association between positive coping style and family resilience, considering the mediating factors of burden and individual resilience within caregivers of chronic obstructive pulmonary disease (COPD) patients.

Design: A cross-sectional survey.

Methods: A total of, 204 caregivers of COPD patients were recruited using convenient sampling from April 2023 to May 2024 to investigate general information, family resilience, individual resilience, caregiver burden and positive coping styles on caregivers of COPD patients.

Application of Chatbots to Help Patients Self-Manage Diabetes: Systematic Review and Meta-Analysis.

Background: The number of people with diabetes is on the rise globally. Self-management and health education of patients are the keys to control diabetes. With the development of digital therapies and artificial intelligence, chatbots have the potential to provide health-related information and improve accessibility and effectiveness in the field of patient self-management.

ABHD1 Facilitates Intermediate Filament-Mediated Endothelial Cell Chemotaxis by Regulating KRT1 and KRT2 in Diabetic Retinopathy.

Diabetic retinopathy (DR) is one of the most common complications of diabetes and induces severe visual impairment worldwide. Endothelial cell dysfunction plays an important role in the pathogenesis of DR. Here, we keep a watchful eye on /-hydrolase domain-containing 1 (ABHD1), a potential regulator in lipid metabolism and neovascularization.

Bimetallic nanozymes for effectively removing Enterococcus faecalis biofilms in pulp and periapical infection treatment.

Pulpal and periapical infections, primarily caused by the biofilms of Enterococcus faecalis (E. faecalis), pose significant challenges due to their resistance to eradication, making them prevalent oral health concerns. Herein, we synthesized a bimetallic Zn-Fe nanozymes (ZFNs) with enhanced peroxidase-like (POD-like) activity, capable of activating hydrogen peroxide (HO) into highly reactive hydroxyl radicals to combat E.

Advancements in phasor-based FLIM: multi-component analysis and lifetime probes in biological imaging.

Fluorescence lifetime imaging microscopy (FLIM) is a reliable method that achieves imaging by detecting fluorescence lifetimes within samples. Owing to its unique temporal characteristic, it can complement fluorescence intensity measurement. Technological and methodological advancements in FLIM have broadened its applications across various domains.

Integrating progressive screening strategy-based continuous wavelet transform with EfficientNetV2 for enhanced near-infrared spectroscopy.

Near-infrared (NIR) spectroscopy has gained wide acceptance across various fields as a result of advances in portable equipment that can record spectra on site or at production lines. Continuous wavelet transform (CWT) can transform traditional one-dimensional (1D) NIR spectra into more informative two-dimensional (2D) spectrograms, thus enhancing the analysis and interpretation of spectral information. This study introduces a high-efficiency 2D CWT-EfficientNetV2 regression model to optimize NIR spectroscopy applications.

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability.

Background: Limited understanding of the biology predisposing certain human papillomavirus-related (HPV+) oropharyngeal squamous cell carcinomas (OPSCCs) to relapse impedes therapeutic personalization. We aimed to identify molecular traits that distinguish recurrence-prone tumors.

Methods: 50 HPV+ OPSCCs that later recurred (cases) and 50 non-recurrent controls matched for stage, therapy, and smoking history were RNA-sequenced.

Attention demands modulate brain electrical microstates and mental fatigue induced by simulated flight tasks.

Prolonged engagement in tasks with varying attention demands is thought to elicit distinct forms of mental fatigue, potentially indicating variations in neural activity. This study aimed to investigate the association between mental fatigue and changes in electroencephalogram microstate dynamics during tasks with varying attention demands.In the present study, we employed a 2 × 2 repeated measures ANOVA to analyze the temporal parameters of four distinct microstates (A, B, C, and D) across different levels of attention demands (high vs.

Polygenic risk score, healthy lifestyle score, and colorectal cancer risk: a prospective cohort study.

Background: Both genetic factors and lifestyle play a critical role in colorectal cancer (CRC), but the extent to which an increased genetic risk can be offset by a healthy lifestyle remains unclear.

Methods: We included 51,171 participants from the PLCO cohort. A polygenic risk score was created based on 205 genetic variants associated with CRC, and a healthy lifestyle score was constructed based on six lifestyle factors.

Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A.

Studies of laminopathy-based progeria offer insights into aging-associated diseases and highlight the role of LMNA in chromatin organization. Mandibuloacral dysplasia type A (MAD) is a largely unexplored form of atypical progeria that lacks lamin A post-translational processing defects. Using iPSCs derived from a male MAD patient carrying homozygous LMNA p.

Specific and high-affinity adsorption of volatile organic compounds on titanium dioxide surface.

The interaction between metal oxides and volatile organic compounds (VOCs) from the ambient atmosphere plays an important role in environmental and catalytic applications. Previous scanning probe microscopy and x-ray spectroscopy studies revealed surprisingly that the TiO2 [rutile (110)] surface selectively adsorbed atmospheric carboxylic acids, which typically exist in only parts-per-billion concentrations. In this work, we used in situ sum-frequency vibrational spectroscopy to study the interaction between rutile (110) and typical VOC molecules, including formic acid, acetic acid, and formaldehyde.

Binding properties of olfactory proteins to host volatiles, free fatty acids and cuticular hydrocarbons in the termite Reticulitermes aculabialis.

As eusocial insects prevalent in tropical and subtropical regions, termites are characterized by highly organized behaviors and exceptional adaptability, rooted in caste differentiation and chemical communication. These traits make them excellent models for studying insect social structures and ecological interactions. Investigating how termites use chemical signals to perceive and respond to their environment provides insights into their coordination and adaptation within complex ecosystems.

Screening Anti-Rheumatoid Arthritis Synovitis Effective Ingredients of Total Flavonoid From Artemisia argyi Folium Based on Spectrum-Effect Relationship.

Introduction: Flavonoids are the main nonvolatile component responsible for the anti-rheumatoid arthritis (RA) synovitis activities of Artemisia argyi Folium. However, the effective ingredient remains unidentified. Spectrum-effect relationships analysis was a reliable and efficient strategy for herbal effective ingredient discovery.