Self-assembled injectable Icariin@ TiCTx/doxorubicin hydrogel preserving osteogenesis while synergizing photodynamic and chemodynamic therapy for osteosarcoma.

Local therapy involving injectable hydrogel systems loaded with doxorubicin (DOX) has garnered significant attention in the realm of osteosarcoma (OS) research. Nevertheless, it has been noted that the local delivery of high-dose DOX exerts a pronounced inhibitory impact on osteogenesis, which is detrimental to the restoration of functional capabilities after OS treatment. To address this challenge, we have designed a self-assembled injectable hydrogel system that integrates photodynamic and chemodynamic therapy, aiming to enhance efficacy while mitigating adverse effects on osteogenic differentiation.

Optimization of hemolytic performance of artificial heart pump based on CFD.

Hemolytic performance is the key performance of artificial heart pumps. To reduce the damage to blood during the operation of artificial heart pumps and improve hemolysis performance, this paper investigates the influence of several key parameters of artificial heart pumps (volute type, inlet guide cone, blade wrap angle, tip clearance) on hemolysis performance. Firstly, a fluid domain model of the artificial heart pump was established, and mesh partitioning and fluid simulation parameter settings were carried out.

Associations between sleep duration and quality and physical frailty in community-dwelling older adults: a cross-sectional study.

The effects of sleep duration and quality on physical frailty may differ. We examined the association between sleep duration/quality and frailty phenotype according to frailty components. This cross-sectional study analyzed 848 community-dwelling Japanese adults aged 65-75 years (mean age 70.

spores displaying GRA12 induce immunity against acute toxoplasmosis.

Background: () is a widely prevalent intracellular parasite that infects almost all warm-blooded animals and causes serious public health problems. The drugs currently used to treat toxoplasmosis have the disadvantage of being toxic and prone to the development of resistance, and the only licensed vaccine entails a risk of virulence restoration. The development of a safe and effective vaccine against is urgently needed.

Study on the One-Dimensional Impact Compression Characteristics of Coral Sand Under Conditions of Different Relative Density.

Dynamic compression tests under quasi-one-dimensional strain conditions were conducted on coral sand with different relative densities using the Split Hopkinson Pressure Bar (SHPB) apparatus. The experimental results indicate that the stress-strain curves of coral sand exhibit approximately three basic forms, each encompassing three distinct stages: skeletal sliding and yielding, compaction, and unloading. The occurrence of the lock-up phenomenon is jointly influenced by relative density, strain rate, and moisture content.

Molecular Mechanism of Vine Tea Dihydromyricetin Extract on Alleviating Glucolipid Metabolism Disorder in Mice: Based on Liver RNA-Seq and TLR4/MyD88/NF-κB Pathway.

The primary active compound in vine tea is dihydromyricetin (DMY), which has a longstanding history as a dietary supplement and traditional ethnic medicine. However, the precise molecular mechanism by which vine tea dihydromyricetin extract (VDMY) regulates glucolipid metabolic disorder remains unclear. In this study, we first assessed the effect of VDMY on various physiological parameters in mice, followed by RNA sequencing (RNA-seq) to identify key signaling pathways affected by VDMY in liver tissues.

The Small Molecules of Plant Origin with Anti-Glioma Activity.

Gliomas, originating from glial cells, are prevalent and aggressive brain tumors with high recurrence rates and poor prognosis. Despite advancements in surgical, radiation, and chemotherapeutic treatments, the survival rates remain low. Current standard therapies, such as Temozolomide, have limitations due to cytotoxicity, restricted effectiveness, and severe side effects.

BEL1-like homeodomain transcription factor SAWTOOTH1 (MdSAW1) in Malus domestica enhances the tolerance of transgenic apple and Arabidopsis to zinc excess stress.

In recent years, the phenomenon of zinc pollution in orchards has become increasingly serious, and the safety of apple production is facing a major risk. Therefore, exploring excellent genes for zinc tolerance has a positive effect on apples. Up to now, there is still a lack of attention on genes related to zinc stress tolerance in apples.

Shuxuetong Injection inhibits pyroptosis in acute ischemic stroke via CD44/NLRP3/GSDMD signal.

Ethnopharmacological Relevance: Acute ischemic stroke (AIS) is an important cause of death and disability in the world. Based on the blood stasis syndrome of stroke, Shuxuetong Injection (SXT) is a representative prescription for the treatment of AIS, which extracted by modern technology from Whitmania pigra Whitman (Shuizhi) and Pheretima aspergillum E.Perrier (Dilong).

Isotope-coded hydrazide tags for MALDI-MS based quantitative glycomics.

The detection of glycosylation alterations is essential for elucidating the roles of glycan functions in biological processes and identifying potential disease biomarkers. Stable isotopic chemical labeling, coupled with mass spectrometry (MS), represents a powerful approach in quantitative glycomics. In this study, we synthesized a novel isotopic hydrazide pair, 2,6-Dimethyl-4-chinolincarbohydrazid (DMQCH) and its deuterium isomer DMQCH-d, via an efficient and cost-effective method, and applied it for the first time in MALDI-MS-based quantitative glycomics.

Fluorescent Sensor for the Visualization of Amino Acid Neurotransmitters in Neurons Based on an SAr Reaction.

Glutamate is an important excitatory neurotransmitter, while GABA is an inhibitory neurotransmitter. However, direct and accurate visualization of these important signaling agents by a chemical sensor is still very challenging. Here, a novel coumarin-based fluorescent sensor for the selective labeling and imaging of amino acids in neurons has been developed.

Mechanism of HDAC2 regulating Nrf2 acetylation level in neuronal ferroptosis of neonatal rats with hypoxic-ischemic brain injury.

Objective: We investigated the mechanism of histone deacetylase 2 (HDAC2) modulating nuclear factor erythroid 2-related factor 2 (Nrf2) acetylation level in neuronal ferroptosis of hypoxic-ischemic brain injury (HIBI) neonatal rats.

Methods: The pathological damage and neuronal injury in the hippocampal CA1 region of HIBI neonatal rat models were assessed by HE and Nissl staining. Levels of neuron-specific enolase (NSE), glutathione peroxidase 4 (GPX4), HDAC2, Nrf2, glutathione (GSH), reactive oxygen species (ROS), malondialdehyde (MDA), active Fe, Nrf2 acetylation, and nuclear Nrf2 in hippocampal tissues were determined.

Eukaryotic phytoplankton drive a decrease in primary production in response to elevated CO in the tropical and subtropical oceans.

Ocean acidification caused by increasing anthropogenic CO is expected to impact marine phytoplankton productivity, yet the extent and even direction of these changes are not well constrained. Here, we investigate the responses of phytoplankton community composition and productivity to acidification across the western North Pacific. Consistent reductions in primary production were observed under acidified conditions in the North Pacific Subtropical Gyre and the northern South China Sea, whereas no significant changes were found at the northern boundary of the subtropical gyre.

Interfacing with the Brain: How Nanotechnology Can Contribute.

Interfacing artificial devices with the human brain is the central goal of neurotechnology. Yet, our imaginations are often limited by currently available paradigms and technologies. Suggestions for brain-machine interfaces have changed over time, along with the available technology.

Micro-RNA-140-3p Acts as a Tumor Suppressor Gene in Acute Promyelocytic Leukemia by Targeting Hepatocyte Growth Factor.

MicroRNAs (miRNAs) are noncoding RNAs that regulate the expression of target genes after transcription, and play important roles in the differentiation of hematopoietic stem cells. Many miRNAs are related to the occurrence of acute promyelocytic leukemia (APL) and play roles in the treatment response. Recently, we demonstrated that several miRNAs are differentially expressed in patients with relapsed and newly diagnosed APL; for example, miR-140-3p is significantly downregulated in patients with relapsed APL.

Aspirin enhances the antibacterial activity of colistin against multidrug-resistant Pseudomonas aeruginosa.

Multidrug-resistant (MDR) Pseudomonas aeruginosa (PSA), recently reclassified by the World Health Organization (WHO) as a high-priority antimicrobial-resistant pathogen, continues to impose a substantial global health burden due to escalating resistance and stagnant therapeutic innovation. Colistin retains critical clinical utility against MDR P. aeruginosa infections; however, its dose-limiting nephrotoxicity and neurotoxicity necessitate strategies to optimise therapeutic indices.

Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway.

Objectives: Drug-induced liver injury (DILI) can be improved by modulating gut microbiota. We aimed to investigate a probiotic mixture comprising Bifidobacterium Longum, Streptococcus thermophilus, and Lactobacillus delbrueckii subspecies bulgaricus (BSL) in mitigating acetaminophen induced liver injury (AILI), and to elucidate the underlying mechanisms.

Methods: Gut bacterial communities were analyzed in fecal samples from patients with DILI and healthy controls.

The amphipod genome reveals population dynamics and adaptations to hadal environment.

The amphipod Hirondellea gigas is a dominant species inhabiting the deepest part of the ocean (∼6,800-11,000 m), but little is known about its genetic adaptation and population dynamics. Here, we present a chromosome-level genome of H. gigas, characterized by a large genome size of 13.

Surface-engineered nanofiltration membranes for sustainable lithium recovery from real brine: Addressing fouling and scaling challenges.

Nanofiltration (NF) membranes hold great promise for lithium (Li) recovery from brines, with numerous studies focusing on improving Li/Mg separation performance. However, real brine environments pose significant challenges, as fouling and scaling severely hinder Li recovery efficiency. Despite their critical impact, these challenges have received limited attention.

Study on the degradation of gelled tributyl phosphate combined with DFT calculations in a ternary LiCO-NaCO-KCO molten salt system.

With the rapid development of the global nuclear industry, substantial amounts of radioactive tributyl phosphate (TBP) have accumulated during the PUREX process. Prolonged accumulation poses significant environmental risks. Therefore, this study proposes an efficient molten salt oxidation (MSO) method for the treatment of gelled TBP.

A comprehensive study on the impact of L. fruit polysaccharide on myocardial fibrosis through animal experiments, network pharmacology and molecular docking.

Background: Myocardial fibrosis (MF) is a prevalent pathological condition associated with various heart diseases, such as heart failure and arrhythmias, which disrupt electrical signals and reduce pumping efficiency. This research explored the therapeutic effects and potential mechanisms of L. fruit polysaccharide (LVFP) on MF.

Infiltrated Macrophages Aggravate TMJOA Chronic Pain via Piezo2 in IB4-TG Neurons.

Objective: Recent research indicates that macrophages in ganglia are linked to chronic pain, with Piezo2 ion channels playing a key role in pain sensation. Our study aims to elucidate the interplay between macrophages and Piezo2 in temporomandibular joint osteoarthritis (TMJOA) chronic pain.

Materials And Methods: We induced TMJOA chronic pain in rats via articular injection of monosodium iodoacetate (MIA).

Microbial inoculants modify the functions of soil microbes to optimize plant growth at abandoned mine sites.

Mining activities have caused significant land degradation globally, emphasizing the need for effective restoration. Microbial inoculants offer a promising solution for sustainable remediation by enhancing soil nutrients, enzyme activities, and microbial communities to support plant growth. However, the mechanisms by which inoculants influence soil microbes and their relationship with plant growth require further investigation.

Biotransformation of minocycline by a novel strain Kluyvera sp. DM13 isolated from municipal sludge: Performances, removal pathways, and toxicity.

Minocycline has been widely used in clinical treatment and its residues were considered to have environmental safety risks due to complex chemical structure. Therefore, it is necessary to find an efficient and environmentally friendly method to remove minocycline from the environment. This study screened and isolated a minocycline degrading strain DM13 from the activated sludge for municipal sewage pipeline, and optimized the biodegradation of minocycline by DM13 under various environmental conditions.