Preliminary study of the role of inner ear proteins in vestibular neuritis.

Objective: To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.

Methods: In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension.

Uncovering ZnS growth behavior and morphology control for high-performance aqueous Zn-S batteries.

Aqueous Zn-S batteries provide competitive energy density for large-scale energy storage systems. However, the cathode active material exhibits poor electrical conductivity especially at the discharged state of ZnS. Its morphology generated in cells thus directly determines the cathode electrochemical activity.

Impact of financial support on treatment outcomes of multidrug-resistant tuberculosis: A population-based, retrospective cohort study in Shanghai, China.

Background: To date, the prolonged treatment duration and expensive second-line anti-tuberculosis drugs (SLDs) for multidrug-resistant tuberculosis (MDR-TB) can impose a significant financial burden, which may negatively impact treatment outcomes. This study examines the effect of a subsidy policy on treatment outcomes of MDR-TB patient..

TRIM4 enhances small-molecule-induced neddylated-degradation of CORO1A for triple negative breast cancer therapy.

As a critical member of the Coronin family, Coronin 1A (CORO1A) plays a crucial role in the progression of triple-negative breast cancer (TNBC). However, CORO1A is typically considered "undruggable" due to its smooth surface and complex protein-protein interactions (PPIs). Molecular glues have emerged as one of the most effective strategies to rapidly degrade such "undruggable" targets.

The globular domain of extracellular histones mediates cytotoxicity via membrane disruption mechanism.

Histones are traditionally recognized for structuring nuclear architecture and regulating gene expression. Recent advances have revealed their roles in inflammation, coagulation, and immune responses, where they act as damage-associated molecular patterns. The mechanisms by which histones induce membrane leakage are not well understood, and certain cells, including endothelial cells and peritoneal macrophages, show resistance to histone-mediated pore formation.

Comparative transcriptomic and proteomic analyses of two salt-tolerant alfalfa ( L.) genotypes: investigation of the mechanisms underlying tolerance to salt.

Abiotic stressors such as salt stress restrict plant development and output, which lowers agricultural profitability. In this study, alfalfa ( L.) varieties with different levels of salt tolerance were examined using high-throughput RNA sequencing (RNA-Seq) and Tandem Mass Tags (TMT) technologies to study the reactions of the root systems to salt stress, from transcriptomics and proteomics perspectives.

Clinical efficacy of recombinant human interferon α-2b gel combined with LEEP conization in treating cervical intraepithelial neoplasia with comorbid high-risk HPV infection.

Objective: To evaluate the clinical efficacy of recombinant human interferon α-2b (rHuINF α-2b) gel combined with loop electrosurgical excision procedure (LEEP) conization in treating cervical intraepithelial neoplasia (CIN) with comorbid high-risk human papillomavirus (HR-HPV) infection.

Methods: A retrospective analysis was conducted on the clinical data of 202 CIN patients with HR-HPV infection who were treated at Wuhan Yaxin General Hospital between July 2021 and February 2024. Among these patients, 106 received treatment with rHuINF α-2b gel combined with LEEP conization (study group), and the other 96 were treated with LEEP conization alone (control group).

Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form of .

Seasonal polyphenism enables organisms to adapt to environmental challenges by increasing phenotypic diversity. exhibits remarkable seasonal polyphenism, specifically in the form of summer-form and winter-form, which have distinct morphological phenotypes. Previous research has shown that low temperature and the temperature receptor regulate the transition from summer-form to winter-form in by impacting cuticle content and thickness.

Novel application of cyclo(-Phe-Pro) in mitigating aluminum toxicity through oxidative stress alleviation in wheat roots.

Microbial secondary metabolites are crucial in plant-microorganism interactions, regulating plant growth and stress responses. In this study, we found that cyclo(-Phe-Pro), a proline-based cyclic dipeptide secreted by many microorganisms, alleviated aluminum toxicity in wheat roots by increasing root growth, decreasing callose deposition, and decreasing Al accumulation. Cyclo(-Phe-Pro) also significantly reduced Al-induced reactive oxygen species (ROS) with HO, O, and •OH levels decreasing by 19.

Effect of Soret diffusion on the growth of spherical crystals in supercooled alloy melts under oscillatory flow.

The growth of spherical crystals in binary alloy melts with thermal diffusion effects under oscillatory flow is investigated analytically. Using the multiple scale method, we derive approximate analytical solutions for both the crystal interface growth rate and the solute concentration. Our results demonstrate that the Soret effect significantly influences both the solute concentration near the crystal interface and the crystal growth rate.

Optimized irrigation practices with fertilizer utilization strategies to improve photo-fluorescence efficiency, vascular bundles and maize production in semi-arid regions.

The mechanism of irrigation models combined with fertilizer utilization strategies under the biodegradable film mulching could greatly promote crop photosynthesis, vascular bundles structure; resource utilization and maize production are unclear in semi-arid areas. Unfortunately, this mechanism provides a scientific basis for improving irrigation and fertilizer utilization. A field study was carried out during 2021-2022 years.

Electronic Health Interventions and Cervical Cancer Screening: Systematic Review and Meta-Analysis.

Background: Cervical cancer is a significant cause of mortality in women. Although screening has reduced cervical cancer mortality, screening rates remain suboptimal. Electronic health interventions emerge as promising strategies to effectively tackle this issue.

miRNAs targeted transcription factors HaGATAa/b to mediate the post-mating switch in Helicoverpa armigera female reproductive behavior.

Background: The process of mating induces significant shifts in female reproductive behavior across various species, with the postmating behavioral switch playing a crucial role in insect reproduction. Previous studies have demonstrated the regulatory role of GATA transcription factors in vitellogenin transcription and egg formation in insects, while miRNAs have been implicated in modulating GATA expression and insect reproductive processes. Nevertheless, the precise regulatory mechanism underlying the interaction between miRNAs and GATA transcription factors in the postmating behavioral switch remains largely unexplored.

Varying effect of atrial fibrillation ablation in patients with heart failure with preserved ejection fraction according to CHADS-VASc score.

Background: The impact of comorbidity burden on outcomes of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF) remains unclear.

Objective: The purpose of this study was to evaluate how comorbidity burden influences the association between RFCA and cardiovascular outcomes in AF patients with HFpEF.

Methods: AF patients with HFpEF from the prospective China-AF cohort, recruited between August 2011 and December 2020, were categorized into 2 groups based CHADS-VASc score: low comorbidity burden (score ≤4) and high comorbidity burden (score >4).

An Intelligent Intestine-on-a-Chip for Rapid Screening of Probiotics with Relief-Enteritis Function.

Screening probiotics with specific functions is essential for advancing probiotic research. Current screening methods primarily use animal studies or clinical trials, which are inefficient and costly in terms of time, money, and labor. An intelligent intestine-on-a-chip integrating machine learning (ML) is developed to screen relief-enteritis functional probiotics.

Electrolyte Additive Molecule Disassembly to Reveal the Roles of Individual Groups in Zn Electrode Stabilities in Aqueous Batteries.

Zn metal anodes experience dendritic growth and hydrogen evolution reactions (HER) in aqueous batteries. Herein, we propose an interface regulation strategy with a trace (1.4 × 10 mol kg) all-in-one epicatechin (EC) electrolyte additive to solve the above issues and reveal the roles of individual functional groups.

Characterization of the Metabolic Proteome of Serum From Patients With Diabetic Distal Symmetric Polyneuropathy.

Aims: The pathophysiological of diabetic distal symmetric polyneuropathy (DSPN) remains to be elucidated and there are no diagnostic or prognostic biomarkers for the condition. In this explorative proteomic study, metabolic proteome profiling of serum in patients with/without DSPN was analyzed. We aimed to discover proteins with different abundance ranges through proximity extension assay (PEA) technology.

Lung immune prognostic index is associated with clinical outcomes in recurrent or metastatic (R/M) nasopharyngeal carcinoma receiving immunotherapy: Results from the multicenter, single-arm, phase 2 study.

Background: Immune-related biomarkers are linked to the outcomes of cancer immunotherapy. This study evaluates the baseline and longitudinal association between the lung immune prognostic index (LIPI) and immune checkpoint inhibitor outcomes in previously treated recurrent or metastatic (R/M) nasopharyngeal carcinoma (NPC) patients.

Methods: Data from 153 R/M NPC patients (median age = 49.

Diatomic Catalysts for Aqueous Zinc-Iodine Batteries: Mechanistic Insights and Design Strategies.

There has been a growing interest in developing catalysts to enable the reversible iodine conversion reaction for high-performance aqueous zinc-iodine batteries (AZIBs). While diatomic catalysts (DACs) have demonstrated superior performance in various catalytic reactions due to their ability to facilitate synergistic charge interactions, their application in AZIBs remains unexplored. Herein, we present, for the first time, a DAC comprising Mn-Zn dual atoms anchored on a nitrogen-doped carbon matrix (MnZn-NC) for iodine loading, resulting in a high-performance AZIB with a capacity of 224 mAh g at 1 A g and remarkable cycling stability over 320,000 cycles.

Nanomaterial-Encapsulated dsRNA-Targeting Chitin Pathway─A Potential Efficient and Eco-Friendly Strategy against Cotton Aphid, (Hemiptera: Aphididae).

The -strategy pests are very challenging to effectively control because of their rapid population growth and strong resurgence potential and are more prone to developing pesticide resistance. As a typical -strategy pest, the cosmopolitan cotton aphid, Glover, seriously impacts the growth and production of cucurbits and cotton. The present study developed a SPc/double-stranded RNA (dsRNA)/botanical strategy to enhance the control efficacy of .

Yellow Sticky Cards Reduce the Numbers of (Hymenoptera: Trichogrammatidae) Following Augmentative Releases against the Fruit Borers (Lepidoptera: Carposinidae) and (Lepidoptera: Tortricidae) in a Pear Orchard.

Integrated pest management relies upon mutual compatibility among pest control tactics. The fruit-boring moths and can be devastating pests of pome and stone fruit production. parasitizes the eggs of these pests, preventing their eclosion, but its efficacy can be reduced by other pest control tactics.