Function of N-acetyltransferase in the biotransformation of aniline in green alga Chlamydomonas reinhardtii.

Phytoplankton plays a crucial role in the fate of pollutants in aquatic ecosystems by biotransformation and bioaccumulation. Aniline was listed in priority pollutants due to its toxicity and widespread distribution in the aquatic environment. This study focused on investigating the capacity and mechanism of eukaryotic alga Chlamydomonas reinhardtii in transforming aniline.

Antiosteoporosis and Bone Protective Effect of Phyllanthin Against Glucocorticoid-induced Osteoporosis in Rats via Alteration of HO-1/Nrf2 and RANK/RANKL/OPG Pathway.

Unlabelled: Osteoporosis is a condition where bones weaken due to a loss in density and quality, making them fragile and more susceptible to fractures, even from minor stress or injury. In this experimental study, we scrutinized the antiosteoporosis effect of phyllanthin against glycocorticoid (GIOP) induced osteoporosis in rats.

Methods: : SD rats were used in this study and subcutaneous administration of DEX (3 mg/kg) was used for the induction of osteoporosis and rats were treated with phyllanthin and alendronate for 12 weeks.

[Simultaneous determination of 51 indazole-type synthetic cannabinoids in urine and blood by online solid-phase extraction-liquid chromatography-linear ion trap mass spectrometry].

To evade legal controls, new psychoactive substances (NPS), which have been designed as substitutes for traditional and synthetic drugs, are gradually dominating the drug market. Synthetic cannabinoids (SCs), which account for the majority of NPS, are rapidly being derivatized; consequently, controlling increasing abuse by merely listing individual compounds is difficult. Therefore, China has included the entire SC category of SCs listed as legal controlled substances since July 1, 2021.

Vacancy-Activated B-Doping for Efficient 2e Oxygen Reduction through Suppressing HO Decomposition at High Overpotential.

The production of hydrogen peroxide (HO) through two-electron oxygen reduction reaction (2e ORR) has emerged as a more environmentally friendly alternative to the traditional anthraquinone method. Although oxidized carbon catalysts have intensive developed due to their high selectivity and activity, the yield and conversion rate of HO under high overpotential still limited. The produced HO was rapidly consumed by the increased intensity of HO reduction, which could ascribe to decomposition of peroxide radicals under high voltage in the carbon catalyst.

Research and Performance Evaluation of Environmentally Friendly Shale Inhibitor TIL-NH for Shale Gas Horizontal Wells.

Wellbore instability caused by hydration during the development of shale gas reservoirs poses significant challenges to drilling engineering. In this study, a novel and environmentally friendly shale inhibitor, TIL-NH, was synthesized via free radical polymerization using 1-vinylimidazole and N-(2-bromoethyl)-1,3-propanediamine dihydrobromide as the main raw materials. The molecular structure of TIL-NH was characterized by infrared spectroscopy and nuclear magnetic resonance.

Impact of thrombocytopenia on failure of endoscopic variceal treatment in cirrhotic patients with acute variceal bleeding.

Background: Acute variceal bleeding (AVB), a life-threatening complication of liver cirrhosis, can be effectively treated by endoscopy, but there is a risk of early rebleeding after endoscopic variceal treatment (EVT). Thrombocytopenia is the most common hemostatic abnormality in liver cirrhosis. However, it is still unclear about whether thrombocytopenia increases the failure of EVT in cirrhotic patients with AVB.

In vitro metabolism of seven arolyl-derived fentanyl-type new psychoactive substances.

Over the past decade, fentanyl-type new psychoactive substances (F-NPS) have emerged as the most representative synthetic opioids in third-generation drugs. These substances are characterized by their "low" fatal dose and parent drug levels in biological matrices, "fast" rates of derivatization and metabolism, and "many" derivatization sites and analogs. The low levels of parent fentanyl NPS in biological matrices complicate their detection, necessitating the use of characteristic metabolites as biomarkers for forensic analysis.

Accuracy analysis of the new artificial anatomical marker positioning method (shoulder-to-shoulder) in preventing leg length discrepancy in total hip arthroplasty.

Objective: By comparing the hip arthroplasty parameters planned with the AIHIP three-dimensional simulation surgery system, this study analyzes the accuracy of the new femoral-side "shoulder-to-shoulder" artificial anatomical marker positioning method in femoral-side prosthesis implantation and the prevention of leg length discrepancy in hip arthroplasty.

Methods: A retrospective collection of 47 patients who underwent initial total hip arthroplasty at our hospital from August 2020 to December 2022 and met the inclusion and exclusion criteria was used as the study subjects. The average age was 67.

Robust low threshold full-color upconversion lasing in rare-earth activated nanocrystal-in-glass microcavity.

Visible light microlasers are essential building blocks for integrated photonics. However, achieving low-threshold (μW), continuous-wave (CW) visible light lasing at room temperature (RT) has been a challenge because of the formidable requirement of population inversion at short wavelengths. Rare-earth (RE)-activated microcavities, featuring high-quality factor (Q) and small mode volume of whispering gallery modes, offer a great opportunity for achieving infrared-to-visible upconversion (UC) lasing.

Contrastive Learning Approach for Assessment of Phonological Precision in Patients with Tongue Cancer Using MRI Data.

Magnetic Resonance Imaging (MRI) allows analyzing speech production by capturing high-resolution images of the dynamic processes in the vocal tract. In clinical applications, combining MRI with synchronized speech recordings leads to improved patient outcomes, especially if a phonological-based approach is used for assessment. However, when audio signals are unavailable, the recognition accuracy of sounds is decreased when using only MRI data.

Azvudine efficacy in reducing mortality in COVID-19 patients.

Background: Several therapeutic drugs have been authorized for the treatment of patients with Coronavirus disease 2019 (COVID-19). However, further research on the mechanisms of action, efficacy, and target populations of these novel therapeutic drugs are necessary. This study included mild, moderate, severe, and critical COVID-19 patients to evaluate azvudine's effectiveness across different severity levels.

[Tracing the Surface Water Pollution in a Chemical Park Based on the Fusion of Spectral and Chromatographic Characteristic Data].

Identification of the pollution source of surface water in a chemical park was difficult because many industrial enterprises with complex wastewater components and similar characteristics are located there. Therefore, a national-level chemical park in Jiaxing City was studied, and wastewater samples from ten batches of seven key enterprises in the park were collected and analyzed using 3D excitation emission matrix spectrometry （EEMS） and gas chromatography-mass spectrometry （GC-MS）. Parallel factor analysis was used to extract common components of EEMS spectra from different batches of drainage in the same enterprise to construct an EEMS characteristic data matrix.

STAFNet: an adaptive multi-feature learning network via spatiotemporal fusion for EEG-based emotion recognition.

Introduction: Emotion recognition using electroencephalography (EEG) is a key aspect of brain-computer interface research. Achieving precision requires effectively extracting and integrating both spatial and temporal features. However, many studies focus on a single dimension, neglecting the interplay and complementarity of multi-feature information, and the importance of fully integrating spatial and temporal dynamics to enhance performance.

Scintillating Glass Fiber Arrays Enable Remote Radiation Detection and Pixelated Imaging.

The emerging metal halide perovskites are challenging the traditional scintillators in the field of radiation detection and radiography. However, they lack the capability for remote and real-time radiation monitoring and imaging in confined and hostile conditions. To address this issue, details on an inorganic scintillating glass fiber incorporating perovskite quantum dots (QDs) as highly efficient pixelated radiation emitters are reported, while the glass fibers themselves serve at the same time as low-loss waveguides, enabling long-distance and underwater X-ray detection.

Extreme rainfall disproportionately impacts E. coli concentrations in Texas recreational waterbodies.

Waterborne pathogen contamination poses a significant threat to water resources globally and the exposure to waterborne pathogen contamination is widely recognized as unevenly distributed. Extreme weather events could exacerbate inequalities in waterborne disease as climate variability continues to escalate. However, there is a limited understanding of how extreme rainfall affects E.

Quantifying articulatory variations across phonological environments: An atlas-based approach using dynamic magnetic resonance imaging.

Identification and quantification of speech variations in velar production across various phonological environments have always been an interesting topic in speech motor control studies. Dynamic magnetic resonance imaging has become a favorable tool for visualizing articulatory deformations and providing quantitative insights into speech activities over time. Based on this modality, it is proposed to employ a workflow of image analysis techniques to uncover potential deformation variations in the human tongue caused by changes in phonological environments by altering the placement of velar consonants in utterances.

Dual recombinase polymerase amplification system combined with lateral flow immunoassay for simultaneous detection of Staphylococcus aureus and Vibrio parahaemolyticus.

Development of a highly sensitive visualization platform for multiplex genetic detection could significantly improve efficiency and reliability of on-site detection of foodborne pathogens. In this study, coupling recombinase polymerase amplification (RPA) with lateral flow immunoassay (LFIA) readout system was proposed for Staphylococcus aureus and Vibrio parahaemolyticus detection. Taking the advantage of the isothermal amplification of RPA, dual primers modified with different labeling groups were designed to realize target signal amplification.

Plant U-box E3 ligase PpPUB59 regulates anthocyanin accumulation by ubiquitinating PpBBX24 in 'Zaosu' pear and its red bud mutation.

Ubiquitination is the specific modification of target proteins in cells by ubiquitin molecules, which is under the action of a series of special enzymes such as ubiquitin-activating enzymes, binding, and ligase enzymes. Ubiquitination plays an essential role in anthocyanin accumulation in plants. There are few studies on the coloring of pear peel by ubiquitin ligase E3.

Projections of the Stroke Burden at the Global, Regional, and National Levels up to 2050 Based on the Global Burden of Disease Study 2021.

Background: Stroke is a pressing public health issue worldwide. This study aimed to forecast the future temporal trends and distribution characteristics of the global stroke burden.

Methods And Results: Global data on stroke incidence, prevalence, deaths, and disability-adjusted life years between 1990 and 2021 were obtained from the GBD (Global Burden of Disease) Study 2021.

Sodium cromoglycate exerts anti-pulmonary fibrosis effects by targeting the Keap1 protein to activate Nrf2 signaling.

Oxidative stress has been confirmed to be closely related to the occurrence and development of pulmonary fibrosis (PF). The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid-2 related factor 2 (Nrf2) pathway plays a key role in maintaining cellular redox homeostasis. Targeting the Keap1 protein to activate Nrf2 could be a promising strategy for treating PF.

Increasing phosphorus loss despite widespread concentration decline in US rivers.

The loss of phosphorous (P) from the land to aquatic systems has polluted waters and threatened food production worldwide. Systematic trend analysis of P, a nonrenewable resource, has been challenging, primarily due to sparse and inconsistent historical data. Here, we leveraged intensive hydrometeorological data and the recent renaissance of deep learning approaches to fill data gaps and reconstruct temporal trends.