Loss of N-acetylglucosaminyl transferase V is involved in the impaired osteogenic differentiation of bone marrow mesenchymal stem cells.

The imbalance of bone resorption and bone formation causes osteoporosis (OP), a common skeletal disorder. Decreased osteogenic activity was found in the bone marrow cultures from N-acetylglucosaminyl transferase V (MGAT5)-deficient mice. We hypothesized that MGAT5 was associated with osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and involved in the pathological mechanisms of osteoporosis.

LncRNA TUG1 is upregulated and promotes cell proliferation in osteosarcoma.

Objective: To examine the expression and function of long non-coding RNA () in human osteosarcoma cells.

Methods: Real-time quantitive PCR was used to detect the transcription level of in a series of osteosarcoma cell lines. Knockdown of in U2OS cells was carried out by transient transfection of siRNAs.