Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey.

Background: Limited information is available regarding the application of lung-protective ventilation strategies during one-lung ventilation (OLV) across mainland China. A nationwide questionnaire survey was conducted to investigate this issue in current clinical practice.

Methods: The survey covered various aspects, including respondent demographics, the establishment and maintenance of OLV, intraoperative monitoring standards, and complications associated with OLV.

Epigenetic PPARγ preservation attenuates temporomandibular joint osteoarthritis.

Objective: Previous studies have demonstrated that PPARγ deficiency is associated with osteoarthritis in the knee joint. However, whether epigenetic PPARγ dysregulation has any effect on temporomandibular joint osteoarthritis (TMJOA) is unknown. This study aims to determine the role and mechanism of epigenetic PPARγ dysregulation in TMJOA.

Intra-articular injection of kartogenin promotes fibrocartilage stem cell chondrogenesis and attenuates temporomandibular joint osteoarthritis progression.

Kartogenin (KGN) is a small-molecule compound that has been reported to improve the chondrogenic differentiation of mesenchymal stem cells and to alleviate knee joint osteoarthritis in animal models. However, whether KGN has any effect on temporomandibular joint osteoarthritis (TMJOA) remains unclear. We first performed partial temporomandibular joint (TMJ) discectomy to induce TMJOA in rats.

Anesthesia management of patients undergoing off-pump coronary artery bypass grafting: A retrospective study of single center.

Background: To summarize the current practice of anesthesia management for Chinese patients undergoing off-pump coronary artery bypass (OPCAB) surgery at a large-volume cardiovascular center.

Materials And Methods: The clinical data of consecutive patients undergoing isolated, primary OPCAB surgery during the period from September 2019 to December 2019 were retrospectively analyzed. Patient characteristics, intraoperative data, and short-term outcomes were extracted from the Hospital Information System and the Anesthesia Information Management System.

Fabrication of an ultra-high quality MgF micro-resonator for a single soliton comb generation.

Crystalline micro-resonators are attractive for a wide range of applications due to their extremely high quality (Q) factor. In this paper, we develop a semi-automatic method for fabricating ultra-high Q-factor MgF crystalline micro-resonators. By utilizing a force feedback sensor and corresponding control, we made a semi-automatic precision grind-and-polishing machine, and successfully fabricated trapezoid MgF resonators with diameter of 9.

Wnt16 signaling in bone homeostasis and osteoarthristis.

Wnts are secreted cysteine-rich glycoproteins involved in joint development and skeletal homeostasis and have been implicated in the occurrence of osteoarthritis. Over the past decade, Wnt16, a member of the Wnt family, has received widespread attention for its strong association with bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk. In recent years, further studies have shed light on the role of Wnt16 a positive regulator of bone mass and protective regulator of osteoarthritis progression.

Intra-articular injection of a novel Wnt pathway inhibitor, SM04690, upregulates Wnt16 expression and reduces disease progression in temporomandibular joint osteoarthritis.

Abnormal Wnt signaling has been shown to be involved in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA). Recent studies demonstrates that SM04690, a small-molecule inhibitor of the Wnt signaling pathway, is able to promote cartilage regeneration in a rat model of knee joint osteoarthritis. However, whether SM04690 has any effect on TMJOA is unknown.

The Efficacy and Safety of Remimazolam Tosilate versus Etomidate-Propofol in Elderly Outpatients Undergoing Colonoscopy: A Prospective, Randomized, Single-Blind, Non-Inferiority Trial.

Objective: The optimal sedation regime during endoscopy remains controversial, especially for elderly outpatients. In this study, we compared the efficacy and safety between remimazolam tosilate (RT) and etomidate-propofol (EP) in elderly outpatients undergoing colonoscopy.

Methods: A total of 260 elderly outpatients undergoing sedative colonoscopy were randomized into two groups.

Aluminum nitride nanophotonics for beyond-octave soliton microcomb generation and self-referencing.

Frequency microcombs, alternative to mode-locked laser and fiber combs, enable miniature rulers of light for applications including precision metrology, molecular fingerprinting and exoplanet discoveries. To enable frequency ruling functions, microcombs must be stabilized by locking their carrier-envelope offset frequency. So far, the microcomb stabilization remains compounded by the elaborate optics external to the chip, thus evading its scaling benefit.

Gait phase detection based on inertial measurement unit and force-sensitive resistors embedded in a shoe.

This study proposes a system to detect the phases of gait. It consists of an intelligent shoe equipped with an inertial measurement unit (IMU) and force-sensitive resistors (FSRs), and it uses a compound method to recognize gait. The continuous wavelet transform is applied according to accelerations obtained via the IMU to identify heel strike and toe-off events.

Malignant fibrous histiocytoma of the floor of mouth: a case report and review of the literature.

Malignant fibrous histiocytoma (MFH) is the most common soft tissue sarcoma in late adulthood and usually occurs in the limbs, trunk, and peritoneum. Less than 10% of MFH cases occur in the head and neck region. The clinical manifestations and pathological features of MFH are atypical, and it is difficult to make a clinical diagnosis.

Sevoflurane Limits Glioma Progression by Regulating Cell Proliferation, Apoptosis, Migration, and Invasion via miR-218-5p/DEK/β-Catenin Axis in Glioma.

Purpose: Sevoflurane (SEV) is a frequently used volatile anesthetic in cancer surgery. Sevoflurane treatment has been shown to suppress the migration and invasion of several human cancer cells. However, the effect of sevoflurane on glioma remains largely unclear.

WNT16 is upregulated early in mouse TMJ osteoarthritis and protects fibrochondrocytes against IL-1β induced inflammatory response by regulation of RUNX2/MMP13 cascade.

WNT16 has been shown to play important roles in joint formation, bone homeostasis and knee joint osteoarthritis. However, whether WNT16 has any effect during temporomandibular joint osteoarthritis (TMJOA) is still unknown. Here, we first established a surgically induced TMJOA model by performing partial discectomy in discs of TMJ in mice.

Photonic Dissipation Control for Kerr Soliton Generation in Strongly Raman-Active Media.

Microcavity solitons enable miniaturized coherent frequency comb sources. However, the formation of microcavity solitons can be disrupted by stimulated Raman scattering, particularly in the emerging crystalline microcomb materials with high Raman gain. Here, we propose and implement dissipation control-tailoring the energy dissipation of selected cavity modes-to purposely raise or lower the threshold of Raman lasing in a strongly Raman-active lithium niobate microring resonator and realize on-demand soliton mode locking or Raman lasing.

Development of a five-protein signature for predicting the prognosis of head and neck squamous cell carcinoma.

Currently no reliable indicators are available for predicting the clinical outcome of head and neck squamous cell carcinoma (HNSCC). This study aimed to develop a protein-based model to improve the prognosis prediction of HNSCC. The proteome data of HNSCC cohort was downloaded from The Cancer Proteome Atlas (TCPA) portal.

Ultraviolet to mid-infrared supercontinuum generation in single-crystalline aluminum nitride waveguides.

We demonstrate ultrabroadband supercontinuum generation from ultraviolet to mid-infrared wavelengths in single-crystalline aluminum nitride waveguides. Tunable dispersive waves are observed at the mid-infrared regime by precisely controlling the waveguide widths. In addition, ultraviolet light is generated through cascaded second-harmonic generation in the modal phase-matched waveguides.

Myxofibrosarcoma of the mandible: a case report and review of the literature.

Background: Myxofibrosarcoma (MFS) is a soft tissue sarcoma that commonly occurs in late adult life. It is mainly located in the subcutaneous soft tissues of extremities characterized by a high recurrence rate at the original site. MFS of the head and neck is rare, while it occurs in the maxilla and mandible is extremely rare.

Widely separated optical Kerr parametric oscillation in AlN microrings.

Here, we report $ {\chi ^{(3)}} $χ-based optical parametric oscillation (OPO) with widely separated signal-idler frequencies from crystalline aluminum nitride microrings pumped at $ 2\,\,\unicode{x00B5}{\rm m} $2µm. By tailoring the width of the microring, OPO reaching toward the telecom and mid-infrared bands with a frequency separation of 64.2 THz is achieved.

Notch Signaling Regulates MMP-13 Expression via Runx2 in Chondrocytes.

Notch signaling is involved in the early onset of osteoarthritis. The aim of this study was to investigate the role of Notch signaling changes during proliferation and differentiation of chondrocyte, and to testify the mechanism of MMP-13 regulation by Notch and Runx2 expression changes during osteoarthritis. In this study, Chondrocytes were isolated from rat knee cartilages.

Stokes and anti-Stokes Raman scatterings from frequency comb lines in poly-crystalline aluminum nitride microring resonators.

In optical microresonators, stimulated Raman scattering (SRS) competes with four-wave mixing process and impact Kerr comb generation. Here, we demonstrate Raman frequency combs in poly-crystalline aluminum nitride (AlN) microring resonators. The Raman shifts at transverse-electric (TE) and transverse-magnetic (TM) polarizations are characterized from AlN straight waveguides using backscattering geometries.

Beyond 100 THz-spanning ultraviolet frequency combs in a non-centrosymmetric crystalline waveguide.

Ultraviolet frequency combs enable applications ranging from precision spectroscopy to atomic clocks by addressing electronic transitions of atoms and molecules. Access to ultraviolet light via integrated nonlinear optics is usually hampered by the strong material dispersion and large waveguide attention in ultraviolet regions. Here we demonstrate a simple route to chip-scale ultraviolet comb generators, simultaneously showing a gap-free frequency span of 128 terahertz and high conversion efficiency.

Soliton microcomb generation at 2 μm in z-cut lithium niobate microring resonators.

Chip-based soliton frequency combs have been demonstrated on various material platforms, offering broadband, mutually coherent, and equally spaced frequency lines desired for many applications. Lithium niobate (LN), possessing both second- and third-order optical nonlinearities, as well as integrability on insulating substrates, has emerged as a novel source for microcomb generation and controlling. Here we demonstrate mode-locked soliton microcombs generated around 2 μm in a high-Q z-cut LN microring resonator.

Octave-spanning supercontinuum generation in nanoscale lithium niobate waveguides.

We demonstrate octave-spanning supercontinuum generation in unpoled lithium niobate waveguides, which are engineered to possess anomalous dispersion and pumped by a turn-key femtosecond laser centered at 1560 nm. Tunable dispersive waves and strong phase-matched second-harmonic generation are both observed by controlling the widths of the waveguides. The major features of the experimental spectra are reproduced by numerical modeling of the generalized nonlinear Schrödinger equation, which can be used to guide waveguide designs for tailoring the supercontinuum spectrum.