A new herbal extract carbon nanodot nanomedicine for anti-renal cell carcinoma through the PI3K/AKT signaling pathway.

New Re carbon nanodots with narrow size distribution, good water solubility and high cell membrane permeability were prepared from a herbal extract. They exhibited high inhibitory effects on renal cancer A498 cells and renal cell carcinoma. They could stimulate the production of ROS, induce mitochondrial dysfunction, and accelerate the release of intracellular calcium ions in the A498 cells.

Using multi-omics to explore the genetic causal relationship between colorectal cancer and heart failure in gastrointestinal tumors.

Background: Heart failure (HF) and colorectal cancer are significant public health concerns with substantial morbidity and mortality. Previous studies have indicated a close association between HF and various tumors, including colorectal cancer. Further understanding the potential causal relationship between them could provide insights into their shared pathophysiological mechanisms and inform strategies for prevention and treatment.

A new strategy of using low-dose caffeic acid carbon nanodots for high resistance to poorly differentiated human papillary thyroid cancer.

Thyroid cancer is one of the most common endocrine malignancies in clinical practice. Traditional surgery and radioactive iodine ablation have poor treatment results for poorly differentiated thyroid cancer, and there is a risk of metastasis and recurrence. In this study, caffeic acid, a natural herbal extract with certain biological activity, has been as precursor to prepare new caffeic acid carbon nanodots via a one-step hydrothermal method.

The role of ICT investment, digital financial inclusion, and environmental tax in promoting sustainable energy development in the MENA region: Evidences with Dynamic Common Correlated Effects (DCE) and instrumental variable-adjusted DCE.

His research investigates the interplay among investment in Information and Communication Technology [ICT], digital financial inclusion, environmental tax policies, and their impact on the progression of sustainable energy development within the Middle East and North Africa [MENA] region. Recognizing the distinctive hurdles impeding sustainable energy advancement, effective policy formulation and implementation in MENA necessitate a comprehensive understanding of these variables. Employing a Dynamic Common Correlated Effects [DCE] model alongside an instrumental variable-adjusted DCE approach, this study explores the relationship between ICT investment, digital financial inclusion, environmental tax, and sustainable energy development.

Construction of Hierarchical Yolk-Shell Co/N-Dope C@void@C@MoS Composites with Multiple Heterogeneous Interfaces toward Broadband Electromagnetic Wave Absorption.

The synthesis of materials with a multicomponent hierarchical structure is an essential strategy for achieving high-performance electromagnetic wave (EMW) absorption. However, conventional design strategies face challenges in terms of the rational construction of specific architecture. In this study, we employ a combined space-restricted and hierarchical construction strategy to surface-plant MoS nanosheets on yolk-shell structural carbon-modified Co-based composites, leading to the development of high-performance Co/NC@void@C@MoS absorbers with advanced architecture.

Yolk-shell construction of CoFe modified with dual carbon for broadband microwave absorption.

The rational and effective combination of multicomponent materials and the design of subtle microstructure for efficient microwave absorption are still challenging. In this study, carbon-coated CoFe with heterogeneous interfaces was space-restricted in the void space of hollow mesoporous carbon spheres through a facile approach involving electrostatic adsorption and annealing, and a high-performance microwave absorber (MAs) (denoted as CoFe@C@void@C) was successfully prepared. The heterostructure, three-dimensional lightweight porous morphology, and electromagnetic synergy strategy enabled the CoFe@C@void@C material with yolk-shell structure to exhibit surprising microwave absorption properties.

Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.

Background: We aim to compare the differences in growth characteristics between part-solid and solid lung adenocarcinoma, and to investigate the value of volume doubling time (VDT) or mass doubling time (MDT) in predicting lymph node (LN) metastasis and preoperative evaluation in patients of early-stage (IA) non-small cell lung cancer (NSCLC).

Method: We reviewed 8,653 cases of surgically resected stage IA lung adenocarcinoma between 2018 and 2022, with two follow-up visits at least 3 months apart, comparing diameter, volume, and mass growth of pSN and SN. VDT and MDT calculations for nodules with a volume change of at least 25%.

Material resource decoupling dilemma: Convergence and traps of in-use stock productivity in national economy development.

Various studies have suggested decoupling material stock from economic output as an important measure for promoting sustainable development. Here, we develop three theoretical hypotheses to describe the evolution features and economic effects of material stock intensity, and predict in theory that (1) Countries with higher material stock intensity are more likely to decouple economic growth from material stock. (2) Material stock intensity follows convergence trends.

Large but overlooked carbon differentiations inside China's provinces matters to mitigation strategies design: Evidence from county-level analysis.

In China, wide variations exist not only among different provinces, but also inside provinces. Therefore, intensive policy adjustments are essential for promoting carbon neutral in China, which calls for a clear understanding of carbon emission disparities in each individual province. Based on panel data of 2001 county-level administrative areas from 2004 to 2017, we use Theil index and spatial regression models to measure contributions and distributions of intra-provincial carbon inequality, as well as effects of intra-provincial economic inequality on intra-provincial carbon inequality, in order to design provincial specific strategies considering carbon differentiations inside each province.

Proposal of Modified Lung-RADS in Assessing Pulmonary Nodules of Patients with Previous Malignancies: A Primary Study.

Background: In addition to the diameters of pulmonary nodules, the number and morphology of blood vessels in pure ground-glass nodules (pGGNs) were closely related to the occurrence of lung cancer. Moreover, the benign and malignant signs of nodules were also valuable for the identification of nodules. Based on these two points, we tried to revise Lung-RADS 2022 and proposed our Modified Lung-RADS.

FUSCA3-induced AINTEGUMENTA-like 6 manages seed dormancy and lipid metabolism.

FUSCA 3 (FUS3), a seed master regulator, plays critical role in seed dormancy and oil accumulation. However, its downstream regulation mechanisms remain poorly understood. Here, we explored the roles of AINTEGUMENTA-like 6 (AIL6), a seed transcription factor, in these processes.

Genome-wide analysis revealed the stepwise origin and functional diversification of HSDs from lower to higher plant species.

Hydroxysteroid dehydrogenase (HSDs) is an oil-body sterol protein (steroleosin) with an NADP(H) binding domain that belongs to the short-chain dehydrogenase/reductase (SDR) superfamily. There are numerous studies on the characterization of in plants. However, thus far, the evolutionary differentiation and divergence analysis of these genes remain to be explored.

The influence of different previous cancer histories on the diagnostic efficacy of Lung Imaging Reporting and Data System.

Background: For lung cancer screening in patients with previous malignant tumors, Lung Imaging Reporting and Data System (Lung-RADS) and other lung cancer screening tools are controversial in terms of requirements for the previous cancer history. This study investigated the effect of the length and type of malignancy history on the diagnostic efficacy of Lung Imaging Reporting and Data System (Lung-RADS) 2022 in pulmonary nodules (PNs).

Methods: Chest computed tomography and clinical data of PNs in patients with a history of cancer who underwent surgical resection in The First Affiliated Hospital of Chongqing Medical University from January 1, 2018, to November 30, 2021, were retrospectively collected and evaluated based on Lung-RADS.

Correlations Between Inflammatory Cell Infiltration and Relative Density and the Boundary Manifestation of Pulmonary Non-Neoplastic Ground Glass Nodules.

Purpose: To investigate the influence factors for the various boundary manifestations of pulmonary non-neoplastic ground glass nodules (GGNs) on computed tomography (CT).

Materials And Methods: From January 2015 to March 2022, a total of 280 patients with 318 non-neoplastic GGNs were enrolled. The correlations between degree of inflammatory cell infiltration and relative density (ΔCT) and the boundary manifestations of lesions were evaluated, respectively.

Glycosylphosphatidylinositol anchor lipid remodeling directs proteins to the plasma membrane and governs cell wall mechanics.

Glycosylphosphatidylinositol (GPI) anchoring is a common protein modification that targets proteins to the plasma membrane (PM). Knowledge about the GPI lipid tail, which guides the secretion of GPI-anchored proteins (GPI-APs), is limited in plants. Here, we report that rice (Oryza sativa) BRITTLE CULM16 (BC16), a membrane-bound O-acyltransferase (MBOAT) remodels GPI lipid tails and governs cell wall biomechanics.

Xylan-based nanocompartments orchestrate plant vessel wall patterning.

Nanoclustering of biomacromolecules allows cells to efficiently orchestrate biological processes. The plant cell wall is a highly organized polysaccharide network but is heterogeneous in chemistry and structure. However, polysaccharide-based nanocompartments remain ill-defined.

ABA-INSENSITIVE 3 with or without FUSCA3 highly up-regulates lipid droplet proteins and activates oil accumulation.

ABA-INSENSITIVE 3 (ABI3) has long been known for activation of storage protein accumulation. A role of ABI3 on oil accumulation was previously suggested based on a decrease of oil content in seeds of abi3 mutant. However, this conclusion could not exclude possibilities of indirect or pleiotropic effects, such as through mutual regulatory interactions with FUSCA3 (FUS3), an activator of oil accumulation.

1,8-cineole alleviates bisphenol A-induced apoptosis and necroptosis in bursa of Fabricius in chicken through regulating oxidative stress and PI3K/AKT pathway.

Bisphenol A (BPA), an important chemical raw material, is now a ubiquitous environmental contaminant. As an endocrine disruptor similar to estrogen, BPA increases the risk of various metabolic and chronic diseases. BPA has immunotoxicity to humans and animals.

MYB61 is regulated by GRF4 and promotes nitrogen utilization and biomass production in rice.

Nitrogen (N) is a macronutrient that boosts carbon (C) metabolism and plant growth leading to biomass accumulation. The molecular connection between nitrogen utilization efficiency (NUE) and biomass production remains unclear. Here, via quantitative trait loci analysis and map-based cloning, we reveal that natural variation at the MYB61 locus leads to differences in N use and cellulose biogenesis between indica and japonica subspecies of rice.

Bat mammalian orthoreoviruses cause severe pneumonia in mice.

Mammalian orthoreovirus (MRV) infections are ubiquitous in mammals. Increasing evidence suggests that some MRVs can cause severe respiratory disease and encephalitis in humans and other animals. Previously, we isolated six bat MRV strains.

WRINKLED1 homologs highly and functionally express in oil-rich endosperms of oat and castor.

Oat (Avena sativa) and castor (Ricinus communis) accumulate a large amount of lipids in their endosperms, however the molecular mechanism remains unknown. In this study, differences in oil regulators between oat and wheat (Triticum aestivum) as well as common features between oat and castor were tested by analyzing their transcriptomes with further q-PCR analysis. Results indicated that WRINKLED1 (WRI1) homologs and their target genes highly expressed in the endosperms of oat and castor, but not in the starchy endosperms of wheat.

Rice Homeobox Protein KNAT7 Integrates the Pathways Regulating Cell Expansion and Wall Stiffness.

During growth, plant cells must coordinate cell expansion and cell wall reinforcement by integrating distinct regulatory pathways in concert with intrinsic and external cues. However, the mechanism underpinning this integration is unclear, as few of the regulators that orchestrate cell expansion and wall strengthening have been identified. Here, we report a rice () Class II KNOX-like homeobox protein, (), that interacts with different partners to govern cell expansion and wall thickening.

The Effect of Interleukin 38 on Inflammation-induced Corneal Neovascularization.

Background: Angiogenesis is tightly linked to inflammation. Cytokines of interleukin 1 (IL-1) family are key mediators in modulating inflammatory responses.

Methods: In this study, we examined the role of IL-38, a member of the IL-1 family, in mediating inflammation-induced angiogenesis.

Arabinosyl Deacetylase Modulates the Arabinoxylan Acetylation Profile and Secondary Wall Formation.

Acetylation, a prevalent modification of cell-wall polymers, is a tightly controlled regulatory process that orchestrates plant growth and environmental adaptation. However, due to limited characterization of the enzymes involved, it is unclear how plants establish and dynamically regulate the acetylation pattern in response to growth requirements. In this study, we identified a rice () GDSL esterase that deacetylates the side chain of the major rice hemicellulose, arabinoxylan.