Development of Stable and Intensified Mixing Processes for the Precise and Scalable Production of Uniform Drug Delivery Nanocarriers.

Nanocarriers show great promise in drug delivery but face challenges in stability, uniformity, and morphology control. This work introduces an enhanced mixing process to overcome these obstacles, specifically aiming to produce consistently sized poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with anti-tumor drugs. By innovatively integrating a pulsation dampener into the microfluidic channels of a continuous flow preparation system, the flow stability of piston pumps is improved nearly tenfold.

Construction and validation of a nomogram for predicting the prognosis of breast cancer patients who received adjuvant therapy: an analysis based on the SEER database.

Background: Breast cancer is the most common malignant tumor in women globally. Despite advances in primary treatment, the role of adjuvant therapy in reducing recurrence and improving survival is critical; however, there is a notable lack of tailored prognostic models for patients receiving adjuvant therapy. This study used the Surveillance, Epidemiology, and End Results (SEER) database to develop a prognostic nomogram for breast cancer patients receiving adjuvant therapy.

Arginine Biosynthesis Mediates Wulingzhi Extract Resistance to Busulfan-Induced Male Reproductive Toxicity.

Busulfan, an indispensable medicine in cancer treatment, can cause serious reproductive system damage to males as a side effect of its otherwise excellent therapeutic results. Its widespread use has also caused its accumulation in the environment and subsequent ecotoxicology effects. As a Chinese medicine, Wulingzhi (WLZ) has the effects of promoting blood circulation and improving female reproductive function.

Ultrasound-assisted deep eutectic solvents extraction of polysaccharides from Loquat leaf: Process optimization and bioactivity study.

Loquat leaves are the by-product of loquat fruit production. Polysaccharides are one of the main active ingredients in loquat leaves. In this study, polysaccharides were extracted from loquat leaves by ultrasonic-assisted deep eutectic solvents (DESs) extraction method.

Molten-Salt Electrochemical Preparation of CoB/MoB Heterostructured Nanoclusters for Boosted pH-Universal Hydrogen Evolution.

Boosting the hydrogen evolution reaction (HER) activity of α-MoB at large current densities and in pH-universal medium is significant for efficient hydrogen production. In this work, CoB/MoB heterostructured nanoclusters are prepared by molten-salt electrolysis (MSE) and then used as a HER catalyst. The composition, structure, and morphology of CoB/MoB can be modulated by altering the stoichiometries of raw materials and synthesis temperatures.

The multifaceted role of extracellular ATP in sperm function: From spermatogenesis to fertilization.

Extracellular adenosine 5'-triphosphate (ATP) is a vital signaling molecule involved in various physiological processes within the body. In recent years, studies have revealed its significant role in male reproduction, particularly in sperm function. This review explores the multifaceted role of extracellular ATP in sperm function, from spermatogenesis to fertilization.

Effect and mechanism of microplastics exposure against microalgae: Photosynthesis and oxidative stress.

The occurrence of microplastics (MPs) within aquatic ecosystems attracts a major environmental concern. It was demonstrated MPs could cause various ecotoxicological effects on microalgae. However, existing data on the effects of MPs on microalgae showed great variability among studies.

The prevalence of depression, anxiety, and sleep disturbances in patients with neuromyelitis optica spectrum disorders (NMOSD): A systematic review and meta-analysis.

Objective: To estimate pooled prevalence of depression, anxiety, and sleep disturbances in neuromyelitis optica spectrum disorders (NMOSD) cases.

Methods: Electronic database of PubMed (MEDLINE), the Cochrane Central Register of Controlled Trials (CENTRAL), Embase and Web of Science ware systematically searched to identify relevant studies published not later than June 10, 2022. Specifically, original articles that reported the prevalence of depression, anxiety and sleep disturbances were selected.

Toxic effects of three perfluorinated or polyfluorinated compounds (PFCs) on two strains of freshwater algae: Implications for ecological risk assessments.

Perfluorinated or polyfluorinated compounds (PFCs) continue entering to the environmental as individuals or mixtures, but their toxicological information remains largely unknown. Here, we investigated the toxic effects and ecological risks of Perfluorooctane sulfonic acid (PFOS) and its substitutes on prokaryotes (Chlorella vulgaris) and eukaryotes (Microcystis aeruginosa). Based on the calculated EC values, the results showed that PFOS was significantly more toxic to both algae than its alternatives including Perfluorobutane sulfonic acid (PFBS) and 6:2 Fluoromodulated sulfonates (6:2 FTS), and the PFOS-PFBS mixture was more toxic to both algae than the other two PFC mixtures.

New insights into engineering the core size and carbon shell thickness of Co@C core-shell catalysts for efficient and stable Fenton-like catalysis.

Herein, we engineered the cobalt core size and carbon shell thickness of Co@C by molten salt electrolysis (MSE) to investigate the enhanced essence of decreasing core size as well as the shell thickness dependence-mediated transition of catalytic mechanisms. We found that the reaction activation energy (RAE) of Co@C/peroxymonosulfate (PMS) systems was intimately dependent on the core sizes for sulfamethoxazole (SMX) degradation. The smaller core size of 26 nm provided a lower RAE of 13.

Evaluation of atrial anatomical remodeling in atrial fibrillation with machine-learned morphological features.

Purpose: To elucidate the role of atrial anatomical remodeling in atrial fibrillation (AF), we proposed an automatic method to extract and analyze morphological characteristics in left atrium (LA), left atrial appendage (LAA) and pulmonary veins (PVs) and constructed classifiers to evaluate the importance of identified features.

Methods: The LA, LAA and PVs were segmented from contrast computed tomography images using either a commercial software or a self-adaptive algorithm proposed by us. From these segments, geometric and fractal features were calculated automatically.

Acute effects of three surface-modified nanoplastics against Microcystis aeruginosa: Growth, microcystin production, and mechanisms.

As plastic pollution continues to increase and plastic waste is shredded to form smaller plastic particles, there is growing concern about the potential impact of nanoplastics (NPs) on freshwater ecosystems. In this work, the effects of three surface-modified NPs, including polystyrene (PS), PS-NH, and PS-COOH, on the growth, photosynthetic activity, oxidative damage, and microcystins (MCs) production/release of Microcystis aeruginosa (M. aeruginosa) were investigated.

Oncogenic signaling pathway-related long non-coding RNAs for predicting prognosis and immunotherapy response in breast cancer.

Background: The clinical outcomes of breast cancer (BC) are unpredictable due to the high level of heterogeneity and complex immune status of the tumor microenvironment (TME). When set up, multiple long non-coding RNA (lncRNA) signatures tended to be employed to appraise the prognosis of BC. Nevertheless, predicting immunotherapy responses in BC is still essential.

RASSF8-AS1 displays low expression in colorectal cancer and up-regulates RASSF8 to suppress cell invasion and migration.

Background: Colorectal cancer (CRC) is among the most prevalent cancers. Long non-coding RNAs (lncRNAs) are important participant in various cancers. Based on the literature, lncRNA RASSF8-AS1 inhibits laryngeal squamous cell carcinoma (LSCC) malignant progression.

Joint toxicity mechanisms of binary emerging PFAS mixture on algae (Chlorella pyrenoidosa) at environmental concentration.

Since traditional Per- and polyfluoroalkyl substances (PFAS) were banned in 2009 due to their bioaccumulation, persistence and biological toxicity, the emerging PFAS have been widely used as their substitutes and entered the aquatic environment in the form of mixtures. However, the joint toxicity mechanisms of these emerging PFAS mixtures to aquatic organisms remain largely unknown. Then, based on the testing of growth inhibition, cytotoxicity, photosynthesis and oxidative stress, and the toxicity mechanism of PFAS mixture (Perfluorobutane sulfonate and Perfluorobutane sulfonamide) to algae was explored using the Gene set enrichment analysis (GSEA).

GA4GH: International policies and standards for data sharing across genomic research and healthcare.

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution.

Toxicity mechanism of Nylon microplastics on Microcystis aeruginosa through three pathways: Photosynthesis, oxidative stress and energy metabolism.

Nylon has been widely used all over the world, and most of it eventually enters the aquatic environment in the form of microplastics (MPs). However, the impact of Nylon MPs on aquatic ecosystem remains largely unknown. Thus, the long-term biological effects and toxicity mechanism of Nylon MPs on Microcystis aeruginosa (M.

Anti-oxidant mechanisms of Chlorella pyrenoidosa under acute GenX exposure.

GenX, a substitute for perfluorooctanoic acid, has been widely detected in surface water. Due to its bioaccumulation, toxicity and persistence, GenX can cause adverse effects such as oxidative damage on aquatic organisms. To investigate the toxicity of GenX and the anti-oxidant mechanism of algae under acute exposure, the growth, photosynthetic activity and gene expression of Chlorella pyrenoidosa (C.

Growth inhibition, toxin production and oxidative stress caused by three microplastics in Microcystis aeruginosa.

Microplastics (MPs) have aroused widespread concern due to their extensive distribution in aquatic environments and adverse effects on aquatic organisms. However, the underlying toxicity of different kinds of MPs on freshwater microalgae has not been examined in detail. In this study, we investigated the effects of polyvinyl chloride (PVC), polystyrene (PS) and polyethylene (PE) MPs on the growth of Microcystis aeruginosa, as well as on its toxin production and oxidative stress.

Toxic effects and mechanisms of PFOA and its substitute GenX on the photosynthesis of Chlorella pyrenoidosa.

Perfluorooctanoic acid (PFOA) and its substitute GenX are toxic chemicals that are widespread in the aquatic environment. However, there is little information about their toxicity mechanisms to aquatic organisms. In this study, Chlorella pyrenoidosa (C.

Polystyrene nanoplastics affect growth and microcystin production of Microcystis aeruginosa.

Nanoplastics are widely distributed in freshwater environments, but few studies have addressed their effects on freshwater algae, especially on harmful algae. In this study, the effects of polystyrene (PS) nanoplastics on Microcystis aeruginosa (M. aeruginosa) growth, as well as microcystin (MC) production and release, were investigated over the whole growth period.

Robust performance of a novel stool DNA test of methylated SDC2 for colorectal cancer detection: a multicenter clinical study.

Background And Aims: Stool DNA testing is an emerging and attractive option for colorectal cancer (CRC) screening. We previously evaluated the feasibility of a stool DNA (sDNA) test of methylated SDC2 for CRC detection. The aim of this study was to assess its performance in a multicenter clinical trial setting.

Low platelet count is a risk factor of postoperative pneumonia in patients with type A acute aortic dissection.

Background: Previous studies have already established that low platelet count is related to adverse outcomes in patients with type A acute aortic dissection (AAAD). However, there are yet limited studies investigating the association of platelet count and the risk of postoperative pneumonia in AAAD patients.

Methods: This retrospective cohort study was conducted in Xiangya Hospital of Central South University from January 2014 to May 2019.

Development of a hydrophilic magnetic amino-functionalized metal-organic framework for the highly efficient enrichment of trace bisphenols in river water samples.

Bisphenols, a typical pollutant with endocrine acting the scientific attention for their ascertained toxicity and wide uses. The magnetic Zr-MOFs (FeO@PDA@UiO-66-NH), functionalized with amino groups and proved by a series of material characterization techniques, were successfully prepared as adsorbents for magnetic solid-phase extraction (MSPE) of five bisphenols (including bisphenol A, bisphenol B, bisphenol S, bisphenol AP and bisphenol AF) from water samples. Liquid chromatography coupled with tandem mass spectrometry was used for sample analysis and quantification.