Rapid-calibration optical tunable delay line on 3-µm-thick SOI photonic platforms.

Optical tunable delay lines (OTDLs) which can capture temporal optical signals, and overcome the challenge of halting light are crucial for optical communications and microwave photonics. Here, a rapid-calibration 8-bit OTDL on the 3-µm-thick silicon-on-insulator (SOI) platform consisting of waveguide spirals and integrated optical switches is proposed, achieving a maximum delay time of 3570 ps with a resolution of 14 ps/stage. The large delay is attributed to the spirals of a 3-µm-thick SOI platform featuring a delay efficiency of approximately 11.

Causal role of the pyrimidine deoxyribonucleoside degradation superpathway mediation in Guillain-Barré Syndrome via the HVEM on CD4 + and CD8 + T cells.

Immune system regulation is a key indicator of the gut microbiota (GM) influencing disease development. The causal role of the GM in Guillain-Barré syndrome (GBS) and whether it can be mediated by immune cells is unknown. Genome-wide association study (GWAS) summary statistics for the GM were obtained from the Dutch Microbiota Project (n = 7,738) and the FINRISK 2002 (FR02) cohort (n = 5,959).

Analysis of the Asymmetrical Rolling of Ultra-Thin Strips Considering Elastic Deformation of the Strips.

In normal cold rolling, the elastic deformation of the strip is typically ignored because of the dominant plastic deformation. However, this neglect may introduce additional errors when the strip is very thin. The aim of this study is to investigate the characteristics of the deformation region and thickness reduction in the asymmetrical rolling of ultra-thin strips.

Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress.

Apigenin (API) is a natural flavonoid compound with antioxidant, anti fibrotic, anti-inflammatory and other effects, but there is limited research on the effect of API on liver fibrosis. This study aims to explore the effect and potential mechanism of API on liver fibrosis induced by CCl4 in mice. The results indicate that API reduces oxidative stress levels, inhibits hepatic stellate cell (HSC) activation, and exerts anti liver fibrosis effects by regulating the PKM2-HIF-1α pathway.

Forming Characteristics of Tailor Rolled Blank of Aluminum Alloy during Three-Point Bending.

This paper presents an investigation on the forming characteristics of the tailor rolled blank of an aluminum alloy (Al-TRB) during three-point bending at room temperature through experiments and finite element simulations. The strain distribution, spring-back characteristics, and metal flow law of 6000 series Al-TRB during three-point bending are explored. The prepared Al-TRB has good bending properties, and no surface cracks appear in the bending region of the Al-TRB when bent to 180°.

Review on Cellular Automata for Microstructure Simulation of Metallic Materials.

The cellular automata (CA) method has played an important role in the research and development of metallic materials. CA can interpret the microstructure changes of materials and obtain more abundant, accurate and intuitive information of microstructure evolution than conventional methods. CA can visually represent the process of grain formation, growth, development and change to us in a graphical way, which can assist us in analysis, thinking and solving problems.

[Research on fault diagnosis of patient monitor based on text mining].

The conventional fault diagnosis of patient monitors heavily relies on manual experience, resulting in low diagnostic efficiency and ineffective utilization of fault maintenance text data. To address these issues, this paper proposes an intelligent fault diagnosis method for patient monitors based on multi-feature text representation, improved bidirectional gate recurrent unit (BiGRU) and attention mechanism. Firstly, the fault text data was preprocessed, and the word vectors containing multiple linguistic features was generated by linguistically-motivated bidirectional encoder representation from Transformer.

Analysis of Mechanical Parameters in Multi-Pass Asymmetrical Rolling of Strip by Slab Method.

Mechanical parameters, time consumption and energy consumption are important considerations in the application of a certain rolling process. This study aims to investigate characteristics of the roll force, roll torque, roll power, rolling time and total work in multi-pass asymmetrical rolling of strip. Mathematic models were built using the slab method to calculate parameters in the asymmetrical rolling process, and the characteristics of these parameters were analyzed on the basis of simulation results.

A bibliometric analysis of metastatic breast cancer: two-decade report (2002-2022).

Background: MBC is a lethal form of breast cancer that arises when cancer cells invade other organs or tissues. The treatment of MBC needs personalized approaches based on the tumor and patient characteristics. The purpose of this paper is to analyze MBC studies from 2002 to 2022 using bibliometrics and to investigate its current situation, main contributors, core journals, highly cited papers, and topic evolution.

Microstructure and Mechanical Properties of Ti/Al-SiC/Ti Clad Plates Prepared via the Powder-in-Tube Method.

SiC particle-reinforced Ti/Al/Ti clad plates were successfully fabricated by the powder-in-tube method. The surface micrography, element diffusion, peeling strength and tensile property of clad plates were studied after annealing and cold rolling. The experimental results show that 6 wt.

Exploring the mechanism of Chaihujia Longgu Muli decoction in the treatment of epilepsy in rats based on the RhoA/ROCK signaling pathway.

Background: The Chinese herbal formula Chaihujia Longgu Muli Decoction (CD) has a good antiepileptic effect, but its mechanisms remain unclear. Therefore, in this study we explored the molecular mechanisms of CD against epilepsy.

Methods: Twelve-day-old SD rats were randomly divided into a normal group, model group, valproic acid group, and CD high, medium, and low groups.

Effects of Cold Rolling Reduction on Microstructure, Thickness, Adhesive Force of Al-Si Coating and on Bending Toughness of Al-Si Coated Press-Hardened Steel.

Al-Si coated press-hardened steel (PHS) is widely used along with the development of light-weight vehicles, and the tailor-rolled blank parts based on Al-Si coated PHS have attracted much attention. The preparation process includes cold rolling, austenitization, hot-stamping, and quenching. The most widely used AS60/60 coating will change after cold rolling and austenitization, which has been little-studied.

Melatonin Ameliorates Cisplatin-Induced Renal Tubular Epithelial Cell Damage through PPARα/FAO Regulation.

Previous studies revealed that melatonin ameliorated acute renal injury induced by cisplatin, but the mechanisms remain unclear. Peroxidase proliferative receptor α (PPARα) is considered the major regulator of fatty acid oxidation (FAO), which is an important source of energy for renal tubular epithelial cells. In this study, the aim was to investigate the role of melatonin in cisplatin-induced NRK-52E (rat renal tubular epithelial cell line) cell damage and the underlying mechanisms.

Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1.

Unlabelled: Despite the popular use of dietary supplements during conventional cancer treatments, their impacts on the efficacies of prevalent immunotherapies, including immune-checkpoint therapy (ICT), are unknown. Surprisingly, our analyses of electronic health records revealed that ICT-treated patients with cancer who took vitamin E (VitE) had significantly improved survival. In mouse models, VitE increased ICT antitumor efficacy, which depended on dendritic cells (DC).

Melatonin attenuates cisplatin-induced acute kidney injury in mice: Involvement of PPARα and fatty acid oxidation.

The present study focused on the protective effects of melatonin against cisplatin-induced acute kidney injury in mice and its possible mechanism of action in relation to the major regulator of fatty acid oxidation (FAO), peroxidase proliferative receptor α (PPARα). The experiment consisted of the following four groups: vehicle control, cisplatin (15 mg/kg), cisplatin & melatonin (20 mg/kg/day), and melatonin (20 mg/kg/day). Concomitant administration of melatonin significantly ameliorated cisplatin-induced acute kidney injury in mice by decreasing serum levels of triglyceride, blood urea nitrogen and creatinine, reducing the number and size of lipid droplets in tubular epithelial cells, and decreasing the incidence of histopathological changes including tubular cell apoptosis.

Analysis of Mechanical Parameters of Asymmetrical Rolling Dealing with Three Region Percentages in Deformation Zones.

A series of mathematical models were proposed to calculate the roll force, torque and power for cold strip asymmetrical rolling by means of the slab method, taking the percentages of the forward-slip, backward-slip and cross-shear zones into account. The friction power, plastic work and total energy consumption can be obtained by the models. The effects of variable rolling parameters-such as the speed ratio, entry thickness, friction coefficient and front and back tension-on the process of asymmetrical rolling are analyzed.

The lncRNA ZFAS1 regulates lipogenesis in colorectal cancer by binding polyadenylate-binding protein 2 to stabilize SREBP1 mRNA.

Colorectal cancer (CRC) is the fourth leading cause of cancer-related mortality globally. Therefore, a better understanding of the early molecular events of this disease is needed. Long noncoding RNAs (lncRNAs) play a critical role in the regulation of tumorigenesis and cancer progression.

Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in .

Autophagosomes are double-membrane intracellular vesicles that degrade protein aggregates, intracellular organelles, and other cellular components. During the development of the nematode , many somatic and germ cells undergo apoptosis. These cells are engulfed and degraded by their neighboring cells.

Comprehensive Genomic Characterization Analysis Identifies an Oncogenic Pseudogene RP11-3543B.1 in Human Gastric Cancer.

Gastrointestinal Cancer (GICs) is the most common group of malignancies, and many of its types are the leading causes of cancer related death worldwide. Pseudogenes have been revealed to have critical regulatory roles in human cancers. The objective of this study is to comprehensive characterize the pseudogenes expression profiling and identify key pseudogenes in the development of gastric cancer (GC).

Idiopathic Granulomatous Mastitis: Etiology, Clinical Manifestation, Diagnosis and Treatment.

Idiopathic granulomatous mastitis (IGM) is a rare form of chronic inflammatory breast disease. Although it is a benign breast lesion, it may be sometimes difficult to distinguish from breast cancer. The cause of IGM is unknown, but may be associated with autoimmunity, abnormal hormone levels and infection.