Effect of copy number variation of PLA2G2A gene to growth traits in Chinese cattle.

As a member of genetic polymorphism, copy number variation has been a commonly used method in the world for investigating effect of genetic polymorphism on gene expression. Effect of genetic polymorphism made on livestock development has been more and more important in beef cattle molecular breeding. The characteristics of Chinese cattle are excellent meat quality, tolerant to rough feeding, good environmental adaptability and so on.

Evaluation of photodegradation performance by paper microzones.

Currently, the performance evaluation of catalysts usually requires expensive instruments. Hence, it is imperative to develop an alternative, green and sustainable method to investigate the photocatalytic reaction processes. Herein, the variation of degradation performance of different wastewaters with different dosage of P25 TiO was evaluated to verify the reliability of the paper microzones method (PMZs).

Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice.

Lipoatrophy is characterized as selective loss of adipose tissues, leading to the severity of cardiovascular disorders. Therefore, there was close intraorgan crosstalk between adipose tissue and cardiovascular in lipoatrophy. A-ZIP/F-1 mouse, a well-established lipoatrophic model, and primary cardiomyocytes were used for investigating the pathophysiological changes and molecular mechanisms.

The GABA transaminase GabT is required for full virulence of in tomato.

The utilization of plant gamma-aminobutyric acid (GABA) is essential for the pathogenicity of the bacterial plant pathogen . A knockout mutant in the GABA transaminase-encoding gene is unable to utilize GABA as a nutrient and its ability to cause disease in plants is strongly compromised. However, the proximity of the gene (encoding a succinate semialdehyde dehydrogenase) in the same operon raises the question of whether an impact on the gene underlies or contributes to the virulence attenuation of the mutant.

Metal-Nanoparticles-Loaded Ultrathin g-CN Nanosheets at Liquid-Liquid Interfaces for Enhanced Biphasic Catalysis.

Exploiting new interface-active solid catalysts is crucial to construct efficient Pickering emulsion systems for biphasic catalysis. In this work, ultrathin g-CN nanosheets (g-CN-NSs) were developed as a new solid emulsifier to directly position catalytic sites at oil-water interfaces for improving the reaction efficiency of a biphasic reaction. Exemplified by a metal-involved biphasic reaction of nitroarenes reduction, the developed Pd/g-CN-NSs catalyst with Pd nanoparticles loaded on the surface of g-CN-NSs exhibited excellent activity with a catalytic efficiency of 1220 h.

Tomato Stem Injection for the Precise Assessment of Fitness .

is a soil-borne pathogen with worldwide distribution that causes bacterial wilt disease in more than 250 plant species. invades plants through the roots, reaches the vascular system, and colonizes the whole plant by moving through the xylem, where it eventually replicates rapidly, causing plant death. Usual assays to measure the virulence of under laboratory conditions rely on soil-drenching inoculation followed by observation and scoring of disease symptoms.

Preparation of molecularly imprinted Ag-TiO for photocatalytic removal of ethyl paraben.

Herein, MI-Ag-TiO was prepared by one-step sol-gel method, and its photocatalytic and characterization performance were fully analyzed. Within 120 min, the photocatalytic degradation rate of MI-Ag-TiO to ethyl paraben was 93.4%, which was 1.

Prevalence of epilepsy in autism spectrum disorders: A systematic review and meta-analysis.

Autistic individuals experience higher co-occurring medical conditions than the general population, and yet the estimates of autistic individuals with epilepsy are not updated. Co-occurrence of epilepsy in autistic individuals often aggravated cognitive impairment and increased the risk of poor long-term prognosis. Thus, an updated systematic review and meta-analysis was conducted to study the relevant articles published from inception to 2020, evaluate the prevalence of epilepsy in autistic individuals, and further explore the putative factors influencing the prevalence.

A mild clinical and neuropsychological phenotype of Renpenning syndrome: A new case report with a maternally inherited missense mutation.

Mutations in the gene are associated with Renpenning syndrome (RENS1, ). Most cases are characterized by intellectual disability, but a detailed neuropsychological profile has not yet been established. The present case study of a 8.

Pitx controls amphioxus asymmetric morphogenesis by promoting left-side development and repressing right-side formation.

Background: Left-right (LR) asymmetry is an essential feature of bilateral animals. Studies in vertebrates show that LR asymmetry formation comprises three major steps: symmetry breaking, asymmetric gene expression, and LR morphogenesis. Although much progress has been made in the first two events, mechanisms underlying asymmetric morphogenesis remain largely unknown due to the complex developmental processes deployed by vertebrate organs.

Different modulation effects of 1 Hz and 20 Hz transcutaneous auricular vagus nerve stimulation on the functional connectivity of the periaqueductal gray in patients with migraine.

Background: A growing body of evidence suggests that transcutaneous auricular vagus nerve stimulation (taVNS) may relieve symptoms of migraineurs. Frequency is one of the key stimulation parameters. The aim of this study is to investigate the modulation effect of taVNS frequency on the descending pain modulation system (DPMS) in patients with migraine.

Three-dimensional printed model of impacted third molar for surgical extraction training.

Objectives: Extraction of impacted mandibular third molars is one of the most common surgical procedures performed at dental clinics; however effective training models for teaching oral surgery to dental students are limited. This study aimed to use three-dimension (3D) printing technology to develop an effective training model for impacted third molar extraction.

Methods: The data for the 3D model were digitally processed using high-resolution computed tomography, and two common, but different patterns of impacted third molars were simulated using computer-aided design.

Two cSNPs sites in the fatty acid-binding protein 4 () gene and their association analysis with body measurement data in five Chinese cattle breeds.

Single nucleotide polymorphisms (SNPs) include the transition and transversion of a single base. In this study, we found two cSNPs (rs110757796 and rs110652478) in the (fatty acid-binding protein 4) gene and tested their population genetic parameters in five Chinese cattle breeds. FABP4 is a key marker molecule for lipid production.

TSMiner: a novel framework for generating time-specific gene regulatory networks from time-series expression profiles.

Time-series gene expression profiles are the primary source of information on complicated biological processes; however, capturing dynamic regulatory events from such data is challenging. Herein, we present a novel analytic tool, time-series miner (TSMiner), that can construct time-specific regulatory networks from time-series expression profiles using two groups of genes: (i) genes encoding transcription factors (TFs) that are activated or repressed at a specific time and (ii) genes associated with biological pathways showing significant mutual interactions with these TFs. Compared with existing methods, TSMiner demonstrated superior sensitivity and accuracy.

Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging.

Objective: To evaluate amide proton weighted (APTw) MRI combined with diffusion-weighted imaging (DWI) in predicting neoadjuvant chemoradiotherapy (NCRT) response in patients with locally advanced rectal cancer (LARC).

Methods: 53 patients with LARC were enrolled in this retrospective study. MR examination including APTw MRI and DWI was performed before and after NCRT.

SepPCNET: Deeping Learning on a 3D Surface Electrostatic Potential Point Cloud for Enhanced Toxicity Classification and Its Application to Suspected Environmental Estrogens.

Deep learning (DL) offers an unprecedented opportunity to revolutionize the landscape of toxicity prediction based on quantitative structure-activity relationship (QSAR) studies in the big data era. However, the structural description in the reported DL-QSAR models is still restricted to the two-dimensional level. Inspired by point clouds, a type of geometric data structure, a novel three-dimensional (3D) molecular surface point cloud with electrostatic potential (SepPC) was proposed to describe chemical structures.

Metal-Organic Framework-Derived Carbon/Carbon Nanotubes Mediate Impedance Matching for Strong Microwave Absorption at Fairly Low Temperatures.

The use of magnetic particles and carbon materials, particularly those with compatible dielectric and magnetic loss, is crucial in managing microwave pollution. However, the mismatched impedance of currently available absorbers constrains their practical applications. Herein, we demonstrate the potential of a metal-organic framework (MOF)-derived composite whose impedance matching is optimized through spraying and immersion of MOF precursors in carbon nanotube socks followed by carbonization.

Prevalence and Characteristics of Social Withdrawal Tendency Among 3-24 Months in China: A Pilot Study.

Sustained withdrawal behavior is an obstacle for child development. The present study aimed to preliminarily evaluate the prevalence of social withdrawal tendency in young Chinese children using the Alarm Distress Baby Scale (ADBB) and describe the characteristics of socially withdrawn children. This was a cross-sectional analysis as part of a prospective cohort study.

[Spatio-temporal Variation Characteristics Monitored by Remotely Sensed Technique of PM Concentration and Its Influencing Factor Analysis in Sichuan Basin, China].

The spread of atmospheric pollutants in the Sichuan Basin is difficult because of its unique topography, static wind, high humidity, and other meteorological conditions. Owing to the acceleration of urbanization and industrialization, PM pollution in the region is becoming increasingly severe, and the Sichuan Basin has become one of the key areas of national air pollution prevention and control. In this study, based on the remote sensing inversion product of PM concentration, spatial autocorrelation and gray correlation analyses are used to evaluate the spatial and temporal distribution characteristics and influencing factors of PM concentration in the Sichuan Basin.

Combination of Disulfiram and Copper-Cysteamine Nanoparticles for an Enhanced Antitumor Effect on Esophageal Cancer.

Esophageal cancer (EC) is the sixth leading cause of cancer deaths worldwide with a low 5-year survival rate. More effective chemotherapeutic drugs, either new or repurposing ones, are urgently needed. Disulfiram (DSF) is a safe and public domain drug for alcohol addiction treatment and later shown to have anti-cancer capability, especially when administrated together with copper.

A novel analytical strategy for discriminating antibiotic mycelial residue adulteration in feed based on ATR-IR and microscopic infrared imaging.

The Antibiotic mycelial residue (AMR) contains antibiotic residue, there are safety risks if it is used illegally in feed. This study investigated the feasibility of qualitative identification of AMR in protein feed and self-prepared feed based on attenuated total reflection mid-infrared spectrum (ATR-IR) and microscopic infrared imaging. Cottonseed meal (CM), soybean meal (SM), distillers dried grains with solubles (DDGS), nucleotide residue (NR), oxytetracycline residue (OR) and streptomycin sulfate residue (SR) and two self-prepared feed (broiler and pig) were used as research objects.

Histone Deacetylase 2-Mediated Epigenetic Regulation is Involved in the Early Isoflurane Exposure-Related Increase in Susceptibility to Anxiety-Like Behaviour Evoked by Chronic Variable Stress in Mice.

Increasing studies report that prolonged or multiple anaesthetic exposures early in life are associated with detrimental effects on brain function. Although studies have evaluated the detrimental effects on neurocognitive function, few have focused on long-term neuropsychiatric effects. In the present study, C57BL/6 mice received either three neonatal isoflurane exposures or control exposure.

Evaluation of the photocatalytic performance of molecularly imprinted S-TiO by paper microzones.

The paper microzones method (PMZs) is a green chemical method that uses the principle of the three primary colors of red, green and blue (RGB) to detect the water quality of the droplets on white paper. However, this method is rarely used in the performance evaluation of photocatalysts. The paper details the first use of paper microzones utilized in the evaluation of photocatalyst performance.

Overview of the molecular mechanisms of migration and invasion in glioblastoma multiforme.

Glioblastoma (GBM) is one of the most devastating cancers, with an approximate median survival of only 16 months. Although some new insights into the fantastic heterogeneity of this kind of brain tumor have been revealed in recent studies, all subclasses of GBM still demonstrate highly aggressive invasion properties to the surrounding parenchyma. This behavior has become the main obstruction to current curative therapies as invasive GBM cells migrate away from these foci after surgical therapies.