Insight into Robust Anion Coordination Behavior of Organic Cathode with Dual Elongated π-Conjugated Motifs.

Organics electrode materials offer multi-electron reactivity, flexible structures, and redox reversibility, but encounter poor conductivity and durability in electrolytes. To overcome above barriers, we propose a dual elongation strategy of π-conjugated motifs with active sites, involving extended carbazole and electropolymerized crosslinked polymer, which enhances electronic conductivity by the electronic delocalization of electron-withdrawing conjugated groups, boosts theoretical capacity by increasing redox-active site density, and endows robust electrochemical stability attributed to crosslinked organic structures. As a proof-of-concept, 5,11-dihydridoindolo[3,2-b]carbazole (DHIC) is selected as the model cathode material for a dual-ion battery, with elongated carbazole groups functioning both as redox-active centers and polymerization anchors.

Electroacupuncture ameliorates inflammatory pain through CB2 receptor-dependent activation of the AMPK signaling pathway.

Background: Chronic inflammatory pain is a pervasive condition, and electroacupuncture (EA) is an effective treatment, but its mechanisms are not fully understood. AMP-activated protein kinase (AMPK), a key energy sensor, is involved in pain relief and EA's effects. EA may work by increasing endocannabinoids, upregulating CB2 receptors (CB2R), and stimulating β-endorphin (β-END).

Comparative morphology and mitogenomics of freshwater mussels Koreosolenaia, Parvasolenaia, and Sinosolenaia (Bivalvia: Unionidae: Gonideinae).

Background: Amidst the escalating loss of global biodiversity, freshwater mussels (family Unionidae) have become one of the most imperiled animal groups. Acquiring more biological and phylogenetic information on understudied taxa constitutes a pivotal aspect of conservation biology. Consequently, a comprehensive examination was conducted on Koreosolenaia, Parvasolenaia, and Sinosolenaia from China encompassing morphology, anatomy, distribution, and molecular systematics to provide theoretical support for future species endangerment assessments and biodiversity conservation.

Doublecortin regulates the mitochondrial-dependent apoptosis in glioma via Rho-A/Net-1/p38-MAPK signaling.

Doublecortin (DCX) is a microtubule-associated protein known to be a key regulator of neuronal migration and differentiation during brain development. However, the role of DCX, particularly in regulating the survival and growth of glioma cells, remains unclear. In this study, we utilized CRISPR/Cas9 technology to knock down DCX in the human glioma cell line (U251).

[Study on drug resistance and molecular typing of food-borne Staphylococcus aureus in Ningxia, 2011-2022].

Objective: To investigate the molecular typing characteristics, drug resistance status and drug resistance gene carrying of food-borne Staphylococcus aureus in Ningxia.

Methods: Staphylococcus aureus isolated from food safety risk monitoring project in Ningxia in the past ten years were collected, drug resistance was detected using microbroth dilution method, enterotoxins were detected by real-time PCR. The strains were genotyped by pulsed field gel electrophoresis(PFGE) using SmaI endonuclease.

[Relationship between birth weight and mineral levels in umbilical artery and vein serum].

Objective: To compare the mineral levels in umbilical vein and artery serum and to analyze the relationship between newborn birth weight and the mineral levels in umbilical vein and artery serum by measuring the mineral levels in umbilical vein and artery serum.

Methods: A cross-sectional study was conducted to recruit 101 pairs of maternal and newborn who were hospitalized in Danyang People's Hospital, Jiangsu Province from June to September 2021 as the participants. After delivery, umbilical vein and artery blood were collected, and the levels of manganese(Mn), iron(Fe), cobalt(Co), copper(Cu), zinc(Zn), selenium(Se), magnesium(Mg) and calcium(Ca) in umbilical vein and artery serum were detected by inductively coupled plasma mass spectrum(ICP-MS).

[Differences and correlations in phenolic acid content in the pulp of various categories of fruits in Shenzhen].

Objective: To detect phenolic acid compounds in various fruits and explore the differences in phenolic acids among different types of fruits.

Methods: The collected 75 types of fruits were classified into 6 categories: citrus、melon、drupe、berry、tropical fruit and pome fruits. The phenolic acid compounds were detected by high performance liquid chromatography-mass spectrometry.

The effect of molecular chaperone mediated autophagy on ApoE expression in retinal pigment epithelial cells: Molecular structure and protein action mechanism.

Chaperone mediated autophagy (CMA) represents a specialized mechanism of lysosomal protein breakdown, playing a crucial role as a metabolic pathway that helps to regulate and sustain cellular and systemic physiological equilibrium. Within the CMA process, proteins that contain sequences similar to KFERQ are specifically identified by the heat shock cognate protein 70. These proteins are then chaperoned to the lysosomes for subsequent degradation, a process facilitated by the lysosome associated membrane protein 2A.

Labeling and isolating cell specific neuronal mitochondria and their functional analysis in mice post stroke.

Dendritic and axonal plasticity, which mediates neurobiological recovery after a stroke, critically depends on the mitochondrial function of neurons. To investigate, in vivo, neuronal mitochondrial function at the stroke recovery stage, we employed Mito-tag mice combined with cerebral cortical infection of AAV9 produced from plasmids carrying Cre-recombinase controlled by two neuronal promoters, synapsin-I (SYN1) and calmodulin-kinase IIa to induce expression of a hemagglutinin (HA)-tagged enhanced green fluorescence protein (EGFP) that localizes to mitochondrial outer membranes of SYN1 positive (SYN) and CaMKIIa positive (CaMKIIa) neurons. These mice were then subjected to permanent middle cerebral artery occlusion (MCAO) and sacrificed 14 days post stroke.

Enrichment of a heterotrophic nitrifying and aerobic denitrifying bacterial consortium: Microbial community succession and nitrogen removal characteristics and mechanisms.

This study cultivated a bacterial consortium (S60) from landfill leachate that exhibited effective heterotrophic nitrification and aerobic denitrification (HN-AD) properties. Under aerobic conditions, the removal of NH-N reached 100 % when the S60 consortium utilised NH-N either as the sole nitrogen source or in combination with NO-N and NO-N. Optimal HN-AD performance was achieved with sodium acetate as a carbon source and a pH of 7.

Lifespan trajectories of the morphology and tractography of the corpus callosum: A 5.0 T MRI study.

The corpus callosum (CC) is the largest white matter fiber bundle connecting the two hemispheres, facilitating interhemispheric integration and hemispheric specialization. Neuroimaging studies have identified the CC as a marker for aging and various neuropsychiatric disorders. However, high-resolution imaging and detailed lifespan characterizations of CC morphology and connectivity remain limited.

Fabrication of strain-sensing fibers with silver nanoparticles and reduced graphene oxide via wet spinning.

To advance the industrialization of flexible strain sensors, an innovative flexible sensing fiber was developed through a sophisticated wet spinning process. Silver trifluoroacetate (C2AgF3O2) and graphene oxide (GO) were combined with thermoplastic polyurethane (TPU) to prepare the fibers via wet spinning. Ascorbic acid (L-AA) was used to in situ reduce the silver trifluoroacetate and graphene oxide within the polyurethane, causing the growth of silver nanoparticles to bond with reduced graphene oxide, forming a dual conductive pathway.

Data-Driven Machine Learning Strategy for Designing Metal-Ion-Doped γ-BiMoO Photocatalysts to Enhance Degradation Performance.

Doped semiconductors are often used to improve photocatalytic efficiency and address the challenges of easy recombination of electron-hole pairs and poor photoluminescence. However, the reproducibility and complexity of experimental studies result in time-consuming and less cost-effective studies, and it is difficult to gain insights into the intrinsic properties of doped photocatalysts to control their performance. Introducing a machine learning approach, we constructed a photocatalytic model of transition-metal- and rare earth metal-ion-doped γ-BiMoO.

Self-powered InSe/Ge photodetector from a visible to short-wave infrared region.

An InSe/Ge heterojunction is fabricated via molecular beam epitaxy. The p-n junction device features a broadened photosensitive spectrum ranging from a visible (VIS) to short-wave infrared (SWIR) region (400-1700 nm). Notably, self-powered high responsivity of 0.

Association between malnutrition, depression, anxiety and fatigue after stroke in older adults: a cross-lagged panel analysis.

Background: Malnutrition, post-stroke depression (PSD), post-stroke anxiety (PSA), and post-stroke fatigue (PSF) in stroke survivors have complex relationships and are associated with adverse stroke outcomes.

Aims: This research aims to explore the temporal and directional relationships between malnutrition, PSD, PSA, and PSF after stroke in older adults.

Methods: Patients aged 65 years and older with their first ischemic stroke from two centers were selected and assessed at baseline, 3 months and 12 months.

Accumulation of microtubule-associated protein tau promotes hepatocellular carcinogenesis through inhibiting autophagosome-lysosome fusion.

Dysregulated expression of microtubule-associated protein tau (MAPT) has been reported in a variety of human cancers. However, whether and how Tau influences hepatocellular carcinogenesis remains elusive. This study was aimed to investigate the role and the underlying mechanism of Tau in the proliferation, invasion, migration and sorafenib sensitivity of hepatocellular carcinoma (HCC) cells.

Assessment of normal portal vein diameter in children and adolescents on abdominal contrast-enhanced CT.

Purpose: To establish the normal ranges of the main portal vein (MPV), left portal vein (LPV), and right portal vein (RPV) diameters in children and adolescents using abdominal contrast-enhanced CT.

Methods: We retrospectively enrolled children and adolescents (under 19 years) who underwent abdominal contrast-enhanced CT examinations in our hospital between January 2018 and January 2024. Subjects with conditions potentially affecting the portal vein diameter were excluded.

A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.

There has been an increase in the incidence and poor prognosis of colorectal cancer in recent years. In several studies, piperine has been shown to inhibit colon cancer cell growth and induce apoptosis. This study aimed to investigate whether a novel piperine-derived compound, HJ-23 (2,2-difluorobenzo[d][1,3]dioxol-5-yl)(4-(2,4-difluorophenyl)piperazin-1-yl)methanone), can effectively inhibit the development of colorectal cancer through specific molecular mechanisms.

Oral Immunization of Mice with a Nonantibiotic Recombinant Coexpressing TsNd and gp43 Protein Vaccine Combined with a Murine Interleukin-33 Adjuvant.

Trichinellosis, a zoonotic disease transmitted through food and caused by , is a significant health concern worldwide. Therefore, developing a safe and effective vaccine to combat infection is essential. In this study, a nonantibiotic strain lacking the gene served as a live bacterial vector to deliver antigens to the host, creating a novel oral vaccine.

Causal effects of circulating lipids and lipid-lowering drugs on the risk of atopic dermatitis: a mendelian randomization study.

Lipid metabolism disorders are frequently noted in atopic dermatitis (AD) patients, prompting the long-term use of lipid-lowering drugs. However, the causal effects of circulating lipids and different lipid-lowering drugs on the risk of AD are not thoroughly understood. Using publicly available genome-wide association studies (GWAS) summary data from two different cohorts, a series of Mendelian randomization (MR) analyses were conducted to explore the causal effects of genetically proxied circulating lipids and lipid-lowering drugs on the risk of AD.

Development and Characterisation of an Immortal Cell Line From Largemouth Bass (Micropterus salmoides) for Viral Studies.

Largemouth bass (Micropterus salmoides), a freshwater fish species, is cultivated widely across China. The industry has been greatly affected by various viral diseases. We generated a new immortal cell line from the fin of M.

Effect of 4-methylbenzoquinone concentration on its covalent conjugates with β-lactoglobulin: Structural and functional properties.

This study examined the effect of quinone concentration on covalent interaction between β-lactoglobulin (β-Lg) and 4-methylbenzoquinone (4MBQ). β-Lg-4MBQ-0.2, β-Lg-4MBQ-0.

Design, synthesis, and characterization of an Ag-Bi-S-based multifunctional nanotheranostic platform.

This paper reports an Ag-Bi-S-based nanotheranostic platform with an ingeniously designed heterostructure, an appropriate size, and good imaging and therapy performances. By comparing the fluorescence property and Bi element content, the optimal heterostructure was demonstrated to be AgS/BiS core/shell. The hydrophilic AgS/BiS-PEG nanocrystals with hydrodynamic diameter of 37.

Rationally Engineering Pro-Proteins and Membrane-Penetrating α‑Helical Polypeptides for Genome Editing Toward Choroidal Neovascularization Treatment.

Ribonucleoprotein (RNP)-based CRISPR/Cas9 genome editing holds great potential for the treatment of choroidal neovascularization (CNV), which however, is challenged by the lack of efficient cytosolic protein delivery tools. Herein, reversibly-phosphorylated pro-proteins (P-proteins) with conjugated adenosine triphosphate (ATP) tags are engineered and coupled with a membrane-penetrating, guanidine-enriched, α-helical polypeptide (GP) to mediate robust and universal cytosolic delivery. GP forms salt-stable nanocomplexes (NCs) with P-proteins via electrostatic interaction and salt bridging, and the helix-assisted, strong membrane activities of GP enabled efficient cellular internalization and endolysosomal escape of NCs.