A Signal-Harmonizing Hybrid Neural Pathway Enabled by Bipolar-Chemo-Synapse Spiking Interneuron.

To realize human-machine fusion, a hybrid neural pathway operating in the same modality with biological systems becomes imperative, which requires an interneuron unit to encode information in biorecognizable spike sequences and tune the frequency upon excitatory and inhibitory neurotransmitters. Existing artificial interneurons cannot encode information upon different neurotransmitters, and the activation threshold and frequency responsivity do not align with those of biological counterparts, leading to limited success in constructing a signal-harmonizing hybrid neural pathway for neuroprosthetics, neurorehabilitation, and other neuroelectronic applications. Herein, we develop a bipolar-chemosynapse interneuron to encode the spike frequency in a highly bionic paradigm.

Treatment of femoropopliteal arterial lesions with excimer laser atherectomy and drug-coated balloon.

ObjectivesProximal to mid-term effects of contrast excimer laser atherectomy (ELA) + drug-coated balloon (DCB) versus PTA + drug-coated balloon (DCB) in the treatment of new lesions in the femoral popliteal segment of patients with lower extremity arteriosclerosis and occlusion.MethodsThe clinical data of 105 patients with CT-confirmed femoropopliteal segment lesions (Rutherford grades 3-6) were retrospectively analyzed. According to the computerized randomization method, 58 patients (44 males, mean 72.

CVFSNet: A Cross View Fusion Scoring Network for end-to-end mTICI scoring.

The modified Thrombolysis In Cerebral Infarction (mTICI) score serves as one of the key clinical indicators to assess the success of the Mechanical Thrombectomy (MT), requiring physicians to inspect Digital Subtraction Angiography (DSA) images in both the coronal and sagittal views. However, assessing mTICI scores manually is time-consuming and has considerable observer variability. An automatic, objective, and end-to-end method for assigning mTICI scores may effectively avoid observer errors.

Stroke-Homing Peptide-DNase1 Alleviates Intestinal Ischemia Reperfusion Injury by Selectively Degrading Neutrophil Extracellular Traps.

Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI). However, we observed that after intestinal injury, intestinal bacteria and lipopolysaccharides (LPS) can enter the circulatory system, leading to a significant secondary increase in NETs production and the subsequent activation of a coagulation cascade. This phenomenon contributes to a pathological process known as the 'second strike' of NETs, which exaggerates intestinal damage and microcirculation disturbance.

Biodegradable cellulose scaffolds embedding kartogenin-loaded microspheres for cartilage regeneration.

Due to the extreme difficulty of cartilage, we endeavored to fabricate a novel biodegradable scaffold using natural polysaccharide cellulose and poly(lactic-co-glycolic acid) (PLGA) microspheres incorporating controllably released the cartilage inducer kartogenin (KGN) for enhancing regenerative healing in cartilage tissue. Initially, to facilitate the loading of KGN, PLGA/KGN microspheres were fabricated using the solvent volatilization method. These microspheres exhibited high sphericity, with particle sizes diminishing from 12.

Investigating the role of inflammatory cytokines in mediating the effect of gut microbiota on gastrointestinal cancers: a mendelian randomization study.

Purpose: The purpose of this study is to explore the causal relationship between gut microbiota and gastrointestinal (GI) cancers and to investigate the potential mediating factors influencing the development of GI cancers.

Methods: Using data from genome-wide association studies (GWAS), we employed two-sample Mendelian randomization (TSMR) to explore the relationship among gut microbiota, inflammatory cytokines and GI cancers. Subsequently, a multivariable Mendelian randomization (MVMR) analysis was meticulously conducted to perform a mediation analysis, thereby estimating the proportion of mediation effects conferred by inflammatory cytokines.

SH: Long-tailed classification via spatial constraint sampling, scalable network, and hybrid task.

Long-tailed classification is a significant yet challenging vision task that aims to making the clearest decision boundaries via integrating semantic consistency and texture characteristics. Unlike prior methods, we design spatial constraint sampling and scalable network to bolster the extraction of well-balanced features during training process. Simultaneously, we propose hybrid task to optimize models, which integrates single-model classification and cross-model contrastive learning complementarity to capture comprehensive features.

Niacin alters ruminal microbial composition and metabolites in sheep fed a high-concentrate diet.

This study aimed to investigate the effects of niacin supplementation to a high-concentrate diet (ratio of concentrate supplement to forage = 70:30) on the growth performance, rumen fermentation, rumen microbiota, and metabolomics of sheep. Twelve sheep were randomly divided into two groups: (1) a control group (CON,  = 6) fed a basal diet and (2) a niacin group (NA,  = 6) fed a basal diet supplemented with 130 mg/day niacin for 35 days: days 1-14 were the adaptation period, days 15-35 were the experiment period. On days 15 and 35 of the experiment period, all trial sheep were weighed before the morning feed (07:30 am).

East and West admixture in eastern China of Tang Dynasty inferred from ancient human genomes.

The ancestry composition and Sinicisation process of the descendants of the immigrants of Hu people living in ancient China are largely unknown due to the lack of genetic evidence. Tang Dynasty people in Fudamen cemetery () excavated from Shandong province in eastern China are believed to be related to the descendants of Hu people, as some of the individuals with the surnames An (). The genetic origin of the Fudamen population requires genetic clarification using ancient DNA data.

AMPK activation mitigates inflammatory pain by modulating STAT3 phosphorylation in inflamed tissue macrophages of adult male mice.

Inflammatory pain presents a significant clinical challenge. AMP-activated protein kinase (AMPK) is recognized for its capacity to alleviate inflammation by inhibiting transcription factors such as nuclear factor kappa B (NF-κB) and signal transducer and activator of transcription (STAT). Our prior research demonstrated that AMPK reduces inflammatory pain by inhibiting NF-κB activation and interleukin-1 beta (IL-1β) expression.

Immunomagnetic bead-based sample preparation method and immunoassay for detecting higenamine in herbal products.

Higenamine (HM), classified as an S3 β2 agonist and prohibited by the World Anti-Doping Agency (WADA), is prevalent in spices and traditional Chinese herbal medicines.Accidental consumption can lead to HM positivity in athletes, necessitating daily monitoring. However, current detection strategies predominantly involve instrumental analysis, with limited development of rapid methodologies incorporating sample preparation for practical, daily applications.

Graded Anterior Partial-thickness Blepharotomy for the Correction of Idiopathic Unilateral Upper Eyelid Retraction: A Case Report and Literature Review.

Idiopathic upper eyelid retraction is a rare ocular symptom characterized by abnormal upward displacement of the upper eyelid, often without any identifiable systemic disease. This condition not only affects the patient's appearance but may also have a certain impact on their daily life and mental health. We report a case of adult idiopathic unilateral upper eyelid retraction, and based on the patient's specific condition, we used graded anterior plate blepharoplasty for treatment.

What sustain Chinese adult second language (L2) learners' engagement in online classes? A sequential mix-methods study on the roles of L2 motivation and enjoyment.

Recent research has integrated positive psychology with the Second Language Motivational Self System (L2MMS) to explore how enjoyment, L2 self-guides (including ideal L2 self and ought-to L2 self), and engagement interact among school-aged second-language (L2) learners. However, there is a significant gap in understanding these dynamics among adult learners, particularly those who primarily learn a second language online-a group that has been largely overlooked. To address this gap, our study examined the underlying mechanisms connecting these constructs.

Inhibition of NETs prevents doxorubicin-induced cardiotoxicity by attenuating IL-18-IFN-γ-Cx43 axis induced cardiac conduction abnormalities.

Doxorubicin-induced cardiotoxicity (DIC) is one of the most severe side effects of doxorubicin, yet the underlying mechanisms remain incompletely understood. Our results showed that Neutrophil extracellular traps (NETs) accumulated in plasma and cardiac tissue after doxorubicin treatment. The inhibition of NETs formation by Pad4 gene ablation significantly attenuated doxorubicin-induced arrhythmia, prolonged survival time and reduced the levels of Troponin T (cTnT) and creatine kinase MB (CK-MB) in mice.

mir-330-5p from mesenchymal stem cell-derived exosomes targets SETD7 to reduce inflammation in rats with cerebral ischemia-reperfusion injury.

This study was to investigate the role of microRNA (miR)-330-5p derived from mesenchymal stem cells-secreted exosomes (MSCs-Exo) in cerebral ischemia-reperfusion injury (CI/RI) through targeting lysine N-methyltransferase SET domain containing 7 (SETD7). MSCs-Exo were separated and identified. MSCs-Exo were used to treat the middle cerebral artery occlusion (MCAO) rat model.

YTHDF2 influences hepatic fibrosis by regulating ferroptosis in hepatic stellate cells by mediating the expression of ACSL4 in an m A-dependent manner.

Hepatic fibrosis (HF) is an abnormal reparative response of the liver to chronic injury and is histologically reversible. In recent years, increasing interest has been given to changes in m A in liver disease. In this study, we explore the role of the m A-modified reading protein YTHDF2 in HF and its regulatory mechanism.

Steering perovskite precursor solutions for multijunction photovoltaics.

Multijunction photovoltaics (PVs) are gaining prominence owing to their superior capability of achieving power conversion efficiencies (PCEs) beyond the radiative limit of single-junction cells, for which improving narrow-bandgap (NBG) tin-lead perovskites is critical for thin-film devices. Here, with a focus on understanding the chemistry of tin-lead perovskite precursor solutions, we find that Sn(II) species dominate interactions with precursors and additives and uncover the exclusive role of carboxylic acid in regulating solution colloidal properties and film crystallization and ammonium in improving film optoelectronic properties. Materials that combine these two functional groups, amino acid salts, considerably improve the semiconducting quality and homogeneity of perovskite films, surpassing the effect of the individual functional groups when introduced as part of separate molecules.

Ozone promotes macrophage efferocytosis and alleviates neuropathic pain by activating the AMPK/Gas6-MerTK/SOCS3 signaling pathway.

Background: Neuropathic pain (NPP) is a multifaceted pain syndrome that occurs as a consequence of physical injury or underlying diseases, with an incidence rate of 7%-10%, NPP poses a significant clinical challenge as current treatment options are ineffective. The accumulation of apoptotic cells and neuroinflammation play crucial roles in the pathological mechanisms of NPP. Here, we aim to investigate strategies for effectively clearing apoptotic cells and provide therapeutic interventions for NPP.

Granulocyte-like myeloid-derived suppressor cells: The culprits of neutrophil extracellular traps formation in the pre-metastatic niche.

Neutrophil extracellular traps (NETs) have been shown to exhibit chemotactic effects on circulating tumor cells at metastatic sites, promoting the progression of colorectal cancer liver metastasis (CRLM). However, the origin and factors contributing to the formation of NETs (NETosis) in the pre-metastatic niche (PMN) of target organs remain unclear. In this study, we investigated the relationship between phosphatase of regenerating liver-3 (PRL-3), myeloid-derived suppressor cells (MDSCs), neutrophils, and NETs through a retrospective clinical cohort study and a mouse model of CRLM.

Modulation of Charge Redistribution in Heterogeneous CoSe-NiSe Coupling with TiCT MXene for Hydrazine-Assisted Water Splitting.

Integrating abundant dual sites of hydrazine oxidation reaction (HzOR) and hydrogen evolution reaction (HER) into one catalyst is extremely urgent toward energy-saving H production. Herein, CoSe-NiSe heterostructure coupling with TiCT MXene (CoSe-NiSe/MXene) is fabricated on nickel foam (NF) to enhance the catalytic performance. The heterogeneous CoSe-NiSe and MXene coupling effect can change the coordination of Ni and Co, resulting in adjusted interfacial electronic field and enhanced electron transfer from NiSe to CoSe especially near MXene surface.

PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC.

Clear cell renal cell carcinoma (ccRCC), the most common subtype of renal cell carcinoma, often exhibits resistance to tyrosine kinase inhibitors (TKIs) when used as monotherapy. However, the integration of PD-1 blockade with TKIs has significantly improved patient survival, making it a leading therapeutic strategy for ccRCC. Despite these advancements, the efficacy of this combined therapy remains suboptimal, necessitating a deeper understanding of the underlying regulatory mechanisms.