Designing Polar Covalent Hybrid Cadmium-Based Chalcohalides Ultraviolet Nonlinear Optical Crystal with Strong Optical Anisotropy via Double-Site Dual FBUs Tailoring.

The pressing demand for both established and innovative technologies to expand laser wavelengths has rendered high-performance nonlinear optical (NLO) crystals with large optical anisotropy indispensable. Here, centrosymmetric [SHC(NH)]CdBr (1) and pseudo-2D layered [SC(NH)]CdBr (2), as well as pseudo-3D noncentrosymmetric [SC(NH)]CdCl (3) are successfully synthesized through the introduction of π-conjugated SC(NH) groups. Compared to ionic compound 1 containing full-halogen coordination tetrahedra, covalent compounds 2 and 3 featuring novel polar [SC(NH)]CdX (X = Br, Cl) tetrahedral units demonstrate enhanced bandgaps (>4 eV) and birefringences (>0.

Inhibitory Effect of Propofol on Type II Inflammation in Mice with Allergic Rhinitis.

Propofol, a quick‑acting systemic anesthetic agent widely used in general anesthesia, can alleviate airway T-helper 2 (TH2) inflammation. Group 2 innate lymphoid cells (ILC2s) are a newly discovered group of lymphoid cells and play key roles in allergic rhinitis (AR). We aimed to investigate the regulation of ILC2s treated with propofol and its possible mechanisms in a mouse model.

Aeroallergen Sensitization Patterns and Related Factors in Children With Allergic Rhinitis in Guangzhou.

Certain patterns of children's serum immunoglobulin E (IgE) sensitivity to aeroallergens may offer useful clinical insight into forecasting the course and prognosis of allergic rhinitis (AR). The study aimed to investigate the changes in aeroallergen sensitization patterns in children with AR during the last decade and compare the sensitization pre- and post-coronavirus disease 2019 (COVID-19) pandemic in Children who visited our center. This is a retrospective study, examining the serum IgE of nine aeroallergens from 21,362 children (1-12 years old) from AR who visited Guangzhou Women and Children's Medical Center from June 2013 to June 2023.

Mitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.

Dysfunctional mitophagy is a key component of Alzheimer's disease (AD) pathology, yet direct evidence and mechanistic insights remain limited. Using a mitophagy reporter in an AD mouse model ( / /mt-Keima), we identified mitochondrial plaques (MPs) composed of accumulated mitochondria within or outside lysosomes in AD, but not normal mouse brains. Similar structures were also found in AD human brains, but not in healthy controls.

Unique Porous Oxide Shell on Liquid Gallium Nanoparticles.

The oxide "skin" that is easily formed on the surface of liquid gallium plays an important role in controlling the wettability of gallium. However, the oxidation mechanism of liquid gallium is still under debate. Herein, experiments and reactive molecular dynamics simulations were performed to systematically investigate the oxidation mechanism of gallium nanoparticles (GNPs).

Chitosan films incorporated with cinnamon essential oil Pickering emulsions stabilized by methyl tetrahydrophthalic anhydride esterified corn starch for pork preservation.

Chitosan films containing cinnamon essential oil Pickering emulsions (CEO-PEs) stabilized by methyl tetrahydrophthalic anhydride esterified corn starch (MeCS) were prepared and characterized. The incorporation of CEO-PEs was confirmed by Fourier transform infrared spectroscopy and scanning electron microscopy. The cinnamon essential oil content affected the color of film significantly (p < 0.

"All-four-in-one": a novel mercury tellurite-nitrate Hg(TeO)(TeO)(NO) exhibiting exceptional optical anisotropy.

In recent years, birefringent crystals have attracted much attention in the field of optical materials and play a significant role in laser technology and optical imaging. However, commercially available birefringent crystals are still relatively scarce and need improvement. Low-dimensional structures and well-oriented anisotropic units are conducive to obtaining excellent birefringent materials.

From (CHN)CdCl to (CHN)ZnCl, Chirality Transformation to Realize a Nonlinear Optical Organic-Inorganic Hybrid Halide with Balanced Comprehensive Performance.

Nonlinear optical (NLO) crystals are critical for modern optical devices. In this study, two new hybrid metal halides, (CHN)CdCl () and (CHN)ZnCl (), were synthesized by a mild solution method. and crystallize in different chiral space groups of 422 and 222, respectively.

New insights into exploring new functional enzymes through the enzyme promiscuity.

Enzyme promiscuity, defined as the ability of enzymes to catalyze reactions beyond their primary physiological functions, has emerged as a pivotal concept in modern enzyme engineering. This review provides a comprehensive exploration of enzyme promiscuity and its implications for the discovery and development of novel functional enzymes. Through targeted strategies such as (semi-)rational design, directed evolution, and de novo design, enzyme promiscuity has been harnessed to broaden substrate scopes, enhance catalytic efficiencies, and adapt enzymes to diverse reaction conditions.

Characteristics of Pediatric Allergic Rhinitis With Different Disease Severity.

Although numerous studies have focused on diagnostic biomarkers to help identify allergic rhinitis (AR), data on the characteristics of pediatric AR with different severity is limited. We aimed to compare the characteristics of pediatric AR with different severity. A total of 1054 children with AR were enrolled and classified into mild intermittent AR, mild persistent AR, moderate-to-severe intermittent AR, and moderate-to-severe persistent AR.

Metabolomics analysis of anaphylactoid reactions induced by Xueshuantong injection in normal and immunocompromised mice.

Background: Xueshuantong injection (Lyophilized) (XSTI) is widely used to treat cardiovascular and cerebrovascular diseases. However, anaphylactoid reactions (ARs) are frequently reported as one of its side effects, and the mechanisms of ARs and their relationship with the different immune status are still not well understood.

Purpose: This article aims to examine the sensitizing effect of XSTI, explore the impact of normal and immunocompromised states on ARs, and analyze AR-related metabolic pathways by metabolomics.

IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis.

Background: Allergic rhinitis (AR) represents a persistent inflammatory condition affecting the upper respiratory tract, characterized by abnormal initiation of the immunoglobulin E (IgE)-mediated cascade. Follicular helper T (Tfh) cells and regulatory T (Tfr) cells are pivotal in orchestrating the development of IgE production in AR patients. IL-35, an anti-inflammatory cytokine, secreted by various cellular subpopulations.

Diagnosis of Parkinson's disease by eliciting trait-specific eye movements in multi-visual tasks.

Background: Parkinson's Disease (PD) is a neurodegenerative disorder, and eye movement abnormalities are a significant symptom of its diagnosis. In this paper, we developed a multi-task driven by eye movement in a virtual reality (VR) environment to elicit PD-specific eye movement abnormalities. The abnormal features were subsequently modeled by using the proposed deep learning algorithm to achieve an auxiliary diagnosis of PD.

A Retrospective Comparison of Aeroallergen Sensitization Among Different Allergic Diseases in Guangzhou, China.

Numerous studies have reported on the types of aeroallergen sensitization in various pediatric allergic diseases, but limited data compared the types of aeroallergen sensitization across different pediatric allergic diseases. The aim of this study is to explore the nature and significance of aeroallergen sensitization in diverse pediatric allergic conditions. A comparative analysis was carried out on aeroallergen sensitization in children suffering from allergic diseases who visited the Otolaryngology, Respiratory, and Dermatology Departments between January 2019 and December 2023.

Prediction of bladder cancer prognosis and immune microenvironment assessment using machine learning and deep learning models.

Bladder cancer (BCa) is a heterogeneous malignancy characterized by distinct immune subtypes, primarily due to differences in tumor-infiltrating immune cells and their functional characteristics. Therefore, understanding the tumor immune microenvironment (TIME) landscape in BCa is crucial for prognostic prediction and guiding precision therapy. In this study, we integrated 10 machine learning algorithms to develop an immune-related machine learning signature (IRMLS) and subsequently created a deep learning model to detect the IRMLS subtype based on pathological images.

Exploring Eye Movement Features of Motion Sickness Using Closed-Track Driving Experiments.

Objective: To explore and validate effective eye movement features related to motion sickness (MS) through closed-track experiments and to provide valuable insights for practical applications.

Background: With the development of autonomous vehicles (AVs), MS has attracted more and more attention. Eye movements have great potential to evaluate the severity of MS as an objective quantitative indicator of vestibular function.

Pharmacological efficacy study of the cardio-cerebral stasis transforming medicines on cerebral ischemia and myocardial infarction in rats.

The purpose of this study was to investigate the efficacy and mechanisms of cardio-cerebral stasis transforming medicines (CCSTM) against cerebral infarction (CI) and myocardial infarction (MI). CI modeling was conducted using the refined Longa suture-occluded technique, while MI modeling was accomplished through the occlusion of the anterior descending branch of the left coronary artery. We found that compared with the model groups, CCSTM decreased the infarct size in models of CI and MI in a dose-dependent manner.

Rare but elevated incidence of hematological malignancy after clozapine use in schizophrenia: A population cohort study.

Background: Clozapine is widely regarded as a highly efficacious psychotropic drug that is largely underused worldwide. Recent disproportionality analyses and nationwide case-control studies suggested a potential association between clozapine use and hematological malignancy (HM). Nevertheless, the absolute rate difference is not well-established due to the absence of analytic cohort studies.

[Expert consensus on the diagnosis and treatment of chronic sinusitis in children].

Pediatric chronic sinusitis （CRS） is a common disease within the field of otolaryngology-head and neck surgery. Due to the immaturity of sinus development and immune competence in children, its etiology and pathophysiology are complex, and its clinical features and outcomes differ significantly from those in adult patients. Currently, there are issues in the diagnosis and treatment of pediatric CRS, particularly in areas such as antibiotic use and surgical interventions, owing to a lack of sufficient attention.

Chemically Bonded Graphene Oxide/Covalent Organic Framework Nanosheets as Robust Membranes for Fast Desalination.

Graphene oxide (GO) is widely used to prepare 2D laminar separation membranes because of its single atomic thickness and good processability. However, due to the tortuous transport path and excessive swelling effect, it is difficult to improve permeability, salt rejection, and stability of GO membranes simultaneously. Herein, we chemically laminated GO with covalent organic framework nanosheets (CONs) to fabricate membranes for fast and stable desalination.

Corrigendum: Clinical efficacy of unilateral laminotomy for bilateral decompression in the treatment of adjacent segment disease after lumbar fusion.

[This corrects the article DOI: 10.3389/fsurg.2024.

Effects of Ion Valence States and Radii on the Performance of Solid-State PEDOT:PSS Electrochromic Devices.

Ion transport is a critical factor influencing the performance of electrochromic devices (ECDs). In this work, the effects of the valence state and ionic radius of six cations, Li, Na, K, Mg, Zn, and Al, on the performance of poly(3,4-ethylenedioxythiophene)-polystyrene sulfonic acid (PEDOT:PSS)-based ECDs are investigated. Both ion migration and diffusion are discussed as processes that were analyzed, with results indicating that the primary contributor to the response of ECDs is ion migration.

Biological Characteristics of the Cytochrome P 450 Family and the Mechanism of Terpinolene Metabolism in (Acari: Ixodidae).

The CYP450 enzyme is a superfamily enzyme ubiquitously found in nearly all organisms, playing a vital role in the metabolism of both endogenous and exogenous compounds, and in biosynthesis. Unfortunately, an understanding of its classification, functions, expression characteristics, and other biological traits in , a vector for Crimean-Congo Hemorrhagic Fever, as well as of the genes implicated in its natural product metabolism, is lacking. Towards this end, this study has identified 120 CYP450 genes via transcriptome data in the face of a joint genome threat from terpinolene.

Rare-Earth/d Dual-Metal Oxychalcogenides as Infrared Nonlinear-Optical Materials.

Oxychalcogenides are receiving increasing interest as nonlinear-optical (NLO) materials because of the possible combination of advantages from oxides and chalcogenides. Here, two new pentanary oxythiogermanates EuMGeOS [M = Zn (), Cd ()] were obtained by the facile metal oxide-boron-sulfur solid-state route. They crystallize with a melilite-type structure and feature {[MGeOS]} layers built by GeOS dimers and MS tetrahedra.

Optimal control of Hydrocarbon Reducer (HC) injection based on Trust-Region-Reflective Algorithm (TRRA) and physical models for Diesel Oxidation Catalyst (DOC).

The aim of this paper is to control the DOC outlet gas temperature between 600 ± 15 °C by optimizing the hydrocarbon (HC) injection into the Diesel Oxidation Catalyst (DOC) for active regeneration of the downstream Diesel Particulate Filter (DPF). First, based on the physical model of the DOC thermal dynamics, the energy conservation equation for the gas phase temperature is simplified by using variable substitution, and the energy conservation equation for the solid phase temperature is simplified by considering only the heat generated by the HC injection. By solving the simplified model using the Trapezoidal Rule-Backward Differentiation Formula 2 (TR-BDF2) method and optimizing the model parameters in combination with the Gauss-Newton method, the computational efficiency and accuracy were significantly improved.