Stress-driven dynamic regulation of multiple genes to reduce accumulation of toxic aldehydes.

Aldehydes are ubiquitous metabolites in living cells. As reactive electrophiles, they have the capacity to form adducts with cellular protein thiols and amines, leading to potential toxicity. Dynamic regulation has proven to be an effective strategy for addressing the accumulation of toxic metabolites.

Clinical combined PET/CT radiomics model prediction of benefit from platinum-based chemotherapy and chemoradiotherapy in patients with small cell lung cancer.

Objective: To develop and validate a clinical combined radiomics model for predicting the treatment response and long-term survival prognosis of small cell lung cancer (SCLC) patients receiving platinum-based chemotherapy, as well as survival outcomes following chemoradiotherapy.

Methods: A total of 98 SCLC patients treated with platinum-based first-line chemotherapy were included in this study. Five prediction models for assessing the short-term efficacy of platinum-based first-line chemotherapy were developed using a logistic regression algorithm.

Preoperative imaging biomarkers combined with tap test for predicting shunt surgery outcome in idiopathic normal pressure hydrocephalus: a multicenter retrospective study.

Objectives: The study aims to investigate the predictive performance of preoperative imaging features combined with tap test for the outcomes of ventriculoperitoneal (VP) shunt in idiopathic normal pressure hydrocephalus (iNPH).

Methods: In this multicenter retrospective study, 166 iNPH patients who underwent VP shunt surgery between August 2019 and November 2023 were included. Preoperative clinical characteristics and imaging features were collected.

TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis.

Pancreatic cancer (PCa) is one of the most malignant diseases in the world. Different from ferroptosis and apoptosis, disulfidptosis is a novel type of cell death. The role of disulfidptosis in PCa remains uncovered.

Efficiency comparison between new single-needle dialysis and conventional double-needle dialysis and exploration of the optimal prescription parameters for single-needle hemodialysis.

Objective: To compare the dialysis efficiency parameters between new single-needle dialysis and conventional double-needle dialysis and to explore the optimal prescription parameters for single-needle hemodialysis.

Methods: This study involved a prospective, cross-over design. Eight patients were randomly divided into two cohorts, which received the appropriate treatment.

Immune training enhances anti-viral responses and improves outcomes in Pax5 mice susceptible to chronic infection.

Viral infections pose a significant global burden. Host susceptibility to pathogens is determined by many factors including genetic variation that can lead to immunodeficient or dysregulated antiviral immune responses. Pax5 heterozygosity (Pax5), resulting in reduced PAX5 levels in mice, mimics germline or somatic PAX5 dysregulation contributing to diseases such as childhood B-cell precursor acute lymphoblastic leukemia (B-ALL).

Comparative structural analysis of holocellulose from sugarcane bagasse, poplar, and spruce: Unraveling the interplay between structural characteristics and enhanced enzymatic hydrolysis.

This study investigated the structural recalcitrance of holocellulose from lignocellulosic biomasses (LCBs): sugarcane-bagasse (R-SCB), R-Poplar, and R-Spruce, considering their heterogeneous recalcitrance. Acidic sodium chlorite (ASC) pretreatment was employed for different time intervals (0-4 h) and extracted holocellulose samples (SCB, poplar, and spruce) with comparable lignin content (~7 %) were further alkaline-incubated (1-SCB, 1-Poplar, and 1-Spruce) with 1 % NaOH at 50 °C for 1 h. Varying enzymatic hydrolysis (EH) results indicate distinct structural heterogeneity, which was further investigated through the deconvolution of FTIR, XRD, XPS, and 13CP MAS NMR spectra, highlighting the synergistic interplay among various allomorphs of cellulose that determine the glucose yield.

TLR5's Role in Obesity-related Hypertension: Updated Evidence and Prospects.

Toll-like receptor 5 (TLR5), integral to the immune system as a primary sensor for flagellin, is central to the link between innate and adaptive immunity, modulating immune responses and cytokine production essential for defense against flagellated pathogens and immune tolerance. This review consolidates the understanding of TLR5's structural and signaling mechanisms and its interactions with flagellin, shedding light on its dual role in immune responses and its promise as a therapeutic target. It highlights TLR5's intricate role in the pathogenesis of obesity-related hypertension, a growing global health concern that correlates with rising obesity rates and is characterized by a complex interplay of immune responses and metabolic dysregulation.

Achieving Extraordinary Power Factors in GeTe Epitaxial Films through Carrier Transport Engineering.

GeTe-based films have attracted tremendous attention from the thermoelectric community owing to their excellent thermoelectric performance. It is vital to reduce the hole density and maintain a high carrier mobility for GeTe films; however, this remains a significant challenge. To overcome this drawback, we succeeded in fabricating high-crystalline quality GeTe-based films and remarkably improve their electrical properties using molecular beam epitaxy under a low substrate temperature and optimized Te/GeTe flux ratios.

Recent Progress in Oxygen Reduction Reaction Toward Hydrogen Peroxide Electrosynthesis and Cooperative Coupling of Anodic Reactions.

Electrosynthesis of hydrogen peroxide (HO) via two-electron oxygen reduction reaction (2e ORR) is a promising alternative to the anthraquinone oxidation process. To improve the overall energy efficiency and economic viability of this catalytic process, one pathway is to develop advanced catalysts to decrease the overpotential at the cathode, and the other is to couple 2e ORR with certain anodic reactions to decrease the full cell voltage while producing valuable chemicals on both electrodes. The catalytic performance of a 2e ORR catalyst depends not only on the material itself but also on the environmental factors.

A Metal-Organic Framework with Mixed Electron Donor TTF and Electron Acceptor NDI Ligands for High-Performance Hybrid Lithium-Ion Capacitors.

Integrating mixed electron donor (D) and electron acceptor (A) ligands into metal-organic frameworks (MOFs) is an effective yet relatively unexplored approach for improving the anode performance of hybrid lithium-ion capacitors (HLICs). In this study, using an electron donor 2,6-bis(4'-pyridyl)tetrathiafulvalene and an electron acceptor ,'-bis(5-isophthalic acid) naphthalene diimide as ligands, a new Zn-TTF/NDI MOF () is constructed as a pseudocapacitive anode of HLICs. Crystallographic characterization revealed that MOF adopts a two-dimensional (2D) coordination network.

Lactic Acid Bacteria Exopolysaccharides Unveiling Multifaceted Insights from Structure to Application in Foods and Health Promotion.

Lactic acid bacteria (LAB) exopolysaccharides (EPSs) have garnered significant scientific interest due to their multifaceted roles in food technology and health promotion. This comprehensive review systematically examines the structural classification of LAB EPSs, emphasizing distinctions between homo-and heteropolysaccharides, as well as the influence of substituent groups (e. g.

Proppant embedding-based optimal design method for fracturing coalbed methane wells in Qingshui basin.

Fracturing design needs to consider the effect of proppant embedding as the production decreases rapidly due to proppant embedding after fracturing of coalbed methane wells. Coal fracture conductivity experiments were carried out to analyze the changes in coal fracture conductivity due to proppant embedding. A model of coal fracture conductivity was established considering proppant embedding.

In-situ quantitative detection of hypochlorous acid in food samples by employing a near-infrared fluorescent probe in association with a portable optical data acquisition system.

Background: Hypochlorous acid (HClO) is a crucial disinfectant in the food industry. It can be used to soak perishable foods like vegetables, fruits, eggs, fish, and raw meat before processing and storage, eliminating microorganisms, bacteria, fungi, and pathogens to ensure food safety. HClO also helps preserve vegetables and fruits by reducing ethylene production, delaying rotting, decreasing cell membrane permeability, inhibiting polyphenol oxidase activity, and postponing discoloration.

Artificial intelligence-based automated surgical workflow recognition in esophageal endoscopic submucosal dissection: an international multicenter study (with video).

Background: Endoscopic submucosal dissection (ESD) is a crucial yet challenging multi-phase procedure for treating early gastrointestinal cancers. This study developed an artificial intelligence (AI)-based automated surgical workflow recognition model for esophageal ESD and proposed an innovative training program based on esophageal ESD videos with or without AI labels to evaluate its effectiveness for trainees.

Methods: We retrospectively analyzed complete ESD videos collected from seven hospitals worldwide between 2016 and 2024.

Molecular Mechanisms Underlying Heart Failure and Their Therapeutic Potential.

Heart failure (HF) is a prominent fatal cardiovascular disorder afflicting 3.4% of the adult population despite the advancement of treatment options. Therefore, a better understanding of the pathogenesis of HF is essential for exploring novel therapeutic strategies.

Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.

Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).

The impact of jawbone regions (molar area, premolar area, anterior area) and bone density on the accuracy of robot-assisted dental implantation: a preliminary study.

Robotic-assisted dental implantation represents a transformative innovation in modern dentistry, offering enhanced surgical precision and reduced variability. Despite its clinical adoption, the impact of anatomical and bone-related factors on placement accuracy remains underexplored. This retrospective study evaluated 54 implants placed in 30 patients using cone-beam computed tomography (CBCT) and virtual planning software to analyze deviations in crown position, apex position, and angulation.

Chinese Expert Consensus on the Diagnosis and Treatment of Inflammatory Myofibroblastic Tumor.

Inflammatory myofibroblastic tumor (IMT) is a rare spindle-cell neoplasm. IMT currently suffers from a paucity of standardized diagnostic and therapeutic guidelines. The Chinese expert consensus committee on the diagnosis and treatment of IMT formed an "Expert consensus on the diagnosis and treatment of inflammatory myofibroblastic tumor".

Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study.

Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells. Standard first-line immunosuppressive treatments have limitations, achieving complete remission (CR) rates of up to 50%. Immune system dysregulation is implicated in LGLL.

Potent synergistic effect of natural product-inspired Sinomenine derivatives with fluconazole against azole-resistant Candida albicans.

Candida albicans (C. albicans) is the most common cause of invasive Candida infections worldwide. The acquired resistance of C.

Transient receptor potential vanilloid-1 (TRPV1) is a mediator of noise-induced neural damage in zebrafish and mice.

Sound pollution (noise) is an increasing environmental concern, particularly associated with neurological and neurobehavioral abnormalities. However, the molecular mechanisms underlying noise-induced neural damage remain unclear. In this study, we conducted transcriptional profiling of zebrafish to investigate the mechanisms underlying acoustic stimulation (1,000 Hz, 130 dB).

Comprehensive evaluation of the development of traditional Chinese medicine industry in Shaanxi province based on PMC index model.

Background: The high-quality development of the traditional Chinese medicine (TCM) industry is dependent on supportive policies and requires higher levels of coordination and integration. National and local government policies must coordinate the integrated development of the TCM industry under modern governance principles. However, the policy structure and its impact on the development of the TCM industry have not been thoroughly explored from the perspectives of policy design and empirical evidence.

Integrated bulk RNA sequencing and mass cytometry analysis reveal the circulating immune landscape in ischemic and hemorrhagic Moyamoya disease.

Background: Moyamoya disease (MMD) is increasingly recognized as being influenced by chronic inflammation, with circulating immune cells playing a role in its progression. However, research on the immune characteristics of different MMD subtypes is limited. This study aims to compare the peripheral immune profiles of ischemic and hemorrhagic MMD patients.