Alterations in spontaneous brain activity of maintenance hemodialysis patients with restless legs syndrome: a cross-sectional case-control study.

Objective: Through resting state functional magnetic resonance imaging (rs-fMRI) we evaluate the spontaneous brain activity changes of maintenance hemodialysis (MHD) patients with restless legs syndrome (RSL) and analyzed the imaging features and related mechanisms of RLS in patients with MHD.

Method: We select 27 MHD patients with RLS and 27 patients without RSL matched by age, gender, cognitive function. Both groups underwent neuropsychological tests and MRI scans.

Effect of denosumab, an anti-osteoporosis drug, on vascular calcification: A meta-analysis.

Background: Denosumab is an effective drug for the treatment of osteoporosis. This meta-analysis was conducted to evaluate efficacy of denosumab on the treatment of vascular calcification (VC).

Methods: Databases including PubMed, EMbase, the Cochrane Library, CNKI, Wanfang database were searched from the inception to January 10th, 2024.

Abnormal Functional Attributes of Central Executive Network in Patients with Mild Cognitive Impairment Associated with End-Stage Renal Disease.

Rationale And Objectives: To assess changes in the central executive network (CEN) of patients with mild cognitive impairment (MCI) associated with end-stage renal disease (ESRD).

Methods: A total of 121 patients with ESRD and 66 healthy controls (HCs) were enrolled. Patients were divided into an MCI group (n = 67) and a cognitively unimpaired group (n = 54).

Multiparameter neuroimaging study of neurovascular coupling changes in patients with end-stage renal disease.

Purpose: To assess changes in neurovascular coupling (NVC) by evaluating the relationship between cerebral perfusion and brain connectivity in patients with end-stage renal disease (ESRD) undergoing hemodialysis versus in healthy control participants. And by exploring brain regions with abnormal NVC associated with cognitive deficits in patients, we aim to provide new insights into potential preventive and therapeutic interventions.

Materials And Methods: A total of 45 patients and 40 matched healthy controls were prospectively enrolled in our study.

End-stage renal disease accompanied by mild cognitive impairment: A study and analysis of trimodal brain network fusion.

The function and structure of brain networks (BN) may undergo changes in patients with end-stage renal disease (ESRD), particularly in those accompanied by mild cognitive impairment (ESRDaMCI). Many existing methods for fusing BN focus on extracting interaction features between pairs of network nodes from each mode and combining them. This approach overlooks the correlation between different modal features during feature extraction and the potentially valuable information that may exist between more than two brain regions.

Cerebral blood flow changes in maintenance hemodialysis patients with restless legs syndrome and their clinical significance:a cross-sectional case-control study.

Objective: Restless legs syndrome (RLS) stands as a prevalent neurological complication within maintenance hemodialysis (MHD) patients. However, the alterations in cerebral blood flow (CBF) among MHD-RLS patients remain uncharted. Through the utilization of the arterial spin labeling (ASL) technique, we evaluated the fluctuations in CBF within distinct brain regions and analyzed the risk factors for the development of RLS in MHD patients in the context of the clinic.

Predicting the cognitive function status in end-stage renal disease patients at a functional subnetwork scale.

Brain functional networks derived from functional magnetic resonance imaging (fMRI) provide a promising approach to understanding cognitive processes and predicting cognitive abilities. The topological attribute parameters of global networks are taken as the features from the overall perspective. It is constrained to comprehend the subtleties and variances of brain functional networks, which fell short of thoroughly examining the complex relationships and information transfer mechanisms among various regions.

Tolerability, safety and efficacy of a novel phosphate binder VS-505 (AP301): a Phase 2 dose-escalation and dose-ranging study in patients undergoing maintenance hemodialysis.

Background: VS-505 (AP301), an acacia and ferric oxyhydroxide polymer, is a novel fiber-iron-based phosphate binder. This two-part Phase 2 study evaluated the tolerability, safety and efficacy of oral VS-505 administered three times daily with meals in treating hyperphosphatemia in chronic kidney disease (CKD) patients receiving maintenance hemodialysis (MHD).

Methods: In Part 1, patients received dose-escalated treatment with VS-505 2.

Improvement of restless leg syndrome in maintenance hemodialysis patients with limb ischemic preconditioning: a single-center randomized controlled clinical trial.

Objective: This study evaluated the efficacy and safety of limb ischemic preconditioning (LIPC) in treating restless leg syndrome (RLS) in maintenance hemodialysis (MHD) patients.

Methods: A total number of 45 patients participated in the study. They were randomly divided into LIPC group and control group.

HCTMFS: A multi-modal feature selection framework with higher-order correlated topological manifold for ESRDaMCI.

Background And Objective: The diagnosis of end-stage renal disease associated with mild cognitive impairment (ESRDaMCI) mainly relies on objective cognitive assessment, clinical observation, and neuro-psychological evaluation, while only adopting clinical tools often limits the diagnosis accuracy.

Methods: We proposed a multi-modal feature selection framework with higher-order correlated topological manifold (HCTMFS) to classify ESRDaMCI patients and identify the discriminative brain regions. It constructed brain structural and functional networks with diffuse kurtosis imaging (DKI) and functional magnetic resonance imaging (fMRI) data, and extracted node efficiency and clustering coefficient from the brain networks to construct multi-modal feature matrices.

Multi-modal feature selection with self-expression topological manifold for end-stage renal disease associated with mild cognitive impairment.

Effectively selecting discriminative brain regions in multi-modal neuroimages is one of the effective means to reveal the neuropathological mechanism of end-stage renal disease associated with mild cognitive impairment (ESRDaMCI). Existing multi-modal feature selection methods usually depend on the Euclidean distance to measure the similarity between data, which tends to ignore the implied data manifold. A self-expression topological manifold based multi-modal feature selection method (SETMFS) is proposed to address this issue employing self-expression topological manifold.

Evaluation of fused multisource data of air temperature based on dropsonde and satellite observation.

Continuous vertical air temperature (AT) from in-situ observation is of crucial importance for understanding the atmospheric environment, but the satellite data that have complete spatial coverage lacked vertical in-situ observation data, and the vertical dropsonde data from in-situ observations only were single-point observations. Therefore, this article introduced machine learning algorithms for fusing in-situ observation and multi-satellite data to achieve spatial continuity of vertical data on a large scale. Specially, random forest (RF), support vector regression (SVR), artificial neural network (ANN) and recurrent neural network (RNN) were employed to capture the non-linear relationships between the variables and estimated AT.

Roles of noncoding RNAs in septic acute kidney injury.

Septic acute kidney injury (SAKI) is one of the most common and life-threatening complications of sepsis. Patients with SAKI have increased mortality. However, the underlying pathogenesis is unclear, and the treatment targeting SAKI is unsatisfactory.

A systematic review for prevention of cisplatin-induced nephrotoxicity using different hydration protocols and meta-analysis for magnesium hydrate supplementation.

Background: Nephrotoxicity remains the most serious side effect of cisplatin therapy. Cisplatin-induced nephrotoxicity (CIN) limits the use of this drug and affects up to 20% of patients. Several possible interventions such as magnesium supplementation may prevent CIN.

Application Value of Limb Ischemic Preconditioning in Preventing Intradialytic Hypotension during Maintenance Hemodialysis.

Introduction: The aim of this study was to investigate the efficacy and safety of limb ischemia preconditioning (LIPC) in the treatment of intradialytic hypotension (IDH) in patients with maintenance hemodialysis (MHD).

Methods: This was a single-center, prospective, and randomized controlled case study. A total of 38 patients with MHD who met the inclusion criteria from September 2021 to August 2022 were selected from the Blood Purification Center of our hospital.

Altered spontaneous brain activities in maintenance hemodialysis patients with cognitive impairment and the construction of cognitive function prediction models.

Objective: The brain neuromechanism in maintenance hemodialysis patients (MHD) with cognitive impairment (CI) remains unclear. The study aimed to probe the relationship between spontaneous brain activity and CI by using resting-state functional magnetic resonance imaging (rs-fMRI) data.

Methods: Here, 55 MHD patients with CI and 28 healthy controls were recruited.

Hypergraph representation of multimodal brain networks for patients with end-stage renal disease associated with mild cognitive impairment.

The structure and function of brain networks (BN) may be altered in patients with end-stage renal disease (ESRD). However, there are relatively few attentions on ESRD associated with mild cognitive impairment (ESRDaMCI). Most studies focus on the pairwise relationships between brain regions, without taking into account the complementary information of functional connectivity (FC) and structural connectivity (SC).

Left ventricular hypertrophy, carotid atherosclerosis, and cognitive impairment in peritoneal dialysis patients.

Background: Left ventricular hypertrophy (LVH) and carotid atherosclerosis (CAS) have been identified as factors associated with cognitive impairment (CI) but have not been studied in patients undergoing peritoneal dialysis (PD). This study investigated the relationship between LVH and CAS and cognitive function in patients undergoing PD.

Methods: In this single-center cross-sectional study, the clinically stable patients who were over 18 years of age and had undergone PD for at least 3 months were enrolled.

Abnormal cerebral micro-structures in end-stage renal disease patients related to mild cognitive impairment.

Purpose: To investigate the mediating effect of abnormal brain micro-structures on the relationship between clinical risk factors and mild cognitive impairment (MCI), and further predict individual cognitive function in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis.

Methods: In total, 40 ESRD patients and 30 healthy controls were prospectively enrolled in our study. All subjects completed diffusion kurtosis imaging (DKI) examinations and Montreal cognitive assessment (MoCA) test.

Aberrant brain gray matter and functional networks topology in end stage renal disease patients undergoing maintenance hemodialysis with cognitive impairment.

Purpose: To characterize the topological properties of gray matter (GM) and functional networks in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis to provide insights into the underlying mechanisms of cognitive impairment.

Materials And Methods: In total, 45 patients and 37 healthy controls were prospectively enrolled in this study. All subjects completed resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion kurtosis imaging (DKI) examinations and a Montreal cognitive assessment scale (MoCA) test.

Brain Micro-Structural and Functional Alterations for Cognitive Function Prediction in the End-Stage Renal Disease Patients Undergoing Maintenance Hemodialysis.

Rationale And Objectives: The goal of this study was to investigate the relationship between altered brain micro-structure and function, and cognitive function in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis. Specially, diffusion kurtosis imaging (DKI), the resting-state functional connectivity (FC) algorithm, and the least squares support vector regression machine (LSSVRM) were utilized to conduct our study.

Materials And Methods: A total of 50 patients and 36 matched healthy controls were prospectively enrolled in our study.

Intravoxel incoherent motion to assess brain microstructure and perfusion in patients with end-stage renal disease.

Background And Purpose: This study aimed to investigate the clinical value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in evaluating the brain microstructure and perfusion changes in end-stage renal disease (ESRD) patients.

Methods: The routine head MRI sequences and IVIM were performed on 40 ESRD patients and 30 healthy subjects. The IVIM was executed with 10 b-values varying from 0 to 1000 seconds/mm .

The Effects of Febuxostat on Urine NGAL and Urine KIM-1 in Patients with Hyperuricemia.

Retrospective analysis of the effects of febuxostat on urine neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in patients with hyperuricemia was performed. From January 2018 to June 2018, there were 45 patients with asymptomatic hyperuricemia in the outpatient or inpatient of Changzhou Second People's Hospital, which were divided into the febuxostat group (25 cases) and the control group (20 cases). We collected the patients' baseline indicators and testing indicators after three months of treatment, including blood urea nitrogen, blood creatinine, blood uric acid, urine microalbumin, urine NGAL, urine KIM-1, and other indicators.