Endpoint Distribution Modeling-Based Capture Algorithm for Interfering Multi-Target.

In physical spaces, pointing interactions cannot rely on cursors, rays, or virtual hands for feedback as in virtual environments; users must rely solely on their perception and experience to capture targets. Currently, research on modeling target distribution for pointing interactions in physical space is relatively sparse. Area division is typically simplistic, and theoretical models are lacking.

Investigating the Impact of Polymers on Clay Flocculation and Residual Oil Behaviour Using a 2.5D Model.

In the process of oilfield development, the surfactant-polymer (SP) composite system has shown significant effects in enhancing oil recovery (EOR) due to its excellent interfacial activity and viscoelastic properties. However, with the continuous increase in the volume of composite flooding injection, a decline in injection-production capacity (I/P capacity) has been observed. Through the observation of frozen core slices, it was found that during the secondary composite flooding (SCF) process, a large amount of residual oil in the form of intergranular adsorption remained in the core pores.

Innovative Biotherapies and Nanotechnology in Osteoarthritis: Advancements in Inflammation Control and Cartilage Regeneration.

Osteoarthritis (OA) is among the most prevalent degenerative joint disorders worldwide, particularly affecting the aging population and imposing significant disability and economic burdens. The disease is characterized by progressive degradation of articular cartilage and chronic inflammation, with no effective long-term treatments currently available to address the underlying causes of its progression. Conventional therapies primarily manage symptoms such as pain and inflammation but fail to repair damaged tissues.

Exploration of Key Regulatory Factors in Mesenchymal Stem Cell Continuous Osteogenic Differentiation via Transcriptomic Analysis.

Background/objectives: Mesenchymal stem cells (MSCs) possess the remarkable ability to differentiate into various cell types, including osteoblasts. Understanding the molecular mechanisms governing MSC osteogenic differentiation is crucial for advancing clinical applications and our comprehension of complex disease processes. However, the key biological molecules regulating this process remain incompletely understood.

PPI-CoAttNet: A Web Server for Protein-Protein Interaction Tasks Using a Coattention Model.

Predicting protein-protein interactions (PPIs) is crucial for advancing drug discovery. Despite the proposal of numerous advanced computational methods, these approaches often suffer from poor usability for biologists and lack generalization. In this study, we designed a deep learning model based on a coattention mechanism that was capable of both PPI and site prediction and used this model as the foundation for PPI-CoAttNet, a user-friendly, multifunctional web server for PPI prediction.

Spatially-resolved analyses of muscle invasive bladder cancer microenvironment unveil a distinct fibroblast cluster associated with prognosis.

Background: Muscle-invasive bladder cancer (MIBC) is a prevalent cancer characterized by molecular and clinical heterogeneity. Assessing the spatial heterogeneity of the MIBC microenvironment is crucial to understand its clinical significance.

Methods: In this study, we used imaging mass cytometry (IMC) to assess the spatial heterogeneity of MIBC microenvironment across 185 regions of interest in 40 tissue samples.

The mechanism-specific injury mortality burden associated with heatwave in China in a warming world.

Numerous studies have investigated the impact of heatwaves on non-accidental mortality, yet the association and burden of heatwaves on mechanism-specific injury mortality remain underexplored. This study collected 257,267 injury-related fatalities and corresponding daily maximum temperatures (DMT) across seven Chinese provinces from 2013 to 2023. A heatwave was characterized by two or more successive days where the DMT surpassed its 92.

A preliminary exploration of establishing a mice model of hypoxic training.

Altitude training has been widely adopted. This study aimed to establish a mice model to determine the time point for achieving the best endurance at the lowland. C57BL/6 and BALB/c male mice were used to establish a mice model of hypoxic training with normoxic training mice, hypoxic mice, and normoxic mice as controls.

A Retrospective Study of Laparoscopic Distal Gastrectomy Guided by Carbon Nanoparticle Suspension Injection Lymphography for Gastric Cancer.

Background: The use of lymph node (LN) tracers can help obtain a complete dissection of the LNs and increase the detection rate of metastatic LNs. Carbon nanoparticle suspension injection (CNSI) has become increasingly used in radical gastrectomy procedures. This study is designed to evaluate the quality of LN dissection in gastric cancer patients with laparoscopic distal gastrectomy under the guidance of CNSI lymphography.

Triboelectric tactile sensor for pressure and temperature sensing in high-temperature applications.

Skin-like sensors capable of detecting multiple stimuli simultaneously have great potential in cutting-edge human-machine interaction. However, realizing multimodal tactile recognition beyond human tactile perception still faces significant challenges. Here, an extreme environments-adaptive multimodal triboelectric sensor was developed, capable of detecting pressure/temperatures beyond the range of human perception.

Finite element analysis of the plantar support for the medial longitudinal arch with flexible flatfoot.

Purpose: The present study is to explore the appropriate plantar support force for its effect on improving the collapse of the medial longitudinal arch with flexible flatfoot.

Methods: A finite element model with the plantar fascia attenuation was constructed simulating as flexible flatfoot. The appropriate plantar support force was evaluated.

Emerging Wearable Acoustic Sensing Technologies.

Sound signals not only serve as the primary communication medium but also find application in fields such as medical diagnosis and fault detection. With public healthcare resources increasingly under pressure, and challenges faced by disabled individuals on a daily basis, solutions that facilitate low-cost private healthcare hold considerable promise. Acoustic methods have been widely studied because of their lower technical complexity compared to other medical solutions, as well as the high safety threshold of the human body to acoustic energy.

Enhancing Rotator Cuff Repair in Rabbit Osteoporosis With Chitosan Quaternary Ammonium Salt-Coated Nickel-Titanium Memory Alloy Anchors.

Background: For patients with osteoporosis and rotator cuff tears, there is still no consensus on current treatment methods. The material, structure, and number of anchors have important effects on the repair outcome.

Purpose: To investigate the use of chitosan quaternary ammonium salt-coated nickel-titanium memory alloy (NTMA) anchors to treat rotator cuff injury in shoulders with osteoporosis in a rabbit osteoporosis model.

Lightweight and Mechanically Robust Cellulosic Triboelectric Materials for Wearable Self-Powered Rehabilitation Training.

Lightweight and robust self-powered wearable devices are of great importance in rehabilitation and medical assistance, but this places greater demands on the development of functional materials. In particular, a balance between reducing the weight of materials and enhancing their mechanical performance is urgently needed. Here, this study reports a design strategy based on a cross-scale strengthening mechanism, which endows triboelectric materials with mechanically robust properties, and can withstand more than 16,600 times its weight without any deformation.

Interplay between disorder and topology in Thouless pumping on a superconducting quantum processor.

Topological phases are robust against weak perturbations, but break down when disorder becomes sufficiently strong. However, moderate disorder can also induce topologically nontrivial phases. Thouless pumping, as a (1+1)D counterpart of the integer quantum Hall effect, is one of the simplest manifestations of topology.

Recombinant avian metapneumovirus subtype C expressing HA protein of H9N2 avian influenza virus are stable and induce protection.

To prevent H9N2 avian influenza virus (AIV) and Avian metapneumonovirus/C (aMPV/C) infections, we constructed recombinant aMPV/C viruses expressing the HA protein of H9N2 AIV. In addition, EGFP was inserted into the intermediate non-coding region of P-M protein in the aMPV/C genome using a reverse genetic system. The conditions for rescuing the recombinant virus were enhanced followed by insertion of the H9N2 AIV HA gene into the same location in the aMPV/C.

Association between urinary arsenic and hearing threshold shifts in adults in the United States, National Health and Nutrition Examination Survey, 2015-2016.

Background: Hearing loss (HL) is a common sensory disorder in humans. Studies on the relationship between arsenic, which is a highly toxic and widely distributed heavy metal with a health risk to humans, and hearing status in humans are contradictory and mostly focused on people living in arsenic-contaminated areas. This study investigated the association between urinary arsenic levels and hearing threshold shifts in the general population in the United States.

Continuous decoupled redox electrochemical CO capture.

Electrochemical CO capture driven by renewable electricity holds significant potential for efficient decarbonization. However, the widespread adoption of this approach is currently limited by issues such as instability, discontinuity, high energy demand, and challenges in scaling up. In this study, we propose a scalable strategy that addresses these limitations by transforming the conventional single-step electrochemical redox reaction into a stepwise electrochemical-chemical redox process.

Genetic Code Expansion: Recent Developments and Emerging Applications.

The concept of genetic code expansion (GCE) has revolutionized the field of chemical and synthetic biology, enabling the site-specific incorporation of noncanonical amino acids (ncAAs) into proteins, thus opening new avenues in research and applications across biology and medicine. In this review, we cover the principles of GCE, including the optimization of the aminoacyl-tRNA synthetase (aaRS)/tRNA system and the advancements in translation system engineering. Notable developments include the refinement of aaRS/tRNA pairs, enhancements in screening methods, and the biosynthesis of noncanonical amino acids.

Precise identification of somatic and germline variants in the absence of matched normal samples.

Somatic variants play a crucial role in the occurrence and progression of cancer. However, in the absence of matched normal controls, distinguishing between germline and somatic variants becomes challenging in tumor samples. The existing tumor-only genomic analysis methods either suffer from limited performance or insufficient interpretability due to an excess of features.

An artificial intelligence application to predict prolonged dependence on mechanical ventilation among patients with critical orthopaedic trauma: an establishment and validation study.

Background: Prolonged dependence on mechanical ventilation is a common occurrence in clinical ICU patients and presents significant challenges for patient care and resource allocation. Predicting prolonged dependence on mechanical ventilation is crucial for improving patient outcomes, preventing ventilator-associated complications, and guiding targeted clinical interventions. However, specific tools for predicting prolonged mechanical ventilation among ICU patients, particularly those with critical orthopaedic trauma, are currently lacking.