Model-based interactive visualization for complex systems requirements and design in joint tests.

This study presents an interactive visualization-based Model-Based Systems Engineering (MBSE) technique that is especially designed to handle requirements analysis and design issues in joint test settings. Standardized operational requirement description, test requirement analysis, test design, and first test system plan generation are the four primary phases that make up the technique. This method provides a more thorough and approachable depiction of both operational and test requirements by utilizing interactive visualization techniques.

The recent advance and prospect of natural source compounds for the treatment of heart failure.

Heart failure is a continuously developing syndrome of cardiac insufficiency caused by diseases, which becomes a major disease endangering human health as well as one of the main causes of death in patients with cardiovascular diseases. The occurrence of heart failure is related to hemodynamic abnormalities, neuroendocrine hormones, myocardial damage, myocardial remodeling , lead to the clinical manifestations including dyspnea, fatigue and fluid retention with complex pathophysiological mechanisms. Currently available drugs such as cardiac glycoside, diuretic, angiotensin-converting enzyme inhibitor, vasodilator and β receptor blocker are widely used for the treatment of heart failure.

Cross-cultural adaptation and construct validity of the Chinese Version of Visual Vertigo Analogue Scale by using structural equation modeling.

Background: Visual vertigo (VV) is a disease characterized by various visual signal-induced discomforts, including dizziness, unsteady balance, activity avoiding, and so forth. Distinguishing it from other kinds of dizziness is important because it needs the combination of visual training and vestibular rehabilitation together. However, there is no appropriate tool to diagnose VV in China, thus we would like to introduce an effective tool to China.

Temporal trends in the prevalence of autoimmune diseases from 1990 to 2019.

Aim: To describe current situation and analyze temporal trends of prevalence for four autoimmune diseases including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis (MS) and psoriasis, at the global, continental, and national levels.

Methods: The estimates and 95% uncertainty interval (UI) for age-standardized prevalence rate (ASPR) of RA, IBD, MS and psoriasis were obtained from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. ASPR of RA, IBD, MS and psoriasis in 2019 was illustrated at the global, continental, and national levels.

The expression profile of Gasdermin C-related genes predicts the prognosis and immunotherapy response of pancreatic adenocarcinoma.

Pancreatic adenocarcinoma (PAAD) has a poor prognosis and is relatively unresponsive to immunotherapy. Gasdermin C (GSDMC) induces pyroptosis in cancer cells and inflammation in the tumor microenvironment. However, whether GSDMC expression in PAAD is associated with survival or response to immunotherapy remains unknown.

LCN2 Inhibits the BMP9-induced Osteogenic Differentiation through Reducing Wnt/β-catenin Signaling Interacting with LRP6 in Mouse Embryonic Fibroblasts.

Background: Due to its effective osteogenic ability, BMP9 is a promising candidate for bone regeneration medicine. Whereas, BMP9 can also induce adipogenesis simultaneously. LCN2 is a cytokine associated with osteogenesis and adipogenesis.

Identification and Functional Analyses of Host Proteins Interacting with the P3a Protein of Brassica Yellows Virus.

Viruses are obligate parasites that only undergo genomic replication in their host organisms. ORF3a, a newly identified non-AUG-initiated ORF encoded by members of the genus , is required for long-distance movement in plants. However, its interactions with host proteins still remain unclear.

Matricellular Protein SMOC2 Potentiates BMP9-Induced Osteogenic Differentiation in Mesenchymal Stem Cells through the Enhancement of FAK/PI3K/AKT Signaling.

Mesenchymal stem cells (MSCs) can self-renew and differentiate into multiple lineages, making MSC transplantation a promising option for bone regeneration. Both matricellular proteins and growth factors play an important role in regulating stem cell fate. In this study, we investigated the effects of matricellular protein SMOC2 (secreted modular calcium-binding protein 2) on bone morphogenetic protein 9 (BMP9) in mouse embryonic fibroblasts (MEFs) and revealed a possible molecular mechanism underlying this process.

Effects of the Lipid Metabolites and the Gut Microbiota in ApoE Mice on Atherosclerosis Co-Depression From the Microbiota-Gut-Brain Axis.

The diagnosis, treatment, and prevention of atherosclerosis co-depression are poor, so it is urgent to explore new targets. Based on the "microbiota-gut-brain axis," this study aimed to investigate the changes of lipid metabolites in the prefrontal cortex and hippocampus regions and the characteristics of the gut microbiota in ApoE mice with atherosclerosis co-depression. ApoE mice (hyperlipid feeding combined with binding, HFB group, = 14, male) fed a high-fat diet for 16 weeks with binding stimulation were used as an animal model for atherosclerosis co-depression.

The Correlation Between Detection Value of Distortion-Product Otoacoustic Emissions and the Early Prognosis of Sudden Sensorineural Hearing Loss.

Background: To explore the correlation between the detection value of distortion-product otoacoustic emissions and the early prognosis of sudden sensorineural hearing loss.

Methods: Seventy-eight patients with first-onset sudden sensorineural hearing loss (all frequencies) from April 2018 to July 2019 were included in this study. Distortion-product otoacoustic emissions and pure-tone audiometry tests were performed at days 0, 3, and 6 of admission.

Improvement of electroacupuncture on APP/PS1 transgenic mice in behavioral probably due to reducing deposition of Aβ in hippocampus.

Alzheimer's disease (AD) is a fatal neurodegenerative disease for which currently no cure is available. Electroacupuncture (EA) has been widely used in China as an alternative therapeutic approach for neurological diseases. The cognitive decline in patients with AD has been reported to be closely related to the deposition of amyloid-β (Aβ) in the hippocampus of the brain, and the Morris water maze (MWM) test is a widely used method for assessing the behavior of animal models.

Pd-Catalyzed β-C-H Arylation of Aldehydes and Ketones Based on a Transient Directing Group.

The direct Pd-catalyzed β-C-H arylation of aldehydes and ketones was developed by using 2-amino-,'-diisopropylsuccinamide as a novel transient directing group (TDG). The TDG showed good versatility in functionalizing unactivated β-C-H bonds of aldehydes and ketones. It was effective not only for aliphatic aldehydes and ketones but also for aromatic aldehydes and ketones.

Enantioselective Silicon-Directed Nazarov Cyclization.

The Nazarov electrocyclization reaction is a convenient, widely used method for construction of cyclopentenones. In the past few decades, catalytic asymmetric versions of the reaction have been extensively studied, but the strategies used to control the position of the double bond limit the substituent pattern of the products and thus the synthetic applications of the reaction. Herein, we report highly enantioselective silicon-directed Nazarov reactions which were cooperatively catalyzed by a Lewis acid and a chiral Brønsted acid.

Global distribution and environmental drivers of methylmercury production in sediments.

Neurotoxic methylmercury (MeHg) in environments poses substantial risks to human health. Saturated sediments are basic sources of MeHg in food chains; however, distribution patterns and environmental drivers of MeHg at a global scale remain largely unexplored. Here, we characterized global patterns of MeHg distribution and environmental drivers of MeHg production based on 495 sediment samples across five typical ecosystems from the literature (1995-2018) and our own field survey.

MiR-743a-5p regulates differentiation of myoblast by targeting in skeletal muscle development and regeneration.

The microRNAs (miRNAs) play an important role in regulating myogenesis by targeting mRNA. However, the understanding of miRNAs in skeletal muscle development and diseases is unclear. In this study, we firstly performed the transcriptome profiling in differentiating C2C12 myoblast cells.

Water-soluble host-guest complexes between fullerenes and a sugar-functionalized tribenzotriquinacene assembling to microspheres.

A sugar-functionalized water-soluble tribenzotriquinacene derivative bearing six glucose residues, , was synthesized and its interaction with C and C-fullerene in co-organic solvents and aqueous solution was investigated by fluorescence spectroscopy and ultraviolet-visible spectroscopy. The association stoichiometry of the complexes with C and with C was found to be 1:1 with binding constants of = (1.50 ± 0.

Progress on genome-wide CRISPR/Cas9 screening for functional genes and regulatory elements.

The CRISPR/Cas9 system is a powerful tool which has been extensively used for genome editing in the past few years. Nuclease-dead Cas9 (CRISPR/dCas9), a Cas9 protein mutant without splicing ability, along with loss-of- function (LOF), gain-of-function (GOF), or non-coding genes scanning approaches can reveal genome-scale functional determinants. CRISPR/Cas9 has been widely adopted to decipher disease mechanisms and pinpoint drug targets in the life science field, and also provide novel insights into animal genetics and breeding.

Network embedding for link prediction: The pitfall and improvement.

Link prediction plays a significant role in various applications of complex networks. The existing link prediction methods can be divided into two categories: structural similarity algorithms in network domain and network embedding algorithms in the field of machine learning. However, few researchers focus on comparing these two categories of algorithms and exploring the intrinsic relationship between them.

Protecting quantum correlations of the XXZ model by topological boundary conditions.

The differences between the XXZ model with topological and periodical boundary conditions were compared by studying their entanglement, quantum discord, and critical temperature above which the entanglement vanishes. It shows that the different boundary conditions mainly affect bipartite quantum correlations of the boundary spins rather than that of other spin pairs. The topological boundary spins can protect entanglement and discord against strong magnetic fields while the periodical boundary spins can protect them against nonuniform magnetic fields.

[Spatiotemporal Variability and Source Apportionment of Soil Heavy Metals in a Industrially Developed City].

In the present study, a total of 1130 soil samples were collected in 2003 and 2013 in the Ningbo city district, and the content of eight typical heavy metals were measured. The degree of heavy metal pollution in the soil in the study area was evaluated using the pollution index evaluation method. The temporal and spatial variation in the pollution were analyzed by the geostatistics method, and principal component analysis (PCA) and the UNMIX model were used to analyze the heavy metal pollution sources.

Coherence as resource in scattering quantum walk search on complete graph.

We investigate the behavior of coherence in scattering quantum walk search on complete graph under the condition that the total number of vertices of the graph is significantly larger than the marked number of vertices we are searching, N ≫ v. We find that the consumption of coherence represents the increase of the success probability for the searching, also it is related to the efficiency of the algorithm in oracle queries. If no coherence is consumed or an incoherent state is utilized, the algorithm will behave as the classical blind search, implying that coherence is responsible for the speed-up in this quantum algorithm over its classical counterpart.

[Improving Nitrogen and Phosphorus Removal from Reclaimed Water Using a Novel Sulfur/Iron Composite Filler].

In order to improve the ability of denitrification and phosphorus removal from reclaimed water, a novel composite filler was prepared using sulfur powder and sponge iron powder, and a comparative experiment was constructed at different HRT(hydraulic retention time) and C/N(carbon-nitrogen ratio) conditions between the novel filler and the composite filler. The results showed that the efficiency of nitrogen and phosphorus removal on the novel filler was higher than that on the grain filler (more than 30% higher at HRT=4 h and C/N=1). Moreover, based on the 16S rRNA gene clone library, the denitrification system in the two reactors included sulfur autotrophic denitrification bacteria and heterotrophic denitrification bacteria, while the proportion of sulfur autotrophic denitrification bacteria in the novel filler system was higher.

Mechanical properties of epoxy nanocomposites filled with melamine functionalized molybdenum disulfide.

In this work, a melamine functionalized molybdenum disulfide (M-MoS) was prepared and used as fillers to form epoxy (EP)/MoS nanocomposites. The effects of molybdenum disulfide (MoS) and melamine functionalized molybdenum disulfide (M-MoS) loading on the mechanical properties of epoxy composites were investigated and compared. With only addition of 0.

The sudden death and sudden birth of quantum discord.

The interaction of quantum system and its environment brings out abundant quantum phenomenons. The sudden death of quantum resources, including entanglement, quantum discord and coherence, have been studied from the perspective of quantum breaking channels (QBC). QBC of quantum resources reveal the common features of quantum resources.