Fabrication of Dialkyl Dithiophosphate-Functionalized Carbon Aerogel Microspheres for Enhanced Lubrication Performance.

Herein, functionalized carbon aerogel microspheres (CAMs) were successfully prepared by the pyrolysis of resorcinol-formaldehyde (RF) microspheres followed by surface modification. First, RF microspheres were carbonized to obtain CAMs. Afterward, the polyphenolic compound of epigallocatechin gallate (EGCG) was reacted with melamine to form a poly(EGCG) layer onto the CAM surface, followed by bonding the antiwear molecule dialkyl dithiophosphate (DDP) by the Michael addition, resulting in DDP-functionalized CAMs (DDP-CAMs).

Controllable fabrication of hierarchical porous anode for exoelectrogens internal colonization in microbial electrochemical system.

Efficient interfacial energy conversion and rapid charge transfer are crucial for application-oriented microbial electrochemical systems (MES) and depend on affordable high-performance anodes. Herein, hierarchically porous 3D anodes with controlled millimeter-scale macropores (1-2 mm) were fabricated via carbonization of phenolic foam embedded with expanded polystyrene (EPS) sacrificial templates. Optimizing EPS loading (4 wt%) and pore-sizes yielded anode L-4M, exhibiting appropriate hydrophilicity (contact angle: 60.

Semiconductor-mediated radiosensitizers: progress, challenges and perspectives.

Radiotherapy has become one indispensable treatment strategy for treating malignant tumors. However, the therapeutic effect of radiotherapy is limited due to the low sensitivity and large side effects of existing radiosensitizers. The rapid development of nanotechnology has created opportunities for various novel kinds of radiosensitizers with excellent radiosensitivity to sprout recently.

Stability study of recombinant 9-valent human papillomavirus vaccine based on expression system.

This study reports on the long-term stability of a recombinant 9-valent HPV vaccine, addressing a gap in the literature as previous research did not extend beyond 72 months. The vaccine targets HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58 and was produced using an expression system. We optimized soluble HPV L1 protein expression by truncating the - and C-termini, resulting in HPV L1 virus-like particles (VLPs).

Multielement-Doped Porous Carbon Nanosheets Derived from Metal-Organic Frameworks as Lubricating Additives for Antifriction and Antiwear Properties.

The development of advanced lubricant additives is crucial for improving the tribological properties in mechanical systems. Doping has been certified as one of the effective methods for enhancing the lubricating properties of carbon nanomaterials. Herein, multielement (B, N, P)-doped porous carbon nanosheets (B, N, P@PCNs) were successfully prepared using ionic liquid-assisted pyrolysis of "copper-pyridine" coordination metal-organic frameworks (Cu-MOFs).

Association of hippocampal atrophy with tau pathology of temporal regions in preclinical Alzheimer's disease.

BackgroundHippocampal atrophy is linked to memory and cognitive deficits, preceding clinical diagnosis of mild cognitive impairment (MCI) by decades. Morphometry changes in the hippocampal formation (HF) and their relationship to tau deposition in non-demented individuals remains unclear.ObjectiveTo investigate morphometry changes in the HF and their association with tau deposition in a non-demented cohort.

METTL3-mediated NFAT5 Upregulation Promotes Cervical Cancer Progression Through Enhancing the Mitochondrial Function by Transcriptional Regulation of PRDX1.

Nuclear factor of activated T-cells 5 (NFAT5) is recognized as an oncogene in a variety of tumors. However, the role of NFAT5 in cervical cancer (CC) cell phenotypic alterations remains to be elucidated. Here, we demonstrated that NFAT5 expression was elevated in CC samples and cells using quantitative real-time reverse transcription PCR, Western blot analysis, and immunohistochemistry assays, and high NFAT5 expression showed a poor prognosis.

Quadratic scaling path integral molecular dynamics for fictitious identical particles and its application to fermion systems.

Recently, fictitious identical particles have provided a promising way to overcome the fermion sign problem and have been used in path integral Monte Carlo to accurately simulate warm dense matter with up to 1000 electrons [T. Dornheim et al., J.

The Rising of Flexible Organic Electrochemical Transistors in Sensors and Intelligent Circuits.

Flexible electronic devices in biomedicine, environmental monitoring, and brain-like computing have garnered significant attention. Among these, organic electrochemical transistors (OECTs) have been spotlighted in flexible sensors and neuromorphic circuits for their low power consumption, high signal amplification, excellent biocompatibility, chemical stability, stretchability, and flexibility. However, OECTs will also face some challenges on the way to commercialized applications, including the need for improved long-term stability, enhanced performance of N-type materials, integration with existing technologies, and cost-effective manufacturing processes.

CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α.

Mitochondrial dysfunctions are closely associated with different types of disease, including cancer. Carnitine acetyltransferase (CRAT) is a mitochondrial-localized enzyme catalyzing the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. Our bioinformatics analysis using public database revealed a significant decrease of CRAT expression in ovarian cancer (OC).

Impact of carrier capacitance on Geobacter enrichment and direct interspecies electron transfer under anaerobic conditions.

Direct interspecies electron transfer (DIET) enhances anaerobic digestion by facilitating electron exchange between electroactive bacteria and methanogenic archaea. While Geobacter species are recognized for donating electrons to methanogens via DIET, they are rarely detected in mixed microbial communities. This study examined various non-electrode biological carriers (zeolite, carbon cloth, activated carbon and biochar) to promote Geobacter cultivation under anaerobic conditions and identify pivotal factors influencing their symbiosis with methanogens.

Ovarian cancer-derived TGF-β1 induces cancer-associated adipocytes formation by activating SMAD3/TRIB3 pathway to establish pre-metastatic niche.

Ovarian cancer (OC) is prone to adipose tissue metastasis. However, the underlying molecular mechanisms remain elusive. Here, we observed that omental adipocytes were induced into cancer-associated adipocytes (CAAs) by OC-derived TGF-β1 to establish a pre-metastatic niche (PMN) through collagen and fibronectin secretion.

High-Precision Printing Sandwich Flexible Transparent Silver Mesh for Tunable Electromagnetic Interference Shielding Visualization Windows.

Flexible transparent conductive films (FTCFs) with electromagnetic interference (EMI) shielding performance are increasingly crucial as visualization windows in optoelectronic devices due to their capabilities to block electromagnetic radiation (EMR) generated during operation. Metal mesh-based FTCFs have emerged as a promising representative in which EMI shielding effectiveness (SE) can be enhanced by increasing the line width, reducing the line spacing, or increasing mesh thickness. However, these conventional approaches decrease optical transmittance or increase material consumption, thus compromising the optical performance and economic viability.

Jianghua Kucha black tea containing theacrine attenuates depression-like behavior in CUMS mice by regulating gut microbiota-brain neurochemicals and cytokines.

Theacrine and theaflavins are known for their potential to mitigate depression and cognitive impairment. Jianghua Kucha black tea (JH) contains both compounds, yet its antidepressant properties are seldom documented. This study evaluated the effects of JH on depression in chronic unpredictable mild stress (CUMS) mice and explored the underlying mechanisms through integrative analyses of gut microbiota and fecal metabolomics.

Resolving severely overlapping ion mobility peaks using enhanced Fourier self-deconvolution.

Fourier self-deconvolution is an effective method for resolving overlapping spectra. However, the selection of the half-width for the deconvolving function is often subjective, which can lead to either excessive convolution or insufficient resolution enhancement. Additionally, ion mobility peaks exhibit tailing effects, which may be misinterpreted as new peaks when the deconvolving function is modelled with a Gaussian function.

Fabrication of Ionic Supramolecular Oleogel Lubricants Enhanced with Liquid Metal Nanodroplets for Superior Tribological Performance.

Supramolecular Oleogel lubricants provide a versatile and reliable strategy for optimizing the long-term dispersion stability of nanoadditives in the base oils. In this work, GLM-based ionic gelators constructing supramolecular oleogels were prepared by adding ultrasonically treated gallium-based liquid metal (GLM) nanodroplets carrying free radicals and vinyl-containing ionic liquids (ILs) directly to a free radical polymerization system of polymer gelators. The electrostatic interactions between the ionic liquids and GLM nanodroplets enhanced the cross-linking degree of supramolecular gels and formed denser self-assembled structures.

The E3 ligase TaE3V-B1 ubiquitinates proteins encoded by the vernalization gene TaVRN1 and regulates developmental processes in wheat.

In wheat (Triticum aestivum), early maturity is desired to avoid the hot and dry summer season, especially in view of climate change. Here, we report that TaE3V1, a C3H2C3 RING-type E3 ligase that interacts with TaVRN1, is associated with early development. Aside from its RING domain, TaE3V1 does not harbor any domains that are conserved in other RING-type or other E3 ligase proteins.

Clinical study of different frequency transcranial magnetic stimulation combined with paroxetine in the treatment of poststroke depression with insomnia.

Background: Study the treatment of poststroke depression and insomnia using varied repetitive transcranial magnetic stimulation (rTMS) frequencies alongside paroxetine. Aim to enhance rTMS effectiveness for depression, insomnia, neurological impairment, and daily living skills.

Methods: Ninety poststroke depression (PSD) patients were randomly divided into a low-frequency group (low-frequency rTMS + enteric-coated paroxetine), a high-frequency group (high-frequency rTMS + enteric-coated paroxetine), and a control group (sham stimulation + enteric-coated paroxetine).

Overexpression of tae-miR9670 enhances cadmium tolerance in wheat by targeting mTERFs without yield penalty.

Cadmium (Cd) is a widely distributed heavy metal that poses significant hazards to both crop productivity and human health. MicroRNAs (miRNAs) play pivotal roles in plant growth, development and responses to environmental stresses, yet little is known about their roles in regulating Cd tolerance in wheat. In this study, we identified tae-miR9670, a Triticeae-specific miRNA, as responsive to Cd exposure in wheat through miRNAome analysis.

Risk and survival outcomes of secondary pelvic neoplasm after radiotherapy in female patients with genital neoplasms: A large Population-Based cohort study.

Background And Purpose: To investigate the impact of radiotherapy (RT) on the risk of secondary pelvic neoplasms (SPN) and the survival outcomes of patients following a diagnosis of female patients with genital neoplasm(FGN).

Materials And Methods: Utilizing SEER databases, this study involved 102,895 patients from nine oncology centers, spanning 1990 to 2015. We employed the Fine-Gray competing risks regression methodology to chart the trajectory of SPN development and used the Kaplan-Meier method to calculate the 10-year overall survival rates.

Validity of data extraction in acupuncture meta-analysis: a reproducibility study protocol.

Introduction: Systematic review and meta-analysis occupy the apex of the evidence pyramid, serving as the most comprehensive and reliable form of evidence-based assessment. Data extraction is a crucial juncture in meta-analysis, establishing the underpinnings for the outcomes and deductions drawn from systematic reviews (SRs). However, the frequency of data extraction errors in meta-analysis is quite significant.

Electrochemically-Switched Microwave Response of MXene in Organic Electrolyte.

The increasingly complex electromagnetic (EM) environment necessitates advanced electrically controllable electromagnetic interference (EMI) shielding materials that can adapt to varying EM conditions. This study develops a flexible electrochemically tunable EMI shielding device based on ultrathin TiCT MXene films, exhibiting reversible shielding effectiveness (SE) modulation from 18.9 to 26.

Fabrication of Vanadium Oxide-encapsulated Hybrid Carbon Nanospheres for Enhanced Tribological Performance.

A new sulfur-containing carbon nanospheres encapsulated with vanadium oxide (V@SCN) is synthesized through a one-pot oxidation polymerization and then carbonization method. The prepared V@SCNs exhibit good dispersibility as a lubricant additive, which is owing to the inherited lipophilic organic functional groups in the sulfur-containing carbon shell derived from the carbonization of polythiophene. The agglomeration and precipitation of metals in the base oil are also avoided through the encapsulation of lipophilic carbon shells.

Fabrication of Ag Nanoparticle-Embedded Covalent Organic Frameworks for Oil Gel with Long-Term Stability and High Lubrication Performance.

In previous reports, covalent organic frameworks (COFs) have demonstrated significant potential as lubricant additives. Herein, we embedded Ag nanoparticles in the DT-COF (polycondensation polymer of 2,5-dihydroxyterephthalaldehyde and 4,4',4″-(1,3,5-triazine-2,4,6-triyl) trianiline) matrix via the ball milling method and utilized this composite (Ag@DT-COF) as an additive for supermolecule oil gel. The low molecular weight gelator effectively mitigates the dispersion challenges of COFs in lubricant oil, while the embedded Ag nanoparticles enhance the repairing effect and antipressure performance of the lubricant.