Digital symptom management interventions for people with chronic kidney disease: a scoping review based on the UK Medical Research Council Framework.

Background: Chronic Kidney Disease (CKD) is a growing global health issue with a complex symptom phenotype. It negatively impacts patients' health-related quality of life and increases healthcare utilization. While digital health interventions offer promising avenues for improving symptom management in CKD, understanding their development, validation, and effectiveness is crucial for clinical application.

Uterine Artery Embolization for Mixed Adenomyosis and Fibroids: Outcomes According to Initial Particle Sizes.

Purpose: To characterize the effect of embolic particle size on outcomes of uterine artery embolization (UAE) for mixed adenomyosis/fibroids.

Materials And Methods: A single-center retrospective database was compiled of all patients with mixed adenomyosis/fibroids who underwent UAE with particles (Embosphere, Merit, USA; Embozene, Varian, UK) from September 2015 to May 2022 (n=76, mean age: 46.7 ± 5.

Integrated metabolome and microbiome strategy reveals the therapeutic effect of nervonic acid on Alzheimer's disease rats.

Alzheimer's disease (AD) is a complex neurodegenerative disease. Nervonic acid is a component of breast milk and is also found in fish oil and specific vegetable oils. Studies have shown that nervonic acid is essential for the development of the human nervous system.

TTK promotes HER2 + breast cancer cell migration, apoptosis, and resistance to targeted therapy by modulating the Akt/mTOR axis.

Background: HER2 + breast cancer is a malignant neoplasm with a high degree of aggressiveness and therapeutic challenge. In recent years, studies have indicated a strong correlation between TTK and various tumors, though its role in HER2 + BRCA remains unclear.

Objectives: Studying the biological function of the TTK gene in HER2 + BRCA and its resistance to targeted therapy it provides new ideas for targeted drug research.

Mendelian randomization studies of lifestyle-related risk factors for stroke: a systematic review and meta-analysis.

Objective: Stroke risk factors often exert long-term effects, and Mendelian randomization (MR) offers significant advantages over traditional observational studies in evaluating the causal impact of these factors on stroke. This study aims to consolidate and evaluate the relationships between potential causal factors and stroke risk, drawing upon existing MR research.

Methods: A comprehensive search for MR studies related to stroke was conducted up to August 2023 using databases such as PubMed, Web of Science, Embase, and Scopus.

Laser-Induced Breakdown Spectroscopy and a Convolutional Neural Network Model for Predicting Total Iron Content in Iron Ores.

Laser-induced breakdown spectroscopy (LIBS) is a rapid method for detecting total iron (TFe) content in iron ores. However, accuracy and measurement error of univariate regression analysis in LIBS are limited due to factors such as laser energy fluctuations and spectral interference. To address this, multiple regression analysis and feature selection/extraction are needed to reduce redundant information, decrease the correlation between variables, and quantify the TFe content of iron ores accurately.

Hypergraph modeling of complex interactions: Applications from human musculoskeletal structures to complex system dynamics.

The musculoskeletal network is a complex system of different types of nodes and edges interacting with each other. Although there is a wealth of knowledge about the anatomical components of the human body and the connections between them, the interdependence of these components as a system remains largely unexplored. This study aims to understand the structure of musculoskeletal networks by using hypergraphs as a model of the musculoskeletal system with many-to-many connections.

Mitigating environmental toxicity with hydrogen nanobubbles: A mitochondrial function-based approach to ecological restoration.

In biological systems, nanobubbles (NBs) effectively enhance hydrogen molecule retention and scavenging reactive oxygen species (ROS), but the underlying mechanisms remain elusive. To investigate this, we prepared hydrogen NB water samples with consistent dissolved hydrogen levels but varying NB densities to explore their physicochemical properties and effects on green algae (Chlorella vulgaris) under oxidative stress induced by copper ions (Cu) and cadmium ions (Cd). The results indicated a strong correlation between the hydrogen NB number density and the 25 % inhibitory concentration of Cu over 24 h, with ROS removal efficiency increased with the NB number density.

Perioperative body composition changes and their clinical implications in patients with gastric cancer undergoing radical gastric cancer surgery: a prospective cohort study.

Background: This study aimed to investigate perioperative body composition changes and their clinical implications in patients undergoing radical gastric cancer surgery.

Methods: Patient data are prospectively collected. Computed tomography scans were conducted within 30 days preoperatively and on the seventh postoperative day to assess skeletal muscle mass index (SMI), skeletal muscle density (SMD), and subcutaneous adipose tissue (SAT).

Structural connectivity of thalamic subnuclei in major depressive disorder: An ultra-high resolution diffusion MRI study at 7-Tesla.

Background: The thalamus serves as a central relay station within the brain, and thalamic connectional anomalies are increasingly thought to be present in major depressive disorder (MDD). However, the use of conventional MRI scanners and acquisition techniques has prevented a thorough examination of the thalamus and its subnuclear connectional profile. We combined ultra-high field diffusion MRI acquired at 7.

Effect of SiHuangQingXinWan on -induced pneumonia: mechanistic insights.

Introduction: Due to the high mortality rate and increasing severity of antibiotic resistance, there is a growing interest in new treatments for ae (KP)-induced pneumonia. Research has shown that the single herbs of SiHuangQingXinWan (SHQXW) are effective in treating pneumonia caused by KP. The PI3K/AKT signaling pathway has garnered attention for its potential role in the management of bacterial infections.

Risk factors of bowel perforation during hydrostatic enema reduction for paediatric intussusception.

Objective: Bowel perforation is a major, yet unstudied complication of ultrasound-guided hydrostatic enema reduction (UGHR). In this study, we aimed to explore the risk factors and determine the clinical characteristics of bowel perforation during UGHR for paediatric intussusception (P-UGHR).

Methods: We retrospectively analysed the medical records of patients who underwent UGHR for intussusception at our institution between January 2011 and December 2021.

YOLO-Faster: An efficient remote sensing object detection method based on AMFFN.

As a pivotal task within computer vision, object detection finds application across a diverse spectrum of industrial scenarios. The advent of deep learning technologies has significantly elevated the accuracy of object detectors designed for general-purpose applications. Nevertheless, in contrast to conventional terrestrial environments, remote sensing object detection scenarios pose formidable challenges, including intricate and diverse backgrounds, fluctuating object scales, and pronounced interference from background noise, rendering remote sensing object detection an enduringly demanding task.

In Vivo Tissue Distribution and Pharmacokinetics of FITC-Labelled Polyphenol-Polysaccharide Complex in Mice.

In this study, a quantitative method based on fluorescein isothiocyanate (FITC)-labelled polyphenol-polysaccharide complex (HPC) and its purified fractions (PC1, PC4) was used, and its pharmacokinetics and tissue distribution were investigated in mice. The results showed that the FITC-labelled method had good linearity (R > 0.99), intra-day and inter-day precision (RSD, %) consistently lower than 15%, recovery (93.

Solar-Driven Evaporator With "Starburst Turbine" Design Featuring Directional Salt Crystallization, Antibacterial, and Catalytic Multifunctionality for Efficient Water Purification.

Facing the global challenge of water scarcity, solar-driven desalination is considered a sustainable technology for obtaining freshwater from seawater. However, issues such as uncontrolled salt crystallization and bacterial contamination limit its efficiency and practicality. This study proposes an innovative solar-driven evaporator designed to address these challenges using optimized shape design and advanced photothermal materials.

Efficacy and safety of recombinant human thrombopoietin for the treatment of chronic primary immune thrombocytopenia in children and adolescents: A multicentre, randomized, double-blind, placebo-controlled phase III trial.

The efficacy and safety of recombinant human thrombopoietin (rhTPO) in children and adolescent patients with chronic primary immune thrombocytopenia (ITP) remains unclear. A multicentre, randomized, double-blind, placebo-controlled phase III trial was performed. Patients aged 6-17 years, diagnosed with ITP and resistant or relapsed to corticosteroid treatment were included.

A Data-Driven Cognitive Composite Sensitive to Amyloid-β for Preclinical Alzheimer's Disease.

Background: Integrating scores from multiple cognitive tests into a single cognitive composite has been shown to improve sensitivity to detect AD-related cognitive impairment. However, existing composites have little sensitivity to amyloid-β status (Aβ +/-) in preclinical AD.

Objective: Evaluate whether a data-driven approach for deriving cognitive composites can improve the sensitivity to detect Aβ status among cognitively unimpaired (CU) individuals compared to existing cognitive composites.