WITHDRAWN: Surging dynamics of unnamed glaciers at the Abi Gamin Peak in the central Himalayas.

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Monitoring dynamics of Kyagar Glacier surge and repeated draining of Ice-dammed lake using multi-source remote sensing.

Glacier surges, a primary factor contributing to various glacial hazards, has long captivated the attention of the global glaciological community. This study delves into the dynamics of Kyagar Glacier surging and the associated drainage features of its Ice-dammed lake, employing high temporal resolution optical imagery. Our findings indicate that the surge on Kyagar Glacier began in late spring and early summer of 2014 and concluded during the summer of 2016.

Pyridine-Based Covalent Organic Frameworks with Pyridyl-Imine Structures for Boosting Photocatalytic HO Production via One-Step 2e Oxygen Reduction.

Bipyridine-based covalent organic frameworks (COFs) have emerged as promising contenders for the photocatalytic generation of hydrogen peroxide (HO). However, the presence of imine nitrogen alters the mode of HO generation from an efficient one-step two-electron (2e) route to a two-step 2e oxygen reduction pathway. In this work, we introduce 3,3'-bipyridine units into imine-based COF skeletons, creating a pyridyl-imine structure with two adjacent nitrogen atoms between the pyridine ring and imine linkage.

A randomized proof-of-mechanism trial of TNF antagonism for motivational anhedonia and related corticostriatal circuitry in depressed patients with high inflammation.

Chronic, low-grade inflammation has been associated with motivational deficits in patients with major depression (MD). In turn, impaired motivation has been linked to poor quality of life across psychiatric disorders. We thus determined effects of the anti-inflammatory drug infliximab-a potent tumor necrosis factor (TNF) antagonist-on behavioral and neural measures of motivation in 42 medically stable, unmedicated MD patients with a C-reactive protein > 3mg/L.

Yiqi Jiedu Xiaoying Decoction Improves Experimental Autoimmune Thyroiditis in Rats by Regulating Th17/Treg Cell Balance.

Background: Experimental autoimmune thyroiditis (EAT) is a widely used animal model to study the pathogenesis and treatment of autoimmune thyroid diseases. Yiqi Jiedu Xiaoying Decoction (YJXD) is a traditional Chinese medicine formula with potential immunomodulatory effects. In this study, we investigated the therapeutic effects of YJXD on EAT in rats and explored its underlying mechanisms.

Dynamics of algal blooms in typical low-latitude plateau lakes: Spatiotemporal patterns and driving factors.

The alpine lakes distributed on the plateau are crucial for the hydrological, and biogeochemical cycle, and also serve as a guarantee for regional economic development and human survival. However, under the influence of human interference and climate fluctuations, lakes are facing problems of eutrophication and subsequent algal blooms (ABs) with acceleration, and the development and driving factors of this phenomenon need to be considered as a whole. In this study, ten lakes located on the Yunnan-Guizhou Plateau were selected as the study area to analyze the spatiotemporal distribution of ABs and possible controlling forces.

In Vivo Characterization of Cerebellar Peduncles in Chronic Ankle Instability: A Single and Multishell Diffusion-Weighted Imaging Study.

Background: Ankle sprain causes proprioceptor injuries and prolonged joint deafferentation, which might lead to maladaptive neuroplasticity in patients with chronic ankle instability (CAI), especially in the cerebellum. Previous studies have indicated the impairment of superior cerebellar peduncle (SCP), but the inferior cerebellar peduncle (ICP) and middle cerebellar peduncle (MCP) have not been fully analyzed.

Hypothesis: The cerebellar peduncles of participants with CAI would have altered fractional anisotropy (FA) and orientation dispersion index (ODI) in comparison with healthy controls without ankle injury history.

Construction of Covalent Organic Framework Nanofiber Membranes for Efficient Adsorption of Antibiotics.

Techniques beyond crystal engineering are critical for manufacturing covalent organic frameworks (COFs) and to explore them for advanced applications. However, COFs are normally obtained as insoluble, unmeltable, and thus nonprocessible microcrystalline powders. Therefore, it is a significant challenge to implement COFs into larger architectures and structural control on different length scales.

Quantitative Magnetic Resonance Imaging-Based Tendon Healing of Different Regions of the Shoulder: Comparison Between the Suture-Bridge and Single-Row Techniques.

Background: Rotator cuff retears occur more often at the proximal region with the suture-bridge (SB) technique than at the typical footprint region with the single-row (SR) technique. Few longitudinal clinical trials have focused on the postoperative tendon quality of the repaired rotator cuff at different regions between the 2 techniques.

Purpose: To compare tendon healing of the proximal and distal regions between the SB and SR techniques.

Discovery of cysteine-targeting covalent histone methyltransferase inhibitors.

Post-translational methylation of histone lysine or arginine residues by histone methyltransferases (HMTs) plays crucial roles in gene regulation and diverse physiological processes and is implicated in a plethora of human diseases, especially cancer. Therefore, histone methyltransferases have been increasingly recognized as potential therapeutic targets. Consequently, the discovery and development of histone methyltransferase inhibitors have been pursued with steadily increasing interest over the past decade.

A covalent organic framework/graphene aerogel electrocatalyst for enhanced overall water splitting.

The rational design of covalent organic framework (COF) based hybrid materials is of paramount importance to address the fundamental challenges of COFs with respect to their poor electron mobilization and the limited number of accessible active sites. Herein, we propose a new strategy for the fabrication of covalently bonded COF grafted graphene aerogel hybrid materials for electrocatalytic application. An step-growth polymerization approach was developed to achieve the hybridization of COFs along the surface of amino-functionalized graphene nanosheets.

Globally elevated chemical weathering rates beneath glaciers.

Physical erosion and chemical weathering rates beneath glaciers are expected to increase in a warming climate with enhanced melting but are poorly constrained. We present a global dataset of cations in meltwaters of 77 glaciers, including new data from 19 Asian glaciers. Our study shows that contemporary cation denudation rates (CDRs) beneath glaciers (2174 ± 977 Σ*meq m year) are ~3 times higher than two decades ago, up to 10 times higher than ice sheet catchments (~150-2000 Σ*meq m year), up to 50 times higher than whole ice sheet means (~30-45 Σ*meq m year) and ~4 times higher than major non-glacial riverine means (~500 Σ*meq m year).

Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway.

Saponins are the main bioactive substances with anti-hyperglycemic activities of Momordica charantia. This study aimed to verify the effects of M. charantia saponins on insulin secretion and explore the potential underlying mechanisms in INS-1 pancreatic β-cells.

Overview of terrestrial water storage changes over the Indus River Basin based on GRACE/GRACE-FO solutions.

Water resources are under severe stress in the highly populated Indus River Basin due to the increased consumption of water across different sectors and climate change. Coping with these challenges, requires a clear understanding on hydrological processes and anthropogenic activities, and how these are influencing recharging and spatiotemporal availability of groundwater in the basin. The present study aims to investigate the natural and anthropogenic impact on Terrestrial Water Storage (TWS) over the Indus River Basin by using a series of statistical methods and the observation data from the Gravity Recovery and Climate Experiment (GRACE) and Follow-On (GRACE-FO).

Saponins of Momordica charantia increase insulin secretion in INS-1 pancreatic β-cells via the PI3K/Akt/FoxO1 signaling pathway.

Saponins are the main bioactive substances with anti-hyperglycemic activities of Momordica charantia. This study aimed to verify the effects of M. charantia saponins on insulin secretion and explore the potential underlying mechanisms in INS-1 pancreatic β-cells.

Thin debris layers do not enhance melting of the Karakoram glaciers.

The assessment of meltwater sourcing from the clean and debris-covered glaciers is scarce in High Mountain Asia (HMA). The melting rate varies with the debris cover thickness and glacier orientation. The present study quantifies glacier melting rate attributed to varying thickness of debris cover in the Karakoram.

Spatiotemporal variability of glacier changes and their controlling factors in the Kanchenjunga region, Himalaya based on multi-source remote sensing data from 1975 to 2015.

Spatio-temporal behavior of glaciers in the Himalayas has varied greatly in response to reported climate warming and other modulating factors such as topography, debris cover, and glacier morphology. In this paper, 429 glaciers were examined in the Kanchenjunga region in the middle of the Himalayas. Geodetic methods, feature-based image matching, and multi-parametric integrated approaches were used to detect differences of glacier change and the dominant characteristics driving these differences based on digital elevation models (DEMs), Landsat TM/ETM+/OLI images, Envisat/ASAR and Sentinel-1 data.

Fluctuation analysis in the dynamic characteristics of continental glacier based on Full-Stokes model.

Ice thickness has a great influence on glacial movement and ablation. Over the course of the change in thickness, area and external climate, the dynamic process of how glaciers change and whether a glacier's changes in melting tend to be stable or irregular is a problem that needs to be studied in depth. In our study, the changes in the dynamic process of the No.

Pseudomonas sp. ST4 produces variety of active compounds to interfere fungal sexual mating and hyphal growth.

Sexual mating of compatible sporida is essential for Sporisorium scitamineum to form dikaryotic mycelia and then cause infection on sugarcane. Our previous work identified a Pseudomonas sp. ST4 from a soil sample, which showed a promising biocontrol potential by inhibiting the mating of S.

Genetic Modulation of c-di-GMP Turnover Affects Multiple Virulence Traits and Bacterial Virulence in Rice Pathogen Dickeya zeae.

The frequent outbreaks of rice foot rot disease caused by Dickeya zeae have become a significant concern in rice planting regions and countries, but the regulatory mechanisms that govern the virulence of this important pathogen remain vague. Given that the second messenger cyclic di-GMP (c-di-GMP) is associated with modulation of various virulence-related traits in various microorganisms, here we set to investigate the role of the genes encoding c-di-GMP metabolism in the regulation of the bacterial physiology and virulence by construction all in-frame deletion mutants targeting the annotated c-di-GMP turnover genes in D. zeae strain EC1.

Quorum sensing and microbial drug resistance.

Microbial drug resistance has become a serious problem of global concern, and the evolution and regulatory mechanisms of microbial drug resistance has become a hotspot of research in recent years. Recent studies showed that certain microbial resistance mechanisms are regulated by quorum sensing system. Quorum sensing is a ubiquitous cell-cell communication system in the microbial world, which associates with cell density.

SlyA regulates phytotoxin production and virulence in Dickeya zeae EC1.

Dickeya zeae is a causal agent of rice root rot disease. The pathogen is known to produce a range of virulence factors, including phytotoxic zeamines and extracellular enzymes, but the mechanisms of virulence regulation remain vague. In this study, we identified a SlyA/MarR family transcription factor SlyA in D.

Mass Change of Glaciers in Muztag Ata-Kongur Tagh, Eastern Pamir, China from 1971/76 to 2013/14 as Derived from Remote Sensing Data.

The assessment of glacier mass budget is crucial for assessing water reserves stored in glaciers. Derived glacier mass changes in the Muztag Ata and Kongur Tagh (MAKT) region in the eastern Pamir, northwestern China, is helpful in improving our knowledge of the dynamics of glaciers under a changing climate in High Mountain Asia. Here, glacier area and mass changes derived from remote sensing data are investigated for the period 1971/76-2013/14 for glaciers in MAKT.