The protective effect of sodium-glucose cotransporter-2 inhibitor on left ventricular global longitudinal strain in patients with type 2 diabetes mellitus according to disease duration.

Our study aimed to elucidate the impact of sodium-glucose cotransporter-2 inhibitor on left ventricular systolic function using global longitudinal strain in type 2 diabetes mellitus patients and to assess its protective effect depending on disease duration. Type 2 diabetes mellitus patients treated at our institute were included. According to whether sodium-glucose cotransporter-2 inhibitor was used in drug treatment, the patients were divided into SGLT2i group and control group, and propensity score matching was performed.

Point Cloud Completion of Plant Leaves under Occlusion Conditions Based on Deep Learning.

The utilization of 3-dimensional point cloud technology for non-invasive measurement of plant phenotypic parameters can furnish important data for plant breeding, agricultural production, and diverse research applications. Nevertheless, the utilization of depth sensors and other tools for capturing plant point clouds often results in missing and incomplete data due to the limitations of 2.5D imaging features and leaf occlusion.

Leaf shape, planting density, and nitrogen application affect soybean yield by changing direct and diffuse light distribution in the canopy.

When attempting to maximize the crop yield from field-grown soybean (Glycine max (L.) Merr.) by means of improving the light conditions for photosynthesis in the canopy, it is crucial to find the optimal planting density and nitrogen application rate.

Construction of rapid prediction models for TN and TP in dairy farms slurry under different seasons by near infrared spectroscopy.

Rapidly and stably measuring the total nitrogen (TN) and total phosphorus (TP) contents of dairy slurry was a critical step before the field application, which was a key component of sustainable agriculture and slurry resource utilization. In present study, near-infrared spectroscopy (NIRS) models were established for swiftly determining TN and TP contents in the slurry from diverse dairy farms under various conditions. A total of 828 samples were gathered from 33 intensive dairy farms in Tianjin City throughout spring, summer, autumn and winter.

Development and validation of the intellectual property services scale in China.

Existing studies have emphasized the crucial role of intellectual property services (IPS) in the advancement of science and technology, but there was still a lack of a valid scale for assessing IPS. Accordingly, this study aimed to develop a reliable instrument to fill this gap. A three-step process of scale development was described: item generation through grounded theory research (n = 14), scale development through exploratory factor analysis (n = 219) and scale assessment through confirmatory factor analysis (n = 191).

Radiation-sensitive genetic prognostic model identifies individuals at risk for radiation resistance in head and neck squamous cell carcinoma.

Background: The advantages of radiotherapy for head and neck squamous cell carcinoma (HNSCC) depend on the radiation sensitivity of the patient. Here, we established and verified radiological factor-related gene signature and built a prognostic risk model to predict whether radiotherapy would be beneficial.

Methods: Data from The Cancer Genome Atlas, Gene Expression Omnibus, and RadAtlas databases were subjected to LASSO regression, univariate COX regression, and multivariate COX regression analyses to integrate genomic and clinical information from patients with HNSCC.

Use of left atrial automated functional myocardial imaging to identify patients with paroxysmal atrial fibrillation at high risk of stroke.

Background: Left atrial automated functional myocardial imaging (AFILA) is a new software program for analyzing the structure and function of the left atrium (LA). The present study sought to analyze the correlation between the LA function parameters as measured by AFILA echocardiography and the risk of cerebral ischemic stroke (CIS) in patients with non-valvular paroxysmal atrial fibrillation (NVPAF) to explore the diagnostic value of LA strain in patients with congestive heart failure, hypertension, age of ≥75 years (doubled), diabetes mellitus, stroke or transient ischemic attack (TIA) (doubled), age of 65-74 years, and sex category (female) (CHA2DS2-VASc) scores of <2.

Methods: A total of 205 patients with NVPAF were included in the study and divided into the no-CIS group (154 patients) and the CIS group (51 patients).

Copper-Based Electrocatalysts for Nitrate Reduction to Ammonia.

Ammonia (NH) is a highly important industrial chemical used as fuel and fertilizer. The industrial synthesis of NH relies heavily on the Haber-Bosch route, which accounts for roughly 1.2% of global annual CO emissions.

A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy.

The abnormal activation of epidermal growth factor receptor (EGFR) drives the development of non-small cell lung cancer (NSCLC). The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with NSCLC who have an EGFR mutation. However, free osimertinib administration exhibits an inadequate response in vivo, with only ∼3% patients demonstrating a complete clinical response.

Proteomic analysis of protein lysine 2-hydroxyisobutyrylation (K) in soybean leaves.

Background: Protein lysine 2-hydroxyisobutyrylation (K) is a novel post-translational modification (PTM) discovered in cells or tissues of animals, microorganisms and plants in recent years. Proteome-wide identification of K-modified proteins has been performed in several plant species, suggesting that K-modified proteins are involved in a variety of biological processes and metabolic pathways. However, the protein K modification in soybean, a globally important legume crop that provides the rich source of plant protein and oil, remains unclear.

Impact of Dark Triad on Anxiety Disorder: Parallel Mediation Analysis During Pandemic.

The current study aimed to investigate the mediating role of loneliness, ASMR, on the relationship between narcissism, Machiavellianism, and psychopathy and anxiety disorder. The population of the study was professionals working in public and private sector organizations. Non-probability snowball technique was used.

RESIN INFILTRATION MAY BE A FEASIBLE OPTION TO ESTHETICALLY MASK ENAMEL WHITE SPOT LESIONS.

Article Title And Bibliographic Information: Bourouni S, Dritsas K, Kloukos D, Wierichs RJ. Efficacy of resin infiltration to mask post-orthodontic or non-post-orthodontic white spot lesions or fluorosis - a systematic review and meta-analysis. Clin Oral Investig.

The introduction of team-based learning into the clinical pharmacology section of the endodontics clinical course.

Team-based learning (TBL) has been widely applied and evaluated to produce better student outcomes. TBL has been introduced into the clinical pharmacology section of the endodontics clinical course at the School of Stomatology, Wuhan University since 2021. Here, the teaching experience in this course was summarized.

Precision Detection of Dense Plums in Orchards Using the Improved YOLOv4 Model.

The precision detection of dense small targets in orchards is critical for the visual perception of agricultural picking robots. At present, the visual detection algorithms for plums still have a poor recognition effect due to the characteristics of small plum shapes and dense growth. Thus, this paper proposed a lightweight model based on the improved You Only Look Once version 4 (YOLOv4) to detect dense plums in orchards.

Neoadjuvant camrelizumab, nab-paclitaxel, and carboplatin in patients with stage IB-IIIA non-small cell lung cancer (NANE-LC): a study protocol of prospective, single-arm, multicenter, phase II study.

Background: Previous studies have shown that neoadjuvant immune checkpoint inhibitors (ICIs) combined with chemotherapy in patients with stage IB-IIIA non-small cell lung cancer (NSCLC) significantly improved the major pathological response (MPR) and the pathological complete response (pCR) rates. However, high-level evidence-based medical data confirming this effect are still lacking. In addition, there is an urgent need to develop an appropriate strategy to predict the benefit for patients receiving ICIs.

DNA-based plasmonic nanostructures and their optical and biomedical applications.

In the past few decades, DNA nanotechnology has been developed a lot due to their appealing features such as structural programmability and easy functionalization. In the emerging field of DNA nanotechnology, DNA molecules are regarded not only as biological information carriers but also as building blocks in the assembly of various two-dimensional and three-dimensional nanostructures, serving as outstanding templates for the bottom-up fabrication of plasmonic nanostructures. By arranging nanoparticles with different components and morphologies on the predesigned DNA templates, various static and dynamic plasmonic nanostructures with tailored optical properties have been obtained.

A Nucleic Acid/Gold Nanorod-Based Nanoplatform for Targeted Gene Editing and Combined Tumor Therapy.

The CRISPR/Cas9 gene-editing system has become a promising strategy for tumor therapy with its powerful oncogene-editing ability. However, the efficient delivery of sgRNA/Cas9 complex into target tumor cells remains a challenge. Herein, we report a facile strategy for the construction of an sgRNA/Cas9 complex co-assembled nanoplatform for targeted gene editing and combined tumor therapy.

Supramolecular Vesicles Based on Amphiphilic Pillar[n]arenes for Smart Nano-Drug Delivery.

Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties.

Clinical evidence for association of neoadjuvant chemotherapy or chemoradiotherapy with efficacy and safety in patients with resectable esophageal carcinoma (NewEC study).

Background: The efficacy and safety of neoadjuvant treatment over surgery alone and that of neoadjuvant chemoradiotherapy (NCRT) over neoadjuvant chemotherapy (NCT) in resectable esophageal carcinoma remains inconclusive. This study (NewEC) used global data to comprehensively evaluate these comparisons and to provide a preferable strategy for patient subsets.

Methods: This study included a meta-analysis of randomized controlled trials (RCTs) identified from inception to May 2019 from PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, ClinicalTrials.

Site-Specific Synthesis of Silica Nanostructures on DNA Origami Templates.

DNA origami has been widely investigated as a template for the organization of various functional elements, leading to potential applications in many fields such as biosensing, nanoelectronics, and nanophotonics. However, the synthesis of inorganic nonmetallic nanomaterials with predesigned patterns using DNA origami templates has seldom been explored. Here, a novel method is reported to site-specifically synthesize silica nanostructures with designed patterns on DNA origami templates.

Polar layered coordination polymers incorporating triazacyclononane-triphosphonate metalloligands.

Reactions of metalloligands M(notpH) (M = Fe, Co and notpH = 1,4,7-triazacyclononane-1,4,7-triyl-tris(methylenephosphonic acid)) with Zn(OAc) under hydrothermal conditions resulted in new metal phosphonates ZnFe(notp)Cl(HO) (1) and ZnCo(notpH)(HO)·2HO (2). They crystallize in polar space groups P6 (for 1) and Pca2 (for 2), respectively, and exhibit layer structures in which the inorganic layers are separated by the organic groups of the notp ligands. However, the layer topologies of the two compounds are quite different.

Corrigendum: Resveratrol Ameliorates Glucocorticoid-Induced Bone Damage in a Zebrafish Model.

[This corrects the article DOI: 10.3389/fphar.2019.

Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non-Small Cell Lung Cancer: A Meta-analysis and Individual Patient-Level Analysis.

Importance: The beneficial role of immunotherapy and the clinical relevance of current biomarkers in non-small cell lung cancer (NSCLC) remain inconclusive; thus, appropriate strategies and reliable predictors need further definition.

Objectives: To evaluate the association of clinical outcomes with immune checkpoint inhibitors, tumor vaccines, and cellular immunotherapy in patients with advanced NSCLC and to explore appropriate strategies, candidates, and predictors.

Data Sources: The PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched from inception to June 2018, using relevant search keywords and Medical Subject Headings (MeSH) terms, including tumor vaccine, cellular immunotherapy, immune checkpoint inhibitor, cytotoxic T-lymphocyte-associated protein 4, programmed death-ligand 1, programmed death receptor 1, and non-small cell lung carcinoma.