Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the "shield effect".

Background: The distribution of the m6A methylation modification on the transcriptome is highly regionally selective and is mainly concentrated in abnormally long exons and stop codons. However, in-depth research on the selective mechanism of m6A methylation is still lacking.

Methods: In this research, meRIP sequencing, mRNA sequencing, meRIP, luciferase reporter assays and CRISPR/Cas9 conditional knockout mice were used to elucidate the distribution characteristics of NFATc1 m6A.

Nitrous oxide exerts rewarding effect via regulating D1 receptor and BDNF pathway in ventral tegmental area-nucleus accumbens dopamine circuit.

Recreational use of nitrous oxide (NO) has risen dramatically over the past decades. This study aimed to examine its rewarding effect and the underlying mechanisms. The exposure of mice to a subanesthetic concentration (20%) of NO for 30 min for 4 consecutive days paired with NO in the morning and paired with the air in the afternoon produced apparent rewarding behavior in the conditioned place preference (CPP) paradigm.

Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease.

Aim: To describe the multimodal imaging features, treatment, and outcomes of patients diagnosed with adult-onset Coats disease.

Methods: This retrospective study included patients first diagnosed with Coats disease at ≥18 years of age between September 2017 and September 2021. Some patients received anti-vascular endothelial growth factor (VEGF) therapy (conbercept, 0.

Mechanistic Investigation on the Regioselectivity of Electrochemical Co(II)-Catalyzed [2 + 2 + 2] Cycloaddition of Terminal Acetylenes.

In this paper, the regioselectivity of electrochemical Co(II)-catalyzed [2 + 2 + 2] cycloaddition of terminal alkynes was investigated using density functional theory. We explored in detail the energy profiles for both 1,2,4- and 1,3,5-regioselectivity pathways and revealed the origin of the regioselectivity. Two kinds of conformational isomers derived from the different coordination modes of alkynes with cobaltacyclopentadiene have been found, which were formed through electrochemically mediated redox processes.

[Assessment of Emission Reduction Potential of CO Capture, Geological Utilization, and Storage in Cement Industry of China].

The cement industry faces great pressure from the targets of carbon peak and carbon neutrality. COcapture, geological utilization, and storage(CCUS) technology is crucial for CO mitigation in large-scale fossil-based industries. An integrated techno-economic assessment model of CCUS was improved here to assess the potential of CCUS retrofits in the cement industry in China, and the cost curve or supply curve of CCUS in the cement industry was obtained.

[Characteristics of Silent Alpha Thalassemia Gene in Child-Bearing Adults in Guangdong].

Objective: To investigate characteristics of silent alpha thalassemia genes in child-bearing adults in Guangdong, in order to provide data for the prevention and control of hemoglobin H disease.

Methods: A total of 8 752 cases were collected from January 2016 to December 2020. Gap-PCR was used to detect the deletional of α-thalassemia mutations (-α, -α), while PCR reverse dot blot hybridization assay (RDB) was used to detect the non-deletional α-thalassemia mutations (Hb CS, Hb QS and Hb Westmead).

Factors associated with quality of life in Chinese people with psoriasis: a cross-sectional study.

Background: The ultimate goal of medical care is to eradicate disease and restore normality to a person's life. Quality of life (QOL) is a concern as dermatologists and researchers strive to find better drug treatments. However, there have been few reports on the factors associated with QOL among Chinese people with psoriasis.

[Multi-dimensional Analysis of the Synergistic Effect of Pollution Reduction and Carbon Reduction in Tianjin Based on the STIRPAT Model].

Based on the STIRPAT model, this study quantitatively analyzed the synergistic effect of pollution reduction and carbon reduction in Tianjin from three dimensions:total emission, emission reduction, and synergy coefficient. The results showed that the main emission sources of air pollutants and greenhouse gases in Tianjin were industrial sources, and the Pearson correlation coefficient of air pollutants and greenhouse gases was 0.984.

Origins of Stereospecificity and Divergent Reactivity of Pd-Catalyzed Cross Coupling with α,α-Disubstituted Alkenyl Hydrazones.

This article presents an exploration of stereospecificity and divergent reactivity of Pd-catalyzed α,α-disubstituted alkenyl hydrazones to synthesize 1,4-dienes in the configuration and vinylcyclopropane. We calculated the energy profiles of four α,α-disubstituted alkenyl hydrazones. The results show that the energy profiles of the whole catalytic cycle are basically the same before the -carbopalladation step.

[Design and development of quality traceability system for circulation of Chinese herbal medicine based on blockchain and NB-IOT].

The safety of traditional Chinese medicine is an important issue of people's livelihood in China. The traceability process on the quality of traditional Chinese medicine is characterized by long duration, many links, and complex circulation process of traditional Chinese medicine, so the establishment and improvement of traceability system is key to the modernized development of traditional Chinese medicine. The circulation traceability system of Chinese medicinal materials, as an important part of traceability system for Chinese traditional medicine, is built according to the GSP standard by using the block chain technology to ensure the security of information circulation and the low energy consumption of NB-IOT technology, build a safe and reliable system with wide coverage and low cost technology, and provide safe and reliable technical support for the data collection and transmission.

Inhibition of BRD4 triggers cellular senescence through suppressing aurora kinases in oesophageal cancer cells.

Oesophageal cancer is one of the most frequent solid malignancies and the leading cause of cancer-related death around the world. It is urgent to develop novel therapy strategies to improve patient outcomes. Acetylation modification of histones has been extensively studied in epigenetics.

Enhancement of light aromatics from catalytic fast pyrolysis of cellulose over bifunctional hierarchical HZSM-5 modified by hydrogen fluoride and nickel/hydrogen fluoride.

Pore structure and accessible active sites of HZSM-5 (Z5) are the key factors for its catalysis. The bifunctional hierarchical Z5 were prepared with leaching agent HF and loading Ni, and their performance for catalytic fast pyrolysis (CFP) of cellulose was investigated in a drop tube quartz reactor. Z5 modified with 0.

Seven new species of the Stenus cirrus group (Coleoptera, Staphylinidae) from Sichuan, Southwest China.

Seven new species of the Stenus cirrus group collected from Sichuan, Southwest China are described: S. cariniventris Tang, Liu Dong, sp. n.

The Stenus cirrus group (Coleoptera, Staphylinidae) in Fujian, East China.

Species of the Stenus cirrus group in Fujian Province, East China, are reviewed and two new species are described: S. mangdangshanus sp. n.

Three new species of the group from Guizhou, southwest China (Coleoptera, Staphylinidae).

Three new species of the group collected from Guizhou Province, southwest China, are described: , , and The diagnostic characters of the new species are illustrated, and a key to species of the group from Guizhou Province is provided.

New data on the genus (Coleoptera: Staphylinidae: Paederinae) of mainland China.

Material of the genus Domene Fauvel, 1873 from the Chinese provinces Heilongjiang, Anhui, Zhejiang, Fujian, Guizhou, Sichuan, Shaanxi, Yunnan, Guangdong and Guangxi was examined. Twelve species were identified, seven of them described previously, and five are newly described: D. aqiang Peng and Li, sp.

Notes on the group of Zhejiang, East China, with descriptions of two new species (Coleoptera, Staphylinidae).

Two new species of the group collected from Zhejiang Province, East China, are described, Liu, Tang & Luo, , Liu, Tang & Luo, and a new distributional locality for Tang, Li & Zhao, 2005 was discovered. The diagnostic characters of the new species are illustrated, and a key to species of the group from Zhejiang Province is provided.

[Identification of a new 3.8kb deletional α thalassemia and detection of the deletion fragment].

Objective: To report the identification of a novel 3.8-kb deletion that caused α thalassemia and establish the method for detecting the deletion fragment.

Methods: Peripheral blood samples were collected from the proband and his mother for analysis of the hematological parameters and routine test for thalassemia genes.

Seven new species of the Stenus cirrus group (Coleoptera, Staphylinidae) from Guangxi, South China.

Seven new species of the Stenus cirrus group collected from Guangxi, South China are described and illustrated: S. hujiayaoi Liu and Tang, sp. n.

Is brain damage really involved in the pathogenesis of obstructive sleep apnea?

Obstructive sleep apnea (OSA) syndrome is a surprisingly complex and highly individualized disease, with different factors contributing toward the disease process. Many factors can induce OSA disease, such as hypertrophy uvula, adenoidectomy, tonsil caused by mechanical obstruction of the airway, airway obstruction on obesity cause of decubitus, etc.; in addition, abnormal structure and function of the central nervous system (CNS) is also one of the important factors.

Cytotoxicity and apoptosis induced by nanobacteria in human breast cancer cells.

Background: The existing evidence that nanobacteria (NB) are closely associated with human disease is overwhelming. However, their potential toxicity against cancer cells has not yet been reported. The objective of this study was to investigate the cytotoxic effects of NB and nanohydroxyapatites (nHAPs) against human breast cancer cells and to elucidate the mechanisms of action underlying their cytotoxicity.

Nanobacteria may be linked to calcification in placenta.

Aims: Placental calcification is a common pathologic condition in obstetrics. To detect the bacteria infection mechanisms for calcification, an experiment was performed to isolate, culture, and identify the nanobacteria in placental calcification.

Method: Sixteen cases of placental calcification of pregnant women were collected for the purpose of the isolation of nanobacteria, cultivation, and identification of 16S rDNA sequence.

Isolation, cultivation and identification of nanobacteria from placental calcification.

Objective: The etiology of placental calcification (PC) is lack of research. To detect the bacterial infection mechanisms for PC, the experiment of isolating, culturing and identifying the nanobacteria in PC was done.

Method: The calcified placental tissues from 18 confirmed PC cases with normal placental tissue samples from 18 cases were studied by transmission electron microscopy (TEM), special nanobacterial culture methods, and identification of 16S rRNA sequence.

Mal-effects of obstructive sleep apnea on the heart.

Objective: This study aims to examine the impact of chronic intermittent hypoxia on hearts in patients with obstructive sleep apnea (OSA).

Methods: Two hundred twenty patients were divided into groups based on (1) severity of the disease, (2) years of disease history, and (3) with or without secondary hypertension. All subjects underwent blood pressure measurements, polysomnogram monitoring, and cardiac Doppler ultrasound examinations.

A UB3LYP and UMP2 theoretical investigation on unusual cation-pi interaction between the triplet state HB=BH (3 Sigma g-) and H+, Li +, Na +, Be 2+ or Mg 2+.

The nature of the unusual cation-pi interactions between cations (H(+), Li(+), Na(+), Be(2+) and Mg(2+)) and the electron-deficient B=B bond of the triplet state HB=BH (3 Sigma g-) was investigated using UMP2(full) and UB3LYP methods at 6-311++G(2df,2p) and aug-cc-pVTZ levels, accompanied by a comparison with 1:1 and 2:1 sigma-binding complexes between BH and the cations. The binding energies follow the order HB=BH..