Publications by authors named "Liu Ruowu"
Background: L. (commonly known as mallow) has been widely used in traditional Tibetan formulations to treat allergic rhinitis (AR), and malvidin is a key anti-inflammation constituent of this plant.
Objective: The present study aimed to evaluate the potential therapeutic effect and mechanism of malvidin in an AR mouse model.
Nasopharyngeal carcinoma (NPC) is commonly diagnosed at an advanced stage with a high incidence rate in Southeast Asia and Southeast China. However, the limited availability of NPC patient survival data in public databases has resulted in less rigorous studies examining the prediction of NPC survival through construction of Kaplan-Meier curves. These studies have primarily relied on small samples of NPC patients with progression-free survival (PFS) information or data from head and neck squamous cell carcinoma (HNSCC) studies almost without NPC patients.
View Article and Find Full Text PDFBackground: Although oxidative stress is involved in the pathophysiological process of chronic rhinosinusitis with nasal polyps (CRSwNP), the specific underlying mechanism is still unclear. Whether antioxidant therapy can treat CRSwNP needs further investigation.
Methods: Immunohistochemistry, immunofluorescence, western blotting and quantitative polymerase chain reaction (qPCR) analyses were performed to detect the distribution and expression of oxidants and antioxidants in nasal polyp tissues.
Article Synopsis
- Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory condition, and the role of miR-21, a specific microRNA associated with inflammation, remains unclear in these patients.
- In research, miR-21 was found to be upregulated in CRSwNP tissue, particularly in nasal epithelial cells, and it correlated with various cytokines, indicating a complex relationship with pro-inflammatory and anti-inflammatory signals.
- The study identified PDCD4 as a target of miR-21, showing that miR-21 can lower PDCD4 expression and influence the activity of NF-κB, suggesting a pivotal role for miR-21 in the inflammatory processes in CRSwNP.
Myeloid sarcoma of the nasal cavity in a 15-month-old child: A case report.
Medicine (Baltimore)
July 2020
Introduction: Myeloid sarcoma (MS) is a rare tumor mass. It may occur at any extramedullary anatomic sites but is uncommon in the sinonasal location.MS commonly presents concurrently with acute myeloid leukemia (AML), but it may predate AML over several months or years, named isolated MS.
View Article and Find Full Text PDFArticle Synopsis
- Leukotriene signaling is crucial in various diseases, such as asthma and inflammatory bowel disease, but its role in nasal polyps (NPs) and chronic rhinosinusitis is not well understood.
- The study found that cysteinyl leukotrienes (CysLTs) and their receptors (CYSLTRs) were significantly elevated in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), particularly in a subgroup associated with higher IL-5 levels.
- Montelukast, a leukotriene receptor antagonist, effectively reduced the expression of certain inflammatory markers and improved patient outcomes when added to standard treatment for those with refractory CRSwNP.