Environmental Factors Drive the Biogeographic Pattern of Root Endophytic Fungal Diversity in the Arid Regions of Northwest China.

subsp. Rousi (Abbrev. ) stands as a vital botanical asset in ameliorating the ecological landscape of the arid regions in Northwest China, where its rhizospheric microorganisms serve as linchpins in its growth and developmental dynamics.

An Ecological Survey of Chiggers (Acariformes: Trombiculidae) Associated with Small Mammals in an Epidemic Focus of Scrub Typhus on the China-Myanmar Border in Southwest China.

Chiggers (chigger mites) are a group of tiny arthropods, and they are the exclusive vector of (Ot), the causative agent of scrub typhus (tsutsugamushi disease). Dehong Prefecture in Yunnan Province of southwest China is located on the China-Myanmar border and is an important focus of scrub typhus. Based on the field surveys in Dehong between 2008 and 2022, the present paper reports the infestation and ecological distribution of chiggers on the body surface of rodents and other sympatric small mammals (shrews, tree shrews, etc.

Identification and Characterization of Four Novel Viruses in .

(Cicadellidae: Deltocephalinae), a leafhopper prevalent in tropical and temperate regions, is notably abundant in grasses and rice. The virome of was investigated using deep transcriptome sequencing, leading to the first identification of four viruses belonging to the families , , and in . These viruses have been provisionally named B.

Autonomous Robot Task Execution in Flexible Manufacturing: Integrating PDDL and Behavior Trees in ARIAC 2023.

The Agile Robotics for Industrial Automation Competition (ARIAC) was established to advance flexible manufacturing, aiming to increase the agility of robotic assembly systems in unstructured and dynamic industrial environments. ARIAC 2023 introduced eight agility challenges involving faulty parts, flipped parts, faulty grippers, robot malfunctions, sensor blackouts, high-priority orders, insufficient parts, and human safety. Given the unpredictability of these scenarios, it is impractical to develop a specific strategy for each possible situation.

Loss of CCL28 and CXCL17 Expression and Increase in CCR1 Expression May Be Related to Malignant Transformation of LGBLEL into Lymphoma.

To investigate the differential expression of the chemokine signaling pathway in lacrimal gland benign lymphoepithelial lesion (LGBLEL) and lacrimal lymphoma, providing insights into the mechanisms underlying malignant transformation and aiding clinical differentiation. Transcriptome analysis was conducted on patients with LGBLEL, lymphoma, and orbital cavernous hemangioma (CH). Three cases of LGBLEL and three cases of lymphoma were randomly selected as control and experimental groups, respectively.

Real-world data on the efficacy and safety of hedgehog pathway inhibitors in patients with basal cell carcinoma: Experience of a tertiary Australian centre.

Background: Basal cell carcinomas (BCCs) are the most common cancers worldwide. Although most BCCs are amenable to local treatment, there are limited therapeutic options for surgically unresectable locally advanced and metastatic BCCs. Activation of the sonic hedgehog signalling pathway plays a significant role in the development of most BCCs.

The efficiency of liposomal paclitaxel versus docetaxel in neoadjuvant chemotherapy with the TPF regimen for locally advanced nasopharyngeal carcinoma: a retrospective study.

Purpose: This retrospective study aimed to explore the efficiency and untoward reaction of liposomal paclitaxel versus docetaxel for locally advanced nasopharyngeal carcinoma (NPC).

Methods: This retrospective study included 115 patients diagnosed with NPC at our hospital between January 2018 and December 2021. Patients were stratified into two groups based on their treatment with either liposomal paclitaxel ( = 71) or docetaxel ( = 44) as part of the neoadjuvant chemotherapy regimen.

A Role for Clinical Anatomists in Ultrasound Education.

More educators are needed to deliver comprehensive ultrasound training across the medical education spectrum. Regardless of prior clinical experience level, all new ultrasound learners need to begin their education by gaining the same foundational ultrasound knowledge, skills, and abilities. Ultrasound-trained clinical anatomists are well positioned to teach basic image acquisition and fundamental skills and knowledge.

Integrative bioinformatics and exploration of EVI2A expression: unraveling its immunological and prognostic implications in kidney renal clear cell carcinoma.

EVI2A has emerged as a significant biomarker in various diseases; however, its biological role and mechanism in kidney renal clear cell carcinoma (KIRC) remains unexplored. We used TCGA and GEO databases to analyze EVI2A gene expression comprehensively and performed pan-cancer assessments. Clinical relevance was evaluated through Kaplan-Meier analysis and ROC curves.

[Simultaneous determination of ethylene oxide, 2-chloroethanol and ethylene glycol residues in medical device products by gas chromatography].

A gas chromatography-based method was developed for the simultaneous and rapid determination of ethylene oxide (EO), 2-chloroethanol (ECH), and ethylene glycol (EG) residues in medical devices after EO sterilization. A sample weighing 2.5 g was added with 5 mL of ethanol as the extraction medium, and the residual substances in the sample were extracted at 40 ℃ for 4 h.

Decreased volume of rectus femoris and iliocapsularis in patients with femoroacetabular impingement syndrome after primary hip arthroscopy.

Purpose: (1) to investigate the consecutive changes in hip muscle volume in patients with femoroacetabular impingement syndrome (FAIS) during the initial postoperative period, and (2) to determine the potential effect of the early changes in hip muscle volume on clinical outcomes.

Methods: Data between March 2021 and March 2022 was reviewed. Patients diagnosed with FAIS based on clinical symptoms and radiographic findings, and undergoing hip arthroscopic treatment were included.

Eliminated high lipid inhibition in the anaerobic digestion of food waste for biomethane production by engineered E. coli with cell surface display lipase.

Food waste (FW) with high content of lipid typically inhibits anaerobic digestion (AD) and methane production. In this study, a novel whole-cell catalyst was created to degrade lipid by displaying lipase on the E. coli cells surface to improve FW anaerobic digestion.

Effective prism diopter for strabismus measurement: Conversion from anterior Prentice position to posterior parallel position and from glass prism to acrylic prism.

Purpose: In clinical ophthalmology, prisms, commonly made of glass, are labeled based on the prism diopter (PD) value measured in the anterior Prentice position. However, they are often used in the posterior parallel position for practicality, causing a discrepancy between labeled and effective PD. This study proposes a conversion tool to address this issue.

Long-term Nerve Regeneration in Diabetic Keratopathy Mediated by a Novel NGF Delivery System.

Diabetic keratopathy (DK) is a common chronic metabolic disorder that causes ocular surface complications. Among various therapeutic approaches, local delivery of nerve growth factor (NGF) remains the most effective treatment of DK. However, achieving a sustained therapeutic effect with NGF and the frequent drug delivery burden remain challenging during clinical practice.

Unfractionated Heparin Enhances Sepsis Prognosis Through Inhibiting Drp1-Mediated Mitochondrial Quality Imbalance.

Unfractionated heparin (UFH) is commonly used as an anticoagulant in sepsis treatment and has recently been found to have non-anticoagulant effects, but underlying mechanisms remain unclear. This retrospective clinical data showed that UFH has significant protective effects in sepsis compared to low-molecular-weight heparin and enoxaparin, indicating potential benefits of its non-anticoagulant properties. Recombinant protein chip screening, surface plasmon resonance, and molecular docking data demonstrated that UFH specifically bound to the cytoplasmic Drp1 protein through its zone 2 non-anticoagulant segment.

CRISPR/Cas12a assay for amol level microRNA by combining enzyme-free amplification and single particle analysis.

CRISPR/Cas systems are increasingly utilized for sensitive miRNA detection through enzyme-based pre-amplification. To address challenges such as high costs, non-specific amplification, and interference from primer residues in pre-amplification strategies, herein a dual amplification CRISPR miRNA assay was developed by combining enzyme-free HCR with single-particle analysis. Attomolar detection limits, excellent selectivity, and practicability were achieved by applying this method.

Discovery of quinazoline-benzothiazole derivatives as novel potent protease-activated receptor 4 antagonists with improved pharmacokinetics and low bleeding liability.

Protease-activated receptor 4 (PAR4) plays a critical role in the development of pathological thrombosis, and targeting PAR4 is considered a promising strategy for improving antiplatelet therapies. Here, we reported the design of a series of quinazoline-benzothiazole-based PAR4 antagonists using a scaffold-hopping strategy. Systematic structure-activity relationship exploration leads to the discovery of compounds 20f and 20g, which displayed optimal activity (h.

Engineering of -Based Tryptophan Biosensors for Dynamic Control of Violacein Production.

Tryptophan not only serves as a fundamental building block for protein synthesis but also acts as a metabolic precursor for a diverse array of high-value chemicals. Although a few tryptophan-responsive biosensors are currently available, there is a growing interest in developing high-performance biosensors. In this study, we create a miniature toolkit of tryptophan biosensors based upon the leader regulatory region of the operon, which is responsible for tryptophan catabolism in .

Bioengineered Extracellular Vesicles Delivering siMDM2 Sensitize Oxaliplatin Therapy Efficacy in Colorectal Cancer.

Oxaliplatin (OXA) is the first-line drug for the treatment of colorectal cancer (CRC), and susceptibility to drug resistance affects patient prognosis. However, the exact underlying mechanisms remain unclear. Platinum-acquired resistance in CRC is a continuous transition process; though, current research has mainly focused on the end state of drug resistance, and the early events of drug resistance have been ignored.

BANF1 is a novel prognostic biomarker linked to immune infiltration in head and neck squamous cell carcinoma.

Background: Barrier-to-autointegration factor 1 (BANF1) is an abundant and ubiquitously expressed postnatal mammalian protein that is overexpressed in numerous human cancers and can promote cancer cell proliferation. However, the role of BANF1 in prognosis remains unclear in head and neck squamous cell carcinoma (HNSCC).

Methods: BANF1 expression data were obtained from the GEO and TCGA databases.

"V"-Shaped Changing Electronic Performance of Iodinene-Based Nanoflakes as a Function of Width.

Special structures and prominent performance make 2D iodinene more appealing and valuable at the molecular level. Here, new-type electronic devices have been constructed with iodinene-based nanoflakes in different sizes and are theoretically studied for electronic transport properties. Our findings reveal that iodinene-based nanoflakes possess great electron transport suppression, achieving the same function as SiO on single molecule scale.

Research on the influence of cutter overhang length on robotic milling chatter stability.

Serial industrial robots are widely in demand in the field of large-scale component processing and manufacturing. However, the structure characteristic of serial robots makes it easy to generate chatter during milling and the overhang length of milling cutter has an important influence on the stability of robotic milling. Milling cutter overhang length refers to the length from the tip of the cutter to the protrusion of the spindle, to study the influence of milling cutter overhang length on the stability behavior of robotic milling, the modal parameters of milling cutter under different overhang length were obtained by hammer experiment, and its dynamic characteristics were analyzed.