Hypertension and High-Density Lipoprotein Cholesterol: A Narrative Review.

Hypertension remains the primary driver of Cardiovascular Diseases (CVDs) and mortality. Dyslipidaemia is a common risk factor for CVDs in hypertensive patients, and their coexistence significantly increases the risk of CVDs. Furthermore, epidemiologic studies indicate that there are U-shaped curves between cholesterol levels of HDL-C and CVDs-related mortality in patients with hypertension, in which CVDs are paradoxically increased in those with elevated HDLC levels.

Conformation pattern changes in R1-pS262 tau peptide induced endogenous tau aggregation, synaptic damage, and cognitive impairments.

Background: To date, the effect of tau phosphorylation at different amino acid sites on the conformation and function of tau is still unclear in Alzheimer's disease (AD). Protein fingerprinting, also known as the protein folding shape code (PFSC) method, is a protein structure prediction technique based on protein sequence, which can reveal proteins' most likely spatial conformation.

Objective: To investigate the effect of phosphorylation on tau protein conformation using PFSC technology and further analyze the differences in the effect of phosphorylation on tau aggregation at specific sites.

High-quality reference genome of predatory mite Neoseiulus californicus McGregor (Acari: Phytoseiidae) provides insights into its biological traits and potential RNAi off-target effects.

Background: Neoseiulus californicus is a predatory mite that can control various spider mites and other small arthropods. Despite its acknowledged effectiveness in the natural enemy market, a crucial knowledge gap exists in understanding the genomic features related to its predatory traits and adaptation. With the increasing emphasis on modern pest management strategies and dynamic environmental changes in plant production trends, constructing a reliable genomic resource for N.

Percutaneous nephroscopy combined with ultrasound-guided negative-pressure suction for the treatment of perirenal hematoma.

Percutaneous renal puncture drainage is needed in patients with perirenal hematoma (PRH, renal around hematoma) with poor conservative treatment. Early and thorough removal of hematoma is closely related to the recovery of patients, but percutaneous renal drainage is not effective in some patients. The clinical data of 5 patients with PRH treated in the first affiliated Hospital of Chongqing Medical University from June 2020 to June 2024 were analyzed retrospectively.

Defect Detection and 3D Reconstruction of Complex Urban Underground Pipeline Scenes for Sewer Robots.

Detecting defects in complex urban sewer scenes is crucial for urban underground structure health monitoring. However, most image-based sewer defect detection models are complex, have high resource consumption, and fail to provide detailed damage information. To increase defect detection efficiency, visualize pipelines, and enable deployment on edge devices, this paper proposes a computer vision-based robotic defect detection framework for sewers.

Integrated Transcriptomic and Proteomic Analyses of Antler Growth and Ossification Mechanisms.

Antlers are the sole mammalian organs capable of continuous regeneration. This distinctive feature has evolved into various biomedical models. Research on mechanisms of antler growth, development, and ossification provides valuable insights for limb regeneration, cartilage-related diseases, and cancer mechanisms.

Saliva of (Drepanosiphidae) Activates the SA Plant Hormone Pathway, Inhibits the JA Plant Hormone Pathway, and Improves Aphid Survival Rate.

The spotted alfalfa aphid () is a kind of destructive pest of cultivated alfalfa () that results in significant financial losses for the livestock sector. To understand how navigates the biochemical defenses of its host, we investigated the effects of susceptible and resistant aphid strains on two alfalfa cultivars. was reared for over 50 generations on two cultivars-WL343, which is susceptible to , and Zhongmu No.

B-Site-Ordered and Disordered Structures in A-Site-Ordered Quadruple Perovskites RMnNiMnO with R = Nd, Sm, Gd, and Dy.

ABO perovskite materials with small cations at the A site, especially with ordered cation arrangements, have attracted a lot of interest because they show unusual physical properties and deviations from general perovskite tendencies. In this work, A-site-ordered quadruple perovskites, RMnNiMnO with R = Nd, Sm, Gd, and Dy, were synthesized by a high-pressure, high-temperature method at about 6 GPa. Annealing at about 1500 K produced samples with additional (partial) B-site ordering of Ni and Mn cations, crystallizing in space group -3.

Fresh-Cooked but Not Cold-Stored Millet Exhibited Remarkable Second Meal Effect Independent of Resistant Starch: A Randomized Crossover Trial.

It is well established that cold storage results in increased resistant starch and a reduced glycemic index in carbohydrate food. However, the effects of cold storage on the glycemic response of the second meal of cereals remain unclear. The aim of this study was to compare the postprandial glycemic responses between the paired glutinous and non-glutinous grains, either fresh-cooked or refrigerated, after both the first and second meals.

Single-Crystalline Nanowires of Molecular Ferroelectric Semiconductors for Optoelectronic Memory.

Though much progress has been achieved in the discovery of new molecular ferroelectrics in recent years, practical applications and related physics are still rarely explored due to the difficulty in high-quality film production and patterning issues. Single-crystalline films and patterns are in high demand for high device performance. Through a template-assisted space-confined strategy, herein, ordered single-crystalline nanowire patterns and optoelectronic devices of a semiconducting molecular ferroelectric (SMF), hexane-1,6-diammonium pentaiodobismuth (HDA-BiI), were successfully demonstrated.

The Growth and Ion Absorption of Sesbania ( and Hairy Vetch () in Saline Soil Under Improvement Measures.

Soil salinization is a serious threat to the ecological environment and sustainable agricultural development in the arid regions of northwest China. Optimal soil salinization amelioration methods were eagerly explored under different soil salinity levels. Sesbania and hairy vetch are salt-tolerant plants, and green manure improved the saline environment.

Warming Diminishes the Day-Night Discrepancy in the Apparent Temperature Sensitivity of Ecosystem Respiration.

Understanding the sensitivity of ecosystem respiration (ER) to increasing temperature is crucial to predict how the terrestrial carbon sink responds to a warming climate. The temperature sensitivity of ER may vary on a diurnal basis but is poorly understood due to the paucity of observational sites documenting real ER during daytime at a global scale. Here, we used an improved flux partitioning approach to estimate the apparent temperature sensitivity of ER during the daytime (E) and nighttime (E) derived from multiyear observations of 189 FLUXNET sites.

Study on the Mechanisms of Flavor Compound Changes During the Lactic Fermentation Process of Peach and Apricot Mixed Juice.

This study employed headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) and liquid chromatography-mass spectrometry (LC-MS) for non-targeted metabolomics analyses to examine the impact of mixed fermentation with various lactic acid bacteria (LAB) on the flavor compounds and metabolites of peach and apricot mixed juice (PAMJ), specifically focusing on the alterations of volatile compounds and non-volatile metabolites, as well as their metabolic pathways during the fermentation process. A total of 185 volatiles were identified using HS-SPME-GC-MS analysis, revealing significant differential metabolites, including eugenol, benzaldehyde, and γ-decalactone etc. The results indicated that lactic fermentation significantly enhanced the overall flavor of the juice toward the end of the fermentation process.

High Prevalence of 5'UTR Mutations in Anaplastic Thyroid Cancer.

Anaplastic thyroid cancer (ATC) is a rare but one of the most lethal types of human cancer. Although increasing evidence demonstrated that ATC tumors had a high mutation burden, little is known about the aberrancy of the noncoding genome of ATC except the well-investigated () promoter mutations. The mutational statuses of 5' untranslated region (5'UTR), intron 6, and promoters, as well as the promoter and mutations were determined using Sanger sequencing in 28 patients with ATC (19 women and 9 men) with a median (interquartile range) age of 64 (55-71) years, 14 thyroid cancer cell lines and a normal thyroid cell line.

Comprehensive Comparisons of Different Treatments for Active Graves' Orbitopathy: A Systematic Review and Bayesian Model-Based Network Meta-Analysis.

Objective: This study aims to assess the efficacy and safety of various treatments for active thyroid eye disease.

Method: We conducted a comprehensive search for randomized controlled trials (RCTs), and ongoing RCTs registered on Controlled Trials, targeting treatments for thyroid eye disease up until November 20, 2024. Employing a Bayesian framework, this network meta-analysis calculated risk ratios (RRs) or mean differences (MDs) with 95% confidence intervals (CIs) to size the effects for the predetermined outcomes.

How to balance the live birth rate and the multiple pregnancy rate by selecting the cleavage-stage embryo number and quality for POSEIDON Group 1 and Group 2? A retrospective study.

Purpose: For unexpected low-prognosis patients (Group 1 and Group 2) defined by POSEIDON criteria, how to maximize the live birth rate while controlling the multiple birth rate by tailoring the embryo transfer number and quality?

Methods: This was a retrospective study, including patients from Poseidon Group 1 (N = 672) and Group 2 (N = 503) who underwent cleavage-stage embryo transfer. Logistic regression was used for the comparative analysis of clinical outcomes among subgroups divided by the number and quality of embryos.

Results: For Group 1, compared to transferring a single good-quality embryo (GQE), a good-quality embryo with a poor-quality embryo (GQE + PQE) did not significantly improve the live birth rate, although increasing in value (40.

Groupy: An Open-Source Toolkit for Molecular Simulation and Property Calculation.

In this work, an open-source, versatile, and flexible code named Groupy is present for calculating various molecular properties and preparing input files of molecular simulation software such as Gaussian. This code requires only SMILES as input, but can output many new useful data and files in multiple formats. The output information is clear and easy to read.

Clinical Maternal and Neonatal Features in COVID-19 Infected Pregnancies in Tianjin, China.

Purpose: Outbreak of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic, leading to over 6 million deaths worldwide. Pregnant women suffer from a higher risk facing the pandemic COVID-19, while their related clinical information is limited.

Methods: The clinical information of SARS-CoV-2 positive (n = 30) and negative pregnant women (n = 134) in Tianjin First Central Hospital (from November 30, 2022, to January 20, 2023) were collected.

Development and mechanisms of photo-induced molecule junction device.

The utilization of single molecule electronic devices represents a significant avenue toward advancing next-generation circuits. Recent investigations have notably augmented our understanding of the optoelectronic characteristics exhibited by diverse single molecule materials. This comprehensive review underscores the latest progressions in probing photo-induced electron transport behaviors within molecular junctions.

Dental Caries and Associated Factors in Tibetan School-Age Children in Gannan, China.

Objectives: Data on the oral health status in the Qinghai-Tibetan Plateau are limited. This study aimed to investigate the dental caries status and identify associated risk factors among 8- to 12-year-old children in Gannan, a Tibetan Autonomous Prefecture in Northwest China.

Methods: The study population was recruited using a multistage stratified random sampling procedure.

CircSATB2 modulates fear extinction memory via Robo3-driven synaptic plasticity.

Circular RNAs (circRNAs) are novel class of stable regulatory RNAs abundantly expressed in the brain. However, their role in fear extinction (EXT) memory remains largely unexplored. To investigate the mechanisms of Circular Special AT-rich Sequence Binding Protein 2 (circSatb2) in EXT memory, we constructed a lentivirus overexpressing circSatb2 and injected it into the infralimbic prefrontal cortex (ILPFC) of the mouse brain.

A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus.

Fructus Aurantii, a Chinese herbal medicine, has been indicated to have antidepressant effects in our previous study. However, the main component and specific mechanisms of the antidepressant effects of Fructus Aurantii still need to be further revealed. This study aimed to explore the main antidepressant component of Fructus Aurantii and the underlying mechanisms of its antidepressant effects in the hippocampus.