An Evaluation on Five Dimensions of a Mobile Health Application for Patient Counseling in Ambulatory Care Pharmacy: A Single-center Cross-sectional Survey Based on Pediatric Caregiver's Opinion.

Objective: Due to high workloads and insufficient counseling time in ambulatory care pharmacy, outpatient pharmacists for pediatric patients in China proposed a mobile health application (mHealth app) that they considered could provide patient counseling more efficiently. To improve it accordingly, we need to design a more specific and multi-dimensional evaluation method to obtain pediatric caregivers' evaluations of a mHealth app.

Methods: A cross-sectional survey on five dimensions (transmission, accuracy, accessibility, completeness, and experience) of the mHealth app was conducted using a random questionnaire among outpatient caregivers at a children's hospital.

Spermidine synthase promotes liver cancer progression in a paracrine manner by altering the macrophage immunometabolic state.

Purpose: Understanding the molecular mechanisms of adaptive regulation in the tumor microenvironment is crucial for precision therapy in hepatocellular carcinoma (HCC). We hypothesized that cargo proteins carried by extracellular vesicles (EVs) released in a hypoxic microenvironment might promote HCC progression by remodeling tumor-associated macrophages (TAMs).

Methods: EV protein analysis by label-free proteomics mass spectrometry of HCC cell lines of different tumor grades was performed.

Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease.

Dry eye disease (DED) is an inflammatory disorder in which CD4 T cells play a significant role in its pathogenesis. A CD4 T cell subset termed granulocyte-macrophage colony-stimulating factor-producing T helper (ThGM) cells would contribute to DED pathogenesis. However, the mechanisms by which the activity of ThGM cells is modulated are not thoroughly understood.

Transcriptome-wide dynamics of mA methylation in ISKNV and Siniperca chuatsi cells infected with ISKNV.

Infectious spleen and kidney necrosis virus (ISKNV) is a highly virulent and rapidly transmissible fish virus that poses threats to the aquaculture of a wide variety of freshwater and marine fish. N6-methyladenosine (mA), recognized as a common epigenetic modification of RNA, plays an important regulatory role during viral infection. However, the impact of mA RNA methylation on the pathogenicity of ISKNV remains unexplored.

Rapid on-site colorimetric detection of arsenic(V) by NH-MIL-88(Fe) nanozymes-based ultraviolet-visible spectroscopic and smartphone-assisted sensing platforms.

Background: Because arsenate (As(V)) is a highly toxic pollutant, timely on-site monitoring of its concentration is crucial for mitigating potential environmental and health hazards. Traditional on-site detection methods for As(V) often face limitations of long response time and low sensitivity. Nanozymes are nanomaterials that exhibit enzyme-like catalytic activity.

Fluorescent microsphere-based strip for sensitive and quantitative detection of etomidate and metomidate.

In this research, we fabricated a sensitive monoclonal antibody (mAb) 2C3 that targeted etomidate (ET) and metomidate (MT) to establish a lateral-flow immunoassay (LFIA) that incorporated fluorescent microsphere sensors, enabling both the qualitative and quantitative detection of ET and MT within 10 min. Analysis indicated that the visual colorimetric values for ET and MT in water samples were 0.3 μg kg, respectively, with quantitative detection ranges of 0.

High-Density Polyethylene Janus Fibrous Membrane with Enhanced Breathability and Moisture Permeability via PDA Assisted Hydrophilic Modification.

Functional fibrous membranes with high mechanical properties are intensively developed for different application fields. In this study, to enhance moisture and air permeability without compromising mechanical strength, a facile float-surface modification strategy is employed to fabricate Janus fibrous membranes with distinct hydrophobicity/hydrophilicity using the high-density polyethylene (HDPE) fibrous membranes. By coating one side of the HDPE fibrous membranes with polydopamine (PDA) and a superhydrophilic polyelectrolyte, the obtained Janus HDPE fibrous membranes demonstrate an excellent water transmission rate (577.

Tumor detection on bronchoscopic images by unsupervised learning.

The diagnosis and early identification of intratracheal tumors relies on the experience of the operators and the specialists. Operations by physicians with insufficient experience may lead to misdiagnosis or misjudgment of tumors. To address this issue, a datasets for intratracheal tumor detection has been constructed to simulate the diagnostic level of experienced specialists, and a Knowledge Distillation-based Memory Feature Unsupervised Anomaly Detection (KD-MFAD) model was proposed to learn from this simulated experience.

Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.

Introduction: Hepatocellular carcinoma (HCC), the third leading cancer mortality worldwide, shows rising incidence. The mitochondria in HCC cells are prone to damage from metabolic stress and oxidative stress, necessitating heightened mitophagy for mitochondrial homeostasis and cell survival. Thus, mitophagy inhibition is a promising HCC therapy.

Alleviates Hyperoxia-Induced BPD by Activating IL-22/STAT3 Signaling Pathway in Neonatal Mice.

Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease in preterm infants. Little is known about the regulatory effect of lung and its mechanism in BPD. This study explored the effect of on hyperoxia-induced mice lung injuries and examined whether played a role via the IL-22/STAT3 pathway.

Risk of intraoperative hemorrhage during cesarean scar ectopic pregnancy surgery: development and validation of an interpretable machine learning prediction model.

Background: Current models for predicting intraoperative hemorrhage in cesarean scar ectopic pregnancy (CSEP) are constrained by known risk factors and conventional statistical methods. Our objective is to develop an interpretable prediction model using machine learning (ML) techniques to assess the risk of intraoperative hemorrhage during CSEP in women, followed by external validation and clinical application.

Methods: This multicenter retrospective study utilized electronic medical record (EMR) data from four tertiary medical institutions.

Light-induced charge transfer from a fullerene to a zeolitic imidazolate framework enhances alkaline electrocatalytic hydrogen production.

In the process of water electrolysis, the oxygen evolution reaction (OER) suffers from a high energy barrier, which has become a key factor restricting the large-scale commercial application of renewable energy technology. Therefore, it is necessary to develop a durable, efficient, low-cost and environmentally friendly OER electrocatalyst. In the present work, a photo-responsive fullerene (C) was encapsulated in the cavity of cobalt-containing flake-like zeolitic imidazolate framework-67 (C@F-ZIF-67).

Development and validation of the prediction model based on autophagy-associated genes in bronchopulmonary dysplasia.

Background: Bronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease among preterm infants. Owing to the limitations in current diagnostic methods, developing a predictive model for BPD is crucial.

Methods: Using 243 autophagy-associated genes and dataset GSE32472, differential expression of autophagy-associated genes was identified at postnatal days 5, 14, and 28 between BPD patients and controls.

Improved qualities of cod-rice dual-protein gel as affected by rice protein: Insight into molecular flexibility, protein interaction and gel properties.

Blending plant-based proteins with animal-based proteins to achieve adequate dietary protein intake is a strategy to address dietary deficiencies in the elderly. This research systematically investigated the effect of the ratio of cod protein/rice protein (21:0, 21:1.5, 21:3, 21:4.

Multi-omics reveals the alleviating effect of berberine on ulcerative colitis through modulating the gut microbiome and bile acid metabolism in the gut-liver axis.

The dysfunction of gut microbiome and bile acid metabolism might cause the incidence and relapse of ulcerative colitis (UC). Thus, natural products have been considered effective for UC through the regulation of gut microbiome and bile acid. In this study, we evaluated the regulatory effect of berberine on gut microbiome and bile acid metabolism in UC.

Melatonin treatment maintains the quality properties and storability of carambola fruit by modulating energy metabolism.

The influences of 150 μmol/L melatonin treatment on the quality properties, storability, and energy metabolism in carambola fruit were explored. The results showed that, compared to the control, melatonin treatment significantly retained higher rate of commercially acceptable fruit, and retarded the development of fruit browning and yellowing. Additionally, melatonin treatment displayed higher levels of chromaticity L and h values, titratable acid, total soluble solids, total soluble sugars, sucrose, and vitamin C, but lower respiration rate, chromaticity a and b values, and reducing sugar content.

Attenuating mitochondrial dysfunction-derived reactive oxygen species and reducing inflammation: the potential of Daphnetin in the viral pneumonia crisis.

Amidst the global burden of viral pneumonia, mitigating the excessive inflammatory response induced by viral pneumonia has emerged as a significant challenge. Pneumovirus infections can lead to the persistent activation of M1 macrophages, culminating in cytokine storms that exacerbate pulmonary inflammation and contribute to the development of pulmonary fibrosis. Mitochondria, beyond their role as cellular powerhouses, are pivotal in integrating inflammatory signals and regulating macrophage polarization.

Biological functions and molecular mechanisms of exosome-derived circular RNAs and their clinical implications in digestive malignancies: the vintage in the bottle.

Background: Circular RNAs (circRNAs) are identified as a novel family of endogenous RNA molecules through 'back-splicing' and covalently linked at the 5' and 3' ends. Emerging researches have demonstrated circRNAs are stable and abundant in exosomes called exosomal circRNAs (exo-circRNA).

Materials And Methods: We searched recent studies and references to summary the research progress of exosomal circRNA.

Association between Arsenic Methylation in Early Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study.

The metabolism of arsenic (As) plays a crucial role in its health effects. However, the impact of arsenic methylation during early pregnancy on gestational diabetes mellitus (GDM) remains unclear. This study aimed to investigate the associations between As methylation in the first and second trimesters and the incidence of GDM by conducting a prospective cohort study in Chongqing, China.

[Exogenous EPO protects HT22 cells from intermittent hypoxia-induced injury by activating JAK2-STAT5 signaling pathway].

The aim of this study was to investigate the effects of exogenous erythropoietin (EPO) on intermittent hypoxia (IH)-induced neuronal injury and the underlying mechanism. Mouse hippocampal neuron HT22 cells were exposed to IH for different durations (1% O for 7 min/21% O for 3 min, one cycle for 10 min). Cell viability was detected by CCK-8.

A novel hollow flower shaped CuS antibacterial agent for removing sulfonamide in water environment: effects of composite with magnetic biochar, differential adsorption, and mechanism study.

In this study, hollow nanoflower spherical CuS and CuS/FeO@BC with adsorption and antibacterial properties was prepared by coprecipitation and solvothermal method, respectively. The adsorption results showed that the CuS exhibited excellent adsorption performance on sulfonamide antibiotics (SAs), especially for sulfamethoxazole (SMZ). The optimal addition amount of CuS is 0.

Composition of Higher Alcohols in Different Alcoholic Beverages and Their Metabolic Dynamics in Bama Pigs.

The unique flavour contribution of higher alcohols in alcoholic beverages has received growing attention; however, there is a dearth of information on their in vivo metabolic kinetics. In this study, the composition and content of higher alcohols in different alcoholic beverages from Chinese and were studied via in vivo analysis using Bama pigs to elucidate the mechanisms for intoxication of alcohol in vitro and in drinkers. Direct injection combined with gas chromatography-mass spectrometry (GC-MS) were used to accurately quantify a total of 14 higher alcohols in five alcoholic beverages.