Pro-adrenomedullin as an independent predictive biomarker for heart failure in atrial fibrillation and flutter.

Aims: This study aimed to investigate potential biomarkers for predicting incident heart failure (HF) in patients with atrial fibrillation and flutter (AF and AFL), utilizing proteomic data from the UK Biobank Pharma Proteomics Project (UKB-PPP).

Methods: This study analysed data from AF and AFL patients, split into discovery (n = 1050) and replication (n = 305) cohorts. Plasma biomarkers were screened using a multivariable-adjusted Cox proportional hazards model.

Ferroptosis and tumor immunity.

Ferroptosis is a unique form of cell death driven by iron-dependent lipid peroxidation, with regulatory mechanisms involving metabolic dysregulation and imbalance in redox systems. Ferroptosis is closely related to various immune cells in the tumor immune microenvironment, including both anti-tumor and pro-tumor immune cells, and it demonstrates significant potential in tumor immunotherapy. A systematic review of the regulatory mechanisms of ferroptosis and its relationship with immune cells can provide deeper insights into its application prospects in tumor immunotherapy.

Mechanism of Yinxu Weitong Capsule in the treatment of precancerous lesions of gastric cancer based on network pharmacology and experimental validation.

Ethnopharmacological Relevance: Yinxu Weitong Capsule (YXWTC) is a Chinese patent medicine used to treat chronic gastritis. However, its efficacy and mechanisms of action in treating precancerous lesions of gastric cancer (PLGC) remain unclear.

Aim Of The Study: To evaluate the effects of YXWTC on PLGC and explore the underlying mechanisms.

Real-world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury.

Objective: The short-term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear.

Methods: We used the MIMIC database to compare the efficacy of liberal (10 g/dL) versus conservative (7 g/dL) transfusion strategy in TBI patients. The outcomes were neurological progression (decrease of Glasgow coma scale (GCS) of at least 2 points) and death within 28 days of ICU admission.

Secreted Xylanase PstXyn1 Contributes to Stripe Rust Infection Possibly by Overcoming Cell Wall Barrier and Suppressing Defense Responses in Wheat.

f. sp. () secretes a plethora of cell wall-degrading enzymes (CWDEs) to facilitate fungal invasion during infection.

Electrophoretic deposition of Ag-Cu-CTS coatings on porous titanium with photothermal-responsive antibacterial effect.

Porous architecture of titanium implants offers significant advantages in promoting osseointegration and mitigating the "stress shielding" effect. However, challenges remain in enhancing vascularization and preventing infection, especially given the complexities of modifying the intricate surface structure of porous titanium (PT). This study introduces a novel surface modification technique of PT using anti-gravity perfusion electrophoretic deposition (EPD) technique to fabricate antibacterial coatings containing silver (Ag) and copper (Cu) co-doped mesoporous silica nanoparticles (Ag-Cu@MSN) and chitosan binder on the surface of PT.

Alterations in regional homogeneity in schizophrenia patients comorbid with metabolic syndrome treated with risperidone or clozapine.

The neuroimaging mechanisms that arise in patients with schizophrenia and comorbid metabolic syndrome (MetS) remain poorly understood. This study was devised to examine potential alterations in regional homogeneity (ReHo) that arise in schizophrenia patients with comorbid MetS undergoing risperidone or clozapine treatment. In total, 43 schizophrenia patients undergoing risperidone or clozapine treatment were enrolled in this study, of whom 20 had comorbid MetS (SZ-MetS) while 23 did not (SZ-nMetS).

Cardiac selectivity in pulsed field ablation.

Purpose Of Review: This review examines the selective cardiac injury induced by pulsed electric fields during atrial fibrillation ablation. It consolidates findings from both preclinical and clinical studies on cardiac selectivity and explores the potential mechanisms behind this selectivity.

Recent Findings: Preclinical studies indicate that pulsed electric fields cause significantly more myocardial injury compared with other tissues.

Boosting Tumor Accumulation of Phthalocyanine through Sialylation Engineering for Superior Cancer Phototherapy.

Phthalocyanines (Pcs) are widely developed in cancer phototherapy due to their definite chemical structure and tunable photosensitivity. However, their in vivo application is hampered by low water solubility and non-specific biodistribution. Here,a strategy of sialylation-modulation is developed for the first time to highly improve the bioavailability of Pcs.

DNA damage-inducing endogenous and exogenous factors and research progress.

The substances that cause abnormal DNA structures are known as DNA damage-inducing factors, and their resulting DNA damage has been extensively studied and proven to be closely related to cancer, neurodegenerative diseases, and aging. Prolonged exposure to DNA damage-inducing factors can lead to a variety of difficult-to-treat diseases, yet these factors have not been well summarized. It is crucial to use a combination of environmental science and life science to gain a deep understanding of the environmental sources and biological consequences of DNA damage-inducing factors for mechanistic research and prevention of diseases such as cancer.

The thermal instability of hydrogen-substituted graphdiyne and its role in lithium-sulfur batteries.

This study reveals the role of thermal instability in hydrogen-substituted graphdiyne (HsGDY) and its impact on lithium-sulfur (Li-S) battery performance. HsGDY undergoes significant chemical and physical transformations when subjected to thermal heating, both in the presence and absence of sulfur. Our findings suggest that the structural transformation of HsGDY into a graphene-like structure is primarily responsible for enhancing sulfur trapping and reducing the polysulfide shuttle effect, rather than the previously hypothesized alkyne-sulfur chemical interactions.

Non-early catheter ablation vs drug therapy in atrial fibrillation: Results from the CABANA trial.

Background: Early rhythm control reduces the risk of cardiovascular events in patients with atrial fibrillation (AF). Despite the superiority of catheter ablation in maintaining sinus rhythm, the knowledge gaps regarding the prognostic benefits of non-early (onset of AF ≥1 year) ablation remain.

Objective: The study aimed to describe outcomes of non-early AF in the CABANA trial.

as a potential diagnostic biomarker for autophagy in rheumatoid arthritis: A bioinformatics study.

This study aimed to identify genes associated with autophagy and potential diagnostic biomarkers by comparing the gene expression profiles of synovial tissues in patients with rheumatoid arthritis (RA) and healthy individuals, aiming to offer new insights for clinical treatment strategies. We used publicly available datasets to analyze differentially expressed genes (DEGs) between the synovial tissue of RA patients and healthy individuals. Then, we intersected these DEGs with autophagy-related genes to identify autophagy genes in the synovial tissue of RA patients.

Ibrutinib Promotes Atrial Fibrillation by Disrupting A-Kinase Anchoring Protein 1-Mediated Mitochondrial Quality Surveillance in Cardiomyocytes.

Ibrutinib, a potent Bruton's tyrosine kinase inhibitor with marked efficacy against hematological malignancies, is associated with the heightened risk of atrial fibrillation (AF). Although ibrutinib-induced AF is linked to enhanced oxidative stress, the underlying mechanisms remain unclear. This research aimed to explore the molecular mechanism and regulatory target in ibrutinib-induced AF.

Nuciferine Alleviates High-Fat Diet- and ApoE-Induced Hepatic Steatosis and Ferroptosis in NAFLD Mice via the PPARα Signaling Pathway.

Nonalcoholic fatty liver disease (NAFLD) causes significant global mortality and healthcare costs with no recommended pharmacological intervention for clinical management. Nuciferine (Nuc) is an alkaloid with aromatic rings, abundantly found in . In this study, we explored the protective mechanisms of Nuc against hepatic steatosis and ferroptosis in NAFLD.

Varying effect of atrial fibrillation ablation in patients with heart failure with preserved ejection fraction according to CHADS-VASc score.

Background: The impact of comorbidity burden on outcomes of radiofrequency catheter ablation (RFCA) for atrial fibrillation (AF) in patients with heart failure and preserved ejection fraction (HFpEF) remains unclear.

Objective: The purpose of this study was to evaluate how comorbidity burden influences the association between RFCA and cardiovascular outcomes in AF patients with HFpEF.

Methods: AF patients with HFpEF from the prospective China-AF cohort, recruited between August 2011 and December 2020, were categorized into 2 groups based CHADS-VASc score: low comorbidity burden (score ≤4) and high comorbidity burden (score >4).

Randomized Controlled Trial Comparing Training of Transseptal Puncture With or Without Intracardiac Echocardiography.

Background: Intracardiac echocardiography (ICE) has been widely used in the catheter ablation of atrial fibrillation (AF). However, the value of ICE in the training of transseptal puncture (TSP) is unclear.

Methods: ICE-Training Study was a single-center, parallel-group, unmasked, randomized controlled trial registered in ChineseClinicalTrials.