Polydatin-Mediated Inhibition of HSP90α Disrupts NLRP3 Complexes and Alleviates Acute Pancreatitis.

The NLRP3 inflammasome plays a critical role in various inflammatory conditions. However, despite extensive research in targeted drug development for NLRP3, including MCC950, clinical success remains elusive. Here, we discovered that the activated NLRP3 inflammasome complex (disc-NLRP3) and the activating mutation L351P exhibited resistance to MCC950.

Sex differences in loneliness, social isolation, and their impact on psychiatric symptoms and cognitive functioning in schizophrenia.

Background: Social isolation and loneliness, objective and subjective features of dysfunctional social relationships, are more prevalent in patients with schizophrenia (SCZ) than in the general population. This study aimed to explore sex differences in loneliness and social isolation among Chinese chronic SCZ patients, and to investigate their relationships with psychiatric symptoms and cognitive functioning.

Methods: A total of 323 SCZ patients, comprising 136 males and 187 females, were recruited.

Phenylmethylsiloxanes in the typically human-impacted Xiaoqing River of China: Their distribution and degradation in both waterbodies and mussels.

Based on sampling from Xiaoqing River of China and elimination experiments, this study first investigated spatial/seasonal profiles and fates of phenylmethylsiloxanes (PMSs), as modified products of dimethylsiloxanes (DMSs), in natural waterbody. Overall, the average water (6.7 ng/L) and sediment (28.

Sex-specific differences in the relationship between thyroid hormones and neurocognition in schizophrenia: A large-scale cross-sectional study.

Background: Sex differences in thyroid hormones, cognitive function, and psychiatric symptoms in schizophrenia remain underexplored. The study aimed to investigate the cross-sectional relationships between thyroid hormone levels, cognitive impairments, and clinical symptoms in people with chronic schizophrenia, with a focus on sex differences.

Methods: We included 1007 people with schizophrenia (602 males and 405 females), and 326 healthy controls (193 males and 133 females).

Duration of untreated psychosis and cognitive function in first-episode antipsychotic-naïve schizophrenia: Evidence from auditory P300.

Objective: The relationship between the duration of untreated psychosis (DUP) and cognitive function in schizophrenia (SZ) patients remains debated, with no empirical evidence from event-related potential (ERP) studies supporting their association. This study aims to investigate the relationship between DUP and cognitive functions, as well as psychiatric symptoms, in first-episode antipsychotic-naïve SZ (FEAN-SZ) patients using ERP.

Methods: The study included 321 Chinese FEAN-SZ patients and 146 healthy controls.

Non-target analysis of organic pollutants in oil-production wastewater treatment stations and surrounding soils: Their profiles, electro-transformation, and environmental risks.

Although pollution during crude oil production has been paid attention, there is lack of studies on organic pollutants generated/emitted from oil-production wastewater (OPW) treatment processes, especially advanced oxidation process. Based on GC-Q-Orbitrap-HRMS, the present study performed non-target analysis of volatile/semi-volatile organic compounds in physical and electro-oxidation units of OPW treatment stations located in Shengli Oilfield of China. Overall, 64-227 organic compounds were respectively identified in different units, and electro-oxidation was found elevating (by 2.

Hydrogeochemical characteristics and evolution of formation water in the continental sedimentary basin: A case study in the Qaidam Basin, China.

In deep formations, oil or gas reservoir rocks are generally accompanied by groundwater with high total dissolved solids (TDS), commonly referred to as "formation water". The enrichment of trace and/or metallic elements such as K, B, Li, Br, Sr in this type of groundwater holds significant industrial values and socioeconomic benefits. However, the processes involved in the burial and generation of formation water remain not fully understood.

DAPK enhances DDX20 protein stability via suppression of TRIM25-mediated ubiquitination-based DDX20 degradation.

We have previously found that the DAPK-DDX20 signaling axis exerts an anti-cancer activity in hepatocellular carcinoma (HCC) by inhibiting the GTPase activity of CDC42, thereby reducing the invasive and migratory capabilities of cancer cells without affecting cell proliferation. DDX20 serves as an intermediate protein regulated by DAPK in the control of CDC42. Specifically, DAPK enhances DDX20 protein levels by suppressing DDX20 degradation.

Causal relationships between cortical brain structural alterations and migraine subtypes: a bidirectional Mendelian randomization study of 2,347 neuroimaging phenotypes.

Background: Previous studies have shown that migraines are associated with brain structural changes. However, the causal relationships between these changes and migraine, as well as its subtypes, migraine with aura (MA) and migraine without aura (MO), remain largely unclear.

Methods: We utilized genome-wide association study (GWAS) summary statistics from European cohorts for 2,347 cortical structural magnetic resonance imaging (MRI) phenotypes, derived from both T1-weighted and diffusion tensor imaging scans (n = 36,663), with migraine and its subtypes (n = 147,970-375,752).

Exosomal miR-129-2-3p promotes airway epithelial barrier disruption in PM-aggravated asthma.

Particulate matter 2.5 (PM) exposure is intricately linked to asthma exacerbations. Damage to the airway epithelial barrier function serves as an initiating factor for asthma attacks and worsening symptoms.

Does Platelet-Rich Plasma Improve Adhesion Recurrence and Pregnancy Outcomes in Women with Intrauterine Adhesions? A Systematic Review and Meta-Analysis.

Objective: To determine the role of Platelet-rich plasma (PRP) in improving pregnancy and adhesion recurrence outcomes in women who underwent hysteroscopic treatment of intrauterine adhesions.

Data Sources: A total of 3 databases: Google scholar, PubMed, and clinicaltrials.gov were searched extensively from inception until April 5, 2023, without any language restrictions.

Impact of broader ecological and socio-environmental components on Aedes mosquito population dynamics: a spatial-temporal longitudinal study.

Background: The increasing spread of mosquito-borne diseases is a significant problem globally, but mosquito management strategies are less efficient. Therefore, a comprehensive understanding of the population dynamics of Aedes mosquito is essential for improving mosquito management strategies. Constructing a model to understand Aedes mosquito development in response to environmental factors is crucial to addressing these challenges.

Sex-specific associations between 10-year cardiovascular risk, clinical symptoms and cognitive impairments in schizophrenia.

Background: Schizophrenia (SCZ) shortens life expectancy, with cardiovascular disease (CVD) as the leading cause of death. The links between psychiatric symptoms, cognitive function and CVD are unclear, and sex differences in this relationship are understudied. This study examined the relationship between clinical characteristics and 10-year cardiovascular risk in males and females with SCZ.

A nanofluidic chemoelectrical generator with enhanced energy harvesting by ion-electron Coulomb drag.

A sufficiently high current output of nano energy harvesting devices is highly desired in practical applications, while still a challenge. Theoretical evidence has demonstrated that Coulomb drag based on the ion-electron coupling interaction, can amplify current in nanofluidic energy generation systems, resulting in enhanced energy harvesting. However, experimental validation of this concept is still lacking.

Zinc finger domain of p62/SQSTM1 is involved in the necroptosis of human cisplatin‑resistant ovarian cancer cells treated with sulfasalazine.

Cisplatin resistance in ovarian cancer cells is mainly apoptosis resistant. Although other types of programmed cell death are highly involved in chemoresistance, which type can overcome cisplatin resistance remains unclear. The present study observed that cisplatin-sensitive SKOV3 cells and cisplatin-resistant SKOV3/DDP cells had different levels of sensitivity to sulfasalazine (SAS).

MAPRS: An intelligent approach for post-prescription review based on multi-label learning.

Antimicrobial resistance (AMR) is a major threat to public health worldwide. It is a promising way to improve appropriate prescription by the review and stewardship of antimicrobials, and Post-Prescription Review (PPR) is currently the main tool used in hospitals. Existing methods of PPR typically focus on the dichotomy of antimicrobial prescription based on binary classification which, however, is usually a multi-label classification problem.

Global research trends of antibiotic-loaded bone cement: A bibliometric and visualized study.

Objective: Antibiotic-loaded bone cement (ALBC) plays an indispensable role in the treatment of infectious diseases of bone and joint. Here, we intended to analyze the research status, hot spots and frontiers in the field of ALBC, and to provide reference for future research ideas.

Methods: The related English literature in the field of ALBC in the Web of Science Core Collection database was retrieved from January 1, 2009 to July 11, 2023.

The relationship of cardiovascular disease risk, clozapine antipsychotic use and cognitive function in a large Chinese schizophrenia cohort.

Objective: This study explores the intricate relationship between clozapine use, cardiovascular disease (CVD) risk, and cognitive function in patients with schizophrenia (SCZ).

Methods: A cohort comprising 765 patients was stratified based on clozapine usage. Data on demographics, clinical characteristics, and glycolipid metabolism were collected.