The complete chloroplast genome sequence of × V.

× is a tetraploid grape, a Franco-american species. This study first published the complete chloroplast genome of × was assembled. The chloroplast genome is 160928 bp in length, including a large single copy region (89,148 bp), a small single-copy region (19,072 bp) and a pair of inverted repeats of 26,354 bp.

Development of a target identification approach using native mass spectrometry.

A key step in the development of new pharmaceutical drugs is the identification of the molecular target and distinguishing this from all other gene products that respond indirectly to the drug. Target identification remains a crucial process and a current bottleneck for advancing hits through the discovery pipeline. Here we report a method, that takes advantage of the specific detection of protein-ligand complexes by native mass spectrometry (MS) to probe the protein partner of a ligand in an untargeted method.

Multiple modes of action of myricetin in influenza A virus infection.

Influenza A virus remains a major threat to public health worldwide after its first pandemic. Scientists keep searching novel anti-influenza drugs, of which natural products present to be an important source. Myricetin, a natural flavonol compound, which exists in many edible plants, which has a wide range of biological activities, but its anti-influenza A virus activity is ambiguous.

Fixed Viewpoint Mirror Surface Reconstruction Under an Uncalibrated Camera.

This paper addresses the problem of mirror surface reconstruction, and proposes a solution based on observing the reflections of a moving reference plane on the mirror surface. Unlike previous approaches which require tedious calibration, our method can recover the camera intrinsics, the poses of the reference plane, as well as the mirror surface from the observed reflections of the reference plane under at least three unknown distinct poses. We first show that the 3D poses of the reference plane can be estimated from the reflection correspondences established between the images and the reference plane.

Single-Image Deraining via Recurrent Residual Multiscale Networks.

Existing deraining approaches represent rain streaks with different rain layers and then separate the layers from the background image. However, because of the complexity of real-world rain, such as various densities, shapes, and directions of rain streaks, it is very difficult to decompose a rain image into clean background and rain layers. In this article, we develop a novel single-image deraining method based on residual multiscale pyramid to mitigate the difficulty of rain image decomposition.

Author Correction: Near-real-time monitoring of global CO emissions reveals the effects of the COVID-19 pandemic.

A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20254-5.

Selective packaged circular RNAs in milk extracellular vesicles during infection may have potential against bacterial infection.

Extracellular vesicles (EVs) provide a novel intercellular communication mechanism to transfer biologically important molecules to target cells. Although several pieces of evidence have shown that EVs have potential to respond to bacterial infections, our knowledge about the role of circular RNA (circRNA), an important cargo of EV, behind this process remains poor. In particular, the mechanism by which circRNAs are packaged into EVs remains elusive during bacterial infection.

Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer's Diseases.

Alzheimer's disease (AD) is a neurodegenerative disease with a high incidence rate and complicated pathogenesis. Currently, all anti-AD drugs treat the symptoms of the disease, and with currently no cure for AD. Flavonoid containing natural products, Myricetin (MYR) and Dihydromyricetin (DMY), are abundant in fruits and vegetables, and have been approved as food supplements in some countries.

High Frame Rate Video Reconstruction Based on an Event Camera.

Event-based cameras measure intensity changes (called 'events') with microsecond accuracy under high-speed motion and challenging lighting conditions. With the 'active pixel sensor' (APS), the 'Dynamic and Active-pixel Vision Sensor' (DAVIS) allows the simultaneous output of intensity frames and events. However, the output images are captured at a relatively low frame rate and often suffer from motion blur.

Apigenin 7-O-glucoside promotes cell apoptosis through the PTEN/PI3K/AKT pathway and inhibits cell migration in cervical cancer HeLa cells.

Epidemiologic evidence promote the inclusion of flavones in diet due to their inhibitory effects on certain types of cancers, particularly in women. Among the naturally occurring plant flavonoids, Apigenin 7-O-glucoside (AGL) is endowed with anti-inflammatory, anti-oxidant, and anti-cancer activities. However, its mechanism of action on cervical cancer, the fourth largest cancer in women, has not yet been clarified.

Virulence and Molecular Diversity in the Population Causing Maize Eyespot in China.

Maize eyespot, caused by , has become a major yield-limiting factor in maize planting areas in northeast China. Limited information is available on pathotypes, virulence, and the genetic diversity of the population. We analyzed virulence and genetic diversity of 103 isolates collected from six provinces in China with differential hosts and the amplified fragment length polymorphism (AFLP) technique, respectively.

Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study.

Mismatch negativity (MMN) is suitable for studies of preattentive auditory discriminability and the auditory memory trace. Subjective cognitive decline (SCD) is an ideal target for early therapeutic intervention because SCD occurs at preclinical stages many years before the onset of Alzheimer's disease (AD). According to a novel lifespan-based model of dementia risk, hearing loss is considered the greatest potentially modifiable risk factor of dementia among nine health and lifestyle factors, and hearing impairment is associated with cognitive decline.

Near-real-time monitoring of global CO emissions reveals the effects of the COVID-19 pandemic.

The COVID-19 pandemic is impacting human activities, and in turn energy use and carbon dioxide (CO) emissions. Here we present daily estimates of country-level CO emissions for different sectors based on near-real-time activity data. The key result is an abrupt 8.

Establishment and Empirical Evaluation of a Quality Indicator System for Postoperative Pain Management.

Objectives: This study aimed to establish a quality indicator system for postoperative pain management and test its reliability, validity, and discrimination in China.

Methods: We established a quality indicator system using the Delphi method. Further, we designed and administered a survey questionnaire in the orthopedic departments of nine hospitals, located in the Zhejiang and Jiangsu Provinces, through purposive and convenience sampling methods to examine the reliability, validity, and discrimination of the quality indicator system.

Indole primes defence signalling and increases herbivore resistance in tea plants.

Upon herbivore attack, plants emit herbivore-induced plant volatiles (HIPVs). HIPVs can prime defences and resistance of intact plants. However, how HIPVs are decoded and translated into functional defence responses is not well understood, especially in long-lived woody plants.

A Nickel- and Cerium-Doped Zeolite Composite: An Affordable Cathode Material for Biohydrogen Production in Microbial Electrolysis Cells.

Microbial electrolysis cells (MECs) is one of the promising biohydrogen production technologies for which low-cost cathode materials are required and developed to propel the rapid development of MECs. Herein, the preparation of a low-cost Ce -Ni-Y composite is reported by using Y zeolite as carrier loaded with nickel (Ni) and cerium (Ce) as active components and its prominent electrochemical performance. The XPS analysis reveals that strong electronic interaction between Ni and Ce makes a great contribution to the electrochemical performance enhancement.

Marine natural products from sponges (Porifera) of the order Dictyoceratida (2013 to 2019); a promising source for drug discovery.

Marine organisms have been considered an interesting target for the discovery of different classes of secondary natural products with wide-ranging biological activities. Sponges which belong to the order Dictyoceratida are distinctly classified into 5 families: Dysideidae, Irciniidae, Spongiidae, Thorectidae, and Verticilliitidae. In this review, compounds isolated from Dictyoceratida sponges were discussed with their biological potential within the period 2013 to December 2019.

Effects of Auricular Point Acupressure on Pain Relief: A Systematic Review.

Objectives: This systematic review aimed to summarize and provide an update on clinical studies investigating the effects of auricular point acupressure (APA) on pain relief, in addition to the APA methods of delivery and operation.

Design: A systematic review.

Data Sources: A systematic review on literatures published on five English (PubMed, Web of Science, Embase, EBSCO, and Cochrane databases) and four major Chinese databases (China National Knowledge Infrastructure, Wan Fang Data, Chinese Scientific Journals Database [VIP], and SinoMed) was conducted.

Iodine Redox Chemistry in Rechargeable Batteries.

Halogens have been coupled with metal anodes in a single cell to develop novel rechargeable batteries based on extrinsic redox reactions. Since the commercial introduction of lithium-iodine batteries in 1972, they have shown great potential to match the high-rate performance, large energy density, and good safety of advanced batteries. With the development of metal anodes (e.

Protective effect of quercetin against myocardial ischemia as a Ca channel inhibitor: involvement of inhibiting contractility and Ca influx via L-type Ca channels.

Many studies describe the stimulating effect of quercetin on Ca channels and the treatment of cardiovascular diseases such as myocardial ischemia and hypertension. However, these studies are scattered and contradictory. The aim of this study is to elucidate the protective effects of quercetin against isoproterenol (ISO)-induced myocardial ischemia and verify the cellular mechanisms based on the L-type Ca channel (LTCC), Ca transients, and myocardial contractility.

A light- and heat-driven glycal diazidation approach to nitrogenous carbohydrate derivatives with antiviral activity.

The aminated mimetics of 2-keto-3-deoxy-sugar acids such as the anti-influenza clinical drugs oseltamivir (Tamiflu) and zanamivir (Relenza) are important bioactive molecules. Development of synthetic methodologies for accessing such compound collections is highly desirable. Herein, we describe a simple, catalyst-free glycal diazidation protocol enabled by visible light-driven conditions.

Genome-Inspired Chemical Exploration of Marine Fungus MF071.

The marine-derived fungus MF071, isolated from sediment collected from the Bohai Sea, China, yielded two new compounds 19,20-epoxy-18-oxotryprostatin A () and 20-hydroxy-18-oxotryprostatin A (), in addition to 28 known compounds (-). The chemical structures were established on the basis of 1D, 2D NMR and HRESIMS spectroscopic data. This is the first report on NMR data of monomethylsulochrin-4-sulphate () and pseurotin H () as naturally occurring compounds.

Dihydromyricetin is a new inhibitor of influenza polymerase PB2 subunit and influenza-induced inflammation.

Development of new and effective anti-influenza drugs is critical for the treatment of influenza virus infection. The polymerase basic 2 (PB2) subunit as a core subunit of influenza A virus RNA polymerase complex is considered to be an attractive drug target for anti-influenza drug discovery. Dihydromyricetin, as a natural flavonoid, has a wide range of biological activities, but its anti-influenza A virus activity is ambiguous.

Hepatitis C Virus NS3 Protease and Helicase Inhibitors from Red Sea Sponge () Species in Green Synthesized Silver Nanoparticles Assisted by in Silico Modeling and Metabolic Profiling.

Background: Hepatitis C virus (HCV) infection is a major cause of hepatic diseases all over the world. This necessitates the need to discover novel anti-HCV drugs to overcome emerging drug resistance and liver complications.

Purpose: Total extract and petroleum ether fraction of the marine sponge ( spp.