Navigating (Dis)empowerment: Dialectical Tensions in the Enactment of Resilience of College Students with Eating Disorders.

Research has shown a dramatic increase of eating disorders (EDs) among young people during disruptive times. Understanding the role of communication in impeding or enacting resilience not only helps those with EDs develop better strategies for coping and changing their lives but can also inform effective interventions at familial, community, and system levels. Guided by the communication theory of resilience (CTR), our study explores how college students with EDs enacted resilience through recalled interactions with parents, friends, community members, and health professionals during the COVID-19 pandemic.

Activating Ultralong Room-Temperature Phosphorescence of Mono-Ring Arylboronic Acid by Hydrogen Bond for Tunable Afterglow Color and Stimulus Response.

Activating the ultralong room-temperature phosphorescence (RTP) of mono-ring arylboronic acid remains a great challenge, because the capacious free spaces shaped by a rubbery polymeric matrix allow the benzene ring skeleton to freely rotate. Herein, the ultralong RTP in mono-ring arylboronic acid derivatives embedded in a polyvinyl alcohol (PVA) matrix is activated, leveraging enhanced intermolecular and intramolecular hydrogen bonding and activating ultralong RTP. By incorporating diverse PBA derivatives into PVA via click chemistry, 3-aminophenylboronic acid (3A-PBA) doped PVA films showcase the most extended RTP lifetimes (2.

Process indicators outshine outcome measures: assessing hospital quality of care in breast cancer treatment in China.

Reporting the results of quality indicators can narrow the gap in the quality of care between hospitals. While most studies rely on outcome indicators, they may not accurately measure the quality of care. Process indicators are not only strongly associated with treatment outcomes, but are also more sensitive to whether patients are treated accurately, enabling timely intervention.

Global, regional, and national temporal trend in burden of major depressive disorder from 1990 to 2019: An analysis of the global burden of disease study.

Major depressive disorder (MDD) is one of the leading causes of disability worldwide. Comprehensive description of the global burden of MDD and its attributable risk factors is essential for policymaking but currently lacking. In this study, we aim to estimate the burden of MDD in terms of incidence, prevalence, and years lived with disability (YLDs), along with its attributable risk factors at global, regional, and rational level between 1990 and 2019, using data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019.

Automated measurement and grading of knee cartilage thickness: a deep learning-based approach.

Background: Knee cartilage is the most crucial structure in the knee, and the reduction of cartilage thickness is a significant factor in the occurrence and development of osteoarthritis. Measuring cartilage thickness allows for a more accurate assessment of cartilage wear, but this process is relatively time-consuming. Our objectives encompass using various DL methods to segment knee cartilage from MRIs taken with different equipment and parameters, building a DL-based model for measuring and grading knee cartilage, and establishing a standardized database of knee cartilage thickness.

Room-temperature phosphorescence and fluorescence nanocomposites as a ratiometric chemosensor for high-contrast and selective detection of 2,4,6-trinitrotoluene.

Reports on using complementary colours for high-contrast ratiometric assays are limited to date. In this work, graphitized carbon nitride (g-CN) nanosheets and mercaptoethylamine (MEA) capped Mn-doped ZnS QDs were fabricated by liquid exfoliation of bulk g-CN, and by a coprecipitation and postmodification strategies, respectively. Mn-doped ZnS quantum dots were deposited onto g-CN nanosheets through an electrostatic self-assembly to form new nanocomposites (denoted as Mn-ZnS QDs@g-CN).

Quantification of myelination in children with attention-deficit/hyperactivity disorder: a comparative assessment with synthetic MRI and DTI.

Evaluation of myelin content is crucial for attention-deficit/hyperactivity disorder (ADHD). To estimate myelin content in ADHD based on synthetic MRI-based method and compare it with established diffusion tensor imaging (DTI) method. Fifth-nine ADHD and fifty typically developing (TD) children were recruited.

Assessment of the glymphatic function in children with attention-deficit/hyperactivity disorder.

Objectives: Whether the alternation of the glymphatic system exists in neurodevelopmental disease still remains unclear. In this study, we investigated structural and functional changes in the glymphatic system in the treatment-naïve attention-deficit/hyperactivity disorder (ADHD) children by quantitatively measuring the Virchow-Robin spaces (VRS) volume and diffusion tensor image-analysis along the perivascular space (DTI-ALPS).

Methods: Forty-seven pediatric ADHD patients and 52 age- and gender-matched typically developing (TD) children were recruited in this prospective study.

Trends in the prevalence and treatment of comorbid depression among US adults with and without cancer, 2005-2020.

Background: Understanding trend characteristics of depression among cancer survivors is essential for healthcare policies and planning. This study estimates longitudinal trends in the prevalence and treatment of depression among adults in the United States with and without cancer.

Methods: This cross-sectional study focused on adults aged 20 years or older based on nationally representative data from the National Health and Nutrition Examination Surveys 2005-2020.

Disrupted Small-World Networks in Children with Drug-Naïve Attention-Deficit/Hyperactivity Disorder: A DTI-Based Network Analysis.

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, while the potential neurological mechanisms are poorly understood. To explore the alterations in the white matter (WM) structural connectome in children with drug-naïve ADHD, forty-nine ADHD and 51 age- and gender-matched typically developing (TD) children aged 6-14 years were enrolled. WM structural connectivity based on deterministic diffusion tensor imaging (DTI) was constructed in 90 cortical and subcortical regions, and topological parameters of the resulting graphs were calculated.

Altered neurovascular coupling in the children with attention-deficit/hyperactivity disorder: a comprehensive fMRI analysis.

The coupling between resting-state cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) signals reflects the mechanism of neurovascular coupling (NVC), which have not been illustrated in attention-deficit/hyperactivity disorder (ADHD). Fifty ADHD and 42 age- and gender-matched typically developing controls (TDs) were enrolled. The NVC imaging metrics were investigated by exploring the Pearson correlation coefficients between CBF and BOLD-derived quantitative maps (ALFF, fALFF, DCP maps).

Gene Variants in Two Families with Inherited Coagulation Factor XI Deficiency and Identification of Mutations.

Introduction: Mutations in the F11 gene can cause factor XI (FXI) deficiency, leading to abnormal coagulation activity and injury-related bleeding tendency. Therefore, identifying F11 gene mutations and studying the molecular basis will help us understand the pathogenesis of FXI deficiency.

Methods: Coagulation tests and gene sequencing analysis of all members were performed.

A Novel Homozygous Missense Mutation (Ile583Asn) in a Consanguineous Marriage Family with Hereditary Factor XII Deficiency: A Case Report.

Background:  Hereditary coagulation factor XII (FXII) deficiency is an autosomal recessive disorder. At present, the contribution of severe FXII deficiency to the development of thromboembolism is still undetermined. There are limited reports on the relationship between the FXII defect and thromboembolism.

Evaluation of individual-based morphological brain network alterations in children with attention-deficit/hyperactivity disorder: a multi-method investigation.

To investigate the topological organization of individual-based morphological brain networks (MBNs) in attention-deficit/hyperactivity disorder (ADHD) children with different methods. A total of 60 ADHD children and 60 typically developing (TD) controls matched for age and gender were enrolled. Each participant underwent a structural 3D T1-weighted scan.

[Analysis of the molecular pathogenesis of hereditary protein C deficiency due to a p.Gly86Asp variant of the PROC gene].

Objective: To explore the molecular pathogenesis of hereditary protein C (PC) deficiency due to a p.Gly86Asp variant of the PROC gene through in vitro expression experiment.

Methods: Wild type and Gly86Asp mutant expression plasmids of PC were constructed and respectively transfected into HEK 293FT cells.

The quality disparity of stroke care over time: An analysis based on the national dataset from 2011 to 2017.

Background: Adherence to evidence-based hospital stroke care is variable and may change over time. It is important to determine which process measures are associated with variation in outcome. In a large dataset, we analyzed the association between process and outcome and the fluctuations of indicators over time, and identified quality indicators (QIs) that should be prioritized for improving the quality of stroke care.

Anticoagulant activity of singlet oxygen released from a water soluble endoperoxide by thermal cycloreversion.

Singlet oxygen generated by photosensitization has limited potential due to light attenuation in tissues. However, controlled chemical generation of this reactive oxygen species is likely to open new therapeutic spaces to explore. The fact that its activity is limited by the rate of cycloreversion reaction and the diffusion distance of the excited state molecular oxygen species, is a clear advantage, considering the serious side effects of off-target anticoagulants.

Development and Validation of a Novel Prognostic Model for Lower-Grade Glioma Based on Enhancer RNA-Regulated Prognostic Genes.

Enhancer RNAs (eRNAs) are present specifically in tumors, where they affect the expression of eRNA-regulated genes (ERGs). Owing to this characteristic, ERGs were hypothesized to improve prognosis of overall survival in heterogeneous low-grade and intermediate-grade gliomas. This study aimed to construct and validate an ERG prognostic tool to facilitate clinical management, and offer more effective diagnostic and therapeutic biomarkers for glioma.

A Novel Prognostic Tool for Glioma Based on Enhancer RNA-Regulated Immune Genes.

Gliomas are the most malignant tumors of the nervous system. Even though their survival outcome is closely affected by immune-related genes (IRGs) in the tumor microenvironment (TME), the corresponding regulatory mechanism remains poorly characterized. Specific enhancer RNAs (eRNAs) can be found in tumors, where they control downstream genes.