Fabrication of broadband HgCdTe photodetectors with biomimetic insect corneal arrays.

Broadband photodetectors are of great significance in a wide variety of technologically important areas. Inspired by bionics, insect cornea-mimicking microstructures could reduce surface reflection, thus enabling broadband detection. Here, we fabricate a broadband large-area (1280 × 1024) HgCdTe focal plane array photodetector based on biomimetic ZnS microarrays, which achieves high external quantum efficiency (> 60%, averaging 79%) across the broad wavelength range of 400 nm - 5000 nm.

In-Silico discovery of 17alpha-hydroxywithanolide-D as potential neuroprotective allosteric modulator of NMDA receptor targeting Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, memory impairment, and behavioral alterations. The N-methyl-D-aspartate (NMDA) receptor has emerged as a promising target for AD pharmacotherapy due to its role in the disease's pathogenesis. This study leverages advanced computational methods to screen 80 active constituents of Withania somnifera (Ashwagandha), a traditional herb known for its neuroprotective effects, against the NMDA receptor, using FDA-approved Ifenprodil as a reference.

Improving adsorption and purification performance of Bi2WO6/BiOCl by oxygen vacancies.

Enhancing adsorption ability of photocatalyst by vacancy is a fascinating strategy. Thus, BiWO/BiOCl with millefeuille-like was successfully prepared via multi-pots method. Experimental results discern that BOW-10 can degraded 75.

Deciphering microbial assembly and coexistence in rivers subjected to long-term reclaimed water replenishment.

Reclaimed water recharge into rivers is an important supplementary approach to address water resource shortage in arid and semi-arid areas worldwide. However, the ecology impacts of reclaimed water recharge on the rivers are still unknown, especially for the microbial assemble and species coexistence in different seasons. Here, the evolution of microbiome and its response to different reasons in the Jialu River, which was subjected to long-term reclaimed water recharge, is investigated by using 16S rRNA gene sequencing and multivariate statistical methods.

The anti-tumor efficacy of a recombinant oncolytic herpes simplex virus mediated CRISPR/Cas9 delivery targeting in HPV16-positive cervical cancer.

Cervical cancer, often driven by high-risk human papillomavirus (HPV) infections such as HPV16 or HPV18, remains a leading cause of cancer-related deaths. HPV16, found in about 90% of cervical cancer patients, harbors key oncogenic related genes (E6, E7, E2, E5) and an upstream regulatory region (URR) that contribute to cancer progression. This study introduces a novel approach using a recombinant oncolytic herpes simplex virus type 1 (HSV-1) named SONC103, armed with a CRISPR/Cas9 gene editing system.

Phytotoxicity of HNTs to rice (Oryza sativa L.): Effects on rice growth and development.

The phytotoxicity of halloysite nanotubes (HNTs) to rice (Oryza sativa L.) was evaluated at several stages from germination, seedling growth to spike setting, and the seedling stage was selected to study the effect of HNTs on the growth of rice. Rice was cultured using different concentrations of HNTs dispersions and a blank control group was cultured with deionized water.

Disentangling the role of biotic and abiotic factors in shaping microbial biogeographic patterns in the large spatial scale ocean.

Across large oceanic spatial scales, the mechanisms governing microbial community composition remain poorly understood, particularly regarding the influence of biotic factors. In this study, samples were collected over a 3772.55-km transect in the Western Pacific surface waters, with 16S and 18S ribosomal RNA gene sequencing employed to elucidate the assembly processes and drivers of microbial communities.

Macrophages after myocardial infarction: Mechanisms for repairing and potential as therapeutic approaches.

Macrophages - one of the crucial immune cells, are recruited to the cardiac tissue by chemokines, cytokines and upregulated endothelial adhesion molecules after myocardial infarction (MI). During the course of inflammation in the cardiac tissue, necrotic cells and matrix debris is phagocytosed by M1 macrophages. During the resolution phase of cardiac inflammation, M2 macrophages promote cardiac recovery.

Low-intensity pulsed ultrasound promotes cell viability of hUSCs in volumetric bioprinting scaffolds via PI3K/Akt and ERK1/2 pathways.

The study aimed to investigate the impact of low-intensity pulsed ultrasound (LIPUS) on human urinary-derived stem cells (hUSCs) viability within three-dimensional (3D) cell-laden gelatin methacryloyl (GelMA) scaffolds. hUSCs were integrated into GelMA bio-inks at concentrations ranging from 2.5% to 10% w/v and then bioprinted using a volumetic-based method.

Impact of water physicochemical properties on the survival of Oncomelania hupensis snails, the intermediate host of Schistosoma japonicum.

Background: Schistosoma japonicum, the causative agent of schistosomiasis, heavily relies on its single intermediate host, the Oncomelania hupensis snail, for its life cycle. Controlling these snails effectively plays a pivotal role in curbing the transmission and prevalence of this disease. While prior research has extensively investigated the impact of environmental factors such as temperature and vegetation on snail survival, growth, and reproduction, the contribution of water physicochemical properties has been notably underexplored.

Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity.

We prepared biocompatible and environment-friendly zinc oxide nanoparticles (ZnO NPs) with upconversion properties and catalase-like nanozyme activity. Photodynamic therapy (PDT) application is severely limited by the poor penetration of UV-Visible light and a hypoxic tumor environment. Here, we used ZnO NPs as a carrier for the photosensitizer chlorin e6 (Ce6) to construct zinc oxide-chlorin e6 nanoparticles (ZnO-Ce6 NPs), simultaneously addressing both problems.

Influence of nitrogen water interaction on leaf functional traits of dominant species in warm temperate forest.

Plant functional traits are indicative of plant responses to environmental changes, influencing ecosystem functions. Leaves, as a key focus in studying plant functional traits, present an area where the impact of nitrogen deposition and altered rainfall patterns on functional diversity remains ambiguous. To elucidate plant response mechanisms to environmental factors, we employed a canopy-based platform to add nitrogen, water, and their combination.

CsPbBr Quantum Dot Modified InO Nanofibers for Effective Detection of ppb-Level HCHO at Room Temperature under UV Illumination.

The design of high-performance and low-power formaldehyde (HCHO) gas sensors is of great interest to researchers for environmental monitoring and human health. Herein, InO/CsPbBr composites were successfully synthesized through an electrospinning and self-assembly approach, and their ultraviolet-activated (UV-activated) HCHO gas-sensing properties were investigated. The measurement data indicated that the InO/CsPbBr sensor possesses an excellent selectivity toward HCHO.

Integrated cerebellar radiomic-network model for predicting mild cognitive impairment in Alzheimer's disease.

Introduction: Pathological and neuroimaging alterations in the cerebellum of Alzheimer's disease (AD) patients have been documented. However, the role of cerebellum-derived radiomic and structural connectome modeling in the prediction of AD progression remains unclear.

Methods: Radiomic features were extracted from magnetic resonance imaging (MRI) in the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset (n = 1319) and an in-house dataset (n = 308).

Exploring the Effect of Gomisin A on Non-Small Cell Lung Cancer With Network Pharmacology, Molecular Docking, In Vitro and In Vivo Assays.

Gomisin A is an active ingredient of Schisandra chinensis. Pre-clinical studies suggest Gomisin A has good anti-cancer activities against a variety of cancers, but its mechanism of action in non-small cell lung cancer (NSCLC) is unclear. This study aims to explore the potential mechanism of Gomisin A in treating NSCLC.

Experience Among Postnatal Nurses With Two or Three Children Returning to Work Within 3 Months in China: A Qualitative Study.

Aim: To analyse experience in postnatal nurses returning to work within 3 months following the delivery of a second or third child and recommend appropriate measures to relieve pressure and enhance work engagement among this group.

Methods: This study adopted a descriptive phenomenological approach. Semi-structured interview was carried out with 12 postnatal nurses who had returned to work in the postpartum period following the delivery of a second or third child.

7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.

Objective: This research aimed to delineate the pharmacological mechanisms of 7-Hydroxycoumarin (7-HC) on ulcerative colitis (UC) employing network pharmacology and experimental validation.

Methods: To investigate the therapeutic effects of 7-HC on UC, a UC mouse model was established through the unrestricted intake of 3.0% dextran sulfate sodium (DSS) in their drinking water.

Large Language Models in Dental Licensing Examinations: Systematic Review and Meta-Analysis.

Introduction And Aims: This study systematically reviews and conducts a meta-analysis to evaluate the performance of various large language models (LLMs) in dental licensing examinations worldwide. The aim is to assess the accuracy of these models in different linguistic and geographical contexts. This will inform their potential application in dental education and diagnostics.

[Heat-sensitive moxibustion combined with medication for orthostatic hypotension of - deficiency in the elderly: a randomized controlled trial].

Objective: To observe the effect of heat-sensitive moxibustion combined with medication on orthostatic hypotension (OH) of - deficiency in the elderly.

Methods: Sixty elderly patients with OH of - deficiency were randomly divided into an observation group (30 cases, 1 case dropped out) and a control group (30 cases). The patients in the control group were treated with oral midodrine hydrochloride tablets, 2.