Strong coupling FeVO nanoparticles/3D N-doped interconnected porous carbon derived from MOFs by confined adsorption-assembly-pyrolysis for greatly boosting oxygen reduction.

Low-cost and effective electrocatalysts are critical for energy storage and conversion. Herein, iron(III) and vanadium(III) acetylacetonates were first adsorbed and confined in porous zeolitic imidazolate framework-8 (ZIF-8), which further cross-linked together by the methanol-induced-assembly. Following the pyrolysis, the FeVO nanoparticles were efficiently encapsulated within three-dimensional (3D) N-doped interconnected porous carbon, termed FeVO/NIPC.

Heterogeneous nuclear ribonucleoprotein C promotes non-small cell lung cancer progression by enhancing XB130 mRNA stability and translation.

Background: XB130, a classical adaptor protein, exerts a critical role in diverse cellular processes. Aberrant expression of XB130 is closely associated with tumorigenesis and aggressiveness. However, the mechanisms governing its expression regulation remain poorly understood.

Proton dose deposition in heterogeneous media: A TOPAS Monte Carlo simulation study.

This study investigated the influence of tissue electron density on proton beam dose distribution using TOPAS Monte Carlo simulation. Heterogeneous tissue models composed of 14 materials were constructed to simulate the dose deposition process of a 169.23 MeV proton beam.

First report of causing leaf spot on in China.

During a field study in the Baili Azalea Forest Area in Guizhou Province, China (27°12'N, 105°48'E) between May and July 2023, symptoms of leaf spot were observed on Franch. The incidence of leaf spot on leaves was about 12% in a field of 1 hm2, significantly reducing their ornamental and economic value. The affected leaves bore irregular, grey-white lesions with distinct dark brown borders, accompanied by black conidiomata.

Pollen Morphological Characteristics of 46 Germplasm Resources of and Its Taxonomic Implications.

To elucidate the morphological diversity and genetic characteristics of the pollen of species, this study utilized a total of 46 samples encompassing six species and one variety of . Scanning electron microscopy (SEM) was employed to examine the morphological traits of the pollen and to analyze the evolutionary patterns and genetic relationships among species. The results indicate that the pollen grains of the 46 germplasm are uniformly characterized as monads, heteropolar, bilaterally symmetrical, atreme, and possess a mono-sulcus.

Besides traditional organophosphate esters: The ecological risks of emerging organophosphate esters in the Yangtze River basin cannot be ignored.

In addition to traditional organophosphate esters (tOPEs), emerging organophosphate esters (eOPEs) have increasingly been detected in the environment, but their risks remain unclear. This study detected 12 tOPEs and 7 eOPEs in surface water, sediment, and suspended particulate matter (SPM) samples from important aquatic habitats and drinking water sources in Yibin (YB), Yichang (YC), Shanghai (SH), and Poyang Lake (PY) within the Yangtze River basin. The total concentration of OPEs (ΣOPEs) in surface water, sediment, and SPM from these four regions were 22.

RRM1 promotes homologous recombination and radio/chemo-sensitivity via enhancing USP11 and E2F1-mediated RAD51AP1 transcription.

Ribonucleotide reductase M1 (RRM1), the catalytic subunit of ribonucleotide reductase, plays a pivotal role in converting ribonucleotides (NTP) into deoxyribonucleotides (dNTP), essential for DNA replication and repair. Elevated RRM1 expression is associated with various human cancers, correlating with poorer prognosis and reduced overall survival rates. Our previous study found that RRM1 will enter the nucleus to promote DNA damage repair.

Green Manure Rotation Combined with Biochar Application Improves Yield and Economic Stability of Continuous Cropping of Peppers in Southwest China.

Crop rotation is widely recognized as a key strategy to mitigate the adverse effects associated with continuous cropping. Recent studies have demonstrated that biochar has a significant potential for preventing and controlling these challenges. However, the ameliorative effects of green manure rotation and biochar application on continuous pepper cultivation in the karst mountainous regions of Southwest China remain largely unexplored.

A nomogram for individualized prediction for cervical lymph node metastasis of papillary thyroid carcinoma.

Background: Cervical lymph node metastasis in papillary thyroid carcinoma plays a crucial role in the development of surgical strategy for thyroid patients. The aim of this study was to determine the predictors of cervical lymph node metastasis based on ultrasound features of papillary thyroid carcinoma, and to develop and validate nomogram to help predict cervical lymph node metastasis.

Methods: Patients who underwent thyroid ultrasound examination in Department of Ultrasonography of The First Affiliated Hospital of Nanjing Medical University between January 1, 2021 and October 31, 2021 were selected.

COVID-19-Associated Immune Thrombocytopenic Purpura in a Hemodialysis Patient.

Background: Severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection has been a global threat since the end of 2019. Although the main clinical manifestation of coronavirus disease 2019 (COVID-19) is respiratory, its range of clinical manifestation is extensive and may include various systems, including hematological disorders, such as lymphopenia, thrombotic events, thrombocytopenia and immune thrombocytopenic purpura (ITP). The present case was the first one that aimed to raise awareness of ITP induced by COVID-19 in patients undergoing maintenance hemodialysis.

Machine learning based on multiplatform tests assists in subtype classification of mature B-cell neoplasms.

Mature B-cell neoplasms (MBNs) are clonal proliferative diseases encompassing over 40 subtypes. The WHO classification (morphology, immunology, cytogenetics and molecular biology) provides comprehensive diagnostic understandings. However, MBN subtyping relies heavily on the expertise of clinicians and pathologists, and differences in clinical experience can lead to variations in subtyping efficiency and consistency.

Nocardia farcinica pneumonia complicated by pneumocystis jiroveci infection in children with Neuromyelitis Optica Spectrum Disorders: a case report and literature review.

Background: Nocardiosis is an opportunistic infection that has a low prevalence rate, its clinical manifestations are atypical and can be easily misdiagnosed as other diseases. The correct diagnosis and treatment are frequently delayed by various factors. In this case report, we present a pediatric patient with Neuromyelitis Optica Spectrum Disorders who developed Nocardia farcinica pneumonia complicated by pneumocystis jiroveci infection.

Cyclic nucleotide-gated ion channel 20 regulates melatonin-induced calcium signaling and cold tolerance in watermelon.

Melatonin plays a crucial role in regulating plant cold tolerance, but the mechanisms underlying signal transduction remain elusive. In this study, we discovered that overexpression of the melatonin biosynthetic gene caffeic acid O-methyltransferase1 (COMT1) enhanced watermelon (Citrullus lanatus) cold tolerance, accompanied by the accumulation of cytosolic free calcium ([Ca2+]cyt), a stimulation of Ca2+ influx, and upregulation of four Ca2+-permeable channel genes (CNGC2/10/17/20). Conversely, knockout of COMT1 exhibited contrasting effects compared to its overexpression.

Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus SCNU-F0041.

A new indigotin alkaloid, named talarindigotin A (), along with the analogue 5H, 6H-quinindolin-11-one () were isolated from the mangrove endophytic fungus SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC values ranging from 2.

Prediction of esophageal fistula in radiotherapy/chemoradiotherapy for patients with advanced esophageal cancer by a clinical-deep learning radiomics model : Prediction of esophageal fistula in radiotherapy/chemoradiotherapy patients.

Background: Esophageal fistula (EF), a rare and potentially fatal complication, can be better managed with predictive models for personalized treatment plans in esophageal cancers. We aim to develop a clinical-deep learning radiomics model for effectively predicting the occurrence of EF.

Methods: The study involved esophageal cancer patients undergoing radiotherapy or chemoradiotherapy.

Improving the identification of cancer driver modules using deep features learned from multi-omics data.

Identifying the cancer driver modules or pathways is crucial to understanding the fundamental mechanisms of cancer occurrence and progression. The rapid abundance of cancer omics data provides unprecedented opportunities to study the driver modules in cancer, and many computational methods have been developed in recent years. However, most existing methods have limitations in considering different types of cancer omics data and cannot effectively learn informative omics features for integrated identification of driver modules.

Causal role of the pyrimidine deoxyribonucleoside degradation superpathway mediation in Guillain-Barré Syndrome via the HVEM on CD4 + and CD8 + T cells.

Immune system regulation is a key indicator of the gut microbiota (GM) influencing disease development. The causal role of the GM in Guillain-Barré syndrome (GBS) and whether it can be mediated by immune cells is unknown. Genome-wide association study (GWAS) summary statistics for the GM were obtained from the Dutch Microbiota Project (n = 7,738) and the FINRISK 2002 (FR02) cohort (n = 5,959).

Electron transfer mediated activation of periodate by contaminants to generate O by charge-confined single-atom catalyst.

The electron transfer process (ETP) is able to avoid the redox cycling of catalysts by capturing electrons from contaminants directly. However, the ETP usually leads to the formation of oligomers and the reduction of oxidants to anions. Herein, the charge-confined Fe single-atom catalyst (Fe/SCN) with Fe-NS configuration was designed to achieve ETP-mediated contaminant activation of the oxidant by limiting the number of electrons gained by the oxidant to generate O.

Efficacy and safety of thalidomide in patients with β-thalassemia intermedia and major.

To investigate the short-term and long-term efficacy and safety of thalidomide in the treatment of intermediate and severe β-thalassemia. We analyzed patients with intermediate and severe β-thalassemia treated at our hospital from February 2019 to February 2024. Patients who received treatment for more than 3 months were included.

Environmental Driving of Adaptation Mechanism on Rumen Microorganisms of Sheep Based on Metagenomics and Metabolomics Data Analysis.

Natural or artificial selection causes animals to adapt to their environment. The adaptive changes generated by the rumen population and metabolism form the basis of ruminant evolution. In particular, the adaptive drive for environmental adaptation reflects the high-quality traits of sheep that have migrated from other places or have been distant from their origins for a long time.

Differences in Physicochemical Properties of Stems in Oat ( L.) Varieties with Distinct Lodging Resistance and Their Regulation of Lodging at Different Planting Densities.

Planting density is an effective strategy for regulating both lodging and forage quality. To delve into the regulatory mechanisms of planting density on lodging and forage quality, lodging-resistant variety LENA and lodging-sensitive variety QY2 were grown in 2018 and 2019 growing seasons, and four planting densities were implemented: 2.25 × 10 plants/ha (D1), 4.

Green fabrication of biomass-derived carbon dots and bio-based coatings: Potential of enhancing postharvest quality on Chinese flowering cabbage.

The objective of this study was to develop a bio-nanocomposite coating (CQSC) by combining chitosan quaternary ammonium salt (CQAS) and sericin (SC) with biomass-derived carbon dots (CDs) to extend the shelf life of Chinese flowering cabbage (CFC). The effects of different concentrations of CDs (0.2, 0.

Construction of Thick Myocardial Tissue through Layered Seeding in Multi-Layer Nanofiber Scaffolds.

A major challenge in myocardial tissue engineering is replicating the heart's highly complex three-dimensional (3D) anisotropic structure. Heart-on-a-chip (HOC) is an emerging technology for constructing myocardial tissue in vitro in recent years, but most existing HOC systems face difficulties in constructing 3D myocardial tissue aligned with multiple cell layers. Electrospun nanofibers are commonly used as scaffolds for cell growth in myocardial tissue engineering, which can structurally simulate the extracellular matrix to induce the aligned growth of myocardial cells.