Application of Mendelian randomization in thyroid diseases: a review.

Thyroid diseases are increasingly prevalent, posing significant challenges to patients' quality of life and placing substantial financial burdens on families and society. Despite these impacts, the underlying pathophysiology of many thyroid conditions remains poorly understood, complicating efforts in treatment, management, and prevention. Observational studies can identify associations between exposure variables and disease; however, they often struggle to account for confounding factors and reverse causation.

MIL-53(Al)-derived bimetallic Pd-Co catalysts for the selective hydrogenation of 1,3-butadiene at low temperature.

Selective hydrogenation of 1,3-butadiene is a crucial industrial process for the removing of 1,3-butadiene, a byproduct of butene production. Developing catalysts with high catalytic performance for the hydrogenation of 1,3-butadiene at low temperatures has become a research hotspot. In this study, bimetallic Pd-Co catalysts supported on AlO derived from MIL-53(Al) at various calcination temperatures were synthesised via the co-impregnation method.

Prognostic implications of immune classification based on PD-L1 expression and tumor-infiltrating lymphocytes in endocervical adenocarcinoma.

Background: Endocervical adenocarcinoma (ECA) comprises a heterogeneous group of diseases whose incidence has increased significantly in recent decades. ECA can be histologically classified into human papillomavirus-associated (HPVA) and non-HPVA (NHPVA) types. Given the variability in pathological features and clinical behavior between the subtypes, evaluating their respective immune microenvironments is essential.

Genome-wide CRISPR-based screen identifies E2F transcription factor 1 as a regulator and therapeutic target of aristolochic acid-induced nephrotoxicity.

Aristolochic Acid I (AAI) is widely present in traditional Chinese medicines derived from the Aristolochia genus and is known to cause significant damage to renal tubular epithelial cells. Genome-wide screening has proven to be a powerful tool in identifying critical genes associated with the toxicity of exogenous substances. To identify undiscovered key genes involved in AAI-induced renal toxicity, a genome-wide CRISPR library screen was conducted in the human kidney-2 (HK-2) cell line.

Pharmacokinetics of cisplatin in the systemic versus hyperthermic intrathoracic or intraperitoneal chemotherapy.

Objective: To compare the pharmacokinetics and adverse effects of cisplatin administered via intravenous infusion for systemic chemotherapy (SC) versus injection into the perfusate during hyperthermic intrathoracic chemotherapy (HITHOC) or hyperthermic intraperitoneal chemotherapy (HIPEC).

Methods: Total 60 patients who received SC, HITHOC, or HIPEC in the Department of Oncology, Tangdu Hospital, were enrolled into this study. After administering same dose of cisplatin (40 mg) via either intravenous infusion (SC group) or injection into the perfusate during the HITHOC or HIPEC procedure, concentration of cisplatin in the plasma as well as in the hyperthermic perfusate at various time points was quantified by HPLC analysis.

[Adsorption of Tetracycline in Composite-polluted Water by Biochar from Industrial Production].

Compared to the laboratory preparation of biochar, there is less research on the adsorption of antibiotics by industrial production of biochar in water. In this study, three types of industrial production biochar （peanut shell biochar, sludge biochar, and perishable waste biochar） were selected, and their adsorption performance for tetracycline in composite-polluted water was systematically studied. The results indicated that the Freundlich equation could well fit the adsorption isotherms of the three types of biochar for tetracycline.

Relationship between prenatal ultrasound signs and genetic abnormalities for fetal malformations of cortical development.

To explore the relationship between ultrasound signs of suspected fetal malformation of cortical development (MCD) and genetic MCD.The retrospective study involved fetuses with one of the following 10 neurosonography (NSG) signs: (A) abnormal development of the Sylvian fissure; (B) delayed achievement of cortical milestones; (C) premature or aberrant appearance of sulcation; (D) irregular border of the ventricular wall or irregular shape of the ventricle; (E) abnormal shape or orientation of the sulci; (F) hemispheric asymmetry; (G) non-continuous cerebral cortex; (H) intraparenchymal echogenic nodules; (I) persistent ganglionic eminence (GE) or GE cavitation; (J) abnormal cortical lamination.95 fetuses were included in the study.

KNaCaRe(BO) (Re = Y, Lu): Two NLO Compounds Exhibiting a Short Absorption Edge in the AA'AeRe(BO) ( = 0, 1) Family.

The discovery and synthesis of new NLO materials in the ultraviolet (UV) region are crucial to developing laser technology. The chemical substitution strategy is an effective pathway to design potential UV or DUV NLO crystals. Herein, two new compounds, KNaCaY(BO) and KNaCaLu(BO), have been synthesized using KBO·4HO as the template.

Risk factors for hepatocellular carcinoma in cirrhosis: A comprehensive analysis from a decade-long study.

Background: Cirrhosis is a significant risk factor for the development of hepatocellular carcinoma (HCC). Variability in HCC risk among patients with cirrhosis is notable, particularly when considering the diverse etiologies of cirrhosis.

Aim: To identify specific risk factors contributing to HCC development in patients with cirrhosis.

Cross-Phenotype Genome-Wide Association Study Supports Shared Genetic Susceptibility to Systemic Sclerosis and Primary Biliary Cholangitis.

Objective: An increased risk of primary biliary cholangitis (PBC) has been reported in patients with systemic sclerosis (SSc). Our study aims to investigate the shared genetic susceptibility between the two disorders and to define candidate causal genes using cross-phenotype GWAS meta-analysis.

Methods: We performed cross-phenotype GWAS meta-analysis and Bayesian colocalization analysis for SSc and PBC.

Focal segmental glomerulosclerosis and neurogenic bladder in a Chinese patient with a novel pathogenic variation in TRIM8 gene: A case report.

To report a novel variation in the TRIM8 gene in a Chinese patient who developed focal segmental glomerulosclerosis (FSGS) and neurogenic bladder. Retrospective analysis of the clinical manifestations, laboratory results, renal biopsy results, and genetic data of the patient with FSGS complicated with neurogenic bladder. The patient was a 6-year and 8-month-old Chinese Zang ethnic boy with low-set ears, widely-spaced eyes (inner canthal distance exceeds the 95th percentile of normal inner canthal distance), a small jaw, and a short neck.

T. pallidum achieves immune evasion by blocking autophagic flux in microglia through hexokinase 2.

Increasing evidence suggests that immune cell clearance is closely linked to cellular metabolism. Neurosyphilis, a severe neurological disorder caused by Treponema pallidum (T. pallidum) infection, significantly impacts the brain.

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment.

Osteosarcoma (OS) is the most prevalent malignant bone tumor in children and adolescents worldwide. Identification of novel therapeutic targets and development of targeted drugs are one of the most feasible strategies for OS treatment. Ferroptosis, a recently discovered mode of programmed cell death, has been implicated as a potential strategy for cancer therapy.

Revealing Microplastic risks in stratified water columns of the East China Sea offshore.

Microplastics have been proven to impact a broad range of marine species significantly. This study investigated the vertical distribution characteristics of microplastics (MPs) to verify their potential toxicity, distribution patterns, and affecting probability on organisms offshore of the East China Sea (ECS), China. Significant variations in MP characteristics across stratified water layers were identified and corroborated through artificial neural network (ANN) analysis.

Return Discussions to Reduce Missing Incidents in Persons Living with Dementia: Findings from a Scoping Review and Individual Interviews.

Persons living with dementia are at risk of becoming lost. While return discussions after missing incidents are common with children, these discussions are seldom done with persons living with dementia. Our objective was to describe the use of return discussions with persons living with dementia according to the literature and practice.

Case Report: Diverticulum of the left ventricular outflow tract: multimodal imaging.

The left ventricular diverticulum (LVD) is a rare congenital heart disease commonly discovered during examinations. Herein, we report a LVD on the lateral wall of left ventricular outflow tract. A case of a 22-year-old female patient who visited our hospital with complaints of shortness of breath, accompanied by vomiting, cough, and lower limb and facial edema and was diagnosed with "aortopulmonary septal defect" using transthoracic echocardiography.

MiR-363: A potential biomarker of kidney diseases.

MicroRNAs (miRNAs), a class of endogenous small RNAs with lengths of approximately 19-24 nucleotides, play important regulatory roles in cells. In recent years, miR-363 has emerged as a prominent member of the miR-92a family, participating in various biological functions, including cellular proliferation, cycle, migration, and apoptosis. In particular, miR-363 plays a critical role in acute kidney injury, renal fibrosis, and diabetic nephropathy and can serve as a biomarker for the diagnosis of renal cell carcinoma.

Risk Factors and a Prediction Model for Hemorrhagic Transformation in Acute Ischemic Stroke With Atrial Fibrillation.

Objectives: To identify the risk factors of hemorrhagic transformation (HT) and to establish a prediction model for HT in patients with acute ischemic stroke (AIS) and atrial fibrillation (AF).

Methods: From January 2015 to December 2018, patients with AIS and AF were enrolled. Demographics, lesion features, and blood test results were collected.

Exploring aggressive emotions in women in prison: the role of empathy and perceived social support in moderating the effects of childhood discrimination experiences.

Background: The recent increase in the population of women in prison within the societal context of China has shifted attention towards understanding the unique psychological and social dynamics distinct from those traditionally associated with man offenders. Growing evidence suggests that childhood experiences of discrimination play a crucial role in shaping the aggressive behaviors observed among women in prison. This underscores the necessity for an in-depth examination of the psychological and societal foundations of these behaviors.

Gap plasmonic properties of NPOM structures composed of gold nanoparticles and thin films.

Metal nanoparticles have attracted great interest because of their unique near-field enhancement properties, and have important applications in many fields, such as surface-enhanced Raman scattering (SERS), fluorescence enhancement, solar cell efficiency enhancement and so on. In this paper, we use the finite element method to study the local field enhancement characteristics of the coupling system in which the gold ellipsoidal nanoparticles (GENP) on a mirror. In the coupling system, a hot spot will be formed at the gap between the GENP and the mirror under the appropriate incident light excitation.

Effect of Co Irradiation on Boehmite Dissolution in Caustic Solutions.

Here, we examine how radiation impacts the dissolution behavior of boehmite by subjecting dry nanoparticles of different sizes to Co γ radiation and subsequently analyzing their dissolution behavior in caustic solutions as a function of temperature. The measured kinetics show that irradiation with an amount 228.24 Mrad significantly slows the dissolution rate, particularly for smaller sizes at lower temperatures.

Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study.

Background: Whether blood lipids are causally associated with colorectal cancer (CRC) risk remains unclear.

Methods: Using two-sample Mendelian randomisation (MR), our study examined the associations of genetically-predicted blood concentrations of lipids and lipoproteins (primary: LDL-C, HDL-C, triglycerides, and total cholesterol), and genetically-proxied inhibition of HMGCR, NPC1L1, and PCSK9 (which mimic therapeutic effects of LDL-lowering drugs), with risks of CRC and its subsites. Genetic associations with lipids were obtained from the Global Lipids Genetics Consortium (n = 1,320,016), while genetic associations with CRC were obtained from the largest existing CRC consortium (n = 58,221 cases and 67,694 controls).

Interplay analysis of lead exposure with key cardiovascular gene polymorphisms on blood pressure in a cross-sectional study of occupational workers.

An increasing number of studies have shown that lead is an important cardiovascular risk factor, but the impact of cardiovascular related gene polymorphisms on lead induced cardiovascular diseases is still unclear. To assess the interaction of lead exposure and related key cardiovascular regulating gene polymorphisms on blood pressure traits, three single-nucleotide polymorphisms including NOTCH1 rs3124591, Cerebral cavernous malformations 3 (CCM3) rs3804610 and Vascular endothelial growth factor receptor type 2 (VEGFR2) rs2305948 were selected and genotyped using improved multiplex ligase detection reaction method in 568 lead exposure workers in South China. General characteristics, blood lead and biochemical parameters including glucose, lipid profile and creatinine were also collected according to standard protocols.

Regression Trees With Fused Leaves.

We propose a novel regression tree method named "TreeFuL," an abbreviation for 'Tree with Fused Leaves.' TreeFuL innovatively combines recursive partitioning with fused regularization, offering a distinct approach to the conventional pruning method. One of TreeFuL's noteworthy advantages is its capacity for cross-validated amalgamation of non-neighboring terminal nodes.