Psoralen accelerates osteogenic differentiation of human bone marrow mesenchymal stem cells by activating the TGF-β/Smad3 pathway.

Psoralen, one of the active ingredients in , has been previously reported to regulate the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). A previous study revealed that psoralen can regulate the expression levels of microRNA-488 and runt-related transcription factor 2 (Runx2) to promote the osteogenic differentiation of BMSCs. However, the underlying signalling pathway in this process remains to be fully elucidated.

Curcumin inhibits the growth of liver cancer by impairing myeloid-derived suppressor cells in murine tumor tissues.

Curcumin, one of the active ingredients of (Jianghuang), has been reported to exert multiple bioactivities, including pro-apoptotic and anti-inflammatory activities. In recent years, curcumin has been extensively studied, and it has been revealed that curcumin inhibits the growth of numerous types of cancer. However, to the best of our knowledge, the inhibitory effects of curcumin on the activation or expansion of myeloid-derived suppressor cells (MDSCs) in liver cancer and the underlying mechanism have not yet been determined.

LC01 Regulates Intestinal Epithelial Permeability through miR-144 Targeting of OCLN and ZO1.

Our previous report determined that miR-144 is a key regulator of intestinal epithelial permeability in irritable bowel syndrome with diarrhea (IBS-D) rats. Recent evidence has shown that lactobacilli play an important role in the relief of IBS-D symptoms. However, few studies have addressed the mechanisms by which microRNAs and lactobacilli exert their beneficial effects on intestinal epithelial permeability.

Graphene oxide/polydimethylsiloxane composite sponge for removing Pb(ii) from water.

An efficient adsorbent to remove Pb(ii) from water was prepared by treating polydimethylsiloxane (PDMS) sponge with polyvinyl alcohol and then coating the sponge with graphene oxide (GO). The GO-PDMS sponge was highly hydrophilic, easily handled during and after use, and easily recycled. The kinetics and isotherms of Pb(ii) sorption onto the GO-PDMS sponge were investigated by performing batch sorption tests.

Tong-Xie-Yao-Fang improves intestinal permeability in diarrhoea-predominant irritable bowel syndrome rats by inhibiting the NF-κB and notch signalling pathways.

Background: Tong-Xie-Yao-Fang (TXYF) has been shown to be effective in diarrhoea-predominant irritable bowel syndrome (IBS-D) patients. However, the underlying mechanism remains to be clarified. The aim of this study was to investigate the efficacy and related mechanisms of TXYF in an IBS-D rat model.

Relationship between long-term use of proton pump inhibitors and risk of gastric cancer: A systematic analysis.

Background And Aim: This study aims to systematically analyze the effect of long-term therapy with proton pump inhibitors (PPIs) on the risk of gastric cancer.

Methods: PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and China biomedical literature database (CBM) were searched for studies before February 2019. We evaluated the quality of the included articles through the Newcastle-Ottawa Scale and gathered relevant data to calculate the pooled odds ratio (OR) through Stata14.

A novel "signal-on" photoelectrochemical sensor for ultrasensitive detection of alkaline phosphatase activity based on a TiO/g-CN heterojunction.

The use of alkaline phosphatase (ALP) as a biomarker in some diseases including hepatitis, obstructive jaundice, osteoblastic bone cancer, and osteomalacia is important in clinical diagnosis. Furthermore, ALP activity detection is an essential hot topic in environmental monitoring, biomedical research, and other research fields. In this study, a novel "signal-on" photoelectrochemical (PEC) biosensor based on the ALP-catalyzed phosphorylation reaction was designed to sensitively detect ALP activity.

Corrosion protection for mild steel by extract from the waste of lychee fruit in HCl solution: Experimental and theoretical studies.

Various experimental conditions were tested for the green extract process of corrosion inhibitor from lychee fruit waste, and the optimal extract parameters were selected using potentiodynamic polarization. The best inhibition effect of the ethanol extract of lychee's peel and seed by ultrasound for 1.5 h (EELPS) for mild steel in 0.

Longan seed and peel as environmentally friendly corrosion inhibitor for mild steel in acid solution: Experimental and theoretical studies.

Longan seed and peel were extracted and used for impeding the corrosion of mild steel in hydrochloric acid solution. Experimental analyses indicate that the water extract of Longan's seed and peel, a mixed type inhibitor, can be chemically adsorbed onto the steel surface, and its inhibition effect rises with increasing extract concentration. To understand the adsorption mechanism and the contributions of the four main compounds of the extract to corrosion protection effect, quantum chemical methods and infrared spectrum were also employed.

Application of a cosmetic additive as an eco-friendly inhibitor for mild steel corrosion in HCl solution.

The use of the cosmetic ingredient cocamidopropylamine oxide (CAO) to inhibit the corrosion of steel in 0.5mol/LHCl is investigated. Electrochemical and weight loss methods were used to evaluate the inhibiting effect of CAO and the influences of inhibitor concentration and temperature were determined.

Inhibition of TNF-α/IFN-γ induced RANTES expression in HaCaT cell by naringin.

Context: Naringin is a bioflavonoid derivative and is predominantly found in Citrus paradisi Macf., Citrus sinensis (Linn.) Osbeck, Citrus unshiu Marc.

NMR spectral assignments of two sterols from a soft coral Sinularia brassica.

Two new steroids, named 4α,22-dimethyl-Cholest-22-en-3β-ol (1) and 4α-methyl-Cholest-7,22-dien-3β-ol (2), along with two known steroids, were isolated from the soft coral Sinularia brassica. The structures of the new compounds were determined on the basis of extensive spectroscopic data (MS, (1)H and (13)C NMR, (1)H-(1)H COSY, (13)C-(1)H COSY, HMBC and NOESY) analysis.

Effects of acitretin on proliferative inhibition and RANTES production of HaCaT cells.

Acitretin is one of the first line drugs to treat psoriasis, though the mechanisms are not fully clear. It has been reported that psoriatic keratinocytes secreted high level of RANTES, which can induce chemotaxis and activation of T cells, thus may play an important role in the pathogenesis of psoriasis. However, the effect of acitretin on RANTES production of human keratinocytes and its possible signaling are unclear.