Publications by authors named "Liu Laixin"
The serotonergic system plays important roles in both physiological and pathological processes, and is a therapeutic target for many psychiatric disorders. Although several genetically encoded GFP-based serotonin (5-HT) sensors were recently developed, their sensitivities and spectral profiles are relatively limited. To overcome these limitations, we optimized green fluorescent G-protein-coupled receptor (GPCR)-activation-based 5-HT (GRAB) sensors and developed a red fluorescent GRAB sensor.
View Article and Find Full Text PDFObjective: To investigate injury trends, injury distribution, and disease burden from three surveillance hospitals in Urumqi from 2006 to 2018.
Method: Injury data from the National Injury Surveillance System (NISS) from three hospitals in Urumqi (2006 to 2018) were collected to analyze changes in the characteristics of outpatient injury cases. Years of potential life lost (YPLL) were calculated to determine the disease burden of the injury cases.
Natural polybrominated diphenyl ethers, often isolated from marine sponges, have been reported to possess various biological activities, such as antibacterial, antioxidant and antidiabetic effects. Via a high throughput screening of our marine natural product library, the polybrominated diphenyl ether 3 was found to display a KCNQ potassium channel activation effect. To obtain more compound 3 related natural products and their derivatives for further bioactivity study, a diversity-oriented synthesis was conducted, leading to the successful synthesis of five polybrominated diphenyl ether natural products (1-4, 6) and 30 new derivatives.
View Article and Find Full Text PDFBackground: A recent community-based disease management (CBDM) pilot study reported a 20.5% prevalence of hypertension and a 0.5 and 3.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to assess the prevalence of central obesity among various gender and age groups within the floating population working in five locations in Xinjiang Uygur Autonomous Region.
- A total of 1491 participants over 18 were surveyed using structured questionnaires and measurements of height, weight, and waist circumference were taken.
- Findings revealed that 25.62% of the floating population had central obesity, with the highest rates found in the 50-59 age group (45.63%) and among those with obesity based on BMI (86.15%), indicating these groups require targeted health intervention.