Symmetrical peripheral gangrene caused by urosepsis: Case reports and literature review.

Rationale: Symmetrical peripheral gangrene (SPG) is a serious and rare complication in patients with urosepsis, characterized by distal limb symmetry impairment.

Patient Concerns: In this study, 3 cases of SPG caused by urosepsis were reported, and the Chinese and English literature on SPG caused by urosepsis was reviewed. The demographic, clinicopathological, treatment, and follow-up data of the patients were summarized and analyzed.

Innovative strategies in genitourinary cancer: the role of oncolytic viruses.

Urinary tumors pose a significant health threat because of their high prevalence and recurrence rates. Despite the availability of various treatment options, many patients poorly respond to traditional therapies, highlighting the urgent need for alternative approaches. Oncolytic viruses are promising therapeutic agents.

Tuina Promotes Repair of Chronic Cervical Muscle Injury by Regulating Satellite Cell Proliferation and Differentiation and Inhibiting Myocyte Apoptosis.

Purpose: Chronic cervical muscle injury is the first common cause of the development of cervical spondylosis, and Tuina can effectively promote the repair of chronic cervical muscle injury and alleviate neck pain, but the mechanism behind its efficacy is still unknown. The proliferation and differentiation of muscle satellite cells and the apoptosis of cervical myocytes play important roles in the repair of chronic cervical muscle injuries; therefore, this study aimed to explore the potential mechanisms of Tuina to promote the repair of cervical muscle injuries in terms of the proliferation and differentiation of satellite cells and the apoptosis of myocytes.

Patients And Methods: Twenty-eight Wistar rats were randomly divided into control group, model group, Tuina group, and meloxicam group, with 7 rats in each group.

A Prospective Comparative Study on the Clinical Diagnostic Performance of Blood Inflammatory Markers in Acute Appendicitis.

Objective: Despite the substantial advancements in imaging techniques for the diagnosis and differential diagnosis of acute appendicitis (AA) over recent decades, the specificity and sensitivity of widely utilized laboratory biomarkers in clinical practice remain inadequate.This study aimed to investigate the diagnostic utility of commonly employed blood inflammatory markers for AA.

Methods: A total of 399 participants who either sought medical care or underwent health examinations were enrolled in this prospective study.

On the acceptance, commissioning, and quality assurance of electron FLASH units.

Background And Purpose: FLASH or ultra-high dose rate (UHDR) radiation therapy (RT) has gained attention in recent years for its ability to spare normal tissues relative to conventional dose rate (CDR) RT in various preclinical trials. However, clinical implementation of this promising treatment option has been limited because of the lack of availability of accelerators capable of delivering UHDR RT. Commercial options are finally reaching the market that produce electron beams with average dose rates of up to 1000 Gy/s.

Intranasal immunization with poly I:C and CpG ODN adjuvants enhances the protective efficacy against Helicobacter pylori infection in mice.

Helicobacter pylori (H. pylori) infection is a serious public health issue, and development of vaccines is a desirable preventive strategy for H. pylori.

Biofortification of flavonoids in nuts along the agro-food chain for improved nutritional and health benefits, a comprehensive review and future prespectives.

Flavonoids are found ubiquitous in dietary sources with potential antioxidant properties, and have received widespread attention for their health benefits. Nuts, rich in flavonoids, are popular among consumers for their crunchy flavor and nutritious content. The review summarizes studies pertaining to the diverse types and distribution of flavonoids in nuts, their potential health benefits, as well as management strategies for flavonoids accumulation and enhancement across the whole agro-food chain, including the selection of nut varieties, the suitable growing conditions, the optimal harvesting period of nuts, and appropriate post-harvest measures, such as chemical conditioning, ideal storage conditions, and post-harvest processing methods.

Artemisitene induces apoptosis of breast cancer cells by targeting FDFT1 and inhibits the growth of breast cancer patient-derived organoids.

Artemisitene (ATT) is a natural bioactive compound with anti-breast cancer activity. However, the direct target and clinical efficacy of ATT on breast cancer are still unclear. The current study aimed to identify the target protein and underlying mechanism of ATT in anti-breast cancer.

Conjugated Polymers Based on Carbazole and Tridentate Ligands as the "On-Off-On" Fluorescent Probes for Detection of Ni (II) Ion and Lysine.

Two novel conjugated polymers (polymer 1 and polymer 2) containing trisheterocyclic systems and carbazole as the copolymerization unit were synthesized by the Suzuki coupling reaction and characterized using NMR spectroscopy and other methods. 4'-(3,5-Dibromophenyl)-2,2':6',2''-terpyridine and 2,2'-(4-(3,5-dibromophenyl)pyridine-2,6-diyl)dithiazole were used as the recognizing units of the two polymers respectively. The polymers show blue-violet fluorescence when dissolved in THF.

Motion Control System for USV Target Point Convergence.

The goal of this paper is to establish a motion control system for unmanned surface vehicles (USVs) that enables point-to-point tracking and dynamic positioning. This includes the heading control and path following control of USVs. A hardware and software platform for USVs using microcontrollers is designed.

Biomimetic Modular Honeycomb with Enhanced Crushing Strength and Flexible Customizability.

The integration of biomimetic principles into the sophisticated design of honeycomb structures has gained significant traction. Inspired by the natural reinforcement mechanisms observed in tree stems, this research introduces localized thickening to the conventional honeycombs, leading to the development of variable-density honeycomb blocks. These blocks are strategically configured to form modular honeycombs.

Bis(2-butoxyethyl) Ether-Promoted O-Mediated Oxidation of Alkyl Aromatics to Ketones under Clean Conditions.

Conventional oxidation processes for alkyl aromatics to ketones employ oxidants that tend to generate harmful byproducts and cause severe equipment corrosion, ultimately creating critical environmental problems. Thus, in this study, a practical, efficient, and green method was developed for the synthesis of aromatic ketones by applying a bis(2-butoxyethyl) ether/O system under external catalyst-, additive-, and base-free conditions. This O-mediated oxidation system can tolerate various functional groups and is suitable for large-scale synthesis.

CaARP1/CaSGT1 Module Regulates Vegetative Growth and Defense Response of Pepper Plants against .

Pepper ( L.) suffers severe quality and yield loss from oomycete diseases caused by . CaSGT1 was previously determined to positively regulate the immune response of pepper plants against , but by which mechanism remains elusive.

Role of IL3RA in a Family with Lumbar Spinal Stenosis.

Lumbar spinal stenosis (LSS) is a degenerative spinal condition characterized by the narrowing of the spinal canal, resulting in low back pain (LBP) and limited leg mobility. Twin and family studies have suggested that genetics contributes to disease progression. However, the genetic causes of familial LSS remain unclear.

A review of current developments in RNA modifications in lung cancer.

Lung cancer has the highest incidence and mortality rates worldwide and is the primary cause of cancer-related death. Despite the rapid development of diagnostic methods and targeted drugs in recent years, many lung cancer patients do not benefit from effective therapies. The emergence of drug resistance has led to a reduction in the therapeutic effectiveness of targeted drugs, highlighting a crucial need to explore novel therapeutic targets.

Prevalence of medication overload among older people with HIV: a MedSafer study.

Background: Older people with HIV (PWH) are at risk of polypharmacy (taking multiple medications). Most medications may be necessary and indicated to manage HIV (e.g.

Effects of meteorological factors on tuberculosis and potential modifiers in Zhejiang Province, China.

Although some studies have explored the role of meteorological factors in the development of tuberculosis (TB), the majority have been confined to single regions, leading to inconsistent findings. Consequently, we conducted a multi-city study not only to determine whether meteorological factors significantly influence the risk of developing TB but also to assess the magnitude of these effects and explore potential modifying factors. Data on daily reported TB cases and meteorological factors were collected from January 1, 2013, to December 31, 2022, across 11 cities in Zhejiang Province.

Chiral plasmonic-dielectric coupling enables strong near-infrared chiroptical responses from helicoidal core-shell nanoparticles.

Helicoid plasmonic nanoparticles with intrinsic chirality are an emerging class of artificial chiral materials with tailorable properties. The ability to extend their chiroplasmonic responses to the near-infrared (NIR) range is critically important for biomedical and nanophotonic applications, yet the rational design of such materials remains challenging. Herein, a strategy employing chiral plasmon-dielectric coupling is proposed to manipulate the chiroptical responses into the NIR region with high optical anisotropy.

Application of deep learning reconstruction in abdominal magnetic resonance cholangiopancreatography for image quality improvement and acquisition time reduction.

Purpose: To compare deep learning (DL)-based and conventional reconstruction through subjective and objective analysis and ascertain whether DL-based reconstruction improves the quality and acquisition speed of clinical abdominal magnetic resonance imaging (MRI).

Methods: The 124 patients who underwent abdominal MRI between January and July 2021 were retrospectively studied. For each patient, two-dimensional axial T-weighted single-shot fast spin-echo MRI images with or without fat saturation were reconstructed using DL-based and conventional methods.

Alleviation effect of lutein Pickering emulsion formed by casein-dextran conjugates through Maillard reaction against blue light retinal degeneration.

With the increasing prevalence of electronic devices, awareness of the risks linked to blue light exposure has significantly heightened. Lutein, a powerful antioxidant, safeguards eye tissue by filtering blue light, while supplementation with docosahexaenoic acid (DHA) enhances retinal function. Adequate intake of these nutrients can help reduce the potential damage from prolonged blue light exposure.