Evaluating optimal rehabilitation strategies in ICU: study protocol for a multicentre cohort study to assess Physical Activity dosing, Muscle mass, and physICal outcomeS (IPAMICS study).

Background: Many patients who get discharged from the intensive care unit experience physical dysfunction that persists even after discharge. Physical dysfunction is associated with skeletal muscle atrophy and accompanying intensive care unit-acquired weakness in the early stages of intensive care unit admission, and early diagnosis and prevention with early mobilization are crucial. However, the amount of physical activity required for early mobilization remains controversial in critically ill patients.

Association between serum calcium level and the risk of acute kidney injury in ICU patients with subarachnoid hemorrhage: a retrospective cohort study.

Aim: This study aimed to evaluate the association between serum calcium level and the risk of acute kidney injury (AKI) in patients with subarachnoid hemorrhage (SAH).

Methods: In this retrospective cohort study, data on adults from the Medical Information Mart for Intensive Care (MIMIC-III and MIMIC-IV) databases, spanning from 2008 to 2019, were extracted. In the logistic regression models, confounding variables, including age, white blood cell (WBC), systolic blood pressure (SBP), heart rate, blood urea nitrogen (BUN), glucose, international normalized ratio (INR), and the Charlson Comorbidity Index (CCI), were finally adjusted by stepwise regression.

Case report: Brain infarction following percutaneous drainage of a liver abscess post-chemotherapy for pancreatic head cancer.

Bacterial liver abscesses commonly occur in patients with immune deficiencies such as diabetes, post-chemotherapy, or post-immunosuppressive therapy. The recommended treatment for liver abscesses exceeding 5 cm in a diameter is anti-infection therapy combined with percutaneous catheter drainage. Complications may include local spread to adjacent tissues or organs and thrombosis of the liver and portal veins.

Use of biochar derived from Spartina alterniflora to reduce sediment methane (CH) production potential during non-farming period in earthen aquaculture ponds.

Biochar has been proposed as an effective material for mitigating greenhouse gas emissions from farmlands, but comparable information for earthen aquaculture ponds is limited. A field study was conducted to investigate the effects of adding biochar (200-1600 kg ha) derived from the invasive plant Spartina alterniflora on sediment physico-chemical properties, CH production potential (P), and the relevant functional gene abundances in earthen aquaculture ponds during the non-farming period. The results indicated that biochar treatments increased sediment porosity and salinity, while decreasing dissolved organic carbon and microbial biomass carbon.

LRP4 mutations promote tumour progression and resistance to anti-PD-1 therapy in recurrent hepatocellular carcinoma.

Background And Aims: Hepatocellular carcinoma (HCC) recurrence is a major factor limiting long-time survival and the cause of most deaths in patients with HCC. However, molecular characterisation and potential therapeutic targets of recurrent HCC remain mostly unknown.

Approach And Results: We performed whole-exome sequencing (WES) in 63 matched primary and recurrent HCC tumours and combined the data with whole-genome sequencing (WGS) results in 43 paired samples from our previous study.

Fabrication of Nano Copper Highly Conductive and Flexible Printed Electronics by Direct Ink Writing.

Nanoscale metals have emerged as crucial materials for conductive inks in printed electronics due to their unique physical and chemical properties. However, the synthesis of high-precision and highly conductive copper ink remains a challenge. Herein, a high-precision, highly conductive, and oxidation-resistant nanocopper ink was synthesized to fabricate highly conductive and flexible printed electronic devices.

Photoimmunologic Therapy of Stubborn Biofilm via Inhibiting Bacteria Revival and Preventing Reinfection.

Stubborn biofilm infections pose serious threats to public health. Clinical practices highly rely on mechanical debridement and antibiotics, which often fail and lead to persistent and recurrent infections. The main culprits are 1) persistent bacteria reviving, colonizing, and rejuvenating biofilms, and 2) secondary pathogen exposure, particularly in individuals with chronic diseases.

Hypoalbuminemia and cisplatin-induced acute kidney injury.

Background: Cisplatin binds to serum albumin in the body at a rate of 90%, and high levels of free cisplatin are a significant cause of its nephrotoxicity. Therefore, hypoalbuminemia theoretically poses a significant risk factor for cisplatin-induced acute kidney injury (CIA) and can be easily corrected. However, existing research results are inconsistent.

New eye tracking metrics system: the value in early diagnosis of autism spectrum disorder.

Background: Eye tracking (ET) is emerging as a promising early and objective screening method for autism spectrum disorders (ASD), but it requires more reliable metrics with enhanced sensitivity and specificity for clinical use.

Methods: This study introduces a suite of novel ET metrics: Area of Interest (AOI) Switch Counts (ASC), Favorable AOI Shifts (FAS) along self-determined pathways, and AOI Vacancy Counts (AVC), applied to toddlers and preschoolers diagnosed with ASD. The correlation between these new ET metrics and Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) scores via linear regression and sensitivity and specificity of the cut-off scores were assessed to predict diagnosis.

SPP1-ITGα5/β1 Accelerates Calcification of Nucleus Pulposus Cells by Inhibiting Mitophagy via Ubiquitin-Dependent PINK1/PARKIN Pathway Blockade.

Low back pain (LBP) caused by nucleus pulposus degeneration and calcification leads to great economic and social burden worldwide. Unexpectedly, no previous studies have demonstrated the association and the underlying mechanism between nucleus pulposus tissue degeneration and calcification formation. Secreted Phosphoprotein 1 (SPP1) exerts crucial functions in bone matrix mineralization and calcium deposition.

Optimizing bone transport strategies: a pixel value ratio-based evaluation of regeneration rates in bifocal and trifocal techniques.

Background: Bone transport techniques are crucial for managing large bone defects, but the optimal approach for different defect lengths remains unclear. This study aimed to compare bone regeneration rates between short bifocal bone transport (SBBT), long bifocal bone transport (LBBT), and trifocal bone transport (TBT) using pixel value ratio (PVR) as an objective quantitative measure.

Methods: This retrospective study included 60 patients undergoing lower limb bone transport, divided into SBBT ( = 22, defects <6 cm), LBBT ( = 20, defects ≥6 cm), and TBT ( = 18, defects ≥6 cm) groups.

Characterizing the antibody response to amustaline/glutathione pathogen-reduced red blood cells.

Background: The clinical significance of natural and treatment-emergent antibodies specific for amustaline/glutathione pathogen-reduced red blood cells (PRRBCs) is not known.

Study Design And Methods: A Phase 3, randomized clinical trial of PRRBCs (ReCePI) compared PRRBCs with conventional RBCs in cardiac or thoracic-aorta surgery. Subjects transfused during and for 7 days after surgery were screened for PRRBC-specific antibodies at baseline, 28 and 75 days post-surgery.

[Comparison of clinical efficacy between autologous block bone graft and GBR in horizontal bone augmentation based on Mimics 3D reconstruction].

Purpose: To compare the clinical efficacy of autologous bone block graft and guided bone regeneration (GBR) in horizontal bone augmentation.

Methods: A total of 42 patients were included and divided into two groups. Group A included 20 patients, in whom autologous bone block graft was performed.

Interventions to enhance the core competencies of clinical nursing preceptors: a protocol for a systematic review.

Introduction: Clinical nursing preceptors (CNPs) teach nursing skills to students in real medical scenarios and develop their professionalism. The adequacy of CNPs' teaching competencies affects the effectiveness of student learning, so it is crucial to seek the best evidence for teaching competency interventions. This report describes a protocol for a systematic review to identify and analyse interventions to enhance the teaching competencies of CNPs.

colonic fermentation of fermented Radix Astragali by and anti-hyperuricemia mechanism based on network pharmacology and experiment verification.

Aim: This research aimed to probe the effects of fecal microbiota and on the metabolism of Radix Astragali (RA) and solid fermenting Radix Astragali (FRA). It further explores pharmacological effects of RA, , and FRA on HUA mouse model and the mechanisms in HUA treatment.

Methods: Fecal microbiota and were used to ferment FRA and RA in vitro to probe the impacts of microbiota on the metabolism of active compound.

Unraveling the causal pathways of maternal smoking and breastfeeding in the development of neuropsychiatric disorders: A Mendelian randomization perspective.

Background: Maternal smoking around birth (MSAB) and early-life breastfeeding (BAB) represent critical factors that may exert enduring effects on neuropsychiatric health. Although previous research has examined these exposures separately, the combined impact of both on disorders such as ADHD, ASD, BD, MDD, ANX, and SCZ remains unclear. This study aims to evaluate the causal relationships between MSAB and BAB and the risk of developing these neuropsychiatric disorders through Mendelian randomization (MR) analysis.

Blockade of PVN neuromedin B receptor alleviates inflammation via the RAS/ROS/NF-κB pathway in spontaneously hypertensive rats.

Neuromedin B (NMB) has potentially great impacts on the development of cardiovascular diseases by promoting hypertensive and sympatho-excitation effects. However, studies regarding the NMB function in paraventricular nucleus (PVN) are lacking. With selective neuromedin B receptor (NMBR) antagonist, BIM-23127, we aim to determine whether the blockade of NMB function in PVN could alleviate central inflammation and attenuate hypertensive responses.

Integrative analysis of the transcriptome, proteomics and metabolomics reveals key genes involved in the regulation of breast muscle metabolites in capons.

Castration is widely used in poultry and livestock to enhance fat metabolism and improve the flavor, tenderness and juiciness of meat. However, the genetic regulatory mechanism underlying castration consequences have not been clarified. To investigate the key metabolites affecting the quality of capons and the key regulatory mechanisms, Qingyuan partridge roosters were subjected to castration.

Identification and expression analysis of TALE superfamily genes explore their key roles in response to abiotic stress in Brassica napus.

Background: The three-amino-acid-loop-extension (TALE) superfamily genes are broadly present in plants and play important roles in plant growth, development, and abiotic stress responses. So far, the TALE family in B.napus have not been systematically studied, especially their potential roles in response to abiotic stress.

Efficient Output and Stability Triboelectric Materials Enabled by High Deep Trap Density.

With the increasing global focus on sustainable materials, paper is favored for its biodegradability and low cost. Their integration with triboelectric nanogenerators (TENGs) establishes broad prospects for self-powered, paper-based triboelectric materials. However, these materials inherently lack efficient charge storage structures, leading to rapid charge dissipation.

Charge Manipulation of Porous Coordination Cages Tunes the Efficiency and Selectivity in Electrochemical Synthesis.

Electrocatalytic synthesis of high-value chemicals has been attracting growing interest owing to its environmentally benign reaction pathways. Among these processes, the electrocatalytic reduction of nitrate (NO3-) to ammonia (NH3), known as NO3RR, and the oxidation of 5-hydroxymethylfurfural (HMFOR) stand out as two cornerstone reactions; yet, their efficiency and selectivity pose ongoing challenges. In this study, we introduce a charge manipulation approach for the design of highly efficient electrocatalysts tailored for the simultaneous coupling of NO3RR and HMFOR.

Photosynthesis of H2O2 using Phenothiazine-Based Covalent-Organic Frameworks Mimicking Coenzyme Q.

Mimicking natural enzymes through artificial enzyme engineering represents a powerful strategy to fine-tune the performance of photocatalysts, while the manipulation of electron transfer systems through atomic precision control is challenging. Herein, we reported a series of covalent organic frameworks (COFs) based on progressively oxidized phenothiazine (PTH) core as the platform for emulating Coenzyme Q, achieved through meticulous stepwise adjustments of their redox states. Compared to the original PTH-S-COF, the COFs with incrementally oxidized sulfur sites exhibited enhanced charge transfer efficiencies, facilitating efficient electron donation to O2 and thereby providing a favorable pathway for H2O2 synthesis.

Excited-State Engineering of Chalcogen-Bridged Chiral Molecules for Efficient OLEDs with Diverse Luminescence Mechanisms.

The exploration of circularly polarized luminescence is important for advancing display and lighting technologies. Herein, by utilizing isomeric molecular engineering, a novel series of chiral molecules are designed to exploit both thermally activated delayed fluorescence (TADF) and room-temperature phosphorescence (RTP) mechanisms for efficient luminescence. The cooperation of a small singlet-triplet energy gap, moderate spin-orbital coupling (SOC), and large oscillator strength enables efficient TADF emission, with photoluminescence quantum yields exceeding 90%.

Modernizing histopathological analysis: a fully automated workflow for the digital image analysis of the intestinal microcolony survival assay.

Background: Manual analysis of histopathological images is often not only time-consuming and painstaking but also prone to error from subjective evaluation criteria and human error. To address these issues, we created a fully automated workflow to enumerate jejunal crypts in a microcolony survival assay to quantify gastrointestinal damage from radiation.

Methods And Materials: After abdominal irradiation of mice, jejuna were obtained and prepared on histopathologic slides, and crypts were counted manually by trained individuals.