Publications by authors named "Liu Jie-Xiao"
Introduction: We investigated the effect of defibrase (a proteolytic enzyme extraction of Agkistrodon halys venom) on experimental autoimmune myositis (EAM) in guinea pigs and explored the option of using a modified pig model of EAM to enhance the study of this disease.
Material And Methods: Guinea pigs were divided into 3 groups: group A (control group) was immunized with complete Freund adjuvant (CFA), then received 6 injections of saline weekly; group B (EAM group) was immunized with partially purified rabbit myosin emulsified with CFA, then received an injection of saline; group C (EAM + defibrase group) was immunized with purified rabbit myosin emulsified with CFA, then received an injection of defibrase. The animals were observed for their general health condition and the body weight was measured daily.
[Regulatory T cells in the treatment of autoimmune myositis in mice: efficacy and mechanism].
Nan Fang Yi Ke Da Xue Xue Bao
April 2015
Objective: To investigate effect of CD4(+) CD25(+) Foxp3(+) Tregs in the treatment of autoimmune myositis (EAM) in mice and explore the possible mechanisms.
Methods: Mouse models of EAM were divided randomly into model group and treatment group, and the latter received infusion of CD4(+) CD25(+) Foxp3(+) Tregs separated from normal mouse spleen by magnetic activated cell sorting. The changes of muscle pathology was observed, and the expression of PD-1 and CTLA-4 in spleen CD4(+) CD25(+) Foxp3(+) Tregs was analyzed using flow cytometry; peripheral blood IL-10 and TGF-β levels were tested using double antibody sandwich ELISA.
Nemaline myopathy (NM) is a rare congenital myopathy of great heterogeneity, characterized by the presence of rods in the cytoplasm of muscle fibers. This study aimed to summarize and analyze retrospectively the clinicopathological features of 28 patients with NM. Among the 28 patients, 15 were classified as of the typical congenital type, manifested as lower- or four-limb weakness as the first symptom and slowly progressive course.
View Article and Find Full Text PDFObjective: The purpose of this study was to evaluate the electrophysiological characteristics of polyneuropathy in POEMS syndrome.
Methods: A total 46 patients with POEMS syndrome and 46 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) were included in this study. Six nerve conduction parameters including (1) motor conduction velocity, distal compound muscle action potential; (2) conduction block and temporal dispersion; (3) motor distal latency; (4) F wave; and (5) sensory conduction velocity were reviewed for the subjects in both POEMS and CIDP groups.
Objective: To compare the clinical, pathological, laboratory test and follow-up data between familial and sporadic patients with distal myopathy with rimmed vacuoles (DMRV) and discuss the characteristics of this disorder in Chinese population.
Methods: The clinical and pathological features, laboratory data and follow-up results of 33 sporadic and 4 familial cases of pathologically confirmed DMRV were summarized and compared retrospectively.
Results: The patients age, onset age, or disease duration showed no significant difference between sporadic and familial cases; the onset pattern and affected muscle groups were also similar, but the sporadic cases showed more frequent dysmorphic features than the familial cases.
[MyoD mRNA expression in skeletal muscle of patients with myotonic dystrophy].
Zhonghua Yi Xue Za Zhi
February 2009
Objective: To explore the mRNA expression of MyoD gene in the skeletal muscles of myotonic dystrophy (MD) patients.
Methods: Muscle biopsy specimens were obtained from the biceps muscles of arm of 4 MD patients and 4 healthy controls. Semi-quantitative reverse transcription polymerase chain reaction was performed to evaluate the mRNA expression of MyoD in the specimens.