Potential bacterial resources for bioremediation of organochlorine pesticides and flame retardants recognized from forest soil across China.

Microbe-mediated remediation becomes a desire method for removal of persistent organic pollutants (POPs) due to its eco-friendly and sustainable nature. The improvement of practical feasibility requires constructing comprehensive species pool, while it is still limited by the rapid recognition of potential bacterial resources from environment. Here, based on the relative abundances of bacterial OTUs and pollutant concentrations, we established indexes to assess their tolerance to organochlorine pesticides (OCPs) and flame retardants (FRs) that are atmospheric transported and naturally accumulated in forest soil via forest filter effect.

Measuring Attractive Interaction between a Self-Electrophoretic Micromotor and a Wall.

Chemically driven micromotors exhibit a pronounced affinity for nearby surfaces, yet the quantification of this motor-wall interaction strength remains unexplored in experiments. Here, we apply an external force to a self-electrophoretic micromotor which slides along a wall and measures the force necessary to disengage the motor from the wall. Our experiments unveil that the required disengaging force increases with the strength of chemical driving, often surpassing both the motor's effective gravity and its propulsive thrust.

Identification and dissection of prostate cancer grounded on fatty acid metabolism-correlative features for predicting prognosis and assisting immunotherapy.

Background: Fatty acid metabolism (FAM) plays a critical role in tumor progression and therapeutic resistance by enhancing lipid biosynthesis, storage, and catabolism. Dysregulated FAM is a hallmark of prostate cancer (PCa), enabling cancer cells to adapt to extracellular signals and metabolic changes, with the tumor microenvironment (TME) playing a key role. However, the prognostic significance of FAM in PCa remains unexplored.

Fiber optics-based surface enhanced Raman Spectroscopy sensors for rapid multiplex detection of foodborne pathogens in raw poultry.

A new high-sensitivity, low-cost, Surface Enhanced Raman Spectroscopy (SERS) sensor allows for the rapid multiplex detection of foodborne pathogens in raw poultry. Self-assembled microspheres are used to pattern a hexagonal close-packed array of nanoantennas onto a side-polished multimode fiber core. Each microsphere focuses UV radiation to a photonic nanojet within a layer of photoresist on the fiber which allows the nanoantenna geometry to be controlled.

Study on visual matching cognition of automobile interior and exterior.

This work aims to study the visual matching cognition of people with different professional backgrounds for automobile interiors and exteriors, using gasoline-powered automobiles and electric automobiles as the research objects. First, three classes of automobiles, B-class, C-class, and sport-type class automobiles, of different brands, with large differences in styling and styles, were taken as the experimental sample sources, and high-definition interior and exterior pictures of the two power types of automobiles were randomly selected as the experimental samples. The participants were then divided into expert and general user groups according to their professional background.

Large Band Splitting in g-Wave Altermagnet CrSb.

Altermagnetism (AM), a newly discovered magnetic state, ingeniously integrates the properties of ferromagnetism and antiferromagnetism, representing a significant breakthrough in the field of magnetic materials. Despite experimental verification of some typical AM materials, such as MnTe and MnTe_{2}, the pursuit of AM materials that feature larger spin splitting and higher transition temperature is still essential. Here, our research focuses on CrSb, which possesses Néel temperature of up to 700 K and giant spin splitting near the Fermi level (E_{F}).

Evaluation of cross-protection of a reduced-dose PRRS MLV vaccine against the NADC30-like PRRSV challenge.

Introduction: At present, the NADC30-like strain has become the prevalent strain of PRRSV in China. Many studies have found that existing commercial vaccines are ineffective or provide only limited protection. No study has investigated the cross-protection of different dosages of commercial MLV vaccines against NADC30-like PRRSV.

Mechanical Activation of cPLA2 Impedes Fatty Acid β-Oxidation in Vein Grafts.

High-magnitude cyclic stretch from arterial blood pressure significantly contributes to the excessive proliferation and migration of vascular smooth muscle cells (VSMCs), leading to neointima formation in vein grafts. However, the molecular mechanisms remain unclear. This study highlights the critical role of cytosolic Phospholipase A2 (cPLA2)/ Yin Yang 1 (YY1)/ carnitine palmitoyltransferase 1b (CPT1B) signaling in coordinating VSMC mechanical activation by inhibiting fatty acid β-oxidation.

Trim72 is a major host factor protecting against lethal Candida albicans infection.

Candida albicans is the most common aetiologic pathogen of fungal infections associated with high mortality in immunocompromised patients. There is an urgent need to develop new antifungal therapies owing to the poor efficacy and resistance of current antifungals. Here, we report that Trim72 positively regulates antifungal immunity during lethal fungal infection.

Latent class analysis of loneliness and the influencing factors among school-age children: A cross-sectional survey.

Background: Children's loneliness has become an increasingly pervasive issue of public health due to the vulnerability of school-aged children. This study aims to identify latent classes of school-age children based on their exhibited symptoms of loneliness and explore the influencing factors.

Methods: A cross-sectional study was conducted from March to June 2023 in Shantou, China.

Enhancing time-resolution for radon measurements using airflow-through scintillation cells based on a compartmental model approach.

To overcome the time-resolution limitation inherent in the airflow-through scintillation cell method for radon measurement, this study introduces a compartmental model elucidating the behaviors of radon and its progeny within such cells. The computed results of the normalized equilibrium functions derived from the compartmental model, provide quantitative insights into the equilibrium progression of 222Rn and its progeny over time, substantiating the identified time-resolution limitation of 2-3 hours. Laboratory experiments confirm the efficacy of the proposed correction algorithm, showcasing its ability to surmount the time-resolution limitation and achieve a rapid response in radon measurement using airflow-through scintillation cells.

Enhanced gravitational trapping of bottom-heavy Janus particles over parallel microgrooves.

We report a systematic study on the barrier-crossing dynamics of bottom-heavy self-propelled particles (SPPs) over a one-dimensional periodic potential landscape (), which is fabricated on a microgroove-patterned polydimethylsiloxane (PDMS) substrate. From the measured steady-state probability density function (PDF) (;) of the SPPs with different self-propulsion forces , we find that the escape dynamics of slow-rotating SPPs over the periodic potential () can be well described by an activity-dependent potential (;) under the fixed angle approximation. A theoretical model is developed to include the effects of the gravitational-torque-induced alignment on the polar angle and the hydrodynamic wall alignment on the azimuthal angle as well as their influence on the self-propulsion speed .

Absence of Altermagnetic Spin Splitting Character in Rutile Oxide RuO_{2}.

Rutile RuO_{2} has been posited as a potential d-wave altermagnetism candidate, with a predicted significant spin splitting up to 1.4 eV. Despite accumulating theoretical predictions and transport measurements, direct spectroscopic observation of spin splitting has remained elusive.

Promise and challenges of traditional Chinese medicine, specifically , in liver cancer treatment.

Liver cancer, one of the most common malignancies worldwide, ranks sixth in incidence and third in mortality. Liver cancer treatment options are diverse, including surgical resection, liver transplantation, percutaneous ablation, transarterial chemoembolization, radiotherapy, chemotherapy, targeted therapy, immunotherapy, and traditional Chinese medicine (TCM). A multidisciplinary team (MDT) is essential to customize treatment plans based on tumor staging, liver function, and performance status (PS), ensuring individualized patient care.

Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability.

Background: Atheroprotective shear stress preserves endothelial barrier function, while atheroprone shear stress enhances endothelial permeability. Yet, the underlying mechanisms through which distinct flow patterns regulate EC integrity remain to be clarified. This study aimed to investigate the involvement of Kindlin-2, a key component of focal adhesion and endothelial adherens junctions crucial for regulating endothelial cell (EC) integrity and vascular stability.

Improving the Thrombocytopenia Adverse Reaction of Belinostat Using Human Serum Albumin Nanoparticles.

Background: Belinostat, a histone deacetylase inhibitor used for hematological cancer treatments, however, it caused thrombocytopenia, poor solubility, and rapid clearance. To mitigate these issues, human serum albumin (HSA) was utilized as the core material for its high protein binding affinity and self-binding capabilities. The study focused on developing belinostat-loaded HSA nanoparticles to improve solubility, extend circulation time, and reduce adverse effects.

Evolutionary and Expression Analyses of the Family in Tea Plants () and Functional Characterization of in Response to Environmental Stresses.

Basic leucine zipper (bZIP) transcription factors play crucial roles in various biological processes and responses to environmental stresses. However, the functions of the family in tea plants remain largely unexplored. Here, we identified 74 genes in tea plants () and classified them into 12 phylogenetic groups, supported by analyses of conserved motifs and gene structures.

Controllable Synthesis and Ultrahigh Proton Conduction of a Hydrogen-Bond Network.

The functionalization of polyoxometalates with organic ligands provides a new-style strategy to accurately incorporate polyoxometalates with advanced functional organic moieties on their surfaces, the development of which has attracted increasing research interest due to the potential applications. A germanium tungstate Na(HO)[{Ru(bpy)}{WO(CO)}(GeWO)]·27HO (bpy = 2,2'-bipyridine) with two ligands covalently modified was triumphantly synthesized, using the conventional one-pot hydrothermal method. It was systematically characterized by thermogravimetric analysis (TGA), elemental analysis, infrared (IR) spectroscopy, single-crystal X-ray diffraction, X-ray photoelectron spectroscopy (XPS), powder diffraction (PXRD), scanning electronic microscopy (SEM), and ultraviolet-visible (UV-vis) spectroscopy.

Influence of fermentation with lactic bacteria on the structure, functional properties and antioxidant activity of flaxseed gum.

Flaxseed meal is a by-product of flaxseed oil extraction. In this research, lactic acid bacteria suitable for modification of flaxseed gum were screened based on cellulase activity and the extraction rate of flaxseed gum. The enzyme-weight method was employed to extract flaxseed gum (SDF).

Tauroursodeoxycholic acid targets HSP90 to promote protein homeostasis and extends healthy lifespan.

As the elderly population expands, the pursuit of therapeutics to reduce morbidity and extend lifespan has become increasingly crucial. As an FDA-approved drug for chronic cholestatic liver diseases, tauroursodeoxycholic acid (TUDCA), a natural bile acid, offers additional health benefits beyond liver protection. Here, we show that TUDCA extends the lifespan and healthspan of C.

A Dawson-type {PW} modified using phenylphosphonic acid with excellent proton conductivity.

A case of organic-inorganic hybridized phosphotungstate modified using aromatic organophosphonic acid, KNaH[KCo(HO)PWO{(PhPO)}]·48HO (1), was successfully synthesized in conventional aqueous solution. The prominent structural feature is that the total structure of [KPWO{(PhPO)}] resembles a V-shaped structure, which was stabilized by two [Co(HO)] ions. Furthermore, it can be connected into a three-dimensional mesh structure using K ions.