The comparative study of the efficacy of recombinant human brain natriuretic peptide combined with vasoactive medications for elderly patients with heart failure and hypotension receiving injections.

Background: Heart failure (HF) in elderly patients with concurrent hypotension presents a therapeutic challenge due to limited standard HF therapies' applicability. Recombinant human brain natriuretic peptide (rhBNP) and vasoactive medications have shown potential in HF management, but their combined efficacy in elderly patients with HF and hypotension remains understudied.

Methods: This retrospective cohort study included elderly HF patients with hypotension who received rhBNP alone (Group A, n = 68), rhBNP with dobutamine (Group B, n = 74), or rhBNP with dopamine (Group C, n = 71).

The allogenic non-proteinogenic amino acid BMAA-based vaccine breaks up the immune tolerance against colorectal cancer.

The fundamental issue in immunotherapy is the lack of tumor-specific antigens in most types of tumors, leading to immune tolerance. For approximately 85% of patients with microsatellite stable (MSS) colorectal cancer (CRC), the absence of tumor neoantigens results in poor immunotherapy efficacy. Our previous study demonstrated that the misincorporation of non-proteinogenic proline (Pro) analog azetidine-2-carboxylic acid (AZE) could generate mutated proteins that significantly enhance tumor cell antigenicity and anti-tumor immune responses.

Forsythiaside A Reduces Acetaminophen Hepatotoxic Metabolism by Inhibiting Pregnane X Receptor.

Overdose intake of acetaminophen (APAP) causes liver injury involving hepatic drug metabolism and activation of oxidative stress pathways, and forsythiaside A (FA) has hepatoprotective pharmacological activity, but knowledge of the mechanism of FA treatment for APAP liver injury is still lacking the literature. In this study, we investigated the effects of FA on the pregnane X receptor () by molecular docking and reporter gene assays. In addition, we explored the effects of FA on oxidative stress, endoplasmic reticulum stress (ERS), apoptosis, and hepatic pathology by interfering with in ex vivo and in vivo models.

Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.

Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).

Artificial intelligence driven plaque characterization and functional assessment from CCTA using OCT-based automation: A prospective study.

Background: We aimed to develop and validate an Artificial Intelligence (AI) model that leverages CCTA and optical coherence tomography (OCT) images for automated analysis of plaque characteristics and coronary function.

Methods: A total of 100 patients who underwent invasive coronary angiography, OCT, and CCTA before discharge were included in this study. The data were randomly divided into a training set (80 %) and a test set (20 %).

Early metabolomics revealed the sensitivity of sacubitril/valsartan to person with end-stage renal disease accompanied by heart failure.

Heart failure (HF) is a major complication in patients with end-stage renal disease (ESRD) and is the leading cause of death in this high-risk population. Sacubitril/Valsartan is an angiotensin receptor-neprilysin inhibitor (ARNI) that has been shown to improve treatment outcomes in patients with ESRD accompanied by HF. Unfortunately, in clinical practice, some patients who received sacubitril/valsartan treatment not only did not show a good therapeutic effect, but also got worse with the passage of time.

Zanubrutinib plus Ixazomib and Dexamethasone in newly diagnosed symptomatic Waldenström macroglobulinemia:a phase II study.

Purpose: Waldenström macroglobulinemia (WM) is a rare type of lymphoma, with no optimal treatment. BTK inhibitor have shown promising outcomes, yet achieving deep remission (VGPR or CR) remains challenging and time-limited therapy with proteasome-inhibition has not been reported. We conducted a phase 2 clinical trial (NCT04463953) to evaluate the efficacy and safety of combining zanubrutinib, ixazomib and dexamethasone (ZID) in newly diagnosed WM patients.

[High expression of miR-124 improves cognitive function of sleep-deprived rats by modulating the PI3K/AKT signaling pathway].

Objectives: To explore the molecular mechanism by which miR-124 affects cognitive function of sleep-deprived rats.

Methods: Fifty-four adult male SD rats were randomized into 6 groups (=9), including a normal control group, a sleep deprivation (SD) model group, and 4 intracerebral microinjection groups in which the rats were subjected to stereotactic injection of miR-124 agomir, miR-124 agomir NC, miR-124 antagomir, or miR-124 antagomir into the lateral ventricle 7 days before SD modeling. The cognitive functions of the rats were evaluated with Morris water maze test, and pathological changes in the hippocampus were observed using HE staining.

Is endoscopic submucosal tunnel dissection better than endoscopic submucosal dissection in treating large superficial esophageal neoplastic lesions? A systematic review and meta-analysis.

Background: The resection of large superficial esophageal neoplastic lesions (SENLs) presents significant challenges for traditional endoscopic submucosal dissection (ESD). Endoscopic submucosal tunnel dissection (ESTD) has emerged as an alternative that potentially reduces resection difficulty.

Objectives: We aimed to compare ESTD and ESD in the treatment of large SENLs.

Influence of static magnetic field pretreatment on the structure, physicochemical and functional properties of dietary fiber in corn sprouts.

Dietary fiber (DF) from corn sprouts, subjected to pretreatment with static magnetic field (SMF), was systematically investigated for its structural and functional characteristics using an enzymatic method. After SMF treatment, the surface of soluble DF showed higher pore density and pore structures, and insoluble DF showed more folds and a concave-convex surface profile. FT-IR and thermogravimetric analyses also showed that SMF pretreatment improved the functional group structure and thermal stability of DFs in corn sprouts.

Analyses of CTNNB1 mutation and expression and clinicopathological characteristics in 179 cases of solid-pseudopapillary neoplasm of the pancreas.

Background: Nuclear expression of CTNNB1 is occasionally negative in solid-pseudopapillary neoplasm (SPN) of the pancreas, leading to a missed diagnosis. In the present study, we aimed to investigate the clinical significance of CTNNB1 mutation detection for diagnosing SPN and explore the difference in clinicopathological characteristics at different ages and sex.

Methods: Patients who underwent surgery for a pathologically confirmed SPN in our institution between 2011 and 2020 were collected.

Type 3 diabetes and metabolic reprogramming of brain neurons: causes and therapeutic strategies.

Abnormal glucose metabolism inevitably disrupts normal neuronal function, a phenomenon widely observed in Alzheimer's disease (AD). Investigating the mechanisms of metabolic adaptation during disease progression has become a central focus of research. Considering that impaired glucose metabolism is closely related to decreased insulin signaling and insulin resistance, a new concept "type 3 diabetes mellitus (T3DM)" has been coined.

Gene prediction of the relationship between iron deficiency anemia and immune cells.

Background: Observational studies have shown a potential link between immune factors and the risk of iron deficiency anemia (IDA), yet the causal relationship between immune cells and IDA remains enigmatic. Herein, we used Mendelian randomization (MR) to assess whether this association is causal.

Methods: We selected IDA genetic variants, including 8376 samples and 9810691 single nucleotide polymorphisms, and immune cells from a large open genome-wide association study (GWAS) for a bidirectional MR study.

Correlation between pollen morphology, karyotype, floral pigments, and scent components and morphological classification of 15 species and hybrids of Syringa L.

In this paper, the pollen morphology characteristics, chromosome karyotype characteristics, floral pigments, and scents components of 15 species and hybrids of Syringa L. were obtained by means of scanning electron microscopy, root tips quash method, HPLC-MS, and GC-MS, and the 15 species and hybrids of Syringa L. were clustered separately with each index.

Super Tough Anti-freezing and Antibacterial Hydrogel With Multi-crosslinked Network for Flexible Strain Sensor.

Addressing the diverse environmental demands for electronic material performance, the design of a multifunctional ionic conductive hydrogel with mechanical flexibility, anti-freezing capability, and antibacterial characteristics represents an optimal solution. Leveraging the Dead Sea effect and the strong hydrogen bonding, this study exploits the CaCl and the abundant hydroxyl groups in phytic acid (PA) to induce chain entanglements, thereby constructing a complex, multi-crosslinked network. Furthermore, PA and ternary solvent systems (CaCl/Glycerol/HO) synergistically impart excellent mechanical strength, toughness (with tensile strength of 8.

Innovative Nano Delivery Systems for Astaxanthin: Enhancing Stability, Bioavailability, and Targeted Therapeutic Applications.

Astaxanthin (AST), as a natural antioxidant, has broad application prospects in medicine and health products. However, its highly unsaturated structure and significant lipophilic characteristics limit its dispersibility and bioavailability, thereby restricting its application in food, medicines, and nutraceuticals. To overcome these limitations, researchers have proposed the use of nano delivery systems.

Preparation, characterization, and stability of pectin-whey protein isolate-based nanoparticles with mitochondrial targeting ability.

Quercetin (Que) is a polyhydroxy flavonoid with strong inhibitory activity against cancer cells. However, the poor water solubility and low bioavailability of Que. limit its application in the functional food industry.

Traditional Chinese Baduanjin Exercise With Nursing and Peer Group Support in the Care of Patients After Allogeneic Hematopoietic Stem Cell Transplantation: Evaluation of Application and Survival Analysis.

Background: Sleep problems and anxiety are imperative for continuity of care and rehabilitation in patients following an allogeneic hematopoietic stem cell transplantation (allo-HSCT).

Objective: The aim of this study was to investigate the impact on anxiety, sleep quality, and survival of integrating traditional Chinese Baduanjin exercises to track the control of continuous care in patients receiving an allo-HSCT.

Methods: A total of 75 patients discharged after receiving an allo-HSCT were included.

The molecular receptor NKBB enhances the persistence and anti-hepatocellular carcinoma activity of GPC3 CAR-T cells.

Chimeric antigen receptor (CAR) T cells have encouraging results in the treatment of hematological malignancies. However, CAR-T therapy still faces numerous challenges against solid tumors, such as hepatocellular carcinoma (HCC), owing to heterogeneous antigen expression in tumor cells, limited persistence of CAR-T cells, etc. Therefore, to treat HCC more effectively, we connected the molecular receptor NKBB to a second-generation glypican-3 (GPC3) CAR to construct GC3328z-NKBB CAR-T cells, which have double specific targets of GPC3 and NKG2DLs (natural killer group 2, member D ligands), dual co-stimulation of CD28 and 41BB, and a single CD3ζ chain.

A nomogram for predicting overall survival in patients with gastric cancer based on tumor suppressor RCAN1.4 expression and clinical risk factors.

Gastric cancer (GC) is one of the most prevalent malignant tumors in the world and has an extremely poor prognosis. Regulator of calcineurin 1 (RCAN1), a known tumor suppressor in various cancers, has an undefined role in the proliferation and metastasis of GC. Primary tumor and paired normal gastric tissues were collected from 77 patients with GC for evaluating the mRNA levels of 3 RCAN1 transcripts.

Construction of a red phosphorus-molybdenum dioxide electron-rich interface for efficient photocatalytic reduction of carbon dioxide.

Developing efficient catalysts to enhance photoreduction carbon dioxide (CO) into hydrocarbon fuels is a great challenge. As metallic material, molybdenum dioxide (MoO) has very high conductivity and charge density, which make it a promising candidate as photocatalyst. However, its photocatalytic activity is limited by the serious charge recombination.

The Role of Flavonoids from Aurantii Fructus Immaturus in the Alleviation of Allergic Asthma: Theoretical and Practical Insights.

Flavonoids derived from plants in the citrus family can have an alleviating effect on allergic asthma. The aim of this study was to provide insights into the mechanisms by which these compounds exert their effects on allergic asthma by combining theoretical and practical approaches. Aurantii Fructus Immaturus flavonoids (AFIFs) were obtained by solvent extraction and were determined by high performance liquid chromatography (HPLC).

68 Ga-Pentixafor PET in Combination With MRI Improves the Differential Diagnosis of Glioblastoma and Primary Central Nervous System Lymphoma.

Purposes: This study aims to investigate the diagnostic performance of combining 68 Ga-pentixafor PET with MRI to differentiate primary central nervous system lymphoma (PCNSL) from glioblastoma (GBM), particularly focusing on atypical lymphoma identification.

Patients And Methods: Seventy-one PCNSL and 53 GBM patients who underwent both 68 Ga-pentixafor PET/CT and MRI were retrospectively included. We evaluated the quantitative imaging parameters and MRI features of positive lesions, identifying atypical PCNSL by hemorrhage, necrosis, or heterogeneous enhancement.