Publications by authors named "Liu Hongmei"

Background: Peritoneal dissemination of ovarian cancer (OvCa) can be largely attributed to the formation of a metastatic microenvironment driven by tumoral exosomes. Here, we aimed to elucidate the mechanisms through which exosomal annexin A2 (ANXA2) derived from OvCa cells induces an HPMC phenotypic shift in favour of peritoneal metastasis.

Methods: Immunohistochemistry and orthotopic and intraperitoneal OvCa xenograft mouse models were used to clarify the relationship between tumour ANXA2 expression and peritoneal metastasis.

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Pyrethroids are synthetic products derived from natural pyrethroids present in flowers and are extensively used as pesticides for agriculture, animal husbandry, and household pest control. However, excessive and prolonged usage of pyrethroid insecticides can result in adverse effects on both non-target and target species. Therefore, effective technologies need to be developed to remove pyrethroid contamination and ensure environmental safety.

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The enzyme-linked immunosorbent assay (ELISA) is a powerful and high-throughput method for detecting aflatoxin B (AFB) in food. However, the susceptibility of native enzymes to environmental factors limits their potential applications. This study introduces the combined use of precious metal nanozymes as alternative catalysts to improve the performance of traditional ELISA.

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Background: Effective screening for colorectal cancer (CRC) enables earlier diagnosis and intervention to improve patient survival.

Methods: In this study, we prospectively conducted a blood-based CRC screening program for community residents in Hanjiang District, Yangzhou City, and evaluated the screening efficacy of a blood-based multi-locus DNA methylation assay (ColonAiQ). The ColonAiQ-positive rate and colonoscopy participation rate of the population, detection rate of intestinal lesions, and positive predictive value (PPV) of CRC and advanced adenoma (AA) were calculated, and the associated factors were explored.

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Calcium (Ca) overload therapy gained significant attention in oncology. However, its therapeutic efficacy remained limited due to insufficient Ca accumulation at the tumor site and suboptimal intracellular Ca influx. In this study, gambogic acid (GA), a natural phenolic compound known to promote Ca influx, was encapsulated within an enzyme-triggered, pH-responsive hydrogel (GM@Lip@CHP-Gel) containing Ca hydrogen phosphate nanowires (CHP) to achieve a synergistic approach for bone tumor therapy.

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Plant viruses rely on host factors for successful infection. Non-specific lipid transfer proteins (nsLTPs) play critical roles in plant-pathogen interactions; however, their functions and underlying molecular mechanisms in viral infections remain largely unknown. Jasmonic acid (JA) is a crucial regulatory hormone in the process of plant resistance to viral infection.

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As the world is approaching the eradication of wild poliovirus serotype 1, the last of the three wild types, the question of how to maintain a polio-free world becomes imminent. To mitigate the risk of sporadic vaccine-associated paralytic polio (VAPP) caused by oral polio vaccines (OPVs) that are routinely used in global immunization programs, the Polio Antivirals Initiative (PAI) was established in 2006. The primary goal of the PAI is to facilitate the discovery and development of antiviral drugs to stop the excretion of immunodeficiency-associated vaccine-derived poliovirus (iVDPV) in B cell-deficient individuals.

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Long-term fertilization contributes to the accumulation of cadmium (Cd) in soils and crops, yet the effects of different fertilization regimes on soil Cd dynamics and its uptake in rice remain poorly understood. This long-term field experiment aimed to elucidate how different fertilization regimes influence Cd bioavailability and mobility in soil, thereby affecting Cd accumulation in rice. Four fertilization treatments were tested, including chemical fertilizer (CF), rice straw incorporation (RF), and low (LM) and high (HM) rates of manure fertilizers.

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Background: Community species in different grassland types exhibit unique ecological traits and adaptation strategies, influencing the impact of grazing on species diversity at various scales. This study aimed to elucidate the response characteristics and rules of species diversity in different grassland types to grazing intensity by analyzing plant groups and species diversity.

Results: Grazing intensity, grassland type, and their interaction significantly affected α, β, and γ diversity.

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In recent years, the efficiency of high-efficiency Cu(In,Ga)Se (CIGS) solar cells has been significantly improved, particularly for narrow-gap types. One of the key reasons for the enhancement of narrow-gap device performance is the formation of the "Spike" structure at the CdS/CIGS heterojunction interface. Wide-gap CIGS solar cells excel in modular production but lag behind in efficiency compared to narrow-gap cells.

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The nucleus pulposus (NP) plays a vital role in intervertebral disc degeneration (IVDD). Previous studies have revealed cellular heterogeneity in NP tissue during IVDD progression. However, the cellular and molecular alterations of diverse cell clusters during IVDD remain to be fully elucidated.

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Magnetic solid-phase extraction (MSPE) holds significant scientific and technological interest as a novel sample preparation method for complex samples due to its easy operation, swift separation, high adsorption efficiency, and environmental friendliness. As the core of MSPE, magnetic sorbents have captured tremendous attention in recent years. Various promising nanomaterials, such as metal-organic frameworks and covalent organic frameworks, have been synthesized and utilized as sorbents in pharmaceutical and biomedical analysis.

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Phages and phage-encoded lytic enzymes are promising antimicrobial agents. In this study, we report the isolation and identification of bacteriophage KP2025 from . Bioinformatics analysis of KP2025 revealed a putative endolysin, LysKP213, containing a T4-like_lys domain.

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To date, complete genome sequences of 14 double-stranded RNA (dsRNA) phages are available, and studies have shown that the host range of dsRNA phages is limited. The hosts of most dsRNA phages belong to the genus . However, the dsRNA phage phiNY, which has a non-lytic life cycle, was isolated from .

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Herein, a new, environmentally friendly, and economical magnetic solid-phase extraction method for fluoroquinolones (FQs) from milk samples was developed using novel recyclable zeolitic imidazolate framework functionalized magnetic multiwalled carbon nanotubes (FeO@MWCNTs@SiO@ZIF-8) as adsorbents. Various characterization techniques, including scanning electron microscopy, N adsorption-desorption analysis, and vibrating sample magnetometry, demonstrated that the adsorbent possessed a remarkable specific surface area, pore volume, and superparamagnetic properties, rendering it an excellent adsorbent. Combined with high-performance liquid chromatography, this method exhibited excellent linearity (R ≥ 0.

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Background: Assessing the relationships between spatial and temporal structures and functions of plant communities is an effective way to understand the changing dynamics of plant communities in specific environments. In this study, we investigated the response of structural and functional stabilities of plant communities to stocking rate in the desert steppe over a 16-year grazing period as the research background.

Methods: We used classical statistical methods to investigate the quantitative characteristics of plant communities over time (2014-2019) and space (2017-2019) at four stocking rates (control, CK, 0 sheep·ha·month; light grazing, LG, 0.

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Article Synopsis
  • VGLL3 is identified as a key player in the DNA damage response (DDR), which helps cells repair damaged DNA.
  • Decreasing VGLL3 levels leads to reduced repair efficiency, making cells more sensitive to chemotherapy while delaying tumor growth.
  • The study also reveals that VGLL3 stabilizes certain proteins involved in DNA repair by preventing their degradation, highlighting a unique function separate from its role in regulating gene transcription.
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In this study, xanthine oxidase was immobilized for the first time using a novel magnetic metal-organic framework material (FeO-SiO-NH@MnO@ZIF-8-NH). A ligand fishing method was established to rapidly screen XOD inhibitors from Ligusticum wallichii based on the immobilized XOD. Characterization and properties of the immobilized enzyme revealed its excellent stability and reusability.

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Article Synopsis
  • - The study investigates how nutrient enrichment affects soil microbial populations, focusing on the role of soil microorganisms in nutrient cycling processes.
  • - Nitrogen addition promotes copiotrophic bacteria growth while hindering oligotrophic bacteria, whereas phosphorus addition alleviates deficiency and decreases certain bacterial populations.
  • - The results highlight that changes in nutrient availability, particularly phosphorus, significantly affect soil bacterial diversity and may influence soil ecosystem biogeochemical cycles more than soil pH changes.
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is one of the most important genera of ectomycorrhizal fungi. As a model for studying host specificity, its molecular fragments and nuclear genome have been analyzed. However, its mitochondrial genome has not yet been reported.

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Glioblastoma (GBM), the most common primary brain malignancy in adults, is notoriously difficult to treat due to several factors: tendency to be radiation resistant, the presence of the blood brain barrier (BBB) which limits drug delivery and immune-privileged status which hampers effective immune responses. Traditionally, high-dose irradiation (8 Gy) is known to effectively enhance anti-tumor immune responses, but its application is limited by the risk of severe brain damage. Currently, conventional dose segmentation (2 Gy) is the standard radiotherapy method, which does not fully exploit the potential of high-dose irradiation for immune activation.

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Article Synopsis
  • Vector-borne diseases, like those caused by West Nile virus and Japanese encephalitis virus, are significant global health issues, particularly linked to Culex mosquitoes.
  • Chemical insecticides have been widely used to control these mosquito populations, but the insects are increasingly resistant, prompting interest in biological alternatives like the bacteria Wolbachia.
  • This study in Shandong Province examines Wolbachia's infection rates in Culex pipiens pallens and finds distinct differences from other mosquito species, along with evidence of demographic expansion in the local Culex population.
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