(+)-Borneol enhances the protective effect of edaravone against cerebral ischemia/reperfusion injury by targeting OAT3/P-gp transporters for drug delivery into the brain.

Objectives: Cerebral ischemia-reperfusion (CI/R) injury is a severe neurological condition associated with significant morbidity and mortality. Edaravone-dexborneol is a promising neuroprotective agent for alleviating CI/R injury, which composed of edaravone and (+)-borneol. Several studies have confirmed that combining edaravone with (+)-borneol can exert synergistic effects when compared to using edaravone alone.

Time-dependent interpretable survival prediction model for second primary NSCLC patients.

Objective: Accurate predictive models for second primary non-small cell lung cancer (SP-NSCLC) are limited. This study aimed to develop and validate overall survival (OS) prediction models for SP-NSCLC patients using time-dependent interpretable survival machine learning algorithms.

Methods: This study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database, encompassing 8 and 12 registries, to extract data on patients aged 20-89 diagnosed with SP-NSCLC between 1988 and 2020.

IL-6 Exacerbates Oxidative Damage of RPE Cells by Indirectly Destabilizing the mRNA of DNA Repair Genes.

Chronic inflammation has been associated with the progression of age-related macular degeneration (AMD) and diabetic retinopathy (DR), and the levels of various inflammatory factors are significantly increased in intraocular fluids of patients with AMD and DR. Therefore, elucidating the roles of inflammatory factors in the oxidative damage of RPE cells will help uncover the pathogenesis of AMD and DR. We have previously demonstrated that E2F1 plays an important role in the antioxidant capacity of RPE cells.

Extracorporeal liver support systems in patients with acute-on-chronic liver failure: An updated systematic review and meta-analysis.

Background: The utilization of extracorporeal liver support systems is increasingly prevalent for the management of acute-on-chronic liver failure in clinical settings. Yet, the efficacy of these interventions in terms of tangible clinical benefits for patients remains a matter of debate, underscoring the need for meta-analysis.

Methods: An updated meta-analysis was performed to elucidate the relationship between the application of extracorporeal liver support versus standard pharmacological treatment and the prognostic endpoints of patient survival, specifically assessing 1-month and 3-month mortality rates, as well as the incidence of complications such as hepatic encephalopathy, spontaneous bacterial peritonitis, and hepatorenal syndrome.

Machine learning identification of NK cell immune characteristics in hepatocellular carcinoma based on single-cell sequencing and bulk RNA sequencing.

Background: Hepatocellular carcinoma (HCC) is a highly malignant tumor; however, its immune microenvironment and mechanisms remain elusive. Single-cell sequencing allows for the exploration of immune characteristics within tumor at the cellular level. However, current knowledge regarding the roles of different immune cell populations in liver cancer progression is limited.

Research on the Corrosion Resistance of Electrodeposited Ni-SiC Composites Constructed for Steel Storage Tank Application.

In this paper, the effects of the SiC phase incorporated in Ni substrate deposits on storage tank steel during electrodeposition at different current densities are explored. The microstructure, phase content, and corrosion resistance of the resulting Ni-SiC composites were investigated by scanning electron microscopy (SEM) matched with energy disperse spectroscopy (EDS), X-ray diffraction (XRD), and an electrochemical workstation, respectively. SEM micrographs and EDS results show that at 2.

Silk films with distinct surface topography modulate plasma membrane curvature to polarize macrophages.

The physical properties of a biomaterial play a vital role in modulating macrophage polarization. However, discerning the specific effects of individual parameters can be intricate due to their interdependencies, limiting the mechanism underlying a specific parameter on the polarization of macrophages. Here, we engineered silk fibroin (SF) films with tunable surface roughness while maintaining similar physical properties by combining casting and salting out techniques.

Association of interleukin-6, ferritin, and lactate dehydrogenase with venous thromboembolism in COVID-19: a systematic review and meta-analysis.

Background: Coronavirus disease 2019 (COVID-19) is frequntly accompanied by venous thromboembolism (VTE), and its mechanism may be related to the abnormal inflammation and immune status of COVID-19 patients. It has been proved that interleukin-6 (IL-6), ferritin and lactate dehydrogenase (LDH) may play an important role in the occurrence of VTE in COVID-19 infection. But whether they can server as predictors for VTE in COVID-19 is still unclear.

Unraveling the effect of particle size of active metals in Ni/MgO on methane activation and carbon growth mechanism.

For dry reforming of methane, the active metal particle size of the catalyst has a significant effect on both the reaction activity and the resistance to carbon deposition. In this study, nickel particles of different sizes (Ni13, Ni25, and Ni37) supported on the MgO(100) slab are used to study the mechanism of CH activation and carbon growth based on DFT theoretical calculations. According to the results, the energy of adsorption for reaction intermediates changes depending on the size of the active metal.

Molecular mechanism overview of metabolite biosynthesis in medicinal plants.

Medicinal plants are essential and rich resources for plant-based medicines and new drugs. Increasing attentions are paid to the secondary metabolites of medicinal plants due to their unique biological activity, pharmacological action, and high utilization value. However, the development of medicinal plants is constrained by limited natural resources and an unclear understanding of the mechanisms underlying active medicinal ingredients, thereby rendering the utilization and exploration of secondary metabolites more challenging.

Effects of Cu ratios on the C-C growth mechanism on copper-nickel bimetallic surfaces.

The adsorption and growth mechanisms of C ( = 1-6) on different Cu-Ni surfaces are calculated by density functional theory (DFT). The results demonstrate that Cu doping affects the growth mechanism of the deposited carbon on the catalyst surface. Firstly, the addition of Cu weakens the interaction between C and the adsorbed surface, which is proved by the results of density of states (DOS) and partial density of states (PDOS).

Enhanced Electrochemical Performance of PEO-Based Composite Polymer Electrolyte with Single-Ion Conducting Polymer Grafted SiO Nanoparticles.

In order to enhance the electrochemical performance and mechanical properties of poly(ethylene oxide) (PEO)-based solid polymer electrolytes, composite solid electrolytes (CSE) composed of single-ion conducting polymer-modified SiO, PEO and lithium salt were prepared and used in lithium-ion batteries in this work. The pyridyl disulfide terminated polymer (py-ss-PLiSSPSI) is synthesized through RAFT polymerization, then grafted onto SiO via thiol-disulfide exchange reaction between SiO-SH and py-ss-PLiSSPSI. The chemical structure, surface morphology and elemental distribution of the as-prepared polymer and the PLiSSPSI--SiO nanoparticles have been investigated.

Comprehensive analysis: Necroptosis-related lncRNAs can effectively predict the prognosis of glioma patients.

Glioma is the most common and fatal primary brain tumor in humans. A significant role for long non-coding RNA (lncRNA) in glioma is the regulation of gene expression and chromatin recombination, and immunotherapy is a promising cancer treatment. Therefore, it is necessary to identify necroptosis-related lncRNAs in glioma.

New biomarker: the gene HLA-DRA associated with low-grade glioma prognosis.

Background: Low-grade gliomas (LGG) are WHO grade II tumors presenting as the most common primary malignant brain tumors in adults. Currently, LGG treatment involves either or a combination of surgery, radiation therapy, and chemotherapy. Despite the knowledge of constitutive genetic risk factors contributing to gliomas, the role of single genes as diagnostic and prognostic biomarkers is limited.

Clustering of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.

Acute repetitive seizures or seizure clusters are common in epileptic patients. Seizure clusters are associated with a high risk of developing status epilepticus and increased morbidity and mortality. Seizure clusters are also recognizable in spontaneous recurrent seizures (SRS) that occur in animal models of epilepsy.

Epileptiform activity in mouse hippocampal slices induced by moderate changes in extracellular Mg, Ca, and K.

Background: Rodent brain slices-particularly hippocampal slices-are widely used in experimental investigations of epileptiform activity. Oxygenated artificial cerebrospinal fluid (ACSF) is used to maintain slices in vitro. Physiological or standard ACSF containing 3-3.

Electrographic Features of Spontaneous Recurrent Seizures in a Mouse Model of Extended Hippocampal Kindling.

Epilepsy is a chronic neurological disorder characterized by spontaneous recurrent seizures (SRS) and comorbidities. Kindling through repetitive brief stimulation of a limbic structure is a commonly used model of temporal lobe epilepsy. Particularly, extended kindling over a period up to a few months can induce SRS, which may simulate slowly evolving epileptogenesis of temporal lobe epilepsy.

Processing technology optimization for tofu curded by fermented yellow whey using response surface methodology.

The technological applications utilized for tofu processing are diverse and complex, resulting in different yields and quality characteristics of tofu. The current study investigated the gel-forming principle of soybean protein coagulated using fermented yellow whey (FYW) to produce tofu. The effects of several processing parameters (soybean-to-water ratio, boiling temperature, boiling time, and FYW content) on the yield and protein content of tofu produced by the boiling-to-filtering method (BFM) were studied and optimized using response surface methodology.

Examinations of Bilateral Epileptiform Activities in Hippocampal Slices Obtained From Young Mice.

Bilateral interconnections through the hippocampal commissure play important roles in synchronizing or spreading hippocampal seizure activities. Intact hippocampi or bilateral hippocampal slices have been isolated from neonatal or immature rats (6-7 or 12-21 days old, respectively) and the mechanisms underlying the bilateral synchrony of hippocampal epileptiform activities have been investigated. However, the feasibility of examining bilateral epileptiform activities of more developed hippocampal circuitry remains to be explored.

Fabricating MAPbI/MoS Composites for Improved Photocatalytic Performance.

Although lead halide perovskites are demonstrated to be promising photocatalysts for hydrogen evolution from hydrogen halide splitting, it still remains challenging to fabricate efficient and stable catalysts. Here MoS nanoflowers with abundant active sites are assembled with methylammonium lead iodide (MAPbI) microcrystals to form a new heterostructure. Its hydrogen evolution rate can reach up to about 30 000 μmol g h, which is more than 1000-fold higher than pristine MAPbI under visible light irradiation (λ ≥ 420 nm).

Formation and Encapsulation of Lead Halide Perovskites in Lanthanide Metal-Organic Frameworks for Tunable Emission.

Improving the stability of perovskite quantum dots and adjusting their optical properties are essential for their application in advanced optoelectronic equipment. We provide a simple synthetic method to hybridize perovskite quantum dots and metal-organic frameworks (MOFs) into a polymer matrix. The hybrid material is made by encapsulating perovskite CHNHPbBr quantum dots in lanthanide-based metal-organic frameworks.

Syntaxin-3 is dispensable for basal neurotransmission and synaptic plasticity in postsynaptic hippocampal CA1 neurons.

Recent evidence suggests that SNARE fusion machinery play critical roles in postsynaptic neurotransmitter receptor trafficking, which is essential for synaptic plasticity. However, the key SNAREs involved remain highly controversial; syntaxin-3 and syntaxin-4 are leading candidates for the syntaxin isoform underlying postsynaptic plasticity. In a previous study, we showed that pyramidal-neuron specific conditional knockout (cKO) of syntaxin-4 significantly reduces basal transmission, synaptic plasticity and impairs postsynaptic receptor trafficking.

Lanthanide Coordination Polymer-Based Composite Films for Selective and Highly Sensitive Detection of CrO in Aqueous Media.

Due to the high carcinogenicity and bioaccumulation effects of dichromate ions in the human body, sensitive and rapid detection of CrO ions is necessary. Herein, two lanthanide coordination polymers based on a linear dicarboxylic acid ligand, named {Ln(cpon)(Hcpon)(HO)} [Ln = Tb, ; Eu, ; H cpon = 5-(4-carboxy-phenoxy)-nicotinic acid], have been successfully synthesized. These two isostructural compounds contain one-dimensional zigzag chains that consist of uncoordinated carboxyl groups and pyridine groups in the framework, and the one-dimensional chains can further form a three-dimensional supramolecular stacking structure by intermolecular interaction.