Effect of posterior-stabilized and cruciate-retaining implants on three-dimensional kinematic characteristics after total knee arthroplasty.

Objectives: This study aimed to analyze the effects of posteriorstabilized (PS) and cruciate-retaining (CR) total knee arthroplasty (TKA) on early postoperative three-dimensional (3D) dynamic and kinematic characteristics in patients with unilateral knee osteoarthritis (OA).

Patients And Methods: A retrospective analysis of prospectively collected data from 90 patients with unilateral TKA between February 2021 and September 2021 was conducted using a 3D kinematic analysis system before and six months after TKA. This patient group included 57 patients (10 males, 47 females; mean age: 69.

Types of cell death in diabetic cardiomyopathy: insights from animal models.

Approximately one-tenth of the global population is affected by diabetes mellitus, and its incidence continues to rise each year. In China, 1.4 million patients die from diabetes-related complications every year.

Magnesium Oxide-Supported Single Atoms with Fine-Modulated Steric Location for Polymerization Transfer Removal of Water Pollutants.

Organic pollutants removal via a polymerization transfer (PT) pathway based on the use of single-atom catalysts (SACs) promises efficient water purification with minimal energy/chemical inputs. However, the precise engineering of such catalytic systems toward PT decontamination is still challenging, and the conventional SACs are plagued by low structural stability of carbon material support. Here, we adopted magnesium oxide (MgO) as a structurally stable alternative for loading single copper (Cu) atoms to drive peroxymonosulfate-based Fenton-like reactions.

Effects of PM components on hypertension and diabetes: Assessing the mitigating influence of green spaces.

Background: Particulate matter with diameters ≤2.5 μm (PM) is a significant air pollutant associated with hypertension and diabetes. However, the specific contributions of its components and their joint exposure with green spaces remain poorly understood, especially in developing regions.

Improving WRF-Chem PM predictions by combining data assimilation and deep-learning-based bias correction.

In numerical model simulations, data assimilation (DA) on the initial conditions and bias correction (BC) of model outputs have been proven to be promising approaches to improving PM (particulate matter with an aerodynamic equivalent diameter of ≤ 2.5 μm) predictions. This study compared the optimization effects of these two methods and developed a new scheme that combines DA and BC simultaneously.

Expression of nicastrin, NICD1, and Hes1 in NCSTN knockout mice: implications for hidradenitis suppurativa, Alzheimer's, and liver cancer.

Background: Nicastrin, a subunit of the γ-secretase complex, is encoded by the NCSTN gene and regulates notch signaling, it is involved in the pathogenesis of hidradenitis suppurativa (HS), Alzheimer disease (AD), and liver cancer. However, the animal models for studying HS are relatively scarce.

Methods: CRISPR/Cas-mediated genetic engineering was used to generate targeted knockout offspring mice (C57BL/6J).

Insight into Robust Anion Coordination Behavior of Organic Cathode with Dual Elongated π-Conjugated Motifs.

Organic electrode materials offer multi-electron reactivity, flexible structures, and redox reversibility, but encounter poor conductivity and durability in electrolytes. To overcome above barriers, we propose a dual elongation strategy of π-conjugated motifs with active sites, involving the extended carbazole and electropolymerized polymer, which enhances electronic conductivity by the electronic delocalization of electron-withdrawing conjugated groups, boosts theoretical capacity by increasing redox-active site density, and endows robust electrochemical stability attributed to the nanonetwork feature of polymer structures. As a proof-of-concept, 5,11-dihydridoindolo[3,2-b]carbazole (DHIC) is selected as the model cathode material for a dual-ion battery, with elongated carbazole groups functioning both as redox-active centers and polymerization anchors.

Sex differences in CYP450-based sodium dehydroacetate metabolism and its metabolites in rats.

Sodium dehydroacetate (DHA-Na), a widely used preservative, can induce sex-differentiated coagulation disorders primarily resulting from its metabolism. However, the underlying mechanisms remain poorly understood. Here, we identified several Cytochrome P450 (CYP450) sub-enzymes involved in sex differences related to DHA-Na metabolism, along with two related DHA-Na metabolites.

Integration of Phosphorus in PdCr Metallene for Enhanced CO-Tolerant Alcohol Electrooxidation.

Pd-based alloys are among the most attractive catalysts for direct alcohol fuel cells. However, their widespread use is limited by the high cost of Pd and their susceptibility to deactivation by surface-adsorbed reaction intermediates, particularly CO. In this study, we engineered an ultrathin 2D PdCr metallene to minimize Pd usage and doped it with phosphorus to enhance its CO tolerance.

Dual-Gate Modulation in a Quantum Dots/MoS Thin-Film Transistor Gas Sensor.

Mastering the surface chemistry of quantum dots (QDs) has enabled a remarkable gas-sensing response as well as impressive air stability. To overcome the intrinsic receptor-transducer mismatch of QDs, PbS QDs used as sensitive NO receptors are spin-coated on top of a few-layer MoS and incorporated into a thin-film transistor (TFT) gas sensor. This architecture enables the separation of the electron transduction function from the chemical reception function.

Spatiotemporal distribution characteristics and impact factors of hepatitis C in Chongqing, China, 2014-2020.

Objectives: This study aimed to explore the spatial and temporal distribution of hepatitis C and its influencing factors in Chongqing, providing a scientific basis for the relevant departments to formulate targeted preventive measures for the high prevalence of hepatitis C in the region and population.

Design: We collected data on hepatitis C cases in Chongqing (located in the southwest of China) from 2014 to 2020, and analysed the spatiotemporal heterogeneity of hepatitis C incidence in different populations and identified factors that might influence the incidence of hepatitis C by constructing a Bayesian spatiotemporal model.

Settings: The study subjects included clinically diagnosed cases and confirmed cases of hepatitis C with current address in Chongqing and onset date between 1 January 2014 and 31 December 2020.

The effect of molecular chaperone mediated autophagy on ApoE expression in retinal pigment epithelial cells: Molecular structure and protein action mechanism.

Chaperone mediated autophagy (CMA) represents a specialized mechanism of lysosomal protein breakdown, playing a crucial role as a metabolic pathway that helps to regulate and sustain cellular and systemic physiological equilibrium. Within the CMA process, proteins that contain sequences similar to KFERQ are specifically identified by the heat shock cognate protein 70. These proteins are then chaperoned to the lysosomes for subsequent degradation, a process facilitated by the lysosome associated membrane protein 2A.

Bmpallidin, encoding a subunit of the BLOC-1 complex, is involved in urate granules formation in silkworm integument.

The abnormal development of urate granules in silkworm larvae leads to translucent mutants with a distinct transparent phenotype. Studies on such mutants are expected to enhance current understanding of uric acid metabolism. The hoarfrost translucent (oh) mutant exhibits a mottled, translucent larval integument due to the presence of smaller and irregularly shaped urate granules compared to wild-type individuals.

Novel strategy for comprehensive therapy with sustainably complete response in a patient with limited-stage small cell lung cancer: a case report.

Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumor with the poorest prognosis among all types of lung cancer. Developing an effective comprehensive strategy remains a key focus. We herein present the first documented case of a 68-year-old man with limited-stage SCLC who has maintained a complete response (CR) for over 30 months to date.

How Perceptions of the Accuracy of Parental Praise and Criticism Link With Child Adjustment: The Mediating Role of Perfectionism.

Accurate parental praise and criticism congruent with child performance-often ignored-might have lasting impacts on child development. This study explored whether the levels of the accuracy (from deflated to accurate to inflated) of parental praise and criticism perceived by children linked to a risk for their maladjustment (i.e.

Coupled Stacking Faults in Silver Nanorods for CO Electroreduction.

The interaction of defects has been proven effective in regulating the mechanical properties of structural materials, while its influence on the physicochemical performance of functional materials has been rarely reported. Herein, we synthesized Ag nanorods with dense stacking faults and investigated how the defect interaction affects the catalytic properties. We found that the stacking faults can couple with each other to form a unique structure of opposite atoms with extortionately high tensile strain.

Equipping a Wyatt multiangle, multidetector instrument for real-time particle and polymer sizing by simultaneous multiple-angle dynamic and static light scattering.

Well-constructed instruments may continue to perform beyond their manufacturer-supported service lifetime, which is typically limited by computer operating system compatibility or the availability of spare parts. Often, such equipment is condemned to surplus and destroyed. End-of-life plans that retain some of the material and energy used to create scientific instruments are of interest, just as in other manufacturing sectors.

Interface engineering of 2D dielectric nanosheets for boosting energy storage performance of polyvinylidene fluoride-based nanocomposites with high charge-discharge efficiency.

Polyvinylidene fluoride (PVDF) film, with high energy density and excellent mechanical properties, has drawn attention as an energy storage device. However, conduction loss in PVDF under high electric fields hinders improvement in efficiency due to electrode-limited and bulk-limited conduction. Well-aligned multilayer interfaces of two-dimensional (2D) nanocoatings can block charge injection, reducing electrode-limited conduction loss in dielectric polymers.

A dual-functional monomer-based molecularly imprinted fluorescent aptasensor employing near-infrared carbon dots for selective detection of quinine in food.

A molecularly imprinted fluorescent aptasensor was designed for selective detection of quinine (Qn) based on dual functional monomers. In the sol-gel polymerization of molecularly imprinted polymers (MIPs), 3-aminopropyltriethoxysilane (APTES) and quinine aptamer (Apt) were employed as dual functional monomers, and Qn was the template molecule. Near-infrared carbon dots (RCDs) were used as fluorescence signal probe, and effectively avoided the interference of fluorescence emitted by Qn.

A prospective, self-controlled study of sub-plateau heart rate variability in healthy adults.

Background: The low-pressure, hypoxic environment characteristic of high-altitude regions significantly affects the cardiovascular and autonomic nervous system functions of individuals, consequently impairing their sleep quality. Heart rate variability, a non-invasive indicator of autonomic nervous system activity and balance within the cardiovascular system, has not been thoroughly investigated in terms of its patterns during acclimatization and de-acclimatization phases for individuals traveling to and residing in high-altitude areas and its relationship with sleep stability.

Methods: Data was collected from 22 medical staff members who traveled from Chengdu to Yecheng, with measurements taken before leaving Chengdu, 1 week in Yecheng, 3 months in Yecheng, and 1 week after returning to Chengdu.

Tunable band alignment and large power conversion efficiency in a two-dimensional InS/ZnInS heterostructure.

Heterostructures can efficiently modulate the bandgap of semiconductors and enhance the separation of photocarriers, thereby enhancing the performance of optoelectronic devices. Herein, we design an InS/ZnInS van der Waals (vdW) heterostructure and investigate its electronic and photovoltaic properties using first principles calculation. Compared to its individual monolayers, the InS/ZnInS heterostructure not only possesses a smaller band gap of 2.

CD8 T cell exhaustion in the tumor microenvironment of breast cancer.

CD8+ T cells are crucial cytotoxic components of the tumor immune system. In chronic inflammation, they become low-responsive, a state known as T cell exhaustion (TEX). The aim of immune checkpoint blockade is to counteract TEX, yet its dynamics in breast cancer remain poorly understood.

Predicting sarcopenia risk in stroke patients: a comprehensive nomogram incorporating demographic, anthropometric, and biochemical indicators.

Objective: Although there is a strong correlation between stroke and sarcopenia, there has been a lack of research into the potential risks associated with post-stroke sarcopenia. Predictors of sarcopenia are yet to be identified. We aimed at developing a nomogram able to predict sarcopenia in patients with stroke.

The Impact of Exclosure Duration on Plant Species Diversity in a Desert Grassland and the Relative Contribution of Plant Groups.

Plant species diversity has long been a focal point in ecological studies. In order to study the changes in species diversity at different spatial scales (α, β, and γ diversities) in the restoration process of grassland vegetation in fragile desert steps, this study took desert steppe of Inner Mongolia as the research object and employed a two-factor experimental design that combined exclosure years (the years when an area was isolated to prevent grazing and other disturbances) with years of monitoring (the years when data were collected). It analyzed the plant groups (dominant species, common species, and rare species) and species diversity, and obtained the preliminary conclusions as follows: The optimal exclosure duration for promoting species diversity balance in desert steppe management is between 16 and 18 years.