Publications by authors named "Liu Guodong"

The blood-brain barrier (BBB) is a selectively permeable membrane that plays a crucial role in protecting the brain from harmful substances. Its disruption is associated with various central nervous system (CNS) disorders, including hemorrhagic stroke. Evans Blue (EB) dye, a protein-binding tracer, is commonly used to assess BBB permeability.

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Utilization of xylose as a renewable carbon source has received constant interest. Considering that the structure and state of eukaryotic chromatin are inextricably intertwined, it is significant to explore chromatin regulation for engineering xylose metabolism in yeast. Here, we show that two chromatin remodelers, namely, Swr1 and Isw1, affect xylose utilization in recombinant budding yeast.

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Light and panicle fertilizer are crucial environmental factors that influence rice eating quality. Currently, there is a lack of systematic research on how light and panicle fertilizer alter the morphological structures of starch and protein during cooking, subsequently affecting rice taste. To address this gap, field experiments were conducted under varying conditions of light (100 % light, L1; 50 % light, L2) and panicle fertilizer (no panicle fertilizer, N1; 81 kg/ha of panicle fertilizer, N2), followed by cooking after harvest.

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We present a lateral flow aptasensor for the visual detection of alpha-fetoprotein (AFP) in human serum. Leveraging the precise molecular recognition capabilities of aptamers and the distinct optical features of gold nanoparticles, a model system utilizing AFP as the target analyte, along with a pair of aptamer probes, is implemented to establish proof-of-concept on standard lateral flow test strips. It is the first report of an antibody-free lateral flow assay using aptamers as recognition probes for the detection of AFP.

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Light and nitrogen are crucial environmental factors that significantly impact rice growth and quality formation. Currently, there is a lack of systematic research on how light and nitrogen affect carbon and nitrogen metabolism during grain filling, subsequently affecting the eating quality of rice. To address this gap, field experiments were conducted under varying light intensities and nitrogen fertilizer levels to investigate the changes in carbon and nitrogen metabolism during grain filling, the eating quality of rice at maturity, and the relationship between them.

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This study explores the differences in starch and protein composition, morphological and structure, and their impacts on soft japonica rice eating quality under different light and nitrogen fertilizer conditions. Results showed that decreased light and applied panicle fertilize resulted in a decreased in total starch, accompanied by an increased in long-chain amylopectin, protein, particularly glutelin, and β-sheet, with these effects being more pronounced when panicle fertilizer was applied under 50 % light. RVA, LF-NMR and Rheometer date showed that aforementioned changes in starch and protein were detrimental to water migration and starch gelatinization during rice cooking, resulting in a high-strength rice gel network.

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Colorectal cancer (CRC) is one of the most prevalent and life-threatening malignancies worldwide. Jujuboside B (JUB) is a bioactive compound derived from the seeds of , known for its potential anticancer properties. The present study aimed to investigate the association of JUB with inhibiting the proliferation, apoptosis and ferroptosis of human CRC cells with mitogen-activated protein kinase (MAPK) pathway regulation.

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Detection of infrared objects is essential for applications ranging from remote sensing to thermal imaging. In certain instances, such as when the infrared target is situated at a considerable distance from the detector, the detected object exhibits diminutive dimensions with a concurrently low signal intensity, leading to a challenge in achieving precision in object detection. In this paper, we propose a dual-layer omnidirectional target enhancement (DODTE) module to address the issue of low contrast, which causes the target to be submerged in the background and lose its position information.

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Colon cancer (CC) is the third most common cancer globally and one of the leading causes of death. Therefore, there is an urgent need to develop an efficient and low-toxicity CC treatment regimen. The combination of chemotherapy (CT) and chemodynamic therapy (CDT) has great potential in cancer treatment.

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Glioblastoma (GBM) is a primary central nervous system neoplasm, characterized by a grim prognosis and low survival rates. This unfavorable therapeutic outcome is partially attributed to the inadequate immune infiltration and an immunosuppressive microenvironment, which compromises the effectiveness of conventional radiotherapy and chemotherapy. To this end, precise modulation of cellular dynamics in the immune system has emerged as a promising approach for therapeutic intervention.

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MicroRNA122 (miR-122) is a microRNA that is highly expressed in hepatocytes and has been identified as a prospective therapeutic target and biomarker for liver injury. An expanding body of research has demonstrated that miR-122 is a critical regulator in both the initiation and progression of a wide range of liver diseases. Traditional methods for detecting miR-122 mainly include Northern blotting and qRT-PCR, but they are technically complex and cumbersome, requiring expensive instruments and high technical requirements.

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Spontaneous intracerebral hemorrhagic stroke (ICH) is a highly aggressive disease, with a high incidence and mortality rate. Iron deposition following ICH leads to oxidative damage and motor dysfunction, significantly impacting the overall quality of life for those affected. Here, a polyphenolic nanomedicine, catechin-based polyphenol nanoparticles surface-modified by thiol-terminated poly(ethylene glycol) (CNPs@PEG), was developed through the oxidative polymerization and self-assembly of catechin, a natural compound in tea.

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A series of polyurethanes (PU-GT) were prepared using polyglycolide-block-polytetrahydrofuran-block-polyglycolide (PGA-PTHF-PGA), polytetrahydrofuran homopolymer (PTHF), glycerol, and hexamethylene diisocyanate (HDI) by a one-pot synthesis method. The non-isothermal crystallization and subsequent heating curves showed that the PTHF component in these polyurethanes could crystallize in a temperature range of -11.5~2.

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A SiO@Au@Polyaniline (SiO@Au@PAN) system has been successfully fabricated leveraging the synergistic effects of gold nanoparticles (AuNPs) to realize enhanced photothermal performance. The SiO@Au@PAN exhibited strong near-infrared (NIR) absorbance, excellent photothermal conversion efficiency, good dispersibility, and outstanding photostability. The SiO nanospheres as the template provided numerous binding sites for coating of AuNPs.

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Motor-free visual perception abilities are important reference indicator for children's literacy skills. In the absence of Chinese norms, this study utilized the motor-free visual perception test-4 (MVPT-4) to assess the visual perception abilities of children aged 5-12 years in Xuzhou, China, to lay the foundation for establishing standardized norms in China. From May to July 2023, a stratified random sampling method was used to conduct MVPT-4 evaluation on 525 kindergarten and primary school children in Xuzhou, China.

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The snap bean ( L.) is highly sensitive to both phosphorus (P) deficiency and hypoxic stress, which together can significantly hinder plant growth, nutrient uptake, and yield; however, limited information exists on the effect of P and oxygen (O) fertilization to alleviate these stresses and enhance yield. A two-year field experiment assessed the effects of P and O fertilization on plant growth, pod yield, and P uptake in acidic sandy soil.

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The carbon and nitrogen (N) metabolism of rice under different mid-stage N compensation timings is unclear. Two Japonica super rice cultivars were examined under four N compensation timings (N1-N3: N compensation at mid-tillering, panicle initiation, and spikelet differentiation. N0: no N compensation) and CK with no N application.

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This study aimed to investigate the effects of O-linked N-acetylglucosamine modification (O-GlcNAcylation) on astroglial-mesenchymal transition through connexin43 (Cx43) pathway under high-glucose conditions. The primary rat astrocytes were cultured under normal and high-glucose conditions, and level of GFAP, α-SMA and Cx43 was investigated. To explore the influence of O-GlcNAcylation on astroglial-mesenchymal transition, Thiamet G treatment was employed to enhance O-GlcNAcylation, while Alloxan was used to decrease it.

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Cognitive impairment refers to abnormalities in learning, memory and cognitive judgment, mainly manifested as symptoms such as decreased memory, impaired orientation and reduced computational ability. As the fundamental unit of information processing in the brain, neural circuits have recently attracted great attention due to their functions in regulating pain, emotion and behavior. Furthermore, a growing number of studies have suggested that neural circuits play an important role in cognitive impairment.

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Ferrovalley materials are generally hexagonal lattice systems with a ferromagnetism-valley coupling, in which the intrinsic ferromagnetism can induce valley polarization. However, as of now the number of ferrovalleys found is still limited. In this article, TlX (X = Cl/Br/I) single-layers (SLs) are proposed with a tetragonal lattice structure as well as ferroelectricity-valley coupling.

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Article Synopsis
  • Atmospheric microplastics pose significant threats to the environment and human health, and their presence in the air has been widely documented, but their transport and deposition mechanisms are still unclear.
  • This review discusses how meteorological conditions, particularly through dry and wet deposition, significantly affect the fate of atmospheric microplastics and how wind contributes to their movement between land and sea, creating a global microplastic cycle.
  • It also highlights the current models used to study atmospheric microplastics, suggests areas for future research, and recommends strategies to reduce pollution and safeguard ecosystems and human health.
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Currently, targeted therapeutics against pathogenic filoviruses are very limited, with only two monoclonal antibody (mAb)-based products targeting Ebola virus having received approval from health authorities. More therapeutics are needed to fight against other fatal filoviruses. Here, we describe a protocol using hybridoma technology to generate mAbs that can target not only a single filovirus species but also multiple species for broad protection.

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Article Synopsis
  • - The research focuses on a new two-dimensional ferromagnetic material, CrS, which features multiple Weyl points and can change its topological state by altering the direction of its magnetization.
  • - Distinct types of Weyl points were identified around the Fermi level, with corresponding Fermi arcs observable at the edges of the material, suggesting significant potential for applications in spintronics.
  • - The study shows that while Weyl points remain stable under certain biaxial strains, they are sensitive to uniaxial strain, highlighting the tunable nature of the topological states in CrS through external magnetic fields and strain.
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Objective: To combat the heightened risk of opioid overdose death for individuals with criminal justice involvements, enhanced access to Medicaid remains paramount. This study examines the effect of a 2017 policy change in Pennsylvania that allowed for suspension, rather than termination, of Medicaid coverage while in prison on post-release opioid overdose mortality risk (OOMR) for adults released from Pennsylvania prisons.

Methods: This retrospective cohort study utilizes administrative records from the Pennsylvania Department of Corrections for adults ≥18 years diagnosed with opioid use disorder (OUD) released in either 2015 or 2018.

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While numerous needle-based continuous glucose monitoring (CGM) devices have been available today, the insufficient enzyme immobilization on monitoring sensor severely limited the detection sensitivity of CGM devices. This manuscript describes here a high-sensitivity continuous glucose sensor (CGS) by engineering a porous 3D cellulose/carbon nanotube (CNT) network on the working electrode, which subcutaneously increases the detection enzyme capacity and thus significantly enhances the signal intensity and sensitivity. Furthermore, a tapered needle made of soft resin is engraved into three distinct microgrooves where the glucose oxidase (GOD)-modified working electrode, Pt-modified counter electrode, and Ag/AgCl-modified reference electrode are separately constructed inside the microgrooves.

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