Current and projected incidence rates of pancreatic cancer in 43 countries: an analysis of the Cancer Incidence in Five Continents database.

Objective: The aetiology of pancreatic cancer is complex, and there is limited research on its incidence. We aimed to investigate the incidence trends of pancreatic cancer in 43 countries and predict trends up to 2030.

Methods: The annual incidence of pancreatic cancer was obtained from the Cancer Incidence in Five Continents database, which comprises 108 cancer registries from 43 countries.

Striking Improvement of N Selectivity in NH Oxidation Reaction on FeO-Based Catalysts via SiO Doping.

The emission of NH has been reported to pose a serious threat to both human health and the environment. To efficiently eliminate NH, catalysts for the selective catalytic oxidation of NH (NH-SCO) have been intensively studied. FeO-based catalysts were found to exhibit superior NH oxidation activity; however, the low N selectivity made it less attractive in practical applications.

Escape of Kdm6a from X Chromosome Is Detrimental to Ischemic Brains via IRF5 Signaling.

The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our previous study has suggested that the X escapee genes Kdm6a and Kdm5c are involved in microglial activation after stroke in aged mice.

Coexistence of tubulocystic renal cell carcinoma and polycythemia vera: A rare case report.

Tubulocystic Renal Cell Carcinoma (TC-RCC) and Polycythemia Vera (PV) are both infrequent medical conditions. TC-RCC was recognized as a distinct subtype of kidney cancer by the World Health Organization in 2016, while PV is a rare myeloproliferative neoplasm distinguished by the excessive production of red blood cells. The coexistence of these two conditions is exceptionally uncommon and lacks comprehensive documentation.

Sulfate residuals on Ru catalysts switch CO reduction from methanation to reverse water-gas shift reaction.

Efficient heterogeneous catalyst design primarily focuses on engineering the active sites or supports, often neglecting the impact of trace impurities on catalytic performance. Herein, we demonstrate that even trace amounts of sulfate (SO) residuals on Ru/TiO can totally change the CO reduction from methanation to reverse-water gas shift (RWGS) reaction under atmospheric pressure. We reveal that air annealing causes the trace amount of SO to migrate from TiO to Ru/TiO interface, leading to the significant changes in product selectivity from CH to CO.

A nanoscale natural drug delivery system for targeted drug delivery against ovarian cancer: action mechanism, application enlightenment and future potential.

Ovarian cancer (OC) is one of the deadliest gynecological malignancies in the world and is the leading cause of cancer-related death in women. The complexity and difficult-to-treat nature of OC pose a huge challenge to the treatment of the disease, Therefore, it is critical to find green and sustainable drug treatment options. Natural drugs have wide sources, many targets, and high safety, and are currently recognized as ideal drugs for tumor treatment, has previously been found to have a good effect on controlling tumor progression and reducing the burden of metastasis.

Improved high-current-density hydrogen evolution reaction kinetics on single-atom Co embedded in an order pore-structured nitrogen assembly carbon support.

Single-atom catalysis is a subcategory of heterogeneous catalysis with well-defined active sites. Numerous endeavors have been devoted to developing single-atom catalysts for industrially applicable catalysis, including the hydrogen evolution reaction (HER). High-current-density electrolyzers have been pursued for single-atom catalysts to increase active-site density and enhance mass transfer.

Modifying the Substrate-Dependent Pd/FeO Catalyst-Support Synergism with ZnO Atomic Layer Deposition.

Low-loading Pd supported on FeO nanoparticles was synthesized. A common nanocatalyst system with previously reported synergistic enhancement of reactivity that is attributed to the electronic interactions between Pd and the FeO support. FeO-selective precoalescence overcoating with ZnO atomic layer deposition (ALD), using Zn(CHCH) and HO as precursors, dampens competitive hydrogenation reactivity at FeO-based sites.

Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase.

Telomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while in precancerous lesions of cancer, telomeres in cells are usually significantly shortened.

Engineering a PtCu Alloy to Improve N Selectivity of NH-SCO over the Pt/SSZ-13 Catalyst.

Improving the N selectivity is always a great challenge for the selective catalytic oxidation of ammonia (NH-SCO) over noble-metal-based (especially Pt) catalysts. In this work, Cu as an efficient promoter was introduced into the Pt/SSZ-13 catalyst to significantly improve the N selectivity of the NH-SCO reaction. A PtCu alloy was formed in the PtCu/SSZ-13 catalyst, as confirmed by X-ray diffraction, transmission electron microscopy, energy dispersive spectrometry mapping, and X-ray absorption spectroscopy results.

Pd-CeO catalyst facilely derived from one-pot generated Pd@Ce-BTC for low temperature CO oxidation.

Due to the capacity to offer abundant catalytic sites within porous solids featuring high surface areas, metal-organic frameworks (MOFs) and their derivatives have garnered considerable attention as prospective catalysts in environmental catalysis. To promote the industrial application of MOFs, there is an urgent need for an effective and environmental-friendly preparation approach. Breaking through the limitation of the traditional two-step preparation method that Pd was introduced to the already prepared Ce-BTC (Pd/Ce-BTC, BTC = 1, 3, 5 benzenetricarboxylate), in this work, we present a novel one-pot solvothermal method for synthesizing the Pd material supported by Ce-BTC (Pd@Ce-BTC).

Brain endothelial CD200 signaling protects brain against ischemic damage.

Ischemic stroke induced inflammatory responses contribute significantly to neuronal damage and stroke outcomes. CD200 ligand and its receptor, CD200R, constitute an endogenous inhibitory signaling that is being increasingly recognized in studies of neuroinflammation in various central nervous system disorders. CD200 is a type 1 membrane glycoprotein that is broadly expressed by endothelia and neurons in the brain.

Fine-Tuning of Pt Dispersion on AlO and Understanding the Nature of Active Pt Sites for Efficient CO and NH Oxidation Reactions.

Fine-tuning the dispersion of active metal species on widely used supports is a research hotspot in the catalysis community, which is vital for achieving a balance between the atomic utilization efficiency and the intrinsic activity of active sites. In this work, using bayerite Al(OH) as support directly or after precalcination at 200 or 550 °C, Pt/AlO catalysts with distinct Pt dispersions from single atoms to clusters (. 2 nm) were prepared and evaluated for CO and NH removal.

Hydroxyls on CeO Support Promoting CuO/CeO Catalyst for Efficient CO Oxidation and NO Reduction by CO.

Transition metal catalysts, such as copper oxide, are more attractive alternatives to noble metal catalysts for emission control due to their higher abundance, lower cost, and excellent catalytic activity. In this study, we report the preparation and application of a novel CuO/CeO catalyst using a hydroxyl-rich Ce(OH) support for CO oxidation and NO reduction by CO. Compared to the catalyst prepared from a regular CeO support, the new CuO/CeO catalyst prepared from the OH-rich Ce(OH) (CuO/CeO-OH) showed significantly higher catalytic activity under different testing conditions.

Potential chemoprotective effects of active ingredients in on doxorubicin-induced cardiotoxicity: a systematic review of and studies.

Background: Recently, attention has been paid to the protective properties of active ingredients in (AISM) against organ toxicity induced by chemotherapy drugs. Purpose of the present systematic review is to evaluate the chemoprotective effects and mechanisms of AISM on models of doxorubicin-induced cardiotoxicity (DIC).

Methods: According to the PRISMA guideline, the current systematic review was conducted in the Web of Science, PubMed, Embase, and the Cochrane Library to collect all relevant studies on "the role of AISM on DIC" published up until May 2023.

SDC1 and ITGA2 as novel prognostic biomarkers for PDAC related to IPMN.

The existing biomarkers are insufficient for predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). Intraductal papillary mucinous neoplasm (IPMN) is a precursor to PDAC; therefore, identifying biomarkers from differentially expressed genes (DEGs) of PDAC and IPMN is a new and reliable strategy for predicting the prognosis of PDAC. In this study, four datasets were downloaded from the Gene Expression Omnibus database and standardized using the R package 'limma.

Unique CeZrO Superstructure Promoting the NO Adsorption-Selective Catalytic Reduction (AdSCR) Performance of the WO/CeZrO Catalyst.

Selective catalytic reduction of NO by NH (NH-SCR) for diesel emission control at low temperatures is still a great challenge due to the limit of the urea injection threshold and inferior SCR activity of state-of-the-art catalyst systems below 200 °C. Fabricating bifunctional catalysts with both low temperature NO adsorption-storage capacity and medium-high temperature NO reduction activity is an effective strategy to solve the issues mentioned above but is rarely investigated. Herein, the WO/CeZrO (W/CZ) catalyst containing the CeZrO pyrochlore structure was successfully developed by a simple H reduction method, not only showing superior NO adsorption-storage ability below 180 °C but also exhibiting excellent NH-SCR activity above 180 °C.

Tuning the Interaction between Platinum Single Atoms and Ceria by Zirconia Doping for Efficient Catalytic Ammonia Oxidation.

Aiming at the development of an efficient NH oxidation catalyst to eliminate the harmful NH slip from the stationary flue gas denitrification system and diesel exhaust aftertreatment system, a facile ZrO doping strategy was proposed to construct Pt/CeZrO catalysts with a tunable Pt-CeO interaction strength and Pt-O-Ce coordination environment. According to the results of systematic characterizations, Pt species supported on CeZrO were mainly in the form of single atoms when ≥ 0.7, and the strength of the Pt-CeO interaction and the coordination number of Pt-O-Ce bond (CN) on Pt/CeZrO showed a volcanic change as a function of the ZrO doping amount.

Ultrathin Atomic Layer Deposited AlO Overcoat Stabilizes AlO-Pt/Ni-Foam Hydrogenation Catalysts.

Galvanic exchange seeds the growth of Pt nanostructures on the Ni foam monolith. Subsequent atomic layer deposition of ultrathin AlO followed by annealing under air affords supported Pt catalysts with ultralow loading (0.020 ppm).