Integrating processing factors and large-scale cabbage cultivation to understand the fate tendency and health risks of tolfenpyrad using deterministic and probabilistic models.

Understanding the negative effects of agrochemicals on the environment and human health is indispensable for achieving green agriculture. In this study, the optimized UHPLC-MS/MS method achieved a highly sensitive quantification of tolfenpyrad in cabbage within 4.04 min.

Peptide amphiphiles alleviate myocardial endoplasmic reticulum stress to enhance cardiomyocyte-macrophage communication and promote macrophage M2 polarization.

Myocardial ischemia-reperfusion (I/R) injury represents a significant clinical challenge with limited therapeutic options. Single-cell RNA sequencing and bioinformatics analyses have revealed complex cellular interactions within cardiac tissue, highlighting the crucial role of cardiomyocytes in intercellular communication. During I/R injury, cardiomyocytes experience severe endoplasmic reticulum (ER) stress, leading to detrimental intercellular communication that affects surrounding cells, particularly promoting the transformation of macrophages toward a pro-inflammatory phenotype.

Escin ameliorates CUMS-induced depressive-like behavior via BDNF/TrkB/CREB and TLR4/MyD88/NF-κB signaling pathways in rats.

Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with brain inflammation and neuronal damage. Derived from the Aesculus chinensis Bunge fruit, escin has shown anti-inflammatory and neuroprotective effects. However, its potential as a treatment for MDD is unclear.

Spliceosomal GTPase Eftud2 deficiency-triggered ferroptosis leads to Purkinje cell degeneration.

Spliceosomal GTPase elongation factor Tu GTP binding domain containing 2 (EFTUD2) is a causative gene for mandibulofacial dysostosis with microcephaly (MFDM) syndrome comprising cerebellar hypoplasia and motor dysfunction. How EFTUD2 deficiency contributes to these symptoms remains elusive. Here, we demonstrate that specific ablation of Eftud2 in cerebellar Purkinje cells (PCs) in mice results in severe ferroptosis, PC degeneration, dyskinesia, and cerebellar atrophy, which recapitulates phenotypes observed in patients with MFDM.

Integrated omics characterization reveals reduced cancer indicators and elevated inflammatory factors after thermal ablation in non-small cell lung cancer patients.

Background: Thermal ablation is a minimally invasive treatment for non-small cell lung cancer (NSCLC). Aside from causing an immediate direct tumour cell injury, the effects of thermal ablation on the internal microenvironment are unknown. This study aimed to investigate the effects of thermal ablation on the plasma internal environment in patients with NSCLC.

Optimized Two-Photon Imaging by Stimuli-Responsive Peptide Self-Assembly Facilitates Self-Assisted Counteraction of Cisplatin-Resistance in Cancer Cells.

Accurate diagnosis and effective treatment of tumors remain significant clinical challenges. While fluorescence imaging is essential for tumor detection, it has limitations in terms of specificity, penetration depth, and emission wavelength. Here, we report a novel glutathione (GSH)-responsive peptide self-assembly excimer probe () that optimizes two-photon tumor imaging and self-assisted counteraction of the cisplatin resistance in cancer cells.

No-interfered and visual evaluation of global warming impacts on phytoplankton-based copper bioavailability and then carbon sequestration.

Global warming has an increasingly serious impact on the ecological environment. Copper bioavailability plays an important physiological role in revealing the mechanism of carbon cycle, photosynthesis, and respiration. Here we reported a multifunctional carbon quantum dots fluorescence probe for no-interfered and visual determination of phytoplankton-based intracellular Cu(II), glucose, and reactive oxygen species (ROS).

Dysregulated proteasome activity and steroid hormone biosynthesis are associated with mortality among patients with acute COVID-19.

The persistence of coronavirus disease 2019 (COVID-19)-related hospitalization severely threatens medical systems worldwide and has increased the need for reliable detection of acute status and prediction of mortality. We applied a systems biology approach to discover acute-stage biomarkers that could predict mortality. A total 247 plasma samples were collected from 103 COVID-19 (52 surviving COVID-19 patients and 51 COVID-19 patients with mortality), 51 patients with other infectious diseases (IDCs) and 41 healthy controls (HCs).

One-to-Nine Single Spectroscopic Intelligent Probe for Risk Assessment of Multiple Metals in Drinking Water.

26% of the world's population lacks access to clean drinking water; clean water and sanitation are major global challenges highlighted by the UN Sustainable Development Goals, indicating water security in public water systems is at stake today. Water monitoring using precise instruments by skilled operators is one of the most promising solutions. Despite decades of research, the professionalism-convenience trade-off when monitoring ubiquitous metal ions remains the major challenge for public water safety.

Adaptive enzyme-responsive self-assembling multivalent apelin ligands for targeted myocardial infarction therapy.

Microvascular dysfunction following myocardial infarction exacerbates coronary flow obstruction and impairs the preservation of ventricular function. The apelinergic system, known for its pleiotropic effects on improving vascular function and repairing ischemic myocardium, has emerged as a promising therapeutic target for myocardial infarction. Despite its potential, the natural apelin peptide has an extremely short circulating half-life.

Transcriptome analysis of porcine oocytes during postovulatory aging.

Decreased oocyte quality is a significant contributor to the decline in female fertility that accompanies aging in mammals. Oocytes rely on mRNA stores to support their survival and integrity during the protracted period of transcriptional dormancy as they await ovulation. However, the changes in mRNA levels and interactions that occur during porcine oocyte maturation and aging remain unclear.

ZnInS-based multi-interface coupled photocatalyst for efficient photothermal synergistic catalytic hydrogen evolution.

Photothermal synergistic catalysis is a novel technology that converts energy. In this study, ZnInS with S-vacancy (ZIS-Vs) is combined with Nickel, Nickle Oxide and Carbon Nanofiber aggregates (Ni-NiO@CNFs) to create a multi-interface coupled photocatalyst with double Schottky barrier, double channel and mixed photothermal conversion effect. Theoretical calculation confirms that the Gibbs free energy (ΔG) of the S-scheme heterojunction in the composite material is -0.

Carbon sequestration reduced by the interference of nanoplastics on copper bioavailability.

Microplastics (MPs) have been recognized as a serious new pollutant, especially nanoplastics (NPs) pose a greater threat to marine ecosystem than larger MPs. Within these ecosystems, phytoplankton serve as the foundational primary producers, playing a critical role in carbon sequestration. Copper (Cu), a vital cofactor for both photosynthesis and respiration in phytoplankton, directly influences their capacity to regulate atmospheric carbon.

Agronomic, physiological and transcriptional characteristics provide insights into fatty acid biosynthesis in yellowhorn ( Bunge) during fruit ripening.

Yellowhorn ( Bunge) is an oil-bearing tree species in northern China. In this study, we used yellowhorn from Heilongjiang to analyze the morphological and physiological changes of fruit development and conducted transcriptome sequencing. The results showed that the fruit experienced relatively slow growth from fertilization to DAF20 (20 days after flowering).

Phosphorus forms and zinc concentrations affect the physiological ecology and sinking rate of Thalassiosira weissflogii.

The combined effects of phosphorus (P) forms and zinc (Zn) concentrations on diatom silicification remain unclear. In this study, we investigate the effects of different Zn concentrations on the growth, cellular silicon content and sinking rate of Thalassiosira weissflogii under different P forms. The results showed that under the dissolved inorganic phosphorus (DIP) treatments, the specific growth rate of T.

Potent inhibitors targeting cyclin-dependent kinase 9 discovered virtual high-throughput screening and absolute binding free energy calculations.

Due to the crucial regulatory mechanism of cyclin-dependent kinase 9 (CDK9) in mRNA transcription, the development of kinase inhibitors targeting CDK9 holds promise as a potential treatment strategy for cancer. A structure-based virtual screening approach has been employed for the discovery of potential novel CDK9 inhibitors. First, compounds with kinase inhibitor characteristics were identified from the ZINC15 database virtual high-throughput screening.

Fate characteristics and risk identification of thifluzamide in buckwheat across China: Analytical method development, occurrence, and health assessment.

Elaborating on the fate tendency of thifluzamide (thiazole-amide fungicide) in buckwheat based on nationwide application is vital for grain security and human health based on nationwide application. A rapid and sensitive analytical method was developed to trace thifluzamide in buckwheat matrices using an ultrahigh-performance liquid chromatography-tandem triple quadrupole mass spectrometer (UHPLC-MS/MS), with a retention time of 2.90 min and limit of quantitation (LOQ) of 0.

Baicalin-peptide supramolecular self-assembled nanofibers effectively inhibit ferroptosis and attenuate doxorubicin-induced cardiotoxicity.

Doxorubicin, an anthracycline chemotherapeutic agent, elicits a deleterious cardiotoxicity known as doxorubicin-induced cardiomyopathy (DIC) that circumscribes its chemotherapy utility for malignancies. Recent empirical evidence implicates ferroptosis, an iron-dependent form of regulated cell death, as playing a pivotal role in the pathogenesis of DIC. We postulated that anti-ferroptosis agents may constitute a novel therapeutic strategy for mitigating DIC.

Supramolecular Peptide Amphiphile Nanospheres Reprogram Tumor-associated Macrophage to Reshape the Immune Microenvironment for Enhanced Breast Cancer Immunotherapy.

Tumor immunotherapy has become a research hotspot in cancer treatment, with macrophages playing a crucial role in tumor development. However, the tumor microenvironment restricts macrophage functionality, limiting their therapeutic potential. Therefore, modulating macrophage function and polarization is essential for enhancing tumor immunotherapy outcomes.

Three sesquiterpene lactones suppress lung adenocarcinoma by blocking TMEM16A-mediated Ca-activated Cl channels.

Transmembrane protein TMEM16A, which encodes calcium-activated chloride channel has been implicated in tumorigenesis. Overexpression of TMEM16A is associated with poor prognosis and low overall survival in multiple cancers including lung adenocarcinoma, making it a promising biomarker and therapeutic target. In this study, three structure-related sesquiterpene lactones (mecheliolide, costunolide and dehydrocostus lactone) were extracted from the traditional Chinese medicine and identified as novel TMEM16A inhibitors with comparable inhibitory effects.

Effects of polyethylene and polyvinyl alcohol on growth and protease activity of Acanthopagrus schlegelii juveniles.

Many plastic products are used in aquaculture. Studying the toxicological effects of plastics differing in water solubility on marine organisms can provide valuable information. In this study, different amounts of polyvinyl alcohol (PVA) and polyethylene (PE) films were embedded in the feed and fed to Acanthopagrus schlegelii.

Role of Steric Effects on Rates of Hydrogen Atom Transfer Reactions.

The influence of steric effects on the rates of hydrogen atom transfer (HAT) reactions between oxyradicals and alkanes is explored computationally. Quantum chemical density functional theory computations of transition states show that activation barriers and reaction enthalpies are both influenced by bulky substituents on the radical but very little by substituents on the alkane. The activation barriers remain roughly correlated with reaction enthalpies via the Evans-Polanyi relationship even when steric repulsion effects become important, although dispersion effects sometimes stabilize transition states.

A simplified log creep model for describing triaxial creep of mélange rocks.

This study aims to develop a simplified log creep model (LgCM) for predicting the triaxial three-stage creep behaviors of mélange rocks. The model was deduced from the creep deformation mechanism by considering the competition of strain rate hardening and damage during the steady and accelerating creep stages and was described by two simplified fractal functions. The model was then compared with the previous creep models on the uniaxial three-stage creep data of mortar, rock salt, and sandy shale, as well as the triaxial low-stress creep data of claystone.

Effects of phosphorus species and zinc stress on growth and physiology of the marine diatom Thalassiosira weissflogii.

Human activities, including industrial and agricultural production, as well as domestic sewage discharge, have led to heavy metal pollution and eutrophication in coastal waters. This has caused a deficiency of dissolved inorganic phosphorus (DIP), but an excess dissolved organic phosphorus (DOP) and high concentrations of zinc. However, the impact of high zinc stress and different phosphorus species on primary producers remains unclear.