Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer.

Immune-modulating peptides have shown potential as novel immune-stimulating agents which enhance the secretion of anticancer cytokines in vitro. However, fast clearance from blood hampers the ability of such peptides to accumulate in the tumour and results in limited therapeutic efficacy in animal studies. To address the fast blood clearance, this work reports the development and validation of a novel polymeric nanoparticle delivery system for the efficient localization of an immunomodulating peptide in the tumour microenvironment (TME).

Temperature influence on matric suction in unsaturated soils: experimental insights.

Temperature is a critical factor affecting the matric suction of unsaturated soils. This study employed a simple and time-saving method to investigate the influences of temperature and moisture content on the temperature dependence of matric suction in loess and sand soils. Based on experimental data, the fitting performance of three data-fitting models-Brooks-Corey, van Genuchten, and Fredlund-Xing -was evaluated at temperatures above 0 °C.

[Xinfeng Capsule alleviates RA-FLS-induced angiogenesis in HUVEC cells by inhibiting the lncRNA HOTAIR/PI3K/AKT pathway].

Objective To investigate the effect of serum containing Xinfeng capsule (XFC) on the angiogenesis of human umbilical vein endothelial cells (HUVEC) induced by rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and its mechanism of action. Methods An in vitro co-culture model of RA-FLS and HUVEC was established. Serum containing XFC was prepared by oral gavage of SD rats.

Estimating the Risk of Women Anemia Associated with Ozone Exposure Across 123 Low- and Middle-Income Countries: A Multicenter Epidemiological Study.

Anemia in women of reproductive age (WRA) presents a pressing global public health issue, particularly in low- and middle-income countries (LMICs). Yet, the potential impact of ozone (O) exposure on anemia remains uncertain. The study included 1,467,887 eligible women from 83 surveys of 45 LMICs between 2004 to 2020.

p53 and Ki-67 combined with periodic acid-Schiff staining for the diagnosis of early stage esophageal squamous cell carcinoma lesions in biopsy specimens.

Background: Esophageal cancer is highly prevalent in China, predominantly represented by squamous cell carcinoma. This retrospective study sought to evaluate the diagnostic efficacy of four staining protocols in identifying early stage esophageal squamous cell carcinoma (ESCC).

Methods: A consecutive series of ninety biopsy samples of esophageal mucosa, collected retrospectively from March 2016 to December 2019, were obtained at Beijing Chao-Yang Hospital, a tertiary care facility in Beijing, China.

AH-6809 mediated regulation of lung adenocarcinoma metastasis through NLRP7 and prognostic analysis of key metastasis-related genes.

Introduction: Lung adenocarcinoma (LUAD) has become one of the leading causes of cancer-related deaths globally, with metastasis representing the most lethal stage of the disease. Despite significant advances in diagnostic and therapeutic strategies for LUAD, the mechanisms enabling cancer cells to breach the blood-brain barrier remain poorly understood. While genomic profiling has shed light on the nature of primary tumors, the genetic drivers and clinical relevance of LUAD metastasis are still largely unexplored.

Structural Characterization and Hypoglycemic Activity of a Glycoprotein Extracted from .

Glycoproteins are special proteins and important nutrients for hypoglycemic activity. However, the structure of glycoprotein (AAG) and the stability of its hypoglycemic activity during simulated digestion (including saliva, gastral and intestine digestion) in vitro are still unknown. In this study, AAG-3 was isolated from .

Combined pollution of soil by heavy metals, microplastics, and pesticides: Mechanisms and anthropogenic drivers.

Soil is the foundation of terrestrial ecosystems and a critical resource for agricultural activities. This study investigated internal mechanism and interaction of heavy metals, pesticides (atrazine, pyrimazole and chlorpyrifos) and microplastics in soil. Specifically, certain sampling points exhibited elevated levels of individual heavy metals (Cd, Cr, Zn), exceeding the screening values, while both microplastics and pesticides demonstrated high variability, increasing the potential ecological risks.

Effects of porosity on ultrasonic attenuation coefficient, shear properties and failure mechanisms of CF/EP laminates.

Carbon fiber reinforced epoxy composite (CF/EP) laminates with porosity ranged from 0% to 2.5% were prepared under inadequate curing pressures, and then applied to ultrasonic, metallographic and mechanical testings. Porosity was evaluated using an ultrasonic attenuation model, which was established by taking consideration of surface losses, material attenuation coefficient and void attenuation coefficient.

Study on the Interaction between Polyol Glycerol and Flavor Compounds of Baijiu: A New Perspective of Influencing Factors of Baijiu Flavor.

The interaction among flavor compounds is a crucial determinant of Baijiu's flavor. Yet, the interaction between glycerol, a prominent polyol in Baijiu, and volatile flavor compounds remains elusive. The effect of glycerol concentration on the volatility of 13 Baijiu flavor compounds was analyzed by GC-IMS and GC-MS.

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging.

To systematically characterize the loss of tissue integrity and organ dysfunction resulting from aging, we produced an in-depth spatial transcriptomic profile of nine tissues in male mice during aging. We showed that senescence-sensitive spots (SSSs) colocalized with elevated entropy in organizational structure and that the aggregation of immunoglobulin-expressing cells is a characteristic feature of the microenvironment surrounding SSSs. Immunoglobulin G (IgG) accumulated across the aged tissues in both male and female mice, and a similar phenomenon was observed in human tissues, suggesting the potential of the abnormal elevation of immunoglobulins as an evolutionarily conserved feature in aging.

AuCePt porous hollow cascade nanozymes targeted delivery of disulfiram for alleviating hepatic insulin resistance.

As the pathophysiological basis of type 2 diabetes mellitus (T2DM), insulin resistance (IR) is closely related to oxidative stress (OS) and inflammation, while nanozymes have a good therapeutic effect on inflammation and OS by scavenging reactive oxygen species (ROS). Hence, AuCePt porous hollow cascade nanozymes (AuCePt PHNs) are designed by integrating the dominant enzymatic activities of three metallic materials, which exhibit superior superoxide dismutase/catalase-like activities, and high drug loading capacity. In vitro experiments proved that AuCePt PHNs can ultra-efficiently scavenge endogenous and exogenous ROS.

Validation of a breast cancer assay for radiotherapy omission: an individual participant data meta-analysis.

Background: There are currently no molecular tests to identify individual breast cancers where radiotherapy (RT) offers no benefit. Profile for the Omission of Local Adjuvant Radiotherapy (POLAR) is a 16-gene molecular signature developed to identify low risk cancers where RT will not further reduce recurrence rates.

Methods: An individual participant data meta-analysis was performed in 623 cases of node-negative ER+/HER2-negative early breast cancer enrolled in three RT randomized trials for whom primary tumor material was available for analysis.

Effect of modifications on structure, physicochemical properties and lead ions adsorption behavior of dietary fiber of Flammulina velutipes.

The health effects of dietary fiber have been widely concerned, which are closely related to physicochemical properties. This study focused on soluble dietary fiber of Flammulina velutipes (FDF), evaluated the effects of modifications on structural characterization, the physicochemical properties and the heavy metal adsorption characteristics, and further clarified underlying mechanisms on Pb adsorption behavior of FDFs. The results showed the modifications of extrusion and cellulase improved the yield of FDFs, increased the release of active groups and enhanced the adsorption ability in vitro.

Bifunctional fluorine doped Ru/RuO clusters with dynamic electron modification and strong metal-support interaction boost proton exchange membrane water electrolyzer.

The sluggish kinetics and inherent instability over the Ru/RuO clusters are still enormous challenges in proton exchange membrane (PEM) water electrolyzer. Herein, we innovatively report synergistic modulation of dynamic electron modification and strong metal-support interaction (SMSI) to activate and stabilize bifunctional fluorine doped Ru/RuO clusters anchored on carbon nanotube (CNT), thus achieving efficient and stable acidic overall water splitting. Theoretical and experimental studies found that surface metal-fluorine modification layer could dynamically regulate the interfacial electronic environment to stabilize and activate multiple active Ru species; and the SMSI between Ru/RuO cluster and CNT maintains stable electronic environment for dynamic electron modification and avoids migrating or shedding of active species in acidic environment.

High Genetic Diversity and Limited Regional Population Differentiation in Populations of from Plantations.

causes a serious and widespread disease known as Calonectria leaf blight in plantations of southern China. Little is known regarding the population biology or reproductive biology of this pathogen in the affected areas. The aims of this study were to investigate the genetic diversity, population structure, and reproductive mode of .

Exploring gelation properties and structural features on 3D printability of compound proteins emulsion gels: Emphasizing pH-regulated non-covalent interactions with xanthan gum.

Rational regulation of pH and xanthan gum (XG) concentration has the potential to modulate interactions among macromolecules and enhance 3D printability. This study investigated non-covalent interactions between XG and other components within compound proteins emulsion gel systems across varying pH values (4.0-8.

Pre-treatment plasma retinol binding protein 4 level and its change after treatments predict systemic treatment response in psoriasis patients.

Background: Retinol binding protein 4 (RBP4) is a mediator of inflammation and related to skin lesion formation, which suggests its engagement in psoriasis pathology and progression. This study intended to explore the change in RBP4 after systemic treatments, and its ability to predict treatment response in psoriasis patients.

Methods: This prospective study enrolled 85 psoriasis patients and 20 healthy subjects.

Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic.

Backgrounds: Mycoplasma pneumoniae (M. pneumoniae) is a common pathogen causing respiratory diseases in children. This study aimed to characterize epidemiological and disease severity shifts of M.