[Clinical characteristics and prognosis of childhood acute lymphoblastic leukemia with CD123 expression].

Objectives: To investigate the expression of CD123 in children with acute lymphoblastic leukemia (ALL) and its effect on the clinical characteristics and prognosis of children with B-lineage acute lymphoblastic leukemia (B-ALL).

Methods: A retrospective analysis was conducted on the clinical data of 251 children with ALL who were admitted to the Department of Hematology and Oncology, Children's Hospital of Kunming Medical University, from December 2019 to June 2022. According to the expression of CD123 at initial diagnosis, the children were divided into CD123 group and CD123 group, and the two groups were compared in terms of clinical characteristics and treatment outcome.

FK228 suppress the growth of human malignant pleural mesothelioma tumor independent to epithelioid or non-epithelioid histology.

Human malignant pleural mesothelioma (hMPM) is an aggressive, rare disease with a poor prognosis. Histologically, MPM is categorized into epithelioid, biphasic, and sarcomatoid subtypes, with the epithelioid subtype generally displaying a better response to treatment. Conversely, effective therapies for the non-epithelioid subtypes are limited.

Effect of land use on soil properties, microbial abundance and diversity of four different crop lands in central Myanmar.

Unlabelled: Changing land use systems impact on local edaphic factors and microbial abundance and diversity, however, the information on it in central Myanmar's soils is still lacking. Therefore, soils with four different land uses were analyzed; WAP (soil from perennial tree orchard), PNON (soil from crop rotation of peanut and onion), SESA (soil from mono-crop of sesame) and CHON (soil from mono-crop of onion for 3 years consecutively). Soil organic carbon (SOC), total nitrogen (TN), dissolved organic carbon (DOC), ammonium nitrogen (NH -N) and pH showed the highest in PNON soil, which suggested crop rotation with high fertilizer input and irrigation had positive effect on the edaphic factors of soil.

New members of fluorescent 1,8-naphthyridine-based BF2 compounds: selective binding of BF2 with terminal bidentate N^N^O and N^C^O groups and tunable spectroscopy properties.

Intensely luminescent 1,8-naphthyridine-BF2 complexes 1-9 containing terminal bidentate N^N^O and/or N^C^O groups are synthesized and structurally characterized by X-ray diffraction, electrospray ionization mass spectrometry, (1)H and (19)F NMR spectroscopy and elemental analysis. Complexes 1-4 are synthesized from 2-acetamino-1,8-naphthyridine derivatives by a facile route. Selective bonding modes and the chemical stability of complexes 5 and 6 obtained by reacting BF3·Et2O with 1,8-naphthyridine derivatives bearing dual-functional groups (N^C^O and N^N^O) are investigated by crystal structure analysis and time-dependent density functional theory calculations.

[Studies on the mechanism of the interaction between hydrazide-podophyllic Ni(II), Co(II), Zn(II) metal complexes and DNA].

The mechanism of the interaction between hydrazide-podophyllic (HDPP) metal (Me) complexes and calf thymus (ct) DNA in Tris buffer (pH 7.08) was studied by viscosity measurements, electronic absorption, gel electrophoresis, and ethidium bromide (EB) fluorescence spectroscopy. The results from varied experiments show that the intensity of the maximal absorption peaks from absorption spectra is weakened in the presence of DNA compared with that in the absence of DNA.

[Studies on the interaction of the metal complex of hydrazide of podophyllic acid with DNA].

The interaction between the metal complex of hydrazide of podophyllic acid and calf thymus (CT) DNA was studied by using absorption spectra, fluorescence spectra and DNA heat denaturation. It was found that the intensity of the maximal absorption peaks from absorption spectra is weakened in the presence of the metal complex of hydrazide of podophyllic acid compared with that in the absence of the metal complex. All the experimental results show that the intercalation mode was proved to exist between HDPP-Ni complexes and CT DNA.

DNA Binding and cleavage activity of Ni(II) complex with all-trans retinoic acid.

Absorption, fluorescence spectral, cyclic voltammetry and agarose gel electrophoresis studies have been carried out on the interaction of Ni(II) complex with all-trans retinoic acid ([Ni(RA)(2)(H(2)O)(2)] * H(2)O) with DNA. The results indicate that the [Ni(RA)(2)(H(2)O)(2)] * H(2)O can more effectively promote the cleavage of plasmid DNA than that of all-trans retinoic acid (HRA) and Ni(II) at physiological pH and temperature, which may be one of the reasons why the inhibitory effect of [Ni(RA)(2)(H(2)O)(2)] * H(2)O on the human bladder line EJ cells is much greater than that of retinoic acid. It was found that the process of plasmid DNA cleavage was sensitive to ionic strength and pH, however, these radical scavengers almost had no effect on the DNA cleavage reaction.

Synthesis, crystal structure, and magnetic properties of the first nonanuclear lanthanide(III)-copper(II) complexes of macrocyclic oxamide [NaLn(2)Cu(6)] (macrocyclic oxamide = 1,4,8,11-tetraazacyclotradecanne-2,3-dione, Ln = Pr, Nd).

Two new nonanuclear lanthanide(III)-copper(II) complexes of macrocyclic oxamide [NaPr(2)(CuL)(6)(H(2)O)(6)](ClO(4))(6)Cl small middle dot6H(2)O (1) and [NaNd(2)(CuL)(6)(H(2)O)(6)](ClO(4))(6)Cl small middle dot8H(2)O (2) have been synthesized and characterized by means of elemental analysis, IR, and electronic spectra, where L = 1,4,8,11-tetraazacyclotradecanne-2,3-dione. The crystal structures of the two complexes have been determined. The structures of 1 and 2 consist of nonanuclear cations, perchlorate and chloride anions, and water molecules.